Irccs Azienda Ospedaliero-universitaria Di Bologna

This study looks at three different forms of levothyroxine (a thyroid hormone medicine) in children up to age 11 who were born with congenital hypothyroidism. Researchers want to see if a new oral solution works better than liquid drops or tablets. The goal is to find the safest …

This study looks at two ways to trigger ovulation in women with cancer who are freezing their eggs before starting cancer treatment. About 200 women will receive either one drug (GnRH-a) or a combination of two drugs (GnRH-a plus hCG) to see which method retrieves more eggs and c…

This study tests if a doctor-led counseling program, plus two smartphone apps, can help older adults (60+) who have had a liver or kidney transplant eat better and be more active. Sixty participants will first get lifestyle advice, then use the apps for 12 weeks. The goal is to s…

This study tests whether a fecal microbiota transplant (FMT) can help people with advanced liver cancer whose disease worsened on standard immunotherapy. About 15 participants will receive FMT along with resuming their original drugs. The goal is to see if this combination can co…

This study looks at whether using two antibiotics together is more effective than one for treating Enterococcus faecalis bloodstream infections. Researchers will also analyze patients' gut bacteria to see how it affects treatment success. About 510 adults with this infection will…

This study tests a new imaging system called LungVision to help doctors mark suspicious lung nodules before surgery. The goal is to make it easier to find and remove the entire nodule during surgery, while saving as much healthy lung tissue as possible. Five adults with partially…

This study is testing whether a quick, non-invasive test of blood vessel health can help predict preeclampsia and other high blood pressure disorders in pregnancy. Researchers will measure artery stiffness and tiny blood vessel function in 400 first-time pregnant women during the…

This study explores whether genetic material from lung cancer cells can be collected from a lung wash (bronchoalveolar lavage) instead of a traditional biopsy. Researchers will compare the genetic test results from the wash fluid with those from standard biopsy samples in 10 peop…

This study tests a new way to do PET/CT scans for people with high-risk prostate cancer. Instead of two full scans, it uses one CT and a delayed PET scan 90 minutes after injection, which reduces radiation exposure and time in the hospital. Researchers will check if the images ar…

This study aims to create a computer program that can tell if a newborn's heart sounds are normal or abnormal using a digital stethoscope. Researchers will record heart sounds from 1,000 babies under 30 days old, some healthy and some with known heart disease, to train the progra…

This study compares two breathing therapy techniques—standard chest physiotherapy versus a device called Simeox—in 40 adults with bronchiectasis (not cystic fibrosis). The goal is to see which method better improves lung function, breathing ease, and sputum clearance. Participant…

This study watches how Italian hospitals use methods to make the healthy part of the liver grow bigger before removing tumors. It includes 2,000 adults with liver cancer whose remaining liver is too small for safe surgery. Researchers will compare different techniques to see whic…

This study looks at two ways to help cancer patients preserve their fertility before treatments like chemotherapy. One group will have both ovarian tissue freezing and egg freezing, while the other group will have egg freezing alone. Researchers will compare how many eggs are ret…

This study examines whether certain genetic differences make some women more likely to experience early menopause after chemotherapy for breast cancer or Hodgkin lymphoma. Researchers will analyze stored ovarian tissue from 50 women who had fertility preservation before treatment…

This study is for 100 people with early-stage lung cancer who will have surgery. Researchers will test blood samples for tumor cells and DNA to see if these can predict if the cancer comes back. The goal is to learn more about how lung cancer spreads, not to test a new treatment.

This study looks at 300 children with central precocious puberty (early puberty) to see how often it happens for no known reason versus being linked to other brain development conditions. Researchers will compare the children's diagnosis and growth patterns. The goal is to better…

This study follows 60 girls with classic galactosemia to track their hormone levels, growth, and pubertal development. The goal is to better understand why many develop primary ovarian insufficiency (early menopause). No new treatment is being tested—only observation and measurem…

This study looks at information already collected from 600 people with multiple myeloma. Researchers will combine genetic, clinical, and imaging data to train artificial intelligence models. The goal is to find patterns that could help predict how the disease will progress and ho…

This study looks at the genes of 350 children born with permanent congenital hypothyroidism who have a thyroid gland in the normal position. Researchers will use advanced genetic testing to find which gene changes may cause the condition. The goal is to better understand the unde…

This study looks at whether a type of PET scan (PSMA PET) can predict how well advanced prostate cancer responds to treatments like hormone therapy or chemotherapy. Researchers will track 1,300 men with advanced prostate cancer to see if scan results can forecast treatment succes…

This study is looking for biological markers (biomarkers) in the blood or tissue that can help doctors predict how severe gut graft-versus-host disease (GvHD) will be and how well it will respond to treatment. GvHD is a serious complication that can happen after a stem cell trans…

This study is gathering information from 11,000 people who have had a heart attack or heart muscle injury. The goal is to better understand these conditions and improve future care. No new treatments or drugs are being tested—only data is being collected and analyzed.

