Fondation Ophtalmologique Adolphe De Rothschild

This study compares two invasive treatments—placing a stent in a brain vein or a shunt to drain fluid—for people with idiopathic intracranial hypertension whose vision is at risk despite medication. About 276 adults with confirmed high pressure and narrowed brain veins will be ra…

This early-phase study tests whether using ultrasound to temporarily open the blood-brain barrier is safe when combined with an anti-inflammatory drug (etanercept) in people with mild Alzheimer's disease. The goal is to help the drug reach the brain more effectively. Only 5 parti…

This study looks at whether people with active multiple sclerosis (MS) who have been on ocrelizumab for at least 2 years can switch to getting infusions once a year instead of every 6 months. The goal is to see if the yearly schedule still prevents new brain lesions while lowerin…

This study tests whether adding a fast-acting blood thinner (cangrelor) to the standard clot-removal procedure improves recovery after a stroke. About 368 adults with a large-vessel blockage in the brain will receive either the drug plus the procedure or the procedure alone. The …

This study tests whether the drug bevacizumab, given through a vein, can reduce disabling symptoms like headaches, seizures, and thinking problems in people with brain arteriovenous malformations (AVMs) that cannot be treated with surgery or radiation. About 54 adults with modera…

This study tests whether a daily IV dose of dornase alfa (a drug currently used for cystic fibrosis) given for up to 14 days after a brain aneurysm rupture can help patients regain independence at 6 months. The drug targets tiny blood clots and inflammation in the brain that ofte…

This study tests whether starting steroids right away, followed by rituximab if symptoms return, can prevent eye muscle weakness from spreading to other muscles in people with ocular myasthenia gravis. About 128 adults diagnosed within the last 6 months will be randomly assigned …

This study is testing a new, more detailed MRI sequence (3D FGAPSIR) to see if it can find spinal cord lesions that standard MRI might miss. About 200 adults with multiple sclerosis will get an extra 10-minute scan during their regular MRI. The goal is to improve detection and un…

This study looks at whether a lower-resolution MRI can reliably diagnose giant cell arteritis, a serious condition that inflames arteries and can cause blindness or stroke. Researchers will compare different MRI scans in 133 people suspected of having the disease. If successful, …

This study aims to improve the diagnosis of a rare, non-cancerous brain tumor called MVNT using advanced, ultra-high resolution MRI scans. The goal is to create clearer diagnostic criteria so patients can avoid invasive surgery to remove a harmless lesion. Researchers will compar…

This study aims to see if a special MRI technique can better detect a condition called anterior ischemic optic neuropathy (NOIA), which can cause sudden vision loss. Researchers will add an 8-minute scan to the standard MRI for 250 adults with suspected NOIA. The goal is to impro…

This study compares a new MRI sequence called MP2RAGE with standard scans to see if it finds more spinal cord lesions in people with multiple sclerosis (MS). About 196 adults with MS will get both types of scans, and two radiologists will count the lesions without knowing which s…

This study compares two ways to screen men at high risk for abdominal aortic aneurysm (AAA): having their general practitioner use a small, portable ultrasound device during a regular visit versus the current standard of referring them to a radiologist. The goal is to see if the …

This study looks at whether having cataract surgery on both eyes on the same day is as safe and effective as having them on separate days, and whether it saves money. Researchers will compare costs and quality of life for 242 adults in France who need surgery in both eyes. The go…

This study follows 2000 people who had a brain aneurysm treated with a procedure called embolization. The goal is to collect standard long-term information to see how often the aneurysm comes back and when another treatment is needed. Participants must be over 18 and have had cur…

This study aims to create a database of eye images using a new holographic Doppler laser device. Researchers want to see if this laser can clearly show blood flow in the retina and choroid, which could help diagnose eye diseases. About 123 adults, both with and without eye condit…

This study follows 1000 adults who had embolization for brain arteriovenous malformations (AVMs) to collect standardized long-term data. Currently, follow-up methods vary widely, so reliable information is scarce. Participants will have angiographic checks to see if the AVM remai…

