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Ultrasound pulses aimed at deep brain regions tied to empathy and impulse control

NCT ID NCT06635161

Knowledge-focused Sponsor: The Hong Kong Polytechnic University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Researchers are testing a non-invasive brain stimulation technique called transcranial pulse stimulation, which uses short ultrasound pulses to reach deep brain areas. The trial enrolls 75 healthy adults and randomly assigns them to receive active stimulation to the anterior insula and dorsal anterior cingulate cortex, active stimulation with a different device setup, or a sham procedure. Participants complete computer tasks that measure empathy, risk-taking, and response inhibition, plus brain scans, to see whether a single session changes these functions or brain connectivity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial pulse stimulation, a non-invasive brain stimulation technique using ultrasound pulses
What this could lead to
If it works, this could point toward a non-invasive way to adjust deep brain circuits involved in empathy, risk-taking, and self-control, with possible future use in conditions like depression or Alzheimer's disease.
What could go wrong
This is a small, single-session pilot study in healthy adults, so any brain changes may be temporary or too subtle to matter. Ultrasound brain stimulation can cause discomfort, and its long-term safety is not fully established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

75 people

The number who actually took part.

Started

Aug 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to 65 * Biological and mental health, based on a clinical interview * Able to understand and follow instructions by the study team Exclusion Criteria: * Major internal diseases, neurological disorders, or mental disorders * Having a metal implant in the brain * Corticosteroid treatment within 6 weeks prior to inclusion * Pregnancy or breastfeeding * Common NIBS and MRI exclusion criteria, such as a history of brain surgery, cardiac pacemaker, deep brain stimulation, and intracranial metallic particles * Previous TPS experience * Color blindness

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy adults

Contacts and locations

Locations

  • The Hong Kong Polytechnic University

    Hong Kong, Hung Hom, Kowloon, Hong Kong

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