PREECLAMPSIA

This study tests whether spironolactone, a blood pressure drug, can help women who had high blood pressure during pregnancy (preeclampsia or gestational hypertension) and are overweight. About 204 women will take either spironolactone or a placebo daily for 12 weeks after giving …

This study tests whether taking atorvastatin (a statin) for 3 months after childbirth can reduce the long-term risk of heart disease in women who had high blood pressure disorders during pregnancy. 76 postpartum women will receive either atorvastatin or a placebo, and their cardi…

This study looks at whether a blood test measuring certain markers (sFlt-1/PlGF) can help doctors decide when to induce labor in pregnant women with mild preeclampsia. The goal is to reduce unnecessary inductions without increasing the risk of severe complications for the mother …

This phase 3 trial tests whether metformin, a diabetes drug, can safely prolong pregnancy in women with preterm preeclampsia. Currently, the only treatment is early delivery, which risks the baby's health. The study will enroll 294 women across Nordic countries, giving them metfo…

This early-stage trial tests a single injection of CBP-4888 in 60 pregnant women hospitalized with preterm preeclampsia, a serious condition involving high blood pressure and organ stress. The goal is to find a safe dose and see if the drug can lower a harmful protein called sFlt…

This study tests whether keeping blood pressure below 140/90 mmHg in pregnant women with preeclampsia or gestational hypertension can safely prolong pregnancy. About 132 women between 23 and 35 weeks pregnant will be randomly assigned to tighter blood pressure control or standard…

This study tests a new program called MOMI PODS that provides extra medical and emotional support to new mothers who had pregnancy complications like high blood pressure, diabetes, or depression. About 384 mother-baby pairs will be randomly assigned to either the new program or s…

This study looks at whether using a CPAP machine during pregnancy can reduce the chance of developing high blood pressure disorders like preeclampsia. About 1,500 pregnant women with mild to moderate sleep apnea will be randomly assigned to use CPAP or not. The goal is to see if …

This study tests whether a one-time IV treatment of stem cell exosomes can repair blood vessel damage in 80 women who recently had preeclampsia. Preeclampsia raises the risk of heart disease later in life, and current treatments don't fully heal the blood vessels. Half the partic…

This study tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and health education. Researchers want to see if it lowers blood pressure and helps…

This study tests whether taking low-dose aspirin after pregnancy can repair blood vessel damage in women who had preeclampsia. Preeclampsia increases the risk of heart disease later in life, even in otherwise healthy women. Researchers will measure blood vessel function in 40 wom…

This study tests whether MitoQ, a mitochondrial antioxidant, can improve blood vessel function and placental health in pregnant people with severe preeclampsia. Researchers will measure blood flow in the arm, skin, and placenta to see if MitoQ helps restore normal function and pr…

This study tests a medication called ravulizumab in pregnant women with severe preeclampsia or HELLP syndrome. The goal is to see if the drug can help control the disease by targeting the immune system. About 14 participants will be enrolled, and researchers will measure blood ma…

This study tests whether adding a specially trained doula to usual home blood pressure monitoring helps women with pregnancy-related high blood pressure achieve better blood pressure control one year after giving birth. About 454 women who had preeclampsia, eclampsia, or gestatio…

This study looks at three substances in the blood (sFlt-1/PlGF ratio, osteoprotegerin, and soluble endoglin) to see if they can help doctors diagnose and monitor preeclampsia, a serious pregnancy condition involving high blood pressure. Researchers will measure these markers in 1…

This study looks at whether lung ultrasound can help detect and monitor fluid overload in people with severe preeclampsia, a serious pregnancy condition. Researchers will scan the lungs of 202 participants at three key times: when admitted, right after delivery, and 7-10 days lat…

This study is testing whether a quick, non-invasive test of blood vessel function can help predict and diagnose preeclampsia and other high blood pressure disorders in pregnancy. Researchers will follow 400 first-time pregnant women, measuring vessel health early in pregnancy and…

This study tests whether taking 162 mg of aspirin daily is better than the standard 81 mg dose for preventing high blood pressure disorders (like preeclampsia) in pregnant women at risk. Over 10,000 participants will be assigned to one of the two doses early in pregnancy. The goa…

This study looks at whether natural salicylates found in foods like fruits and vegetables can help prevent preeclampsia, a dangerous pregnancy condition. Researchers will track the diets of 500 pregnant women and measure salicylate levels in their blood and urine. The goal is to …

This study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can prevent preeclampsia in pregnant women at high risk. Preeclampsia is a serious condition causing high blood pressure and organ damage. The trial will enroll 100 women earl…

This study tests whether a non-invasive physiotherapy technique that stimulates the vagus nerve can help lower blood pressure in pregnant women with preeclampsia. About 210 women will receive either standard blood pressure medication alone or medication plus this gentle therapy. …

This study is collecting blood samples from 100 pregnant women with and without preeclampsia to measure key proteins involved in the condition. The goal is to better understand the angiogenic imbalance that causes symptoms and to develop a device that filters out harmful proteins…

This study looks at why women who had preeclampsia during pregnancy are more likely to develop heart disease later in life. Researchers will test a drug called eplerenone on a small patch of skin to see if it improves blood vessel function. The goal is to understand the underlyin…

This study is testing two new ultrasound techniques to see if they can tell the difference between healthy pregnancies and those affected by fetal growth restriction (FGR), where the baby is smaller than expected. Researchers will scan 60 pregnant women every three weeks using a …

This study is testing