SCHIZOAFFECTIVE DISORDER

This study tests whether magnetic seizure therapy (MST) can safely reduce symptoms in people with schizophrenia that hasn't improved with standard medications. About 80 adults with treatment-resistant schizophrenia or schizoaffective disorder will receive MST, which uses magnetic…

This study tests whether valbenazine can help people with tardive dyskinesia (uncontrollable movements) who still have symptoms while taking or after stopping another drug. About 50 adults with schizophrenia, bipolar disorder, or major depression will take valbenazine for 24 week…

This study tests a community-based cognitive remediation program for 160 adults with schizophrenia or schizoaffective disorder. Participants do computer exercises and group sessions to improve memory, problem-solving, and social skills. The goal is to see if this helps them think…

This study tests whether clozapine, a powerful antipsychotic, works better than risperidone for people with schizophrenia, schizoaffective disorder, or bipolar 1 disorder who have a specific brain-based 'biotype.' About 320 adults will be randomly assigned to receive either cloza…

This study tests whether clozapine, a medication for schizophrenia, can reduce violent acts better than standard treatments. It involves 280 adults with schizophrenia or schizoaffective disorder who have been violent in the past six months. Participants will receive either clozap…

This study is testing whether a prebiotic (a type of fiber that feeds healthy gut bacteria) can reduce inflammation and improve thinking and memory in people with schizophrenia or schizoaffective disorder. Researchers will enroll 60 adults who are stable on antipsychotic medicati…

This study looks at whether physical activity in green outdoor spaces can reduce negative symptoms (like lack of motivation or social withdrawal) in people with schizophrenia more than indoor exercise. Researchers will compare the two settings in 45 adults aged 18 to 55. The goal…

This study tests a smartphone app called mSITE that helps people with schizophrenia or related conditions increase their social interactions. Researchers will enroll 125 adults and use the app along with therapy to encourage real-world social engagement. The goal is to reduce soc…

This study tests whether a daily synbiotic (probiotic plus fiber) supplement can reduce symptoms like hallucinations and social withdrawal in people with schizophrenia or schizoaffective disorder. About 68 adults will take either the supplement or a placebo for several weeks, whi…

This study tests a program called Motivation Skills Training (MST) to help people with schizophrenia or schizoaffective disorder improve motivation and reach personal goals. About 80 adults will be randomly assigned to either MST or a healthy behaviors group for 12-14 weeks. Rese…

This study looks at whether safely stopping unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can improve thinking, daily function, and quality of life in people aged 40-70 with schizophrenia or schizoaffective disorder. Participants will be randomly assigned to …

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce symptoms like psychosis, depression, and mania in people recently diagnosed with bipolar I or schizoaffective disorder. Fifty adults aged 18-45 will follow the diet for 12 weeks alo…

This study tests whether a smartphone app called Kiso Mind is acceptable and practical for people with schizophrenia or schizoaffective disorder. About 60 participants will either use the app plus their usual care, or just usual care, for 12 weeks. The main goal is to see if peop…

This study tests a therapy called Targeted Cognitive Training (TCT) for 80 veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. TCT uses computer exercises to improve how the brain processes sounds and information. Researchers will use EEG brain s…

This study looks at how attention and specific thinking strategies influence decision-making and brain activity in people with schizophrenia or schizoaffective disorder compared to those without. Participants will complete computer gambling tasks during brain scans and eye-tracki…

This study uses brain scans (MRI) to compare how the brain works in people with schizophrenia or schizoaffective disorder and healthy volunteers. Researchers aim to understand differences in brain connections and function during memory tasks. Up to 1,000 participants will provide…

This study looks at whether a fast type of brain stimulation, called accelerated intermittent theta burst stimulation (iTBS), can improve thinking and memory in people with schizophrenia or schizoaffective disorder who are already taking the medication clozapine. About 30 adults …

This study looks at whether adding five extra services—like peer support, digital outreach, and family therapy—to standard care helps people with early psychosis stay in treatment longer. About 350 participants from six clinics will either get standard care or the enhanced versio…

This study looks at whether a non-invasive magnetic stimulation technique can improve how quickly people with psychotic disorders (like schizophrenia or bipolar disorder) solve challenging tasks. About 95 participants will do thinking exercises and get brain scans before and afte…

This study is testing a program called iTEST for people with schizophrenia or related disorders. The program combines daily brain-training exercises on a mobile device with coaching to help participants accurately judge their own skills. Researchers want to see if this approach i…

This study looks at 320 people who recently developed psychosis (like schizophrenia or bipolar I) to see if brain scans, eye-tracking, and genetics can predict who will get better with treatment. Participants attend four visits over a year, providing DNA, EEG, and MRI data. The g…