Eli Lilly And Company

This large, late-stage study is testing whether a new injectable drug called lepodisiran can reduce the risk of serious heart problems like heart attacks, strokes, and heart-related death. It involves about 17,300 adults who have high levels of a specific blood fat called lipopro…

This study is testing whether an experimental drug called remternetug can delay the worsening of memory, thinking, and daily function problems in people with early Alzheimer's disease. About 1,400 participants will receive either the drug or a placebo (inactive substance) to see …

This study is testing an experimental drug called LY3541860 for adults with moderate-to-severe rheumatoid arthritis who haven't responded well to other advanced treatments. About 35 participants will receive the drug for 24 weeks, followed by 20 weeks of safety monitoring. Resear…

This study is testing whether adding a new investigational drug called mibavademab to an existing weight loss medication (tirzepatide) helps people lose more weight. About 392 adults with obesity will receive either the combination or tirzepatide alone for about 74 weeks. The mai…

This study aims to learn about the long-term safety and effectiveness of the drug lebrikizumab for children and teenagers with moderate-to-severe eczema. It is an extension study for about 310 participants who completed a previous trial, following them for up to 116 weeks. The ma…

This study is testing whether combining two existing cancer drugs, abemaciclib and pembrolizumab, is safe and effective for people with advanced non-small cell lung cancer or a specific type of advanced breast cancer. It will involve about 100 participants who have stage IV cance…

This study is testing an oral medication called selpercatinib for people with advanced solid tumors that have a specific genetic change called a RET alteration. The trial aims to find a safe dose and see if the drug can shrink tumors in patients who have run out of standard treat…

This study is testing whether a weekly injection called tirzepatide can help adults who have type 1 diabetes and are overweight or obese. Researchers want to see if it improves long-term blood sugar control and leads to weight loss, compared to a placebo injection. About 465 part…

This study is testing a once-daily pill called orforglipron to see if it can reduce breathing pauses during sleep (sleep apnea) and help with weight loss in adults who are overweight or have obesity. It will enroll 600 people, including those who do and do not use a standard brea…

This study aimed to test whether an experimental drug called volenrelaxin could help adults with chronic kidney disease by reducing protein in urine and protecting kidney function. The trial was designed to compare volenrelaxin against a placebo over 24 weeks in participants alre…

This study is testing how well the drug mirikizumab works and how safe it is for people with Crohn's disease over a long period. It follows nearly 1,000 participants who completed earlier studies of the same medication. The main goals are to see if the drug reduces intestinal inf…

This large study is testing whether a new hormone therapy called imlunestrant works better than standard hormone therapy at preventing breast cancer from returning. It's for people with early-stage, hormone-sensitive breast cancer who've already completed 2-5 years of hormone the…

This study follows patients for up to 3 years to see how well mirikizumab controls ulcerative colitis symptoms long-term and how safe it is. It's open to 1,063 people who completed earlier mirikizumab trials and have moderate to severe ulcerative colitis. The research measures wh…

This study is testing whether the medication tirzepatide is better than standard intensified care for long-term management of type 2 diabetes when started early. It will involve about 780 adults recently diagnosed with type 2 diabetes who are currently only taking metformin. The …

This study is testing whether adding a drug called abemaciclib to standard chemotherapy (irinotecan and temozolomide) works better for controlling Ewing's sarcoma that has come back or stopped responding to treatment. It involves about 46 children and young adults. The main goal …

This early-stage study is testing a new drug called LY3537031 to see if it is safe and how it affects the body. It involves about 300 participants, including people who are overweight or obese and healthy volunteers. Researchers will check for side effects, measure how the drug m…

This early-stage study is testing the safety of a drug called abemaciclib when combined with various other breast cancer therapies. It involves 198 people whose breast cancer has spread to other parts of the body. The main goal is to see which drug combinations are safe and toler…

This study is testing a new weekly injection called retatrutide for adults with type 2 diabetes and moderate-to-severe kidney problems. It aims to see if the injection is better than a placebo (dummy shot) at lowering blood sugar and body weight over about 14 months. The goal is …

