Pfizer compares two pill versions in small Healthy-Volunteer study
NCT ID NCT07117799
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 1 study by Pfizer enrolled 24 healthy adults to compare how two different tablet forms of the drug PF-07248144 are absorbed by the body. Participants received single doses of each form in a crossover design, with some taking the drug after eating. The goal was to measure drug levels in the blood and check for side effects, not to treat any disease.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- PF-07248144
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
-
24 people
The number who actually took part.
- Started
-
Feb 2025
- Finished
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Jul 2025
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * Participants of nonchildbearing potential , inclusive, at screening, who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, vital signs, and 12-lead electrocardiograms (ECGs). * Body mass index (BMI) of 18-32 kg/m2; and a total body weight \>50 kg (110 lb) Exclusion Criteria * Use of prescription or nonprescription drugs and dietary and herbal supplements within 14 days or 5 half-lives (whichever is longer) prior to the first dose of study intervention * Prior use of epigenetic modifying agents * Current use of any prohibited concomitant medication(s) or unwillingness or inability to use a required concomitant medication(s) * Additionally, current use or anticipated need for food or drugs that are known strong inducers or inhibitors of CYP2C9 or CYP3A4, including their administration within 14 days or 5 half-live of the strong inducers or inhibitors of CYP2C9 or CYP3A4, whichever is longer, prior to first dose of study intervention, during the treatment period, and within 2 days after the last dose of PF-07248144 * Proton pump inhibitors must be discontinued at least 5 days prior to the first dose of study medication and throughout treatment period.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Pfizer Clinical Research Unit - New Haven
New Haven, Connecticut, 06511, United States
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