MRNA flu shots enter human testing – could they beat traditional vaccines?

NCT ID NCT07431853

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Pfizer study tests several experimental mRNA-based flu vaccines in 770 healthy adults aged 18 and older. Participants receive one dose and are monitored for about 6 months for safety and immune response. The goal is to see if these new vaccines are safe and trigger a strong defense against the flu.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mRNA influenza vaccine
What this could lead to: If successful, this could lead to a more effective flu vaccine that is quicker to update each year.
What could go wrong: This is an early Phase 2 trial with only 770 people, so results may not apply to everyone. Side effects like injection site pain or fever are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY ADULTS

Contacts and locations

Locations

AMR Clinical
RECRUITING

Mobile, Alabama, 36608, United States
AMR Clinical
RECRUITING

Kansas City, Missouri, 64114, United States
Charlottesville Medical Research Center, LLC
RECRUITING

Charlottesville, Virginia, 22911, United States
Clinical Research Atlanta
RECRUITING

Stockbridge, Georgia, 30281, United States
Clinical Research Consulting, LLC
RECRUITING

Milford, Connecticut, 06460, United States
DM Clinical Research
RECRUITING

Tomball, Texas, 77375, United States
DM Clinical Research - Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Diablo Clinical Research, LLC d/b/a Flourish Research
RECRUITING

Walnut Creek, California, 94598, United States
East-West Medical Research Institute
RECRUITING

Honolulu, Hawaii, 96814, United States
George Washington Medical Faculty Associates
RECRUITING

Washington D.C., District of Columbia, 20037, United States
Indago Research & Health Center, Inc
RECRUITING

Hialeah, Florida, 33012, United States
J. Lewis Research, Inc. / Foothill Family Clinic
RECRUITING

Salt Lake City, Utah, 84109, United States
Palm Springs Community Health Center
RECRUITING

Miami Lakes, Florida, 33014, United States
Rochester Clinical Research, LLC
RECRUITING

Rochester, New York, 14609, United States
SMS Clinical Research LLC
RECRUITING

Mesquite, Texas, 75149, United States

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