This clinical trial is testing a new targeted radiation treatment called [Ac-225]-PSMA-62 for men with advanced prostate cancer that has spread. The treatment uses a radioactive drug designed to find and deliver radiation directly to prostate cancer cells throughout the body. The…

This study is testing whether an investigational drug called LY3541860 can safely slow the formation of new brain lesions in adults with relapsing forms of multiple sclerosis. About 63 participants will receive either the drug or a placebo for approximately 9 months, followed by …

This study is testing whether an investigational drug called mazdutide can help people with alcohol use disorder reduce their drinking. About 300 participants will receive either mazdutide or a placebo (inactive substance) for several months, and researchers will track their drin…

This study is testing different dosing schedules for the Alzheimer's drug donanemab to find the best balance between clearing harmful brain plaques and minimizing a serious side effect called ARIA-E, which is brain swelling. It involves about 1,175 adults with early memory proble…

This study tested whether adding a new drug called abemaciclib to standard hormone therapies helps postmenopausal women with advanced breast cancer live longer without their cancer getting worse. It involved 463 women whose cancer had returned or spread and was fueled by hormones…

This study is testing whether a new drug called LY3841136, alone or combined with an existing drug called tirzepatide, can help with weight management in adults who have type 2 diabetes and are overweight or have obesity. About 350 participants will receive either the active drug…

This study is testing an investigational drug called lebrikizumab in children and teenagers with moderate-to-severe eczema. Participants are randomly assigned to receive either the drug or a placebo to see if it improves their skin condition and reduces itching. The main goals ar…

This large, late-stage study is testing whether adding an investigational drug called ramucirumab to a standard targeted therapy (erlotinib) works better for people newly diagnosed with a specific type of advanced lung cancer. It involves 545 participants whose cancer has spread …

This large, late-stage study aims to see if the medication retatrutide can lower the risk of serious heart problems like heart attacks and strokes, and slow the worsening of kidney disease. It will involve 10,000 adults who are overweight or obese and already have heart disease a…

This study is testing whether a monthly injection called galcanezumab can safely reduce the number of migraine days for teenagers with chronic migraine. About 312 participants aged 12 to 17 will receive either the real medicine or a placebo (dummy shot) for 3 months, followed by …

This study is comparing a new targeted drug called selpercatinib to standard chemotherapy and immunotherapy for people with advanced lung cancer that has a specific genetic change called a RET fusion. The goal is to see if selpercatinib is more effective at controlling the cancer…

This early-stage study is testing the safety and initial effectiveness of a new oral drug called LOXO-338 for patients with advanced blood cancers like leukemia and lymphoma who have already received standard therapies. The trial has two parts: first testing LOXO-338 alone, and t…

This early-stage study is testing the safety of an experimental drug called LY3200882 in people with advanced solid tumors. Researchers are enrolling 223 participants to determine the highest dose that can be given safely and to look for initial signs that the drug might help con…

This study is investigating how well the drug mirikizumab improves the sudden, urgent need to have a bowel movement in adults with moderate-to-severe ulcerative colitis. About 172 participants who have not responded well to other treatments will receive mirikizumab for 36 weeks. …

This study aimed to test how well and safely two different drugs, bimagrumab and tirzepatide, worked alone or together to help adults with obesity or overweight and type 2 diabetes lose weight. The trial was designed to last about 13 months but was withdrawn before any participan…

This study is testing whether adding a drug called abemaciclib to standard chemotherapy (temozolomide) works better for controlling aggressive brain tumors in children and young adults who have just finished radiation. About 45 participants will be randomly assigned to receive ei…

This study is testing whether adding the drug ramucirumab to standard chemotherapy can help control a rare and aggressive cancer called desmoplastic small round cell tumor (DSRCT) in children and young adults whose cancer has returned or stopped responding to previous treatments.…

This study is testing if using two drugs together works better than one for adults who have both moderate-to-severe plaque psoriasis and are overweight or have obesity. About 250 participants will receive the psoriasis drug ixekizumab alone or combined with the weight-loss drug t…

This study is testing two different treatment approaches for women with advanced breast cancer that has grown despite prior hormone therapy and chemotherapy. It compares a new drug called abemaciclib taken alone versus abemaciclib combined with the hormone drug tamoxifen. The mai…

