Pfizer

This study tested a single-dose gene therapy called SB-525 for adults with severe hemophilia A. The goal was to see if it was safe and if it could teach the liver to produce its own missing clotting factor (Factor VIII) for years. If successful, this one-time treatment could prov…

This study tested a new vaccine designed to protect older adults from Respiratory Syncytial Virus (RSV). Researchers compared the vaccine to a placebo (a dummy shot) in 378 healthy Korean adults aged 60 and older to check for side effects and measure the body's immune response. P…

This study aimed to see if it's safe and effective to give two important vaccines—one for RSV (a respiratory virus) and one for shingles—at the same time to adults aged 50 and older. Researchers enrolled 526 participants to check for side effects and measure the body's immune res…

This study tested a new vaccine designed to protect infants against 20 strains of bacteria that can cause pneumonia, ear infections, and meningitis. Healthy babies around 2 months old in India and Taiwan received either the new 20-strain vaccine or an older 13-strain vaccine in f…

This study tested the safety and immune response of two pneumococcal vaccines (20vPnC and 13vPnC) in Chinese adults aged 50 and older who had never received a pneumococcal vaccine before. Four hundred participants received one dose of either vaccine and were monitored for six mon…

This study looked at how well the Prevnar 13 (PCV13) vaccine works to prevent pneumonia in adults living with HIV. Researchers analyzed the health records of over 350,000 people to compare rates of pneumonia between those who received the vaccine and those who did not. The goal w…

This study tested the safety and immune response of an RSV vaccine packaged in multidose vials, which are easier to store and transport. It compared the multidose version, which contains a preservative, to the standard single-dose version without a preservative. The trial involve…

This study tested a new vaccine candidate, VLA15, designed to prevent Lyme disease. It involved 600 healthy participants aged 5 to 65 to see how safe the vaccine was and how well it triggered an immune response. Researchers compared different vaccination schedules and included pe…

This study tested the safety and immune response of a new pneumococcal vaccine in healthy toddlers aged 12 to 15 months. The trial involved 225 children who received either one or two doses of the vaccine over 6-8 months. Researchers monitored for side effects and measured antibo…

This study tested the safety and immune response of a new mRNA vaccine designed to protect against pandemic influenza strains. Healthy adults received either the experimental vaccine, a standard flu shot, or a placebo. Researchers monitored participants for over a year to see how…

This study tested the safety of a new type of flu vaccine that uses self-amplifying RNA technology. Pfizer enrolled 440 healthy adults aged 18-49 to receive either the experimental vaccine, a standard flu shot, or a placebo. The main goal was to check for side effects and see how…

This study tested new mRNA-based flu vaccines to see if they are safe and how well they trigger an immune response. It involved 1,202 generally healthy adults who received either a new mRNA vaccine or a standard approved flu shot. Researchers monitored participants for about six …

This study tested whether a single injection combining a licensed COVID-19 vaccine and a licensed flu vaccine is safe and works as well as getting two separate shots. It involved 644 healthy adults aged 50 and older. Researchers compared the combo shot to getting the vaccines sep…

This study tested the safety of an experimental Lyme disease vaccine called VLA15 in healthy children ages 5-17. Over 3,500 participants received either the vaccine or a placebo saltwater shot over two years. Researchers compared side effects between groups to see if the vaccine …

This study tested if adding a new drug called palbociclib to a standard hormone therapy (letrozole) was better at controlling advanced breast cancer. It involved 340 Asian, postmenopausal women whose cancer had spread and who had not yet received treatment for their advanced dise…

This large, completed Phase 3 trial tested whether adding the drug enzalutamide to standard hormone therapy could help men with a high-risk form of prostate cancer. The cancer had stopped responding to standard treatment but had not yet spread. The main goal was to see if the dru…

This study aimed to monitor the safety of the drug Tafamidis (VyndaMx®) in Indian patients with a specific heart condition called ATTR-CM, where a protein clumps in the heart. Six adult patients who were already prescribed the drug participated, and researchers tracked any side e…

This study tested a new way of giving the drug elranatamab to people with multiple myeloma that has returned or stopped responding to treatment. The main goal was to check the safety of starting with lower 'step-up' doses and then giving the drug less often. Researchers enrolled …

