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Breathe easy, climb higher: study tests simple tricks for altitude endurance

NCT ID NCT07216755

Knowledge-focused Sponsor: Embry-Riddle Aeronautical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether strengthening your breathing muscles with a handheld device and taking nitrate supplements (like those in beetroot juice) can improve exercise performance in simulated high altitude. Eighty healthy adults will train for 4-6 weeks and then do a cycling test in a low-oxygen chamber. The goal is to see if these simple, non-drug strategies can help the body use oxygen more efficiently.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nitrate supplement
What this could lead to
If it works, this could point toward simple, non-drug ways to help people exercise better in low-oxygen conditions, like at high altitudes or with certain lung conditions.
What could go wrong
This is a small, early study in healthy adults, not patients. The simulated altitude may not reflect real-world conditions, and results may not apply to people with medical issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy adults between 18 and 40 years old. Recreationally active (performing ≥3 hours of structured physical activity per week). Non-smokers for at least the past 6 months. Free from any known cardiovascular, pulmonary, metabolic, or neuromuscular disease as determined by health screening questionnaire and medical history. Able to perform cycle ergometer exercise to volitional fatigue. Willing to abstain from high-nitrate foods and supplements (e.g., beets, spinach, arugula) for 48 hours prior to each testing session. Able and willing to provide written informed consent and comply with all study procedures. Exclusion Criteria: * Diagnosis of or history of heart disease, hypertension, diabetes, or chronic respiratory disorders (e.g., asthma, COPD). Current use of medications or supplements known to affect cardiovascular, metabolic, or respiratory function (e.g., beta-blockers, nitrates, stimulants). Smoking, vaping, or tobacco use within the past 6 months. Known allergy or intolerance to beetroot products or nitrates. Participation in another interventional research study within the past 30 days. Pregnant or breastfeeding women. Any orthopedic or musculoskeletal limitation preventing safe exercise testing. Failure to meet inclusion criteria or inability to complete familiarization and baseline testing.

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Conditions

The condition(s) this trial relates to.

Hypoxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dietary supplement Exercise intolerance Exercise training Healthy adults Hypoxia Inspiratory muscle training Mechanical ventilation dependence Nitrate supplementation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Embry-Riddle Aeronautical University

    RECRUITING

    Daytona Beach, Florida, 32114, United States

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