This study is testing whether an injectable drug called lebrikizumab can help control moderate-to-severe eczema that specifically affects the hands and feet. It will involve 206 adults and teenagers whose eczema hasn't responded well to standard creams and ointments. Participants…

This study is testing whether higher doses of the medication tirzepatide can help people with both type 2 diabetes and obesity lose weight and better control their blood sugar. About 414 participants who are already taking metformin will receive either the study drug or a placebo…

This study is testing a pill called LOXO-292 in children and teenagers with advanced solid or brain tumors that have a specific genetic change called a RET alteration. The goal is to find a safe and effective dose and to see if the medicine can shrink these difficult-to-treat tum…

This study is testing a new weekly medicine called retatrutide to see if it helps people with type 2 diabetes recover faster from episodes of dangerously low blood sugar. About 78 participants will receive either the real medicine or a placebo for 16 weeks. Researchers will then …

This study compared two drug approaches for people with advanced non-small cell lung cancer that has a specific genetic change called a KRAS mutation and has worsened after standard chemotherapy. 453 participants were randomly assigned to receive either the experimental drug abem…

This study is testing if using two drugs together works better than one for adults with psoriatic arthritis who are also overweight or have obesity. One drug (ixekizumab) treats the arthritis, and the other (tirzepatide) is a weight-loss medication. The goal is to see if the comb…

This study is testing how well the weekly injection tirzepatide works and how safe it is for adults with type 2 diabetes who plan to fast during the month of Ramadan. Researchers will measure changes in blood sugar control and body weight, and track any side effects like low bloo…

This study is for people with a specific type of advanced breast cancer that has continued to grow despite previous hormone therapy and a targeted drug. It tests whether adding a medication called abemaciclib to standard fulvestrant therapy is better at controlling the cancer tha…

This large Phase 3 trial tested whether adding a new drug called abemaciclib to standard hormone therapy (fulvestrant) works better for women with a common type of advanced breast cancer. The study involved 669 women whose cancer had progressed after prior hormone treatment. Rese…

This study is testing whether a weekly injection called tirzepatide can help adults with type 1 diabetes who are also overweight or obese. It will compare the medicine to a placebo (dummy shot) to see if it improves long-term blood sugar levels and helps with weight loss. The tri…

This study is testing whether a medication called ixekizumab is safe and effective for children with two specific types of juvenile arthritis: enthesitis-related arthritis and juvenile psoriatic arthritis. It compares ixekizumab against an existing treatment, adalimumab, in about…

This program aims to make a long-acting injectable medication for schizophrenia safer by closely monitoring patients for a rare but serious side effect. It enrolls all patients who receive the medication, Zyprexa Relprevv, to track their health and ensure they are observed in a c…

This is an early-stage study to check the safety and side effects of a new drug called LY3849891 in people with fatty liver disease (MASLD) who have a specific genetic marker (PNPLA3 I148M). About 176 participants will receive injections of the drug, and researchers will use bloo…

This early-stage study is testing an oral medication called LOXO-260 for people with advanced cancers driven by specific changes in the RET gene. The goal is to find a safe dose and see if it can help control tumors that have stopped responding to other similar targeted drugs. Th…

This study is testing whether the drug selpercatinib can delay or prevent cancer from returning in people with early-stage non-small cell lung cancer who have already had surgery or radiation treatment. Participants will receive either the active drug or a placebo for up to three…

This study is testing a drug called retatrutide to see if it helps people with obesity maintain weight loss after they've already lost weight. About 643 participants will first take the drug for 80 weeks to lose weight, then some will continue the drug or switch to a placebo for …

This study is testing whether a monthly injection called galcanezumab can safely reduce how often kids and teens get migraines. It involves about 533 participants, aged 6 to 17, who have episodic migraines. For the first 3 months, participants receive either the real medicine or …

This study tested whether adding a new drug called abemaciclib to standard hormone therapy works better for controlling advanced breast cancer. It involved nearly 500 postmenopausal women whose cancer had returned or spread and who had not yet received treatment for this advanced…