This study looks at tiny markers on the surface of eye cells in people with severe dry eye. Researchers want to see how these markers differ between patients and healthy people, and how they change after starting treatment. The goal is to better understand the disease, not to tes…

This study looks at copper levels in breast milk from women with Wilson's disease who are on treatment. Wilson's disease causes copper buildup, and medicines can lower copper, which might affect breast milk. Researchers will measure copper in milk from 20 new mothers to see if br…

This study looks at how Wilson's disease affects dental health. Researchers will compare tooth decay and gum health in people with two forms of Wilson's disease (liver vs. nervous system) and healthy volunteers. They will also check if copper levels in saliva can show how well tr…

This study looks at how the immune system and blood clotting change in the first 24-36 hours after a stroke treated with a clot removal procedure (thrombectomy). Researchers will collect blood samples from 1,200 participants to find patterns that might predict how well people rec…

This study compares the inner lining of blood vessels (called the glycocalyx) in 100 people with and without primary open-angle glaucoma. Researchers want to see if damage to this lining is linked to the eye disease. Participants will have a non-invasive test to measure the linin…

This study surveys 400 adults with epilepsy in France to understand why they are less physically active than the general population. Researchers will look at how fear, stigma, and personal beliefs about epilepsy affect exercise habits. The goal is to find better ways to help peop…

This study follows 5,000 people who had a stroke and received a procedure to remove a blood clot. Researchers want to see how well patients recover 3 months later. The goal is to collect information that is rarely tracked but important for understanding recovery.

This study is testing whether a special type of MRI, called resting-state fMRI, can help predict how well people with optic neuritis (inflammation of the eye nerve) will recover their vision. About 200 adults with suspected optic neuritis will get an extra MRI scan and eye exams,…

This study looks at blood clots removed from people having a stroke to see if their makeup is linked to what caused the stroke, how well treatment works, and how the person recovers. Researchers will also test participants' blood for related markers. The goal is to learn more abo…

This study tests whether a high-resolution MRI can better show how close a parotid (salivary gland) tumor is to the facial nerve. About 88 adults scheduled for first-time parotid surgery will get this special MRI before their operation. The goal is to help surgeons plan more prec…

This study tests whether a special type of MRI, called resting-state fMRI, can predict how well children with drug-resistant epilepsy will do after brain surgery. Researchers will scan 200 children aged 6-18 before surgery and analyze brain network patterns using graph theory. Th…

This study is looking for specific smells (volatile organic compounds) that people with epilepsy might give off before, during, or after a seizure. Researchers will collect odor samples from 100 adults with drug-resistant epilepsy during a hospital stay. The goal is to identify t…

This study looks at how safe and effective DMEK eye surgery is for people who have already had other eye surgeries like vitrectomy or glaucoma surgery. Researchers will track serious problems and vision improvement over 12 months in 80 participants. The goal is to see if DMEK can…

This study looks at how the brain learns to control fine movements, like playing a musical instrument. Researchers will ask 50 people already scheduled for awake brain surgery (for epilepsy or brain tumors) to use a theremin-like device. By recording brain activity directly, they…

This study looks at why some stroke patients don't recover well even after treatment to reopen large brain arteries. Researchers think tiny blood clots in smaller vessels may be the cause. They will use special MRI scans and tissue samples from 15 patients who need surgery to rel…

This study follows 1,000 nearsighted children in Europe to track how their eyes grow over time. Researchers will use advanced eye scans and exams to better understand myopia progression. The goal is to improve prevention and treatment strategies for this common vision problem.

