SCHIZOAFFECTIVE DISORDER

This study is testing if the antipsychotic medication clozapine is more effective than standard antipsychotic treatment at preventing violent acts in people with schizophrenia or schizoaffective disorder. It will involve 280 adults with a recent history of violence who will be ra…

This study is testing a 12-week program called iTEST, which combines daily exercises on a mobile device with personal coaching. The goal is to help adults with schizophrenia or similar conditions improve their ability to accurately judge their own skills, which may help them func…

This study aims to see if a specific brain activity pattern, called Biotype-1, can predict which people with schizophrenia, schizoaffective disorder, or bipolar disorder with psychosis will respond exceptionally well to the medication clozapine. About 320 participants will be ran…

This study is testing whether adding five extra support elements to standard early psychosis care helps young adults stay engaged in treatment. The enhanced program includes peer support, family therapy, digital outreach, care coordination, and cognitive training. Researchers wil…

This study is testing whether Magnetic Seizure Therapy (MST) can work as well as electroconvulsive therapy (ECT) for people with schizophrenia who haven't responded to standard medications. Researchers will compare the two treatments in 80 participants who have tried at least two…

This study is testing a medication called valbenazine for people with tardive dyskinesia (TD), which causes uncontrollable movements. It is for adults with TD who still have symptoms while taking a similar medication or after stopping one. The main goal is to see if switching to …

This study is testing if following a ketogenic diet (high-fat, very low-carb) alongside usual treatment can help people recently diagnosed with bipolar disorder or schizoaffective disorder. Researchers will measure if the diet changes how the brain uses energy and if it improves …

This study is testing if a prebiotic fiber supplement can help people with schizophrenia or schizoaffective disorder. Researchers think the supplement might reduce harmful inflammation in the body and brain, which could improve thinking skills and other symptoms. For 12 weeks, 60…

This study is testing a therapy program designed to help adults with schizophrenia or schizoaffective disorder improve their thinking skills, like memory and problem-solving. Participants will do computer exercises and attend group sessions to learn strategies for daily life, whi…

This study is testing a new program called mSITE that uses a smartphone app to help people with schizophrenia or schizoaffective disorder have more social interactions. The program combines brief in-person therapy with phone-based reminders and coaching. Researchers will compare …

This study is testing whether a non-invasive magnetic brain stimulation technique can improve thinking skills like memory and focus in people with schizophrenia or schizoaffective disorder. Participants are adults who are already taking the medication clozapine but may still have…

This study is testing whether a new smartphone app called Kiso Mind is practical and helpful for people living with schizophrenia or schizoaffective disorder. About 60 participants will either use the app alongside their usual care or receive only their usual care for 12 weeks. R…

This small pilot study is testing whether physical activity done outdoors in green spaces is more helpful for reducing certain persistent symptoms of schizophrenia than the same activity done indoors. It will involve 45 adults with schizophrenia who have these specific symptoms. …

This study is testing if safely stopping certain medications that are no longer needed can help improve thinking skills, quality of life, and daily functioning for adults aged 40-70 with schizophrenia. About 105 participants will be randomly assigned to either continue their curr…

This study is testing a new group therapy called Motivation Skills Training (MST) for adults with schizophrenia or schizoaffective disorder. It aims to help participants understand and manage their motivation to improve daily functioning and reach personal goals. The therapy is c…

This study is testing a computer-based brain training program for veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. The goal is to see if this training can improve thinking skills, reduce symptoms, and help with daily life activities. Researche…

This study aims to understand if a non-invasive magnetic brain stimulation technique can change how quickly people with psychotic disorders think and solve problems. Participants with schizophrenia, bipolar disorder, or schizoaffective disorder will perform thinking tasks and hav…

This study aims to understand how attention and thinking strategies affect decision-making in people with schizophrenia or schizoaffective disorder. Researchers will compare brain activity during gambling tasks and track real-world choices through daily surveys. The goal is to le…

This study aims to understand the early stages of psychotic disorders like schizophrenia and bipolar disorder. Researchers will collect information from 320 people recently diagnosed, including brain scans, eye movement tests, and genetic samples, to see if these biological marke…