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New drug cocktail shows promise for spreading breast cancer

NCT ID NCT02057133

First seen Jan 31, 2026 · Last updated May 22, 2026 · Updated 18 times

Summary

This early-stage study tested the safety of a drug called abemaciclib when combined with various other breast cancer treatments (like letrozole, tamoxifen, or trastuzumab) in 198 people whose breast cancer had spread to other parts of the body. The goal was to find safe combinations and understand how the drugs work in the body. Participants had either hormone receptor-positive or HER2-positive metastatic breast cancer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Columbia University College of Phys & Surgeons

    New York, New York, 10032, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Highlands Oncology Group - Duplicate 2

    Rogers, Arkansas, 72758, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905-0002, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Peggy and Charles Stephenson Oklahoma Cancer Center

    Nashville, Tennessee, 37203, United States

  • Providence Cancer Center Oncology Hematology Care

    Portland, Oregon, 97213, United States

  • South Texas Accelerated Research Therapeutics (START)

    San Antonio, Texas, 78229-3307, United States

  • Tennessee Oncology PLLC

    Nashville, Tennessee, 37203, United States

  • Univ of Pittsburgh Cancer Inst. (UPCI)

    Pittsburgh, Pennsylvania, 15213, United States

  • University of California - San Diego

    La Jolla, California, 92037-0845, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27514, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232-6307, United States

Conditions

Explore the condition pages connected to this study.