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New daily pill could help control blood pressure in overweight individuals

NCT ID NCT06948422

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial is testing a once-daily pill called orforglipron in nearly 1,000 people with high blood pressure who are also overweight or have obesity. The study compares the drug to a placebo to see if it safely lowers blood pressure. Participants may be untreated or on stable blood pressure medications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
orforglipron (a daily pill)
What this could lead to
If it works, this could provide a new once-daily medication to help control blood pressure in people who are overweight or have obesity.
What could go wrong
This is still an early Phase 3 trial, and results may not confirm benefit. Side effects or lack of effectiveness compared to placebo are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 974 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Has systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg (if DBP criteria alone is met, SBP must be ≥130 mmHg) at screening (Visit 1). * Has SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg (if DBP criteria alone is met, SBP must be ≥130 mmHg) at week 0 (Visit 3). * Untreated for hypertension, or on stable antihypertensive medications ≥ 30 days prior to Visit 1. * Have a body mass index (BMI) ≥ 25 kg/m². Exclusion Criteria: * Has SBP ≥170 mmHg and/or DBP ≥110 mmHg at Visit 1 or at Visit 3. * Has known secondary causes of hypertension * Have heart failure with reduced ejection fraction (HFrEF) diagnosis * Have had any of the following conditions within 90 days prior to screening. * hospitalization for hypertension or for congestive heart failure * acute coronary syndrome or acute myocardial infarction, or * cerebrovascular accident (stroke). * Have type 1 diabetes (T1D) * Have acute or chronic hepatitis, including a history of autoimmune hepatitis

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Conditions

The condition(s) this trial relates to.

hypertensive disorder obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypertension

Contacts and locations

Locations

  • AHEPA University General Hospital of Thessaloniki

    Thessaloniki, 546 36, Greece

  • Advanced Research Institute

    Ogden, Utah, 84405, United States

  • Advanced Research Institute - Tigard

    Tigard, Oregon, 97223, United States

  • All India Institute of Medical Sciences

    Bhubaneswar, 751019, India

  • AmBeNet GmbH

    Leipzig, 04107, Germany

  • Angiocentrum Komorany

    Prague, 143 00, Czechia

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, Michigan, 48098, United States

  • Ascension Saint Agnes Heart Care

    Baltimore, Maryland, 21229, United States

  • Ashirwad Hospital and Research Centre

    Ulhasnagar, 421004, India

  • Athens Medical Center - Psychikon branch

    Athens, 115 25, Greece

  • Balsam Medica

    Warsaw, 01-249, Poland

  • Beijing Pinggu District Hospital

    Beijing, 101200, China

  • CCR Ostrava s.r.o

    Ostrava, 702 00, Czechia

  • CEMEDIC

    Buenos Aires, C1407GTN, Argentina

  • CHUAC-Complejo Hospitalario Universitario A Coruña

    A Coruña, 15001, Spain

  • CIPREC

    Buenos Aires, C1061AAS, Argentina

  • CIPREC

    Buenos Aires, C1119ACN, Argentina

  • CTC Hodonin s.r.o.

    Hodonín, 695 01, Czechia

  • Care Access - Brandon

    Brandon, Florida, 33510, United States

  • Care Access - Mauldin

    Mauldin, South Carolina, 29662, United States

  • Care Access - St. Petersburg

    St. Petersburg, Florida, 33710, United States

  • Carient Heart & Vascular - Manassas

    Manassas, Virginia, 20109, United States

  • Centro de Investigaciones Clínicas Baigorria

    Granadero Baigorria, 2152, Argentina

  • Centrum Medyczne "Hipokrates" S.C. Elżbieta I Grzegorz Grześk

    Bydgoszcz, 85-092, Poland

  • Changde First People's Hospital

    Changde, 415000, China

  • Chase Medical Research, LLC

    Waterbury, Connecticut, 06708, United States

  • China-Japan Union Hospital

    Changchun, 130033, China

  • Clinoxus

    Prague, 140 00, Czechia

  • Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)

    Seville, 41003, Spain

  • Complejo Asistencial Universitario de León - Hospital de León

    León, 24071, Spain

  • Dallas Heart and Vascular Consultants, PA

    Duncanville, Texas, 75137, United States

  • Diahelp s.r.o

    Pardubice V, 530 02, Czechia

  • Dorado Medical Complex

    Dorado, 00646, Puerto Rico

  • EAP Osona Sud - Alt Congost S.L.P

    Centelles, 08540, Spain

  • EAP Sardenya

    Barcelona, 08025, Spain

  • East-West Medical Research Institute

    Honolulu, Hawaii, 96814, United States

  • Eastside Research Associates

    Redmond, Washington, 98052, United States

  • Elite Clinical Studies, LLC

    Phoenix, Arizona, 85018, United States

  • Excel Clinical Research, LLC

    Las Vegas, Nevada, 89109, United States

  • Excel Medical Clinical Trials

    Boca Raton, Florida, 33434, United States

  • Familienmedizinisches Zentrum Radowsky

    Leipzig, 04179, Germany

  • Fukuwa Clinic

    Chūōku, 104-0031, Japan

  • FutureMeds GmbH

    Berlin, 10629, Germany

  • G. Gennimatas General Hospital of Thessaloniki

    Thessaloniki, 546 35, Greece

  • G.B. Pant Institute of Postgraduate Medical Education & Research

    New Delhi, 110002, India

  • General Hospital of Athens "G. Gennimatas"

    Athens, 11527, Greece

  • Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien

    Dresden, 01277, Germany

  • Health Research of Hampton Roads, Inc.