This study monitored the safety of Lorbrena, an approved lung cancer medication, in real-world patients after it became available. It tracked 1,290 patients with non-small cell lung cancer to better understand side effects, specifically focusing on brain-related issues and liver …

This study looked at real-world medical records to compare two common drugs for advanced prostate cancer: enzalutamide and abiraterone. Researchers analyzed data from over 2,700 men who had not yet received chemotherapy to see which treatment was associated with longer survival a…

This study tested the drug inotuzumab ozogamicin in 44 Chinese adults with a specific type of acute lymphoblastic leukemia (ALL) that had returned or not responded to prior treatments. The goal was to confirm how well the drug works and how safe it is for this patient group. The …

This study tested whether a daily oral capsule called ritlecitinib could help restore skin color (repigmentation) in people with nonsegmental vitiligo. Over 600 adults and adolescents took either the drug or a placebo for one year to see if it improved the appearance of vitiligo …

This study explored whether two different doses of the acid-reducing drug pantoprazole could safely keep erosive esophagitis (damage to the food pipe from stomach acid) healed in children aged 1 to 17. The 43 participants, who already had their esophagitis healed, were randomly a…

This study tested the long-term safety and effectiveness of an oral medication called abrocitinib for people aged 12 and older with moderate to severe eczema (atopic dermatitis). Over 3,100 participants who had completed a previous related trial took either a 100 mg or 200 mg pil…

This study compared how well different drug combinations work for controlling rheumatoid arthritis in real-world patients. Researchers followed over 9,000 people to see whether taking certain arthritis drugs alone or with another medication called methotrexate provided better sym…

This Phase 3 study tested whether rimegepant, taken every other day, could help prevent migraines in Chinese adults with frequent episodes. The 787 participants were randomly assigned to receive either the active drug or a placebo pill for 12 weeks, with some continuing for anoth…

This study monitored the safety and effectiveness of the approved drug BESPONSA in real-world patients in Japan. It included 421 adults and children with a specific type of acute lymphocytic leukemia that had returned or was not responding to other treatments. The main goal was t…

This study looked back at how well the oral drug lorlatinib worked for 73 Taiwanese patients with a specific genetic type of advanced lung cancer. All participants had already tried at least one other treatment that stopped working. The goal was to see how effective and safe lorl…

This study looked at how well the medicine Tafamidis 61mg worked for Korean patients with a specific heart muscle disease called ATTR-CM. It observed 13 patients who were already prescribed this medicine in real-world settings, not as part of a controlled trial. The goal was to c…

This study tested whether a medication called rimegepant, taken regularly, could help prevent migraines in Japanese adults who get them frequently. Nearly 500 participants were randomly assigned to receive either rimegepant or a placebo pill for 12 weeks to see if it safely reduc…

This study aimed to learn about the safety and real-world effects of the approved COVID-19 medicine Paxlovid. Over 3,300 participants aged 12 and up who were prescribed Paxlovid were followed for 28 days. Researchers watched for any side effects and checked whether their COVID-19…

This study monitored the safety and effectiveness of the drug Besponsa in Korean patients with a hard-to-treat form of blood cancer (B-cell ALL). It was a required safety check after the drug was approved for sale, involving 108 patients who received the drug as part of their nor…

This study observed how well the existing drug tofacitinib worked for people with psoriatic arthritis in their normal, everyday treatment. It followed 116 patients for a year to see if the drug could reduce their disease activity, help them achieve remission, and improve their qu…

This study monitored the safety and effectiveness of the breast cancer drug IBRANCE in real-world medical settings in Korea. It followed over 550 women with advanced, hormone-sensitive breast cancer who were prescribed the drug as part of their normal care. The goal was to collec…

This study tested the long-term safety of taking rimegepant daily to prevent episodic migraine attacks. Researchers followed 441 adults with frequent migraines for up to a year to monitor side effects and how well they tolerated the medication. The goal was to understand the risk…

This study looked back at existing medical records to compare how long patients lived after receiving two different treatments for advanced breast cancer. It included 779 Medicare patients aged 65 and older whose cancer had already spread when first diagnosed. Researchers analyze…

