Pfizer

This study looked back at health records to see how well the updated 2024-2025 Pfizer/BioNTech COVID-19 vaccine protected people from getting sick with COVID-19. Researchers analyzed data from CVS MinuteClinic patients aged 5 and older who got tested for the virus and reported sy…

This study tested a new shingles vaccine made with mRNA technology, similar to some COVID-19 vaccines. It aimed to see if the vaccine was safe and how well it triggered an immune response in healthy adults aged 50 to 85. Researchers compared different versions of the new vaccine …

This study follows boys with Duchenne muscular dystrophy for 10 years after they received an experimental gene therapy in previous Pfizer trials. The goal is to monitor long-term safety and see how well the treatment continues to work over time. Participants will have annual chec…

This early-stage study tested the safety of a single dose of an experimental gene therapy, called PF-06939926, in boys with Duchenne muscular dystrophy (DMD). The main goal was to see if the treatment was safe and tolerable, while also checking if it helped produce the missing mu…

This early-stage study aimed to test the safety and find the right dose of a new drug, PF-07265028, for people with advanced cancers that have spread. The drug was tested alone and in combination with another cancer therapy called sasanlimab. The trial was terminated after enroll…

This early-stage study tested the safety and initial effectiveness of a new drug called PF-07820435, both alone and combined with an existing immunotherapy (sasanlimab), in people with advanced solid tumors. The trial involved a small group of participants with cancers like lung …

This was a first-in-human study to test the safety and early signs of effectiveness of a new drug, PF-07284890, for people with advanced solid tumors that have a specific genetic change called a BRAF V600 mutation. The trial enrolled 65 participants with cancers like melanoma, lu…

This study tested the safety and effects of a new oral drug, PF-06873600, for people with advanced or metastatic breast and ovarian cancers. Participants took the drug alone or combined with standard hormone therapy. The main goals were to find a safe dose and see if the treatmen…

This study followed 265 people with sickle cell disease who were already taking Oxbryta, a medication approved to help manage the condition. Researchers collected real-world data over 5 years to understand how the drug affects patients' blood markers, complications, and quality o…

This study looked at whether a smart electronic device for injecting the rheumatoid arthritis drug etanercept helps patients take their medication more consistently. Researchers reviewed the medical records of 60 patients in Colombia over 40 weeks to see if using the device impro…

This study tested an experimental oral medicine, PF-07054894, to see if it could help control ulcerative colitis. It involved 44 adults with mild to severe forms of the disease who hadn't responded well to standard treatments. The trial was terminated early, and its main goal was…

This early-stage study tested whether combining a new immunotherapy drug (sasanlimab) with other targeted cancer therapies was safe and effective for people with advanced non-small cell lung cancer. The trial involved 34 participants and was designed in two parts, testing differe…

This early-stage study tested the safety and determined the right dosage of a new drug called PF-08046031 for adults with advanced melanoma and other solid tumors that have spread and have no other approved treatment options. The main goal was to identify side effects and see how…

This study tested an experimental drug called PF-06823859 for adults with lupus who have active skin symptoms. The goal was to see if the drug could reduce skin inflammation and improve symptoms compared to a placebo. The trial was terminated early after enrolling only 8 particip…

This study aimed to check the long-term safety of the drug voxelotor for people with sickle cell disease. It was open to patients who had already taken part in earlier voxelotor trials. The main goal was to monitor for side effects and sickle cell complications over a longer peri…

This study aimed to check the long-term safety of the experimental drug GBT021601 for people with sickle cell disease. It enrolled 47 participants who had already taken the drug in earlier trials, allowing them to continue treatment while researchers monitored for side effects ov…

This study allowed patients with sickle cell disease who had already completed a previous clinical trial of the drug voxelotor to continue taking it long-term. Researchers monitored 179 participants to understand the drug's safety over extended use and whether it continued to hel…

This study tested whether an oral medication called sisunatovir could prevent Respiratory Syncytial Virus (RSV) from causing severe illness in high-risk adults. It involved adults with RSV symptoms who were at risk of getting very sick due to age or other health conditions. Half …

This early-stage study tested a combination of three medicines for people with an aggressive type of blood cancer called diffuse large B-cell lymphoma that had returned or stopped responding to prior treatment. The trial was for patients who could not receive a stem cell transpla…

This study tested a one-time gene therapy in boys aged 2 to 4 with Duchenne muscular dystrophy (DMD). The main goals were to check if the treatment was safe and to see if it could help their muscles produce a crucial protein called dystrophin. The trial was small, with 10 partici…

This study tested two different combinations of cancer drugs for people with advanced melanoma that had a specific genetic change (BRAF mutation) and had stopped responding to a common first-line immunotherapy. Participants received either a three-drug combination (encorafenib, b…

This study aimed to find a safe and effective dose of an experimental drug called sisunatovir for infants and young children (up to 5 years old) with serious RSV lung infections. It was a small, early-stage trial that compared the drug to a placebo to check for side effects and h…

This was an early-stage study to test the safety and find the right dose of a new cancer drug called PF-07826390. It was given alone or combined with another immunotherapy drug to people with advanced solid tumors that had spread or stopped responding to treatment. The main goal …

This study observed how well the approved drug tofacitinib worked for adults in Switzerland with moderate to severe ulcerative colitis. It aimed to gather real-world data on symptom control and gut inflammation by having patients complete questionnaires and use a home stool test.…

This study aimed to check the long-term safety of inclacumab, an experimental drug for sickle cell disease. It was for people who had already received the drug in a previous Pfizer trial. Participants received the drug every 12 weeks, and researchers tracked any side effects and …

This study tested whether a medication called voxelotor could help protect children with sickle cell disease from strokes. It involved about 224 children, aged 2 to 15, who were at risk for stroke due to abnormal blood flow in their brains. Researchers compared the drug to a plac…

This study tested a new drug, PF-07258669, to see if it is safe and can help older adults who are losing weight without trying. The goal was to improve appetite and nutrition. It was a small, early-stage trial that was later stopped.

This study tested whether a new injectable medicine called Ponsegromab could improve symptoms, physical function, and quality of life for adults with heart failure. About 455 participants received either the study medicine or a placebo injection every four weeks for about nine mo…

This was an early-stage study to check the safety and see how the body processes an experimental oral drug called PF-07899895. It involved 37 healthy adult volunteers who received either the drug or a placebo dummy pill. The main goals were to see if the drug was safe and to meas…

This study aimed to understand how doctors use the antibiotic ceftazidime-avibactam in real-world hospital settings to treat serious infections like pneumonia and abdominal infections. Researchers observed about 220 patients in China who were already prescribed this medication as…

This was an early-stage study by Pfizer to check the basic safety of a new, unnamed medicine called PF-07314470 and see how the body processes it. It involved a small group of healthy adults who received injections of the medicine or a placebo. The main goal was to identify any s…

This study aimed to observe how well the prescription pill abrocitinib works and how safe it is for adults with moderate to severe eczema (atopic dermatitis) in real-world German clinics. It followed 112 patients who were already starting this medication as part of their normal c…