    Newport News, Virginia, 23606, United States

  • Hospital Quiron Infanta Luisa

    Seville, 41010, Spain

  • Hospital San Rafael - La Coruña

    A Coruña, 15006, Spain

  • INECO Neurociencias Oroño

    Rosario, 2000, Argentina

  • IRMED

    Piotrkow Trybunalski, 97-300, Poland

  • Instituto Médico Especializado (IME)

    Buenos Aires, 1405, Argentina

  • Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica

    Rosario, 2000, Argentina

  • Instituto de Investigaciones Clínicas Córdoba

    Córdoba, 5000, Argentina

  • Jinan Central Hospital

    Jinan, 250013, China

  • Life Care Hospital and Research Centre

    Bangalore, 560092, India

  • Lishui Central Hospital

    Lishui, China

  • Lucida Clinical Trials

    New Bedford, Massachusetts, 02740, United States

  • MUDr. Sarka Drinkova

    Ledeč nad Sázavou, 584 01, Czechia

  • Medical Corporation Yuga Tsuruma Kaneshiro Diabetes Clinic

    Yamato-shi, 242-0004, Japan

  • Medizentrum Essen Borbeck

    Essen, 45355, Germany

  • Mikannohana Clinic, Diabetes, Endocrinology and Metabolism

    Matsuyama, 7900034, Japan

  • NZOZ Centrum Medyczne KERmed

    Bydgoszcz, 85-231, Poland

  • NZOZ Regionalna Poradnia Diabetologiczna

    Wroclaw, 50-127, Poland

  • National Clinical Research, Inc

    Richmond, Virginia, 23294, United States

  • North Hills Family Medicine/North Hills Medical Research

    North Richland Hills, Texas, 76180, United States

  • Northeast Research Institute - Downtown Office

    Jacksonville, Florida, 32204, United States

  • Ordinace Rihackovi, s.r.o.

    Brno, 641 00, Czechia

  • Palm Research Center Sunset

    Las Vegas, Nevada, 89148, United States

  • Papageorgiou General Hospital of Thessaloniki

    Thessaloniki, 56403, Greece

  • Praglandia s.r.o

    Prague, 150 00, Czechia

  • PriMED Clinical Research

    Dayton, Ohio, 45429, United States

  • Private Practice - Dr. Robert Witek

    Tarnów, 33-100, Poland

  • Puerto Rico Medical Research

    Ponce, 00717, Puerto Rico

  • RED-Institut GmbH

    Oldenburg, 23758, Germany

  • Remington-Davis, Inc

    Columbus, Ohio, 43215, United States

  • Rochester Clinical Research, LLC

    Rochester, New York, 14609, United States

  • Ruijin Hospital Shanghai Jiaotong University School of Medicine

    Shanghai, 200001, China

  • Santa Maria de la Salud Centro Medico

    San Isidro, 1642, Argentina

  • Shaanxi provincial people's hospital

    Xi'an, 710068, China

  • Sichuan Provincial People's Hospital

    Chengdu, 610072, China

  • Sinai Hospital Of Baltimore

    Baltimore, Maryland, 21209, United States

  • Siping Central People's Hospital

    Siping, 136000, China

  • StudyMetrix Research

    City of Saint Peters, Missouri, 63303, United States

  • Takai Internal Medicine Clinic

    Kamakura-shi, 247-0056, Japan

  • Texas Institute of Cardiology, PA

    McKinney, Texas, 75071, United States

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang Shi, 471003, China

  • The Second Affiliated Hospital of Chongqing Medical University - Yuzhong Campus

    Chongqing, 400010, China

  • Tokyo-Eki Center-building Clinic

    Chūōku, 103-0027, Japan

  • Top Moravia Health

    Brno, 61500, Czechia

  • Universitaetsklinikum Carl Gustav Carus Dresden

    Dresden, 01307, Germany

  • University Hospital of Ioannina

    Ioannina, 45500, Greece

  • Uniwersytecki Szpital Kliniczny w Białymstoku

    Bialystok, 15-276, Poland

  • Valley Clinical Trials, Inc.

    Covina, California, 91723, United States

  • Valley Clinical Trials, Inc.

    Northridge, California, 91325, United States

  • Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu

    Przemyśl, 37-700, Poland

  • Wuxi People's Hospital

    Wuxi, 214023, China

  • Zentrum fur klinische Forschung - Köln

    Cologne, 51069, Germany

  • Zentrum für klinische Studien Bad Homburg

    Bad Homburg, 61348, Germany

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