This study is testing an investigational drug called eltrekibart for adults with moderate-to-severe hidradenitis suppurativa (HS), a painful chronic skin condition. The main goal is to find the safest and most effective dose and dosing schedule to reduce the number of painful abs…

This study is testing two investigational drugs, bimagrumab and tirzepatide, to see how well and how safely they help with weight loss. It will involve about 240 adults who have obesity or are overweight with a related health condition, but who do not have type 2 diabetes. Partic…

This study is investigating whether the medication tirzepatide, which is approved for weight loss and diabetes, can improve kidney health in people who are overweight or obese and have chronic kidney disease. Researchers will use special MRI scans to see if the drug increases oxy…

This large, late-stage study is testing whether a once-daily oral medication called orforglipron can help adults with obesity or overweight lose weight and improve related health conditions like high blood pressure or cholesterol. Over 3,100 participants will take the drug or a p…

This study is testing whether a new daily medication called LY3549492 can help adults with obesity or overweight manage their weight. About 288 participants will take either the drug or a placebo (inactive pill) for roughly one year. Researchers will measure changes in body weigh…

This study is testing whether an experimental drug called mevidalen is safe and can help control symptoms in people with mild to moderate Alzheimer's disease. About 300 participants will take the drug or a placebo for 26 weeks to see if it improves their memory, thinking, and abi…

This early-stage study is testing a new drug called LOXO-783, both alone and combined with other cancer treatments. It is for adults with advanced breast cancer or other solid tumors that have a specific genetic change called a PIK3CA H1047R mutation. The main goals are to find a…

This large, late-stage study is testing whether a new once-daily pill called orforglipron is as safe and effective as standard insulin injections for adults with type 2 diabetes who also have obesity or are overweight and are at higher risk for heart problems. It will involve abo…

This is an early-stage trial to test the safety and determine the right dose of a new experimental drug called LY4066434. The drug is designed to block a common cancer-driving protein called KRAS in people with advanced solid tumors, including pancreatic, lung, and colorectal can…

This study is testing whether a new injectable drug called lebrikizumab, used alone or with a standard steroid cream, can better control moderate-to-severe eczema. About 300 adults and adolescents whose eczema isn't well-controlled by current creams will participate for about 62 …

This large, late-stage study is testing whether the weight-loss medication tirzepatide can reduce serious health events like heart attacks, strokes, and death in adults with obesity. It involves over 15,000 participants who are either over 40 with existing heart disease or are at…

This large, late-stage study is testing whether the drug donanemab can prevent or significantly delay the onset of Alzheimer's disease in people who are at risk but do not yet show clear symptoms. It involves nearly 3,000 participants who have early biological signs of Alzheimer'…

This study is testing an experimental drug called LY3848575 to see if it is safe and effective at reducing chronic nerve pain that starts in the feet and moves up the legs. It will compare the drug to a placebo in about 450 adults who have had this type of pain for at least six m…

This is an early safety study testing a new drug called LY4005130 in healthy volunteers. Researchers want to see what side effects might occur and how the drug moves through the body. The study involves giving single and multiple doses to small groups of healthy people and closel…

This study aims to understand how three different pill versions of an investigational drug, called LY4100511, are absorbed by the body. It will also test if taking a common stomach acid medicine changes this absorption. The study involves 48 healthy participants who will take the…

This early-stage study aims to understand how the body absorbs and processes a new drug called LY3537031. Researchers are testing healthy volunteers to see if injecting the drug under the skin in different body areas changes how much gets into the bloodstream, compared to injecti…

This study aims to understand the healthcare use, costs, and quality of life over time for 1,400 people in the early stages of Alzheimer's disease in the United States. It is purely observational research and does not provide any treatment. Participants and their caregivers will …

This early-stage study aims to check the safety and side effects of a new drug called LY4060874 in healthy people. Researchers will also measure how the body absorbs and processes the medication. The study involves 132 healthy volunteers and is the first step in testing this pote…

This early-stage study aims to understand how two different versions of an experimental drug called LY4064809 are absorbed and processed by the body. Researchers will enroll 24 healthy adults who will stay at a research center for about one month while their blood is tested. The …