Fondation Ophtalmologique Adolphe De Rothschild

This study tested a new clot-removal method called ADAPT for people having a severe stroke caused by a large blood clot in the brain. The goal was to see if using a suction tube first could open the blocked artery better than the standard method using a stent-like device. 381 adu…

This study tested whether adding the drug dornase alfa (Pulmozyme) to standard stroke treatments (clot-busting medicine and mechanical clot removal) could help fully reopen blocked arteries in the brain. The trial included 39 people with ischemic stroke who were already eligible …

This study tested whether using a much lower dose of gadolinium contrast in MRI scans can still accurately detect meningiomas, a common type of brain tumor. Over 500 adults undergoing routine screening or follow-up for meningiomas received both a standard full-dose MRI and a new …

This study tested an artificial intelligence (AI) algorithm that can diagnose multiple neuro-ophthalmologic and neurologic conditions—such as optic nerve diseases and brain tumors—from a single retinal image. Researchers analyzed data from 693 patients with confirmed diagnoses to…

This study looked at whether advanced high-resolution MRI can help doctors better diagnose the cause of optic disc swelling, a sign of various eye or brain conditions. Researchers enrolled 197 adults with optic disc edema and used new MRI sequences to see if they could more accur…

This small study tested whether spinal cord stimulation could improve walking in people with Parkinson's disease whose symptoms are not well controlled by medication. Five participants received a spinal cord stimulator, and researchers measured changes in walking ability and free…

This study tested whether a budesonide nasal spray can improve smell in COVID-19 patients who lost it for at least 30 days. About 120 adults with mild COVID-19 and persistent smell loss took part. The treatment aims to reduce inflammation in the nose and help restore the sense of…

This study tested a technique called thermocoagulation in 100 children with focal drug-resistant epilepsy. Doctors used tiny electrodes to apply heat to the part of the brain causing seizures, aiming to reduce seizure frequency for weeks or months. The goal was to ease symptoms a…

This study looked at 68 adults with wet age-related macular degeneration (AMD) to see if a newer type of eye scan (OCT angiography) changes how doctors decide when to give injections, compared to the standard scan (OCT B-scan). The goal was to see if the newer scan helps keep vis…

This study looked at 20 adults with a flat spot in the center of the retina (fovea plana) but no known albinism or vision problems. Researchers used DNA tests and eye scans to see if these people carry gene changes linked to albinism. The goal was to better understand why some he…

This study looked at eye problems in 23 COVID-19 patients in the intensive care unit. Researchers checked for damage to the cornea, retina, and optic nerve over time. The goal was to find and treat eye issues early to prevent permanent vision loss.

This study tested two different MRI scan methods to see how well they detect the 'central vein sign,' a marker of multiple sclerosis (MS). Researchers compared a standard scan to a newer, faster version in 60 adults with early-stage MS. The goal was to find which technique works …

This study looked at 20 healthy adults to describe tiny bright spots seen in a specific layer of the retina using a special eye scanner (SD-OCT). The goal was to understand what these spots are and how they change with time and light. This is basic research to help future studies…

This study aimed to improve the diagnosis of a rare, non-cancerous brain tumor called MVNT (multinodular and vacuolating neuronal tumor). Researchers used special MRI scans to find unique chemical patterns that help tell MVNT apart from other brain growths. The study included 71 …

This study looked at 63 people who had a central retinal artery occlusion (CRAO), also known as an eye stroke. Researchers used advanced MRI scans before and after treatment to find signs that could help diagnose the condition and predict how much vision might return after one mo…

This study looked at whether using the brain's own temperature to guide cooling treatment works better than using body temperature in people with severe brain injury. Forty-one adults with brain injury and fever were enrolled. The goal was to see if brain-based cooling keeps the …

This study looked at whether using ultrasound to guide a needle into the leg artery of children helps doctors succeed on the first try. 149 children who needed this procedure took part. The goal was to see if ultrasound improves the success rate compared to the usual method of fe…

This study tested two different MRI techniques to see which one better detects active inflammation in the brains of people with multiple sclerosis (MS). 180 adults with MS or similar conditions had brain scans after a recent flare-up. The goal was to find the most sensitive metho…

This study checked if two common hearing aid questionnaires (COSI and IOI-HA) work properly in French. Researchers tested 100 adults with hearing loss who use hearing aids. The goal was to make sure the French versions are accurate and useful for doctors and researchers.

This study looked at 455 people who had a stroke and were treated to reopen blocked arteries. Researchers compared two ways of measuring blood pressure in the first 24 hours after treatment: a continuous monitor (Clearsight) versus the standard arm cuff. The goal was to see which…

This study tested a new questionnaire designed to measure how well babies (0-36 months old) with eye diseases can see, even before they can talk. The goal was to see if the questionnaire is reliable and accurate, so doctors can better decide when surgery is needed. The study incl…

This study looked at whether special eye imaging can help understand stroke. Researchers used a technique called adaptive optics to take detailed pictures of tiny blood vessels in the eyes of 91 people who recently had a stroke and compared them to healthy controls. The goal was …

This study looked at how a contrast dye called gadolinium changes the QSM signal on MRI scans in people with white matter disease. 73 participants had an MRI without dye, then with dye (as part of their normal care), and then another without dye. The goal was to measure the diffe…

This study looked at eye damage in 34 people who were hospitalized for severe COVID-19. Researchers used advanced eye imaging to find problems caused by the virus, inflammation, or treatments like oxygen and medications. The goal was to better understand and describe these eye is…

This study tested whether a technique called compressed sensing can make MRI scans faster without losing image quality. 82 people had extra scan sequences added to their routine MRI. The goal was to see if the faster scans still gave the same brain tissue readings as the standard…

This study tested whether a special MRI scan called IVIM can predict how well people recover 3 months after a stroke. 274 adults with acute ischemic stroke had an initial MRI, and researchers compared the IVIM results to their disability scores 3 months later. The goal was to see…

This study tested whether a central monitoring station outside the operating room is as safe as having an anesthesia nurse in each room during eye surgeries like cataract removal. 900 adults having eye surgery with local anesthesia took part. The goal was to see if this approach …

This study involved 13 adults with drug-resistant epilepsy to create a database for developing a seizure detection algorithm. Researchers used a wearable patch to record heart rate and movement, while patients also underwent video-EEG monitoring as the gold standard. The goal is …

This study checked if leftover COVID-19 virus in the nose is linked to ongoing brain fog and memory problems. Researchers compared 51 adults who had COVID-19 months earlier—some with brain fog, some without. They looked for virus in the nasal cavity and matched it to thinking dif…