This large, completed Phase 3 trial tested whether a new two-drug combination (LGX818 + MEK162) could better control advanced melanoma with a specific BRAF gene mutation. It compared the combo against a standard single-drug treatment (vemurafenib) and against one of the new drugs…

This study tested whether adding the drug enzalutamide to standard hormone therapy (exemestane) could better control advanced breast cancer. It involved 247 postmenopausal women whose cancer had specific hormone receptors but normal HER2 levels. Researchers compared the combinati…

This study collected information on the safety and effectiveness of a biosimilar version of an existing rheumatoid arthritis drug when used in regular medical practice. It involved 77 patients with rheumatoid arthritis who were starting treatment with this specific medication. Th…

This study tested whether adding a new drug called PF-07220060 to standard hormone therapy (letrozole) works better than letrozole alone to shrink breast tumors before surgery. It involved 121 postmenopausal women with a specific type of breast cancer (HR-positive, HER2-negative)…

This study followed children and teenagers with juvenile arthritis who had already been taking the medication tofacitinib in earlier trials. Its main goal was to check the long-term safety and side effects of the drug over several years. Researchers also monitored whether the tre…

This study tested the safety and effectiveness of a two-drug combination (encorafenib + binimetinib) for people with advanced non-small cell lung cancer that has a specific genetic change called a BRAF V600 mutation. It enrolled 98 adults whose cancer had spread and who had recei…

This study looked back at existing medical records to see if a high dose of the drug tafamidis (Vyndamax) could slow down nerve damage in people with a specific type of heart disease called mixed-phenotype ATTR-CM. It involved 50 adults who had already been taking the drug for at…

This study observed 152 French adults with moderate-to-severe ulcerative colitis who were prescribed the drug tofacitinib by their doctors. The goal was to see how well the drug controlled their symptoms and improved their quality of life over two years in a real-world setting, o…

This study tested whether a growth hormone medicine (somatropin) is safe and can improve body composition in Japanese children and adults with Prader-Willi Syndrome (PWS). The 33 participants, who were either new to treatment or had been on it, were monitored for 12 months to see…

This completed Phase 3 trial tested whether inclacumab, given as an IV infusion every 12 weeks, could reduce the frequency of painful vaso-occlusive crises in people with sickle cell disease. The study involved 241 participants aged 12 and older who had experienced 2-10 painful c…

This early-stage study tested the safety and early effects of a new topical medicine, PF-07905428, for acne. It involved 52 healthy adults and people with moderate to severe acne, who applied the gel to their face or back daily for up to 28 days. The main goal was to see if the t…

This study tested a new drug called Elranatamab for Chinese patients with a severe form of multiple myeloma that no longer responds to standard treatments. The drug is an injection that works by activating the body's own immune system to attack the cancer cells. The trial had two…

This study monitored the safety and effectiveness of the lung cancer drug Vizimpro in real-world patients in Korea after it was approved for use. Doctors observed 188 patients with a specific genetic type of advanced lung cancer who were prescribed the drug as part of their norma…

This study tested a drug called lorlatinib for Chinese patients with an advanced form of lung cancer (ALK-positive NSCLC) that had spread and worsened despite treatment with other targeted drugs. The goal was to see if lorlatinib could shrink tumors and control the disease. The t…

This study observed how well two approved kidney cancer drugs work together in real-world European clinics. It followed over 550 patients with advanced kidney cancer who received sunitinib first, then axitinib if needed. Researchers tracked how long the treatments kept the cancer…

This study tested a new weight-loss medicine called PF-07976016 to see if it's safe and effective for adults with obesity. Researchers compared people taking the medicine to those taking a placebo (inactive pill) to measure changes in body weight and side effects. The trial invol…

This study tested whether taking the migraine prevention medication rimegepant daily or every other day was better than a placebo at reducing the number of migraine days. Over 1,400 adults with episodic migraine participated. The goal was to find the most effective and safe dosin…

This study observed how the breast cancer drug palbociclib was used and how patients responded in real-world healthcare settings in Israel. Researchers followed 559 adults with metastatic breast cancer who were already receiving palbociclib as part of their standard care. The goa…