This study aims to understand how common antibiotic-resistant bacteria are in the gut of people using PrEP (HIV prevention medication). Researchers will collect samples from 200 HIV-negative adults during routine STI testing. The goal is to gather information that could lead to b…

This study aims to create a national map of cutaneous lymphoma (a rare skin cancer) in Italy. Researchers will review medical records from about 1,000 patients to see where cases are more common and if they are linked to environmental factors like pollution. Participants follow t…

This study looks at whether advanced heart MRI scans and blood tests can help doctors find early signs of organ rejection in heart transplant patients. Researchers will study 683 stable patients who are at least one year post-transplant. The goal is to see if these non-invasive m…

This study looks at how gut bacteria and the immune system interact in children and adults receiving stem cell transplants or CAR-T therapy. Researchers will collect stool and blood samples over time to find patterns linked to complications like graft-versus-host disease, infecti…

This study looks at whether certain substances from the placenta (sFlt-1 and PlGF) can help doctors know if a baby is in distress during labor. About 428 pregnant women will have their placental markers tested and compared with standard fetal heart monitoring. The goal is to find…

This study looks at DNA methylation patterns in brain, thyroid, and endometrial tumors to better understand how these cancers work. Researchers will analyze tumor samples from 180 adults to find unique epigenetic signatures that could help classify tumors and guide treatment. The…

This study observes 60 adults with hard-to-treat bacterial infections caused by carbapenem-resistant Enterobacterales (CRE). Participants receive either one or two antibiotics (ceftazidime/avibactam with or without fosfomycin). Researchers measure how well the drugs reach effecti…

This study looks at cholesterol and blood sugar levels in 200 people with Noonan syndrome and related conditions, aged 2 to 35. Researchers want to see if these levels differ by age, sex, or genetic cause. No treatment is given; the goal is to better understand health risks to im…

This study looks at 30 infants, aged 3-8 months, having surgery to correct craniosynostosis (early skull bone fusion). Researchers want to see if a new monitoring method (PRAM) can better detect dangerous changes in blood pressure and blood loss compared to standard monitoring. T…

This study looks back at 200 patients who received a lower-limb megaprosthesis (a large artificial joint replacement) to understand how many develop infections and what factors increase that risk. Researchers will compare patients with and without infections to find patterns. The…

This study looks at children born in Italy between 2016 and 2020 who were found to have biotinidase deficiency through newborn screening. Researchers want to see if a child's specific gene changes are linked to their symptoms and how much biotin enzyme activity they have. The goa…

This study looks at 25 people with COPD and high carbon dioxide levels who need a breathing mask (non-invasive ventilation) to help them breathe. Researchers want to see if nighttime breathing problems can predict how well the treatment works over 6 to 12 months. They will also c…

This study looks at 500 people who are offered medications for obesity or overweight. Researchers want to understand what makes someone accept or refuse the prescription, including their medical history, lifestyle, and social factors. For those who start the drug, the study will …

This study aims to find out how often rare hormone disorders cause dangerous salt loss in newborns, beyond the common condition caught by standard screening. Researchers will review medical records of up to 25 babies born between 1989 and 2023 who had low sodium levels in their f…

This study looks at children who received radiation therapy for cancer to see how often they develop thyroid nodules or thyroid cancer. Researchers will track up to 2,550 participants to find risk factors and genetic clues that might predict who is most at risk. The goal is to cr…

This study is looking at a protein called LEF-1 in tissue samples from 350 people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal is to see if measuring LEF-1 can help doctors make a more accurate diagnosis and find new markers for the diseas…

This study looks at how air pollution particles get into the bodies of non-smokers who have lung cancer, COPD, or leukemia. Researchers will compare these patients with healthy volunteers to find new markers that show how pollution causes disease. The goal is to better understand…

This study looks at whether a new way of scoring whole-body MRI scans can reliably measure disease activity in children with Chronic Recurrent Multifocal Osteomyelitis (CRMO), a rare bone condition. Researchers will compare the MRI scores from different doctors and also check if …

This study follows 500 transgender adults who have been on gender-affirming hormone therapy for at least one year. Researchers will measure changes in blood pressure, weight, blood tests, and body composition to see how hormones like testosterone and estrogen affect heart health.…

This study looks at rare lymphomas that are hard to tell apart under the microscope—some look like Hodgkin lymphoma but lack a typical marker (PAX5), while others may be a different type called ALCL. Researchers will study the genetic and protein features of these cancer cells to…

This study collects medical and genetic information from 520 people with multiple myeloma to better understand why the disease progresses or comes back. Researchers will analyze DNA and RNA from patient samples to find patterns linked to treatment response. The goal is to create …

This study uses advanced heart MRI scans to look at blood flow in people with different types of hypertrophic cardiomyopathy (thick heart muscle), including Anderson-Fabry disease and cardiac amyloidosis. Researchers will also study first-degree relatives and genetic carriers. Th…

This study follows 400 adults with severe heart failure who receive a mechanical heart pump (ventricular assist device). Researchers will track survival rates and complications over five years to understand how well these devices work in real-world settings. The goal is to gather…

This study looks at 520 children and teens with a rare condition called 46, XY DSD, where a person's chromosomes (XY) don't match their physical sex development. Researchers will collect genetic and physical information to better understand the condition. The goal is to learn mor…

This study aims to see if advanced imaging techniques, like special ultrasound and MRI, can find heart damage earlier in children, teens, and young adults who have had cancer treatment. Researchers will follow 400 participants to track heart problems that may appear during or aft…