Seoul National University Hospital

This study looks at two different IV fluids given during heart surgery to see which one is safer for the kidneys. About 1,292 adults having heart surgery will be randomly assigned to receive either hydroxyethyl starch or a balanced crystalloid fluid. The main goal is to see which…

This study tests two different methods for slowly reducing steroid medication in people with rheumatoid arthritis whose disease is stable. About 206 adults will be randomly assigned to either a split-dose or a 1 mg-by-1 mg tapering schedule and followed for six months. The goal i…

This study looks at 172 adults with advanced kidney cancer to see if having surgery to remove the kidney tumor before or after immunotherapy (ipilimumab and nivolumab) leads to better outcomes. Participants will be randomly assigned to either upfront surgery followed by immunothe…

This study tests whether naltrexone, a drug already used for addiction, can help reduce nonsuicidal self-injury in people aged 16 and older. About 150 participants will receive either naltrexone or a placebo, and researchers will track how often self-injury occurs. The goal is to…

This study tests whether adding a short course of chemotherapy (capecitabine) after standard chemoradiation but before a minor surgery (local excision) improves outcomes for people with stage I rectal cancer. About 292 participants will be randomly assigned to receive either stan…

This study compares two approaches for people with chronic coronary syndrome (narrowed heart arteries): a procedure to open the arteries plus medication, versus medication alone. About 2,300 participants will be randomly assigned to one of the two groups, and researchers will tra…

This study tests a combination of three drugs (nemtabrutinib, bortezomib, and rituximab) in people with Waldenstrom's macroglobulinemia, a rare blood cancer. The goal is to see how well the treatment shrinks tumors and controls the disease. About 19 adults who have not been treat…

This study tests a method called PIPAC, which sprays chemotherapy directly into the abdomen as a fine mist. It is for women with ovarian cancer that has come back and no longer responds to standard platinum-based chemo. The goal is to see if this approach is safe and can control …

This early-stage trial tests a new combination of three drugs (golcadomide, poseltinib, and rituximab) for adults with relapsed or refractory large B-cell lymphoma, a type of blood cancer. The study aims to see if this combination can shrink tumors in more than 30% of the 20 part…

This study looks at a special pacing method called Bachmann bundle pacing for people with heart failure and a reduced pumping ability. Participants already need an implantable defibrillator. The goal is to see if this pacing improves heart function and quality of life. About 120 …

This study compares standard open surgery to a newer, less invasive surgery using a stapler to prevent cancer spread in people with early-stage cervical cancer (IB2-IIA1). About 494 participants will be randomly assigned to one of the two surgeries. The goal is to see if the less…

This study compares an AI-enhanced electrocardiogram (ECG) to the standard echocardiogram for detecting heart problems in 1,724 adults with atrial fibrillation. The goal is to see if the AI-ECG approach is just as safe and effective, potentially reducing the need for more complex…

This study tests whether playing special sounds called binaural beats through earphones during breast reconstruction surgery can lower the dose of the anesthetic drug remimazolam needed. 88 adults will be randomly assigned to hear binaural beats or silence. The goal is to see if …

This study looks at whether people with Parkinson's disease can safely follow a home exercise program using video instructions. Fifteen participants will exercise at home while a camera monitors their movements and gives real-time feedback. The goal is to see if this approach hel…

This study aims to find the smallest amount of IV fluid that can prevent low blood pressure during planned C-sections under spinal anesthesia. About 45 healthy pregnant women at full term will take part. Each will receive a specific fluid volume while getting a standard blood-pre…

This study compares two types of general anesthesia for nasal surgery to see which leads to a calmer, smoother wake-up. 204 adults will be randomly assigned to receive either remimazolam (reversed with flumazenil) or propofol. The main goal is to measure how often patients experi…

This study looks at whether giving a single dose of the steroid dexamethasone during nasal surgery can improve sleep quality on the first night after the operation. About 102 adults having nasal surgery under general anesthesia will be randomly assigned to receive either dexameth…

This study tests whether a 12-week music therapy program can improve how children and teens (ages 10-19) with cochlear implants perceive sound and enjoy music. About 25 participants will use a smartphone app for therapy and be followed for 12 more weeks. The goal is to see if thi…

This early-stage study tests a new way to deliver medication directly into the ear for people with hearing loss that hasn't improved with standard treatments. About 26 adults with sudden, Meniere's, or noise-induced hearing loss will receive the injection. Researchers will check …

This study tests two noninvasive ultrasound devices to measure liver stiffness and inflammation in people with fatty liver disease. About 95 adults will get same-day scans with both machines to see if results match. The goal is to find a painless way to assess liver damage withou…

This study explores why some people with a chronic lung infection called NTM-PD get worse while others stay stable. Researchers will analyze immune cells from the lungs and blood, along with nutrition and body composition, in 50 adults. The goal is to find better ways to predict …

This study looks at immune cells found in lung fluid from 60 adults with advanced lung cancer. Researchers want to see if these cells can give extra information about how well a patient might respond to treatment, beyond what standard tumor tests show. The goal is to improve pred…

This study compares two types of video laryngoscope blades (hyperangulated vs. Macintosh) to see which one helps doctors place a breathing tube more successfully on the first try in adults having surgery with general anesthesia. About 524 participants will be randomly assigned to…

This study will check how accurate the Dexcom G7 continuous glucose monitor is in 100 adults having heart surgery. Participants will wear the device during their operation so researchers can compare its readings to standard lab tests. The goal is simply to measure performance, no…

This study will create a model to predict complications after major surgery in adults aged 65 and older. Researchers will collect data on physical activity, nutrition, mood, body composition, and physical function from 520 participants before surgery. The goal is to identify thos…