This study aimed to understand how the body processes, absorbs, and eliminates an experimental medicine called PF-07104091. It involved 9 healthy adult male participants who received the medicine both by mouth and through a vein. Researchers measured how much of the drug entered …

This early-stage study aimed to understand how a new drug called Ibuzatrelvir is processed by the body. It involved 12 healthy Chinese adult volunteers who received a single dose. The main goal was to measure how much of the drug gets into the blood, how long it stays there, and …

This study looked at how well different versions of the Pfizer-BioNTech COVID-19 vaccine worked in the real world. Researchers used existing health records from nearly 20 million people in California and Louisiana to see how well the vaccines prevented severe COVID-19, hospital v…

This study looked back at the medical records of over 300 adults in Europe who were treated for serious fungal infections. The goal was to see how well the antifungal drug isavuconazole worked, how safe it was, and how it was used in everyday hospital practice. No new treatments …

This early-stage study aims to understand how a new Pfizer drug is absorbed and processed by the body. Eight healthy adult volunteers will take the drug by mouth and through an IV, with a tiny radioactive marker added to track its path. Researchers will collect blood, urine, and …

This study analyzed the health records of over 8 million people in Taiwan to understand the real-world burden of COVID-19. Researchers looked at who was most likely to be hospitalized, need intensive care, or have a fatal outcome. They also compared outcomes for patients who rece…

This early-stage study aimed to check the safety and how the body processes a single dose of an experimental medicine called PF-07264660 in healthy Chinese adults. Twelve participants received either the medicine or a placebo (inactive substance) through an IV drip and were monit…

This early-stage study aimed to understand how the body processes and eliminates an investigational antiviral drug called PF-07304814. Five healthy volunteers received a single, low-dose infusion containing a tiny, safe amount of radioactive tracer. Researchers then carefully mea…

This study analyzed survey data from over 1,300 people with migraines to compare two common acute treatments: rimegepant (like Nurtec) and triptans. Researchers looked at which treatment led to better patient satisfaction, quality of life, and less impact on work and daily activi…

This study looked back at medical records to understand how long Japanese patients with a specific type of advanced breast cancer lived after receiving a two-drug treatment. It involved 42 patients who had previously participated in an earlier clinical trial. The goal was to gath…

This study aimed to understand how a specific breast cancer drug combination (palbociclib) is used and how well it works in real-world medical practice across Africa and the Middle East. Researchers observed 185 patients with advanced breast cancer who were already prescribed thi…

This study looked back at real-world medical records to understand how long men with advanced prostate cancer that still responds to hormone therapy actually stay on two common medications: apalutamide and enzalutamide. Researchers analyzed data from about 1,300 men who were trea…

This study aimed to see if wearable activity trackers could reliably measure how children walk and sleep in their daily lives. Healthy kids aged 3 to 17 wore devices on their wrist and waist during lab activities and at home for about two weeks. The goal was to collect data to he…

This study aimed to understand how the body absorbs, breaks down, and eliminates an experimental drug called PF-07220060. It involved 12 healthy adult men who received a single dose, either by mouth or by injection. Researchers collected blood, urine, and stool samples to track e…

This study looked back at the medical records of over 1,000 men in Finland with advanced prostate cancer that had spread. Its goal was to understand who gets this disease, what treatments they receive, and how well those treatments work in everyday practice. By analyzing this rea…

This study looked back at medical records to understand how patients with advanced breast cancer fared when treated with specific drug combinations in regular community oncology clinics. It did not test new treatments but aimed to learn from real-world experiences about treatment…

This study looked back at the medical records of 507 veterans with prostate cancer who started taking the oral medication relugolix. The goal was to understand the types of patients who use this newer drug, their health characteristics, and their previous treatments. It did not t…

This study looked back at survey data from US dermatologists and their adult patients with severe alopecia areata, a condition causing significant hair loss. It aimed to understand the real-world experiences of patients taking a medication called ritlecitinib and their doctors' s…

