Eli Lilly and Company

Researchers are testing whether an oral drug called vepugratinib can clear low-grade, intermediate-risk bladder cancer that has not invaded muscle, or low-grade upper tract urothelial cancer. The trial enrolls adults whose tumors carry a specific change in the FGFR3 gene. Partici…

Researchers are studying the safety of selpercatinib, an oral drug, in people in India with advanced cancers that have changes in the RET gene. The trial includes adults with RET fusion-positive non-small cell lung cancer and adults and children aged 12 and older with RET-mutant …

Researchers are testing whether tirzepatide, given as a weekly injection, can help children aged 6 to under 12 who have obesity. All participants also receive support for healthy eating and exercise. The trial compares tirzepatide with a placebo and measures changes in body mass …

Researchers are testing whether adding olomorasib, an experimental drug that targets the KRAS G12C mutation, to cetuximab and standard chemotherapy (mFOLFOX6) helps people with advanced colorectal cancer that cannot be removed by surgery or has spread. The trial enrolls about 50 …

This early-stage trial tests an experimental drug called LY4329090 in adults with obesity or overweight. The main goal is to see how safe and tolerable the drug is, and how the body processes it. Participants receive either the drug or a placebo by injection, and researchers moni…

This trial tests whether orforglipron, a once-daily oral medication, helps Chinese adults with obesity or overweight and related health conditions lose weight. Participants take either orforglipron or a placebo for about a year. Researchers measure changes in body weight, waist s…

This phase 3 trial tests whether adding an experimental drug called brenipatide to standard depression treatment can delay the return of major depressive symptoms in adults with major depressive disorder. Participants receive either brenipatide or a placebo by injection, alongsid…

This master protocol supports several early-phase studies testing different amyloid-targeting drugs in healthy volunteers and people with Alzheimer's disease. The main goals are to check safety and tolerability, and to see whether these drugs can remove amyloid plaques from the b…

This early-stage trial evaluates the safety and tolerability of an experimental drug called LY4405094 in healthy volunteers and people with Alzheimer's disease. Researchers will measure how much of the drug enters the bloodstream and the fluid around the brain, and in Alzheimer's…

This trial tests whether clazakizumab, an experimental anti-inflammatory drug, can lower a blood marker of inflammation called hsCRP in adults who have elevated levels and are at increased risk for heart problems. Participants must have conditions like established heart disease, …

This trial is testing an investigational drug called brenipatide in adults with moderate-to-severe COPD. Participants will receive either brenipatide or a placebo for about a year, alongside standard care. The goal is to see if brenipatide improves lung function and reduces the n…

This study tests a new once-daily oral pill called orforglipron against a weekly injection (dulaglutide) in 170 teens aged 10-18 with type 2 diabetes. The goal is to see if the pill works better at controlling blood sugar and is safe. Participants will be followed for about 61 we…

This early-stage trial is testing whether a new drug called macupatide, given alone or with another drug called eloralintide, is safe and well-tolerated in Japanese adults with obesity or overweight who do not have type 2 diabetes. Participants will receive multiple doses and sta…

This study will test a wearable headband called Somfit that measures brain activity during sleep in people with early or no Alzheimer's symptoms. Researchers want to see if it works as well as a full lab sleep test. If it does, it could make it easier to track sleep changes linke…

This study tests a new, non-invasive eye scan that uses artificial intelligence to look for changes linked to Alzheimer's disease. Researchers will compare the scan results with blood tests in 200 UAE adults who have mild memory problems. The goal is to see if this quick, painles…

This phase 3 trial tests whether orforglipron, a daily oral medication, can help overweight adults reduce their risk of developing obesity-related complications such as type 2 diabetes, high blood pressure, and high cholesterol, as well as progression to class 1 obesity. Particip…

Researchers are testing how the body absorbs three different forms of abemaciclib, a drug used to treat some breast cancers. Fifteen healthy volunteers take each form in turn: a current tablet, a new tablet, and oral granules. The study measures how much and how quickly the drug …

This phase 1 trial examines whether eloralintide, an experimental drug for obesity, changes how the body processes a common birth control pill containing levonorgestrel and ethinyl estradiol. Researchers will give the pill to women with overweight or obesity, with and without elo…

This phase 1 trial asks whether a single dose of tirzepatide changes how quickly the stomach empties in adults with type 1 diabetes who are overweight or have obesity. Researchers will give participants either tirzepatide or a placebo injection, then measure stomach emptying usin…

This phase 1 trial evaluates the safety and tolerability of an experimental oral drug called LY5625575 in healthy volunteers, including Japanese and Chinese participants, and in people with elevated C-reactive protein, a marker of inflammation. Researchers will also measure how m…

This study tests whether the experimental drug olomorasib enters the bloodstream the same way when swallowed as a whole capsule or mixed into water. Healthy volunteers will receive the drug in both forms during a 7-night stay at a research unit. Researchers will measure how much …

This early-stage trial is testing an experimental drug called LY4226695 in healthy volunteers to see how safe it is and what side effects it might cause. Participants receive either the drug or a placebo, given as an injection under the skin or into a vein. The study also measure…

This early-stage trial is testing an investigational drug called LY4355756 in healthy volunteers to see how safe it is and how the body absorbs it. Participants will receive the drug as an oral capsule or tablet, with some also receiving midazolam to check for drug interactions. …