Children's Hospital Of Fudan University

This study tests whether hydroxychloroquine, a drug used for malaria and autoimmune conditions, can improve breathing in children with a rare genetic lung disease. About 60 children under 18 with a confirmed genetic cause will be randomly assigned to receive the drug or not. Rese…

This study looks at whether a special diet high in medium-chain triglycerides (a type of fat that is easier to digest) can help infants with biliary atresia grow better after their Kasai surgery. About 300 babies under 3 months old will take part. Researchers will track their wei…

This study tests whether giving oral antibiotics preventively can lower the chance of cholangitis (a serious bile duct infection) in infants with biliary atresia after Kasai portoenterostomy surgery. About 356 babies will be randomly assigned to receive antibiotics or not, and fo…

This study looks at whether prebiotics and probiotics (supplements that support healthy gut bacteria) can safely help control appetite and weight gain in 60 children with Prader-Willi syndrome, a rare genetic condition that causes severe obesity. The approach aims to improve gut …

This study compares ear acupressure (using small seeds on ear points) with intermittent carbohydrate restriction to help obese children lose weight. The trial includes 240 children who have specific traditional Chinese medicine symptoms. Researchers will measure changes in body w…

This study looks at whether a machine called ECMO can help children with severe septic shock who are not getting better with standard care. ECMO acts like an artificial heart and lungs to support the body. The study will include 60 children and track how many survive after leavin…

This study looks at whether giving gamma globulin (a blood product with antibodies) can help children in intensive care who have severe infections and a dangerous overreaction called an inflammatory storm. The goal is to see if it lowers the death rate and shortens hospital stays…

This study is testing whether a 12-week high-fiber diet can help protect the beta-cells (the cells that make insulin) in children aged 6 to 12 who were recently diagnosed with type 1 diabetes. The goal is to see if this dietary change can slow the loss of insulin production. Part…

This study tests a bundle of early treatments—including intensive rehabilitation, nutrition support, and early tracheotomy—to prevent children from becoming dependent on mechanical ventilation. Researchers will enroll 150 stable children on ventilators and compare outcomes to a c…

This study checks the long-term safety and effectiveness of a gene therapy called CS-101 in 5 people with beta-thalassemia who already received the treatment. Researchers will watch for serious side effects, new cancers, and whether patients can stop needing blood transfusions fo…

This study looks at whether dupilumab can help children with severe eosinophilic gastrointestinal disorders (EGIDs) that haven't responded to other treatments. About 20 kids will receive the drug to see if it can heal ulcers and reduce inflammation in the gut. The goal is to cont…

This study tests whether a structured nutrition program can prevent malnutrition in children with solid tumors. About 400 children will receive personalized diet support from a team of experts. The goal is to improve weight, height, and overall health during treatment.

This study tests a new dosing plan for the blood thinner rivaroxaban in 10 Chinese children who developed giant coronary artery aneurysms (large bulges in heart arteries) after Kawasaki disease. The goal is to see if the adjusted dose can safely prevent new blood clots and major …

This study tests whether high-intensity interval training (HIIT) can improve heart health in children aged 7 to 18 who are at high risk for cardiovascular disease. Researchers will measure if HIIT helps reverse early signs of problems like prediabetes, high cholesterol, or high b…

This study compares two treatments for children with Crohn's disease: a single drug (infliximab or an immunosuppressant) versus a combination of both. The goal is to see which approach better controls the disease and leads to remission. About 128 children aged 6 to 18 with active…

This study tests whether a combination of Chinese herbs and tiny acupuncture needles can help girls with idiopathic precocious puberty (early puberty). The goal is to shrink or stop breast growth and keep bone age from advancing too fast. About 170 girls will be treated for six m…

This study is for children with a rare form of type 1 diabetes caused by a genetic immune disorder. Doctors will first transplant umbilical cord blood stem cells to rebuild the immune system. Then, if the child is stable, they will receive islet cells (cells that make insulin) to…

This study looks at two ways to clean the blood in children with sepsis, a life-threatening infection. It compares continuous blood purification (done without stopping) to non-continuous methods. The goal is to see which approach helps more children survive 28 days after leaving …

This study tests two types of blood purification filters (AN69ST and polysulphone) in 80 children with sepsis. The goal is to see which filter better reduces harmful inflammatory substances and organ damage. Children aged 29 days to 18 years with sepsis-related organ failure may …

This study compares two genetic tests—whole genome sequencing and whole exome sequencing—to see which one better diagnoses children with severe, long-lasting diarrhea and gut problems. Researchers will enroll 180 children and track how often each test finds the cause and helps gu…

This study will use a special brain scan called magnetoencephalography (MEG) to see if it can help doctors better diagnose children with conditions like epilepsy, autism, ADHD, and other brain disorders. Researchers will compare MEG signals from 1,500 children with these conditio…

This study tests whether a high-energy formula helps infants with congenital heart disease grow and develop their brains better after open-heart surgery. About 160 babies aged 0-6 months will receive either high-energy or standard nutrition. The goal is to see if the extra calori…