This study looked back at the medical records of over 12,500 people in Korea with atrial fibrillation (AF), a common heart rhythm problem. Researchers analyzed how the condition's features changed over time and linked those changes to serious health outcomes like stroke and death…

This study aimed to see how two slightly different versions of an experimental pill are absorbed by the body. It involved 12 healthy adults who each took both pill versions. The main goal was to measure and compare the drug levels in the blood to help decide which version to use …

This study tested new, less invasive devices for collecting blood samples at home compared to standard needle draws in a clinic. Fourteen healthy adults received a single dose of a nasal spray migraine medication (zavegepant). Researchers compared blood levels of the drug measure…

This study looked back at the health records of over 2 million French adults with atrial fibrillation (AF), a common heart rhythm problem. Researchers compared how many people had strokes, major bleeding, or died between those who took blood-thinning medication (anticoagulants) a…

This study aimed to understand the economic impact of COVID-19 on the workforce by measuring missed workdays and associated costs. It analyzed over 131,000 US workers with mild-to-moderate COVID-19 who were at high risk for severe disease, comparing those who took the antiviral P…

This early study tested how a potential eczema medicine moves through the body when made in different forms (fast-release vs. slow-release pills). Researchers gave 12 healthy adults five different versions of the pill, some with food and some without, to see which formula is abso…

This early Pfizer study tested how two common medicines—an immunosuppressant and an antibiotic—affect the way the body processes a new drug called PF-07328948. It involved 26 healthy adult volunteers who stayed in a clinic to have their blood levels and safety monitored. The goal…

This study aimed to collect detailed information on how well current standard treatments work for adults with severe hemophilia A or B. Researchers tracked bleeding rates and treatment use in 212 participants for at least six months. This data serves as a crucial baseline to comp…

This study analyzed existing medical records to understand how well different immunotherapy combinations work for people with advanced kidney cancer that has spread. Researchers looked at data from 494 patients who received these modern treatments first, followed by other therapi…

This early-stage study aimed to understand how carbamazepine, an existing medication, changes how the body processes an experimental drug called PF-07220060. It involved 14 healthy adults who took both drugs in a specific sequence. Researchers measured drug levels in the blood to…

This study aimed to understand how the breast cancer drug palbociclib is absorbed and processed in the body of Chinese patients. It involved 26 postmenopausal Chinese women with a specific type of advanced breast cancer. The main goal was to measure drug levels in the blood after…

This study looked at how long men 65 and older with advanced prostate cancer that responds to hormone therapy stayed on newer hormone treatments. Researchers analyzed Medicare insurance claims data from over 3,000 men who were prescribed these medications by their regular doctors…

This study looked back at health insurance data to compare the total healthcare costs for cancer patients who developed dangerous blood clots (VTE). Researchers analyzed over 7,300 patients to see if treatment with the drug apixaban was associated with different costs than treatm…

This study aimed to understand how two different tablet versions of an experimental Pfizer drug (PF-07248144) are absorbed by the body. It involved 24 healthy adults who took single doses of a coated and an uncoated tablet. The main goal was to compare the drug levels in the bloo…

This was Pfizer's first study in people for an experimental oral medicine called PF-06414300. The main goal was to check its safety and see how the body absorbs and processes it. The study involved 63 healthy adults who took either the drug or a placebo dummy pill. Researchers cl…

This study aimed to understand how much of a new drug called PF-07976016 gets into the body and how it is processed. It involved 8 healthy male volunteers over about 12 weeks. The main goal was to measure how the drug is absorbed, broken down, and eliminated.

This study tested whether a new, more concentrated version of an experimental drug tablet works the same way in the body as the current version. It involved 35 healthy adults who each took a single dose of both tablet types after a meal, with the order decided randomly. The goal …

This study looked back at medical records to understand how well a three-drug combination (tucatinib, trastuzumab, and capecitabine) works for people with advanced HER2+ breast cancer after they have already received a different treatment called T-DXd. It involved 86 patients fro…

This study aimed to understand how a new drug, PF-07054894, is absorbed, processed, and eliminated by the body. It involved 10 healthy adult male volunteers who received the drug orally and sometimes by injection, with a tiny radioactive tag to help track it. The main goal was to…