Healthy adults

This study tests two experimental COVID-19 booster vaccines alongside two already-approved ones in 48 healthy adults aged 18 to 65. Participants receive one injection and are monitored for side effects and antibody levels over 48 weeks. The goal is to see if the new vaccines are …

This Pfizer study tests several experimental mRNA-based flu vaccines in 770 healthy adults aged 18 and older. Participants receive one dose and are monitored for about 6 months for safety and immune response. The goal is to see if these new vaccines are safe and trigger a strong …

This early-stage study tests a new experimental drug, PF-08103402, for the first time in people. It includes healthy adults and adults with mild-to-moderate asthma to check safety, how the drug moves through the body, and whether food affects its absorption. Participants take the…

This trial tests whether a daily supplement called RSB11-HI, a heat-inactivated postbiotic, can support weight management and metabolic wellness in healthy adults. Over 8 weeks, 120 participants will take either the supplement or a placebo, with researchers tracking changes in bo…

This study tests whether taking probiotic drops before and during a short overseas trip (less than 7 days) can prevent stomach issues, sleep problems, and other travel-related health problems. 46 healthy adults will take either a mix of three Bifidobacterium strains or a placebo …

This study tests a digital rehabilitation program for people with knee osteoarthritis and healthy older adults. It uses a smart knee brace with sensors, electrical stimulation, and AI to guide exercises at home. The goal is to see if this approach improves pain, muscle strength, …

This study tests whether combining mirror therapy with either mild electrical stimulation or special sound beats can improve leg movement in people who had a stroke at least six months ago. Seventy-two participants will be assigned to one of three groups and will do ankle exercis…

Researchers at the University of Toronto are studying whether what you eat before endurance exercise changes how your body uses fuel, and whether that differs between men and women. Twenty-four recreationally active adults will each complete three cycling sessions after drinking …

This study aims to see if magnetic resonance spectroscopy (MRS) can accurately measure NAD+ levels in the brain and calf muscles of healthy adults. Participants will take an over-the-counter nicotinamide riboside (NR) supplement, and researchers will compare NAD+ measurements bef…

This study investigates how the experimental cancer drug atirmociclib is processed by the body in people with mild, moderate, or severe liver disease compared to those with healthy livers. Participants receive a single oral dose of the drug, and blood samples are taken over time …

This early-phase trial investigates whether psilocybin, the active compound in magic mushrooms, can alter self-awareness in healthy adults. One hundred participants will receive either 15 mg of psilocybin or an active placebo (niacin) and complete tasks measuring metacognition an…

This study explores whether two types of speech training can improve how people learn to adjust their speech after hearing errors. Healthy adults will either practice reducing normal speech variability or train to better detect auditory errors. Researchers will measure how partic…

This study looks at how the experimental drug PF-08049820 is absorbed in healthy adults. It tests three different forms of the drug, taken with or without food, and also with another drug that reduces stomach acid. The goal is to understand the best way to give the drug in future…

This study looks at how eating low or high amounts of fiber changes the compounds in your breath and gut. Twenty healthy adults will try both a low-fiber (10g/day) and a high-fiber (40g/day) diet for three days each, with a three-week break in between. Researchers will measure br…

This study tests whether 5 weeks of breathing endurance training using a special device can reduce breathlessness and improve exercise performance in healthy athletes. Researchers will compare real training to a sham version in 32 cyclists or triathletes. The goal is to understan…

This study looks at how people with mild multiple sclerosis adjust their walking when faced with obstacles or sudden changes, compared to healthy adults. Researchers will use motion sensors and brain activity monitors to measure these skills. The goal is to find better ways to de…

This study watches how healthy adults aged 18 to 65 move their eyes and body when using digital devices while wearing different eyeglasses. Researchers want to see if younger and older (presbyopic) users behave differently. Participants get an eye exam and perform simple screen t…

This early-stage study tests the safety of a new drug called GS3-007a in 32 healthy Chinese adults aged 18-45. Participants receive either the drug or a placebo, and researchers monitor side effects and how the drug moves through the body. The study also checks if food affects dr…

This study looks at whether eating 2 ounces of pecans daily for 3 months can improve blood fats, inflammation, blood pressure, thinking skills, and gut bacteria in healthy adults aged 45 to 75. Participants will follow two diet periods—one with pecans and one without—and provide …

This early-stage study tests a new drug called MIB-725 in 32 healthy adults aged 19 to 60. Participants receive a single dose (100 to 800 mg) and are monitored for side effects and how the drug moves through the body. The goal is to see if the drug is safe before testing it in pe…

This study in Lahore, Pakistan, is recruiting 60 healthy twins to see how genetics and environment influence the effects of a balanced diet. Over 12 weeks, both identical and fraternal twins will follow a WHO-aligned diet. Researchers will measure changes in body fat, blood sugar…

This study tests which method is more accurate for placing dental implants: a custom-made guide or a dynamic navigation system that shows the dentist where to drill on a screen. Twenty healthy adults with at least one missing upper tooth will take part. The goal is to see which a…

This study tests whether strengthening your breathing muscles with a handheld device and taking nitrate supplements (like those in beetroot juice) can improve exercise performance in simulated high altitude. Eighty healthy adults will train for 4-6 weeks and then do a cycling tes…