This study tests a new remote therapy program called STAR for toddlers with autism spectrum disorder. 110 children in Shanghai will be split into two groups: one receives STAR therapy plus standard community care, the other only community care. The goal is to see if STAR helps im…

This study tests a new 'smart weaning' feature on a machine that delivers inhaled nitric oxide to newborns with persistent pulmonary hypertension (PPHN). The device automatically lowers the gas dose in a steady, controlled way, instead of relying on manual adjustments by nurses a…

This study looks at whether a gentle, family-focused care approach called developmental care helps very low birth weight infants (under 1500 grams) leave the hospital sooner. About 1600 babies across 40 hospital intensive care units will take part. The care bundle includes skin-t…

This study tests a program where specially trained nurses start conversations about palliative care early after a child's cancer diagnosis. The goal is to see if this improves the child's quality of life and reduces symptoms. About 120 children with solid tumors or blood cancers …

This study looks at whether measuring a substance called copeptin in the blood can help doctors diagnose central diabetes insipidus (CDI) in children after brain surgery. CDI causes extreme thirst and frequent urination. The study will track copeptin levels in 100 children in the…

This study is creating a large database of medical information, genetic data, and biological samples from 2,000 newborns with brain conditions like encephalopathy. Researchers will collect blood, urine, and spinal fluid to find better ways to monitor and predict brain injury. The…

This project will sequence the genes of 100,000 newborns in China over five years. The goal is to create a large genetic database, improve testing for inherited diseases, and train counselors. Participants are healthy newborns of Chinese parents, and the study focuses on collecti…

This study aims to find kidney disease early in children by using simple urine and ultrasound tests. About 13,000 children from China will be screened and followed for 3-6 years. Those with abnormal results will be referred for further care. The goal is to build a system to predi…

This study looks back at the last 10 years of ECMO (a machine that helps the heart and lungs work) treatment in children across mainland China. Researchers will collect information from about 500 children to see how many survive after leaving the hospital, how long they needed EC…

This study is observing 1,400 newborns in China who have had a seizure to find out how often it happens and how it affects their development. Researchers will use EEG to record brain activity and follow the babies over time. The goal is to better understand neonatal seizures, not…

This study looks at how the antibiotic ceftazidime avibactam behaves in children with severe infections who are in intensive care and on life support. Researchers will measure drug levels in the blood to better understand dosing. The goal is to improve treatment for sepsis and se…

This study watches how social behaviors and brain networks grow in 100 infants and toddlers who have a higher or lower chance of developing autism. Researchers will use safe brain scans (MRI and EEG) during natural sleep, along with developmental tests, to spot early differences.…

This study looks at whether a special matching tool helps nurses choose the right IV device for children. About 394 pediatric nurses will use the tool and record their choices. The goal is to see if it improves nurses' knowledge and reduces errors in selecting the best IV for eac…

This study looks at whether a substance called FGF19 in the blood before surgery can help predict how well babies with biliary atresia will recover. Researchers will follow 200 infants for one year after surgery to see if FGF19 levels relate to liver health and survival without a…

This study looks at 60 children with long-lasting diarrhea (called congenital diarrhea and enteropathy) to understand their symptoms and find biological markers in their blood and stool. Researchers will compare these children to healthy kids to build a tool that helps predict an…

This study is testing whether advanced genetic testing can help doctors diagnose birth defects and genetic diseases faster in newborns in intensive care. By analyzing the babies' DNA, researchers hope to find the cause of their condition more quickly and tailor treatments to each…

This study reviews medical records of 536 children in the pediatric ICU to find out what makes them more likely to get or carry a dangerous, drug-resistant bacteria called CRE. The goal is to identify risk factors and describe the bacteria's traits. No new treatments are tested; …

This study is testing a way to find families with a genetic condition that causes very high cholesterol, called familial hypercholesterolemia. Researchers will screen 15,000 children aged 1-3 years and their parents using a finger-prick blood test. The goal is to see if this scre…

This study will gather health information from 5,000 children in China with severe infections like pneumonia or sepsis. The goal is to learn how common these infections are, how well different treatments work, and to create tools that can predict which children are at highest ris…

This study aims to collect and analyze data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Researchers will track which germs cause these infections, how they are treated, and patient outcomes over a 10-y…

This study looks at the genes of 2,000 newborns and infants who have seizures within their first year of life. By understanding their genetic makeup, doctors hope to find better, personalized treatments. The goal is to see which gene changes are common and how well different trea…

This project works with nurses at multiple children's hospitals to improve how they place feeding tubes in young patients. The team will compare current methods to the latest evidence, train nurses on best practices, and track whether this leads to fewer complications and more su…

This study watches how tube feeding affects weight and length in 110 infants under 6 months who had bowel surgery. It does not test any new treatment or medicine. The goal is to learn more about nutrition in these babies.

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing better. The goal is to improve treatme…