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MRNA flu shots enter human testing – could they beat traditional vaccines?

NCT ID NCT07431853

Vaccine Sponsor: Pfizer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Pfizer study tests several experimental mRNA-based flu vaccines in 770 healthy adults aged 18 and older. Participants receive one dose and are monitored for about 6 months for safety and immune response. The goal is to see if these new vaccines are safe and trigger a strong defense against the flu.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
mRNA influenza vaccine
What this could lead to
If successful, this could lead to a more effective flu vaccine that is quicker to update each year.
What could go wrong
This is an early Phase 2 trial with only 770 people, so results may not apply to everyone. Side effects like injection site pain or fever are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 770 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria • Healthy and medically stable participants who are determined by medical history, physical examination (if clinically required), and clinical judgment of the investigator to be eligible for inclusion in the study. Exclusion Criteria * Tested positive for influenza ≤5 months (150 days) prior to Visit 1 (Day 1). * Vaccination with any investigational or licensed influenza vaccine ≤5 months (150 days) before Visit 1 (Day 1). * Receipt of antiviral therapies for influenza (eg, Tamiflu) ≤5 months (150 days) prior to Visit 1 (Day 1).

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Conditions

The condition(s) this trial relates to.

influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy adults

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    15 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AMR Clinical

    RECRUITING

    Mobile, Alabama, 36608, United States

  • AMR Clinical

    RECRUITING

    Kansas City, Missouri, 64114, United States

  • Charlottesville Medical Research Center, LLC

    RECRUITING

    Charlottesville, Virginia, 22911, United States

  • Clinical Research Atlanta

    RECRUITING

    Stockbridge, Georgia, 30281, United States

  • Clinical Research Consulting, LLC

    RECRUITING

    Milford, Connecticut, 06460, United States

  • DM Clinical Research

    RECRUITING

    Tomball, Texas, 77375, United States

  • DM Clinical Research - Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

  • Diablo Clinical Research, LLC d/b/a Flourish Research

    RECRUITING

    Walnut Creek, California, 94598, United States

  • East-West Medical Research Institute

    RECRUITING

    Honolulu, Hawaii, 96814, United States

  • George Washington Medical Faculty Associates

    RECRUITING

    Washington D.C., District of Columbia, 20037, United States

  • Indago Research & Health Center, Inc

    RECRUITING

    Hialeah, Florida, 33012, United States

  • J. Lewis Research, Inc. / Foothill Family Clinic

    RECRUITING

    Salt Lake City, Utah, 84109, United States

  • Palm Springs Community Health Center

    RECRUITING

    Miami Lakes, Florida, 33014, United States

  • Rochester Clinical Research, LLC

    RECRUITING

    Rochester, New York, 14609, United States

  • SMS Clinical Research LLC

    RECRUITING

    Mesquite, Texas, 75149, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.