This study aims to find genetic mutations in the brain that cause drug-resistant epilepsy in children. Researchers will compare DNA from blood and brain tissue, including samples from special electrodes placed in the brain. The goal is to better understand the root causes of thes…

This study looks at whether special eye scans can detect changes in the retina that are linked to memory disorders like Alzheimer's or Parkinson's. Researchers will compare eye images from 450 people with and without memory complaints. The goal is to find non-invasive markers tha…

This study aims to make MRI scans better and more comfortable by testing new imaging sequences. About 750 adults will have both the standard MRI and experimental versions, and experts will compare image quality and artifacts. The extra scan time ranges from a few minutes to an ho…

This study looks at how genetic changes influence the outlook for people with brain or spinal cord arteriovenous malformations (AVMs). Researchers will analyze DNA from 300 participants to find links between specific gene mutations and disease progression. The goal is to better u…

This study looks at two treatments made from a person's own blood to help heal the clear front part of the eye (cornea) in people with a rare eye condition called aniridia. The goal is to see if a special plasma rich in growth factors works better than the usual serum treatment a…

This study looks at platelets (small blood cells) in brain and spinal cord tumors to see if they affect tumor growth and patient survival. Researchers will examine tumor samples from 50 adults undergoing surgery. No new treatment is given; the goal is to learn how platelets inter…

This study looks at how chronic pain changes the brain's reward system, which can make it harder to feel motivated or learn from rewards. Researchers will compare 50 people with chronic pain to healthy volunteers using brain scans and a learning task. The goal is to better unders…

This study looks at whether sinus infections (sinusitis) are common in people with wet AMD who need many eye injections. Researchers will screen 200 participants for sinusitis and see if treating it reduces the number of injections needed. The goal is to understand the link betwe…

This study aims to validate a virtual reality test called VisionumVR, which uses a Meta Quest 3 headset to measure functional vision in people with low vision. About 60 participants who are starting or already in orthoptic rehabilitation will take a 20-minute VR test that evaluat…

This study looks at how seizures change the brain's wiring in children with hard-to-control focal epilepsy. Researchers will use special brain recordings and MRI scans to measure connections in areas where seizures start. The goal is to understand how ongoing seizure activity aff…

This study aims to find biological markers (biomarkers) in the blood of people with ALS that can show whether a potential new treatment is working. Researchers will collect tiny particles shed by neurons from blood samples of 30 ALS patients and 30 healthy volunteers. By comparin…

This study compares two imaging methods—MRI and ultrasound—to see how well they match in measuring eye layers. About 30 adults who need an eye ultrasound will also get a high-resolution MRI with contrast dye. The goal is to understand when the two tests agree or disagree, not to …

This study looks at how Wilson's disease may affect the heart due to copper buildup. Researchers will use heart scans, blood tests, and heart monitors to check for damage in 150 adults with the condition. The goal is to better understand heart problems in Wilson's disease and imp…

This pilot study aims to describe lymphatic damage in people with brain vein narrowing or clots using a special MRI sequence. About 100 adults who already need an MRI for their condition will get extra scans. The goal is to see if this new method can detect lymph nodes or bundles…

This study looks at how children's brains process language as they grow. Researchers will record brain activity from children (ages 2-20) who already have electrodes implanted for epilepsy monitoring. While listening to stories, their brain signals will reveal how the brain combi…

This study looks at whether a special MRI scan can predict how well children with retinoblastoma (a rare eye cancer) will respond to chemotherapy delivered directly to the eye. Researchers will follow 60 children for 18 months after treatment to see if the MRI findings match the …

This study looks at how the brain's visual networks change in people with inherited retinal diseases. Researchers will use MRI scans to map brain connections before and after treatments like retinal implants or optogenetics. The goal is to understand how the brain adapts to visio…

This study explores whether combining a driving simulator with an EEG (a brain activity test) can better assess driving ability in people with epilepsy. Researchers will measure attention, reaction time, and driving performance in 40 adults with epilepsy who hold a valid driver's…

This study looks at specific blood markers related to inflammation and clotting in people who have lost oxygen to the brain due to stroke or bleeding. Researchers will compare these markers between affected patients and those without brain oxygen loss. The goal is to better under…

This study looks for links between specific genes and the severity of eye surface disease in people with inherited conditions. Researchers will examine 60 participants to see which genetic changes lead to the worst symptoms. No treatment is given; the goal is to better understand…