Pfizer

This study tested new modified RNA (modRNA) flu vaccines in 1,202 healthy adults aged 18 and older. The goal was to see if the vaccines are safe and how well they trigger the body's immune defenses. Participants received either a modRNA vaccine or an approved flu shot, and were f…

This study tested whether giving a combined COVID-19 and flu vaccine as one shot is safe and helps the body build defenses against both viruses. It involved 644 healthy adults aged 50 and older. Researchers measured side effects and antibody levels to see how well the combo worke…

This study tested a new mRNA vaccine designed to protect against a future flu pandemic. Researchers gave the vaccine or a placebo to 157 healthy adults aged 18–49 and 65–84. The main goal was to check safety and how well the vaccine triggers an immune response. Results will help …

This study tested a new vaccine (VLA15) to prevent Lyme disease, a tick-borne illness. About 12,500 healthy people aged 5 and older in high-risk areas received either the vaccine or a placebo. Researchers tracked how many got Lyme disease to see if the vaccine works and is safe.

This study tested a new vaccine called VLA15 to prevent Lyme disease, which is spread by tick bites. Researchers gave the vaccine to 625 healthy people aged 5 to 65, using two different shot schedules, to see which was safer and triggered a stronger immune response. The goal is t…

This study looked at the safety of the RSV vaccine Abrysvo in pregnant women and their infants in Japan. About 500 pregnant women received the vaccine, and researchers tracked any side effects in the mothers for 28 days after vaccination and in the babies for 28 days after birth.…

This study tested an RSV vaccine in 453 healthy women aged 18-49 to see if a multidose vial with a preservative works as well as a single-dose vial. Participants received one shot and were followed for about 6 weeks. The goal was to compare safety and immune response between the …

This early-stage study tested a new type of flu vaccine called a self-amplifying RNA (saRNA) vaccine in 440 healthy adults aged 18 to 49. The goal was to see if the vaccine is safe and how the body responds to it. Participants received either the saRNA vaccine, a licensed flu sho…

This study tested a new vaccine (20vPnC) that protects against 20 types of pneumonia-causing bacteria. It involved 400 Chinese adults aged 50 and older who had never received a pneumonia vaccine. Researchers compared the new vaccine's safety and immune response to an existing 13-…

This study tested a new RSV vaccine in 378 adults aged 60 and older in Korea. The goal was to see if the vaccine is safe and helps the body build defenses against RSV, a virus that can cause serious breathing problems. Participants received either the vaccine or a placebo and wer…

This study tested whether a new Lyme disease vaccine (VLA15) is safe for healthy children ages 5 to 17. Over 3,500 children received either the vaccine or a placebo (saltwater shot) and were monitored for about 2 years. The goal was to see if the vaccine causes any side effects l…

This study tested a new pneumococcal vaccine in 225 healthy toddlers aged 12-15 months. The goal was to see if the vaccine is safe and triggers a strong immune response. Children received either one or two doses and were monitored for side effects like redness, fever, and irritab…

This study looked at whether giving the RSV vaccine and the shingles vaccine at the same time is safe and works well in adults aged 50 and older. About 526 healthy or stable participants received either both vaccines together or one alone. Researchers measured immune responses an…

This study checked how well the Prevnar 13 (PCV13) vaccine works to prevent pneumonia and related infections in adults with HIV. Researchers looked at health records of over 350,000 people with HIV to compare those who got the vaccine with those who did not. The goal was to see i…

This study tested a new vaccine called MenABCWY that protects against five types of meningococcal bacteria, which can cause serious infections like meningitis. About 309 healthy teens aged 11 to 14 received two doses of the vaccine, either 12 or 36 months apart. The goal was to s…

This study tested a new vaccine (20vPnC) that protects against 20 types of pneumonia-causing bacteria. About 541 healthy infants in India and Taiwan received either the new vaccine or an existing one over 4 doses. Researchers checked for side effects and measured immune responses…

This study looked at how safe and effective the drug Cresemba is for adults in Korea with serious fungal infections like invasive aspergillosis or mucormycosis. Researchers tracked side effects and how well patients responded to treatment. The goal was to gather real-world safety…

This study tested a drug called enzalutamide in 1401 men with a type of prostate cancer that has stopped responding to hormone therapy but has not yet spread. The goal was to see if enzalutamide could delay the cancer from spreading to other parts of the body. Participants took e…

This study tested whether a combination of two targeted drugs (LGX818 and MEK162) works better than standard treatments for people with advanced melanoma that has a specific BRAF gene change. About 900 patients took part. The goal was to see if the combo could slow cancer growth …

This study tested whether adding the drug palbociclib to standard hormone therapy (letrozole) helps slow the growth of advanced breast cancer in Asian women who have gone through menopause. About 340 women with a specific type of breast cancer (ER-positive, HER2-negative) that ha…

This study looked at how safe and effective Vyndaqel is for people with a rare heart condition called transthyretin amyloid cardiomyopathy. Over 1,200 patients in Japan were observed during regular medical care. The main goal was to track side effects and see how many patients di…

This study looked at the long-term safety and effectiveness of a daily pill called abrocitinib for people aged 12 and older with moderate to severe eczema. Over 3,000 participants who had already completed a prior study took either 100 mg or 200 mg of abrocitinib for up to 92 wee…

This study tested a cancer drug called elranatamab in 86 people with multiple myeloma that returned or didn't respond to prior treatments. The drug was given as a shot under the skin, starting with low doses that gradually increased to reduce side effects. The goal was to see if …

This study tested whether adding the experimental drug PF-07220060 to the standard hormone therapy letrozole works better than letrozole alone in postmenopausal women with a common type of breast cancer (HR+/HER2-). About 121 women who had not yet received treatment took the pill…

This study looked at the long-term safety of the drug tofacitinib in children with juvenile idiopathic arthritis (JIA). About 300 kids who had already taken tofacitinib in earlier studies continued taking it to see how safe it was over time. The main goal was to track side effect…

This study tested the safety and effectiveness of somatropin, a growth hormone, in 33 Japanese people with Prader-Willi syndrome. The goal was to see if the treatment could improve lean body mass (muscle) over 12 months. Participants included both children and adults, and the stu…

This study tested a trastuzumab biosimilar (a copy of the original drug) in 8 people with advanced or recurrent HER2-positive stomach cancer. The goal was to confirm the drug's safety and how well it works in real-world use. Researchers tracked side effects and tumor shrinkage us…

This study tested a drug called elranatamab in 39 Chinese patients with multiple myeloma that stopped responding to standard treatments. The drug works by helping the body's immune system attack the cancer cells. The goal was to see if it is safe and can shrink or control the can…

This study tested a new gene therapy (SB-525) in 13 adults with severe hemophilia A, a bleeding disorder. The goal was to see if a single infusion could safely raise the body's own clotting factor levels and reduce bleeding episodes. Participants were monitored for up to 5 years …

This study looked at the safety and effectiveness of the drug Besponsa in 108 people in Korea with a relapsed or hard-to-treat type of blood cancer called B-cell ALL. Researchers tracked side effects and how well the drug worked in everyday medical practice. The goal was to confi…

This study followed 152 adults with moderate to severe ulcerative colitis for two years to see how well tofacitinib works in real-life medical practice. Researchers measured symptom improvement and whether patients could avoid surgery or stronger medications. The goal was to unde…

This study looked at how well the drug tafamidis works for Korean patients with a rare heart condition called ATTR-CM. Researchers tracked 13 patients who were already prescribed the drug to see if it improved heart function, symptoms, and quality of life. The goal was to underst…

This study looked at whether taking rimegepant every day or every other day can help prevent migraines in people who have 4 to 14 migraine days per month. Over 1400 adults participated, and researchers compared both dosing schedules to a placebo. The goal was to see which schedul…

This study looked at how safe and effective IBRANCE is for women with advanced or metastatic breast cancer in everyday medical practice. It involved 552 women in Korea who were already taking the drug as part of their routine care. Researchers tracked side effects and how well th…

This study tested whether adding enzalutamide to the hormone therapy exemestane helps control advanced breast cancer that is hormone receptor-positive and HER2-normal. About 247 postmenopausal women who had already tried some treatments took part. The main goal was to see if the …

This study followed 116 adults with moderate to severe psoriatic arthritis who were starting tofacitinib as part of their normal care. Researchers tracked disease activity, remission rates, and quality of life over 12 months. The goal was to see how well the drug works in real-wo…

This study tested a drug called inclacumab in 241 people aged 12 and older with sickle cell disease who often have painful vaso-occlusive crises. The drug works by blocking a protein that helps blood cells stick together, aiming to reduce how often these pain episodes happen. Res…

This study checked how safe and effective the COVID-19 medicine PAXLOVID is in real-world use. Over 3,300 people aged 12 and older who took PAXLOVID were watched for 28 days. Researchers tracked side effects and whether the infection got worse. The goal was to see how well the me…

This study tested a drug called lorlatinib in 109 people in China with a specific type of advanced lung cancer (ALK-positive non-small cell lung cancer) that had gotten worse after treatment with other ALK-targeting medicines. The goal was to see if lorlatinib could shrink tumors…

This study tested an experimental drug called ritlecitinib in over 600 adults and teens with nonsegmental vitiligo, a condition that causes white patches on the skin. The goal was to see if the pill could safely restore skin color over 52 weeks compared to a placebo. Participants…

This study tested a drug called rimegepant to see if it could prevent migraines in Japanese adults. About 496 people took either the drug or a placebo for 12 weeks. The main goal was to see if the drug reduced the number of migraine days per month. Results showed a decrease in mi…

This study looked at how well the drug avelumab works as a maintenance treatment for people with advanced or metastatic bladder cancer (urothelial carcinoma) after initial chemotherapy. Researchers tracked 596 patients in France to measure overall survival and other outcomes in r…

This study looked at the safety of taking rimegepant every day to prevent episodic migraines. 441 adults with a history of migraines took the daily pill, and researchers tracked side effects. The goal was to see how well people tolerated long-term daily use of this medication.

This study looked at how the drug palbociclib works in the body of Chinese women with a certain type of advanced breast cancer (ER+, HER2-). 26 postmenopausal women took the drug to measure its levels and check for side effects. The goal was to gather information needed for Chine…

This study looked at how safe and effective a biosimilar version of infliximab (a drug that blocks inflammation) is for people with rheumatoid arthritis. 77 patients were treated and monitored for side effects and changes in disease activity. The goal was to gather real-world inf…

This study looked at how well the drug lorlatinib works for people with advanced non-small cell lung cancer that has a specific gene change (ALK) and has stopped responding to earlier treatments. Researchers tracked 73 adults in Taiwan who took lorlatinib pills at home. The goal …

This study looked at how well a high dose of the drug tafamidis (61 mg daily) slows nerve damage in people with a heart condition called ATTR-CM. Researchers reviewed medical records of 50 patients who had already taken the drug for at least a year. The goal was to see if the dru…

This study looked at the safety of BESPONSA, a drug already approved for a type of blood cancer called acute lymphocytic leukemia that has come back or not responded to treatment. Researchers tracked 421 patients in Japan who received the drug as part of their regular care. The m…

This study tested a combination of two targeted drugs, encorafenib and binimetinib, in 98 people with a specific type of advanced lung cancer (BRAFV600-mutant non-small cell lung cancer). The goal was to see if the drugs could shrink tumors. Participants had either not received p…

This study looked at over 9,000 people with rheumatoid arthritis to compare how well different treatments work in everyday life. Researchers compared drugs like TNF inhibitors and tofacitinib, taken alone or with methotrexate. The goal was to find which approach controls disease …

This study tested a new medicine called PF-07976016 in 263 adults with obesity to see if it is safe and helps with weight loss. Participants received either the study drug or a placebo (fake pill) for a period of time. The main goal was to measure changes in body weight and any s…

This study looked at the safety of a medicine called VyndaMx (tafamidis) for people with a rare heart condition called transthyretin amyloid cardiomyopathy (ATTR-CM). Six adults in India took the medicine by mouth, and doctors tracked any side effects for 6 months. The goal was t…

This study looked at the long-term safety and effectiveness of an experimental drug (PF-06651600) for adults and teens aged 12 and older with alopecia areata, a condition that causes patchy or total hair loss. Over 1,000 participants received the drug for up to several years, and…

This study tested a drug called inotuzumab ozogamicin in 44 adults from China whose acute lymphoblastic leukemia (ALL) had come back or stopped responding to other treatments. The goal was to see if the drug could make the cancer disappear or reduce it significantly. The drug wor…

This study tested whether a tablet called rimegepant can help prevent migraines in Chinese adults aged 18 and older with at least a one-year history of migraines. About 787 participants took either rimegepant or a placebo every other day for 12 weeks, with some continuing for ano…

This early-stage study tested a new topical medicine (PF-07905428) for acne in 52 healthy volunteers and people with moderate to severe acne. The main goal was to check safety and how the body processes the drug. Participants applied the cream daily for 2 to 4 weeks and were moni…

This study tested a drug called rimegepant for quickly treating migraine headaches in adults who cannot use triptans (common migraine drugs) due to side effects, lack of effectiveness, or heart risks. Over 800 participants took either rimegepant or a placebo and reported their pa…

This study looked back at medical records of women with advanced or metastatic HR+/HER2- breast cancer who received palbociclib combined with hormone therapy in community clinics. The goal was to see how doctors actually prescribe these treatments and what outcomes patients exper…

This study checks if a new, stronger tablet of the medicine atirmociclib works the same as the current version. About 35 healthy adults aged 18-65 will take a single dose of each tablet after a meal, in random order. The goal is to see how the body absorbs and processes the medic…

This early-stage study tested a new medicine called PF-07940369 in 30 healthy adults to see if it is safe and how the body processes it. Participants took the medicine or a placebo by mouth for 14 days. The goal was to gather safety information for future studies, not to treat an…

This study looked at how healthy men process the experimental drug PF-07104091. Nine participants took the drug by mouth and later received a tiny radioactive dose to track where it goes. The goal was to measure how much drug enters the blood and how it leaves the body through ur…

This study looked back at medical records of 42 Japanese patients with a certain type of advanced breast cancer (HR+/HER2-). All patients had been treated with the drugs palbociclib and letrozole in an earlier study. The goal was to see how long they lived after starting treatmen…

This study looked at over 131,000 high-risk adults in the US who had mild-to-moderate COVID-19 during the Omicron wave. Researchers compared those who took the antiviral Paxlovid with those who did not, measuring how many work days they missed and the costs of that lost work. The…

This study looked back at health records of over 2 million people in France with atrial fibrillation (an irregular heartbeat) between 2016 and 2020. Researchers compared those who took blood thinners (oral anticoagulants) to those who did not, to see how many had strokes, major b…

This study looked at whether a wearable device called ActiGraph can accurately record walking patterns and physical activity in healthy children aged 3 to 17. Kids wore the device as a watch and a belt while doing simple tasks like walking at different speeds, rolling dice, and m…

This study reviewed medical records of over 1,100 breast cancer patients in Japan to understand how they are treated with the drug palbociclib. Researchers looked at how often patients had blood tests and how long they stayed on the medication. The goal was to describe real-world…

This study looked at how people with migraine feel about two types of acute medications: rimegepant and triptans. Researchers used data from a large national health survey in the US, focusing on over 1,300 adults who reported a migraine diagnosis. They compared treatment satisfac…

This study looked at medical records from 494 adults with advanced kidney cancer to see how well first-line immunotherapy combinations work and what happens when patients switch to other treatments later. Researchers tracked how long patients stayed on each treatment, how they re…

This study looked at how satisfied patients and dermatologists were with ritlecitinib, a newer treatment for severe alopecia areata, compared to older treatments. Researchers analyzed survey data from 123 adults in the United States. The goal was to understand patient experiences…

This study looked at how carbamazepine, a drug that can change how the body processes other medications, affects the processing of PF-07248144. Twelve healthy adults took PF-07248144 alone and then with carbamazepine. Researchers measured drug levels in the blood to understand th…

This study used a large database to observe the safety and effectiveness of the drug Ibrance (palbociclib) in adult women with advanced or metastatic breast cancer. Researchers looked at side effects and how well the treatment worked in real-world settings, outside of a clinical …

This study reviewed medical charts of 307 adults in five European countries who were treated with isavuconazole for invasive aspergillosis or mucormycosis. Researchers tracked how patients responded to treatment at 6, 12, and 24 weeks, including symptom improvement, imaging resul…

This study looked at how the drug carbamazepine changes the way the body handles another medicine called PF-07220060. Fourteen healthy adults took PF-07220060 alone and then again after taking carbamazepine for several days. Blood samples were collected to measure drug levels, he…

This study gave 5 healthy adults a single dose of the drug PF-07304814 mixed with a tiny radioactive tracer to see how the body breaks it down and gets rid of it. Researchers measured the drug and its byproducts in blood, urine, and stool over time. The goal was to understand the…

This study looked at health records from nearly 20 million people in California and Louisiana to see how well different versions of the Pfizer-BioNTech COVID-19 vaccine prevent severe illness, hospitalization, and death. No new participants were enrolled; instead, researchers use…

This study looked at how two common drugs (itraconazole and probenecid) change the way a new medicine, PF-07220060, moves through the body. Twenty-five healthy adults took the new medicine alone and then with the other drugs. The goal was to see if the other drugs affect the leve…

This study looked at how an experimental medicine for eczema (PF-08049820) is absorbed when made in fast- or slow-release versions, and whether a high-fat meal changes that. Twelve healthy adults each tried five different versions of the pill. The results will help pick the best …

This study looked at medical records of 86 people with HER2+ metastatic breast cancer to see how well a combination of three drugs (tucatinib, trastuzumab, and capecitabine) worked after they had already taken a drug called trastuzumab deruxtecan. The goal was to measure real-wor…

This study checks whether prazosin capsules made in Barceloneta (Puerto Rico) and Ascoli (Italy) are processed the same way in the body. About 69 healthy adults will take the capsules and have blood samples taken. The goal is to confirm the two versions are equivalent, not to tre…

This study tested two different versions of an experimental drug called PF-07976016 in 12 healthy adults. The goal was to see how much of the drug gets into the blood after a single dose. Participants took both forms at different times so the amounts could be compared. This study…

This study looked at how a new medicine called PF-07328948 is handled by the body and whether it is safe in healthy Chinese adults. Ten participants took the drug daily for 7 days. The goal was to gather early safety information for a possible future heart failure treatment.

This study looked at the safety of a drug called Rituximab Pfizer in over 2,700 people in Japan with a type of lymphoma. Researchers checked how often infections and other side effects happened after treatment. They compared these results to those from patients who took a similar…

This study reviewed medical records from cancer clinics to see how long men with metastatic prostate cancer that still responds to hormone therapy take two common drugs, apalutamide and enzalutamide. It included about 1,300 men aged 18 and older who started one of these drugs as …

This study looked at over 12,500 people with atrial fibrillation (an irregular heartbeat) to see how their condition changed over time and how it related to serious events like stroke or bleeding. Researchers used existing hospital and national insurance records in Korea, so no n…

This study analyzed medical records of 507 prostate cancer patients from the Veterans Affairs health system who started taking relugolix. Researchers looked at where patients lived, what other treatments they had, and their overall health. The goal was to describe the types of pa…

This study tested two different pill versions of an experimental drug (PF-07248144) in 24 healthy adults. The goal was to see how well each version is absorbed by the body, not to treat any disease. Participants received a single dose of each pill at different times, and research…

This study observed 185 people with HR+/HER2- metastatic breast cancer in Africa and the Middle East who were starting treatment with palbociclib combined with hormone therapy. Researchers tracked how long the treatment kept the cancer from growing, overall survival, and quality …

This completed Phase 1 study looked at how two common medicines—cyclosporine (an immunosuppressant) and clarithromycin (an antibiotic)—change the levels of a new drug called PF-07328948 in the body. Twenty-six healthy adults took the new drug alone and then with each other medici…

This study looked at 559 adults in Israel with metastatic breast cancer who were prescribed palbociclib as part of their treatment. Researchers tracked how long patients stayed on the drug, what doses they used, and what treatments they received next. The goal was to understand r…

This study tracked 212 adults with moderately severe to severe hemophilia A or B for at least 6 months to record how often they bleed while on their usual clotting factor treatment. The information will be used as a baseline for future gene therapy studies. No experimental treatm…

This completed study looked at how quickly and completely the drug PF-07054894 is absorbed, broken down, and eliminated from the body. Ten healthy adult men took a single dose with a tiny radioactive tag so scientists could follow it. The goal was to understand the drug's path, n…

This study looked at how well the drug axitinib works in everyday medical practice for people with advanced kidney cancer who had already taken sunitinib. Researchers observed 554 patients across multiple countries but did not give any new treatment or change their care. The goal…

This study looked at over 1,000 men in Finland with metastatic prostate cancer to understand their health, treatments, and how the disease progresses. Researchers collected information from medical records to see what treatments were used and how well they worked. The goal was to…

This study looked at medical records of 779 older adults (65+) with a common type of advanced breast cancer (HR+/HER2-). It compared those who received a combination of two drugs (palbociclib plus an aromatase inhibitor) versus those who received only one drug (aromatase inhibito…

This study looked at how doctors in Poland treat a common type of advanced breast cancer (HR+ HER2-). Researchers collected information from 440 patients to understand which treatments are used and how they change over time. The goal was to learn more about real-world care, not t…

This study looked at whether a small device worn on the arm (Tasso) can collect blood samples as accurately as standard needle draws after taking the migraine drug zavegepant nasal spray. Fourteen healthy adults took part, and some also tried a butterscotch candy to see if it cha…

This early-stage study tested a new medicine called PF-06414300 in 63 healthy adults aged 18 to 65. The goal was to check safety and measure how the drug moves through the body. Participants received either the drug or a placebo in one or two parts of the study. This trial does n…

This study used health records from over 8 million people in Taiwan to understand the effects of COVID-19 and how well the oral treatment nirmatrelvir/ritonavir (Paxlovid) worked. Researchers looked at who got severely ill, needed hospital care, or died, and compared those who to…

This study tested a new medicine called PF-07264660 in 12 healthy Chinese adults to see if it is safe and how the body processes it. Participants received a single IV dose, with three-quarters getting the real medicine and one-quarter getting a placebo. The study lasted up to 181…

This study looked at insurance records of over 3,000 men aged 65 and older with metastatic prostate cancer that still responds to hormone therapy. Researchers wanted to see how long patients actually take newer hormonal drugs (abiraterone, apalutamide, or enzalutamide) in everyda…

This study monitored 1,290 patients with non-small cell lung cancer who were already taking the drug Lorbrena after it was approved. The goal was to track side effects, especially brain and liver problems. No new treatment was given; it was purely an observation of real-world saf…

This study reviewed medical records of 693 Japanese patients with a certain type of advanced breast cancer (HR+/HER2-) who received palbociclib plus hormone therapy as their first or second treatment. Researchers wanted to see how long patients lived without the cancer getting wo…

This study tested whether different versions of a CGRP receptor antagonist (a type of migraine medicine) are absorbed and processed by the body in the same way. It involved 64 healthy adults aged 18 and older who received a single dose of each formulation. The goal was to see if …

This study looked at how much of the COVID-19 treatment nirmatrelvir (Paxlovid) passes into breast milk. Eight healthy breastfeeding women took the medicine three times over two days. Researchers collected breast milk samples to measure drug levels and safety.

This study looked at how the experimental drug PF-07248144 is absorbed, processed, and removed from the body. Eight healthy adults received a radiolabeled version of the drug by mouth and by IV. Researchers measured the drug in blood, urine, and stool to understand its movement a…

This study looked at how healthy men absorb, process, and eliminate a drug called PF-07220060. Twelve men took the drug by mouth or by mouth plus an injection. Researchers measured the drug in blood, urine, and stool to understand how it travels through the body. This study did n…

This study watched 188 adults with advanced lung cancer who were prescribed Vizimpro as their first treatment. Researchers recorded any side effects and how well the drug shrank tumors during routine doctor visits. The goal was to confirm the drug works safely in everyday practic…

This study looked at how healthy men absorb, distribute, and eliminate the experimental drug PF-07976016. Eight participants took the drug by mouth, and researchers measured how much of it was processed and left the body. The goal was purely to understand the drug's behavior, not…

This study looked at medical records of over 2,700 men with advanced prostate cancer that no longer responds to hormone therapy. Researchers compared two common treatments, enzalutamide and abiraterone, to see which one helped men live longer and stay on treatment longer. The goa…

This study looked at insurance records from over 7,300 cancer patients who had a blood clot (VTE) and were treated with either apixaban or low molecular weight heparin (LMWH). The goal was to compare total healthcare costs, including hospital stays, outpatient visits, and pharmac…

This study looked at how the experimental drug Ibuzatrelvir is absorbed into the blood in 12 healthy Chinese adults. Participants received a single dose, and researchers measured drug levels and safety. The goal was to understand the drug's behavior, not to treat any disease.