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Bladder cancer drug avelumab tested in Real-World setting

NCT ID NCT04822350

Knowledge-focused Sponsor: Pfizer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study tracked 596 patients in France with advanced bladder cancer who received avelumab as maintenance therapy after initial chemotherapy. Researchers observed how long patients survived and how the drug performed in everyday medical practice, rather than in a controlled trial. The goal was to gather real-world evidence on the drug's effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
avelumab
What this could lead to
If successful, this study could confirm that avelumab maintenance therapy improves survival for advanced bladder cancer patients in everyday practice.
What could go wrong
This is an observational study, not a controlled trial, so results may be influenced by patient selection and real-world variability. It does not prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

596 people

The number who actually took part.

Started

Jul 2021

Finished

Apr 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with advanced or metastatic Urothelial Carcinoma treated with avelumab as a maintenance treatment

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patient ≥ 18 years of age 2. Patient with locally advanced or metastatic urothelial carcinoma (irrespective of tumor histology) whose disease has not progressed (ongoing stable disease, partial response or complete response) following completion of first-line platinum-based chemotherapy and who has been (retrospective), is (retrospective and prospective), will be (prospective) treated with avelumab. * For a patient alive at the moment of the inclusion in the study : the patient must be informed of the study, he/she must be given an information letter signed by the investigator and must not be opposed to the collection of his/her data * For a patient who died before the inclusion in the study : the patient (during his life time) must not be opposed in writing to the collection of his data. 3. Patient benefiting from a social security scheme according to local regulations Exclusion Criteria: 4. For a patient alive at the moment of the inclusion in the study: patient without liberty, under tutelage, or unable to give oral consent. 5. Patient enrolled in a prospective interventional clinical trial assessing an investigational product.

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Conditions

The condition(s) this trial relates to.

transitional cell carcinoma Urinary Bladder Neoplasms urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Urothelial carcinoma

Contacts and locations

Locations

  • CENTRE HOSPITALIER Dr Jean-Eric TECHER

    Calais, 62107, France

  • CHU Amiens-Picardie

    Amiens, 80054, France

  • CHU Charles Nicolle

    Rouen, Haute-normandie, 76031, France

  • CHU Nantes

    Nantes, Pays de la Loire Region, 44093, France

  • CHU de Bordeaux - Hopital Saint Andre

    Bordeaux, 33075, France

  • Centre Alexis VAUTRIN

    Vandœuvre-lès-Nancy, 54511, France

  • Centre Antoine Lacassagne

    Nice, 06189, France

  • Centre D'Oncologie de Gentilly

    Nancy, 54100, France

  • Centre Hopistalier Roanne

    Roanne, 42300, France

  • Centre Hospitalier Annecy Genevois

    Epargny METZ Tessy, 74370, France

  • Centre Hospitalier Auxerre

    Auxerre, 89000, France

  • Centre Hospitalier Bretagne Sud

    Lorient, 56322, France

  • Centre Hospitalier Emile Roux

    Le Puy-en-Velay, 43000, France

  • Centre Hospitalier Haguenau

    Haguenau, 67500, France

  • Centre Hospitalier Intercommunal Louviers

    Elbeuf, 76503, France

  • Centre Hospitalier Intercommunal de Creteil

    Créteil, 94010, France

  • Centre Hospitalier Jura Sud

    Lons-le-Saunier, 39000, France

  • Centre Hospitalier Prive Saint Gregoire

    Saint-Grégoire, 35768, France

  • Centre Hospitalier Regional Universitaire de Brest

    Brest, 29200, France

  • Centre Hospitalier Universitaire Gabriel Montpied

    Clermont-Ferrand, 63011, France

  • Centre Hospitalier Universitaire de Montpellier

    Montpellier, 34295, France

  • Centre Hospitalier Victor Dupouy

    Argenteuil, 95107, France

  • Centre Hospitalier de Boulogne Sur Mer

    Boulogne-sur-Mer, 62321, France

  • Centre Hospitalier de Cornouaille

    Quimper, 29107, France

  • Centre Hospitalier de Grenoble

    Greboble, 38043, France

  • Centre Hospitalier de Soissons

    Soissons, 02200, France

  • Centre Hospitalier de la cote Basque

    Bayonne, 64100, France

  • Centre Hospitalier du Pays d AIX

    Aix-en-Provence, 13100, France

  • Centre Leon Berard

    Lyon, 69373, France

  • Centre Leonard de Vinci

    Dechy, 59187, France

  • Centre de Lutte Contre Le Cancer - Auvergne Jean Perrin

    Clermont-Ferrand, 63011, France

  • Ch Roubais

    Roubaix, 59100, France

  • Chi Alpes Du Sud

    Gap, 5000, France

  • Chi Frejus - Saint Raphael

    Fréjus, 83608, France

  • Chru Besancon

    Besançon, 25030, France

  • Chu Dupuytren Service Oncologie

    Limoges, 87000, France

  • Clinique Clement Drevon

    Dijon, 21000, France

  • Clinique Du Mousseau

    Évry, 91035, France

  • Clinique Mathilde

    Rouen, 76100, France

  • Clinique Pasteur - Lanroze

    Brest, 29200, France

  • Clinique Saint Georges

    Nice, 06105, France

  • Clinique Sainte Anne

    Strasbourg, 67000, France

  • Clinique Tivoli-Ducos

    Bordeaux, 33000, France

  • Clinique Victor Hugo

    Le Mans, 72015, France

  • Clinique de Flandre

    Coudekerque-Branche, 59210, France

  • Clinique de la Louvière

    Lille, 59042, France

  • Clinique de la Sauvegarde

    Lyon, 69337, France

  • Clinique mutualiste de l Estuaire

    Saint-Nazaire, 44606, France

  • Groupe Hospitalier Diaconesse La Croix Saint Simon

    Paris, 75020, France

  • Groupe Hospitalier La Rochelle - Re - Aunis

    La Rochelle, 17019, France

  • Groupe Hospitalier Mutualiste de Grenoble Institut Daniel Hollard

    Grenoble, 38000, France

  • Hia Begin

    Saint-Mandé, 94160, France

  • Hia Sainte Anne

    Toulon, 83041, France

  • Hopital Cochin/Unité de Cancerologie

    Paris, 75014, France

  • Hopital Europeen

    Marseille, 13003, France

  • Hopital Europeen Georges Pompidou

    Paris, 75908, France

  • Hopital Foch

    Suresnes, 92151, France

  • Hopital Louis Pradel

    Bron, 69677, France

  • Hopital Pitie Salpetriere

    Paris, 75013, France

  • Hopital Prive Sainte Marie

    Osny, 95520, France

  • Hopital Saint-Louis

    Paris, 75010, France

  • Hopital de La Timone

    Marseille, 13385, France

  • Hopital prive Arnault Tzanck

    Mougins, 06254, France

  • Hopital prive du Confluent S.A.S

    Nantes, 44277, France

  • ICANS - Institut de cancerologie Strasbourg Europe

    Strasbourg, 67200, France

  • IUCT - Oncopole

    Toulouse, 31059, France

  • Institut Bergonie

    Bordeaux, 33076, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Institut Jean Godinot

    Reims, 51056, France

  • Institut Sainte Catherine

    Avignon, 84918, France

  • Institut de Cancerologie Du Gard

    Nîmes, 30900, France

  • Institut de Cancérologie Lucien Neuwirth

    Saint-Priest-en-Jarez, 42271, France

  • La Roche Sur Yon - Centre Hospitalier Departemetal Vendee

    La Roche-sur-Yon, 85960, France

  • Medipole de Savoie

    Challes-les-Eaux, 73190, France

  • ONCOGARD

    Nîmes, 30900, France

  • Pole Sante Republique

    Clermont-Ferrand, 63050, France

  • Polyclinique Du Bois

    Lille, 59004, France

  • Polyclinique Marzet

    Pau, 64001, France

  • Polyclinique Saint Come

    Compiègne, 60200, France

  • Polyclinique de Blois

    La Chaussée-Saint-Victor, 41260, France

  • Polyclinique de LIMOGE-Clinique François CHENIEUX

    Limoges, 87039, France

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