SCHIZOAFFECTIVE DISORDER

This study tested whether a smartphone app called Quit on the Go helps people with serious mental illness (like bipolar disorder or schizophrenia) quit smoking better than standard methods. 343 smokers who wanted to quit were enrolled. The app was designed specifically for their …

This study tested whether adding a medication to a computer-based cognitive training program could improve thinking skills and daily function in people with schizophrenia or schizoaffective disorder. 68 adults completed the 10-week program, which involved up to 30 training sessio…

This study tested whether a higher dose of a long-acting injectable antipsychotic medication works better than the standard dose for people with schizophrenia or schizoaffective disorder. It involved 160 participants whose symptoms weren't well-controlled on their current medicat…

This study tested whether patients with schizophrenia or schizoaffective disorder could improve their awareness of their illness by watching a video of themselves recorded during a severe episode. 60 patients participated, with half watching the video after they stabilized. The g…

This study tested a visual training program for 79 adults with schizophrenia or schizoaffective disorder. The program aimed to improve two visual skills often impaired in these conditions: seeing contrast and organizing visual information. Participants completed different trainin…

This study tested whether luteolin, a natural substance found in foods like celery and chamomile tea, can improve symptoms of schizophrenia. Researchers gave luteolin or a placebo to 85 adults with schizophrenia or schizoaffective disorder who were already on stable antipsychotic…

This study tested whether adding the drug memantine to a computer-based cognitive training program improves thinking and daily function in people with schizophrenia or schizoaffective disorder. 62 adults took part in a double-blind trial where some received memantine plus trainin…

This study looked at how well valbenazine works for tardive dyskinesia (TD), a condition causing uncontrollable movements often linked to long-term use of certain mental health medications. Fifty-nine adults with schizophrenia, bipolar disorder, or major depression took valbenazi…

This study tested an investigational medication called BXCL501 for calming agitation episodes in people with bipolar disorder, schizophrenia, or related conditions. 452 participants received either the drug or a placebo, and researchers measured changes in agitation levels and sa…

This study tested whether delivering mental health services through telehealth (video calls) helps young adults with psychotic disorders stay engaged in care and avoid hospital stays better than standard in-person clinic visits. Seventy-four participants aged 16 to 35 with recent…

This study looked at how young adults aged 18-30 with early psychosis process information about their surroundings, compared to those without a psychiatric diagnosis. Researchers used computer-based tasks and cognitive training to measure changes in thinking skills. The goal was …

This study looked at whether smartphone data—like activity, sleep, and social patterns—could help track symptoms in 87 veterans with serious mental illnesses such as schizophrenia, bipolar disorder, or PTSD. Participants used an app that passively collected this data. The goal wa…

This study looked at how people aged 15-45 with early psychosis process information about their surroundings, called state representation. Participants completed computer tasks while their brain activity was measured using EEG and MRI. The goal was to understand brain function di…

This study tested whether sending text message reminders to young people (ages 14-35) who had a first episode of psychosis could help them attend their first appointment at an early psychosis program after being seen in the emergency department. The study involved 186 participant…

This study tested a program called Collaborative Decision Skills Training (CDST) to help veterans with serious mental illness, like schizophrenia or major depression with psychosis, become more involved in decisions about their care. 39 veterans took part in an initial small tria…

This completed study from the National Institute of Mental Health looked at over 4,900 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. By studying families, researc…

This pilot study tested a telehealth program called CRAFT-EP for families of people with early psychosis who also use alcohol or cannabis. 65 family members took part to see if the program could improve their wellbeing, including reducing depression and anxiety. The goal was to l…

This study looked at dopamine receptors in the brains of people with schizophrenia and healthy volunteers. Using special PET and MRI scans, researchers measured two types of dopamine receptors to learn more about how schizophrenia develops. The goal was to gather knowledge that c…

This study tested whether customizing cognitive remediation (brain training) based on a person's early auditory processing ability leads to better thinking and daily living skills in people with schizophrenia or schizoaffective disorder. 194 adults from community mental health ce…

This study looked at how people aged 15-45 with early psychosis process information about their surroundings, compared to those without a psychiatric diagnosis. Researchers tested two types of cognitive training and measured changes in thinking and brain activity using computer t…

This study looked at how a supplement called N-acetylcysteine (NAC) affects brain chemicals and thinking in people with schizophrenia. Researchers gave participants tryptophan (an amino acid) to raise a brain chemical called kynurenic acid, then used cognitive tests and MRI scans…

This study looked at whether a program called NAVIGATE helps youth (ages 14-35) having their first episode of psychosis get better coordinated care. Researchers worked with 100 participants across Ontario to see if the program reduces hospital stays and ER visits. The goal was to…

This study looked at whether family members or caregivers can help measure agitation in people with bipolar disorder or schizophrenia. 33 adults took a single dose of an experimental medicine, and researchers compared ratings from doctors, patients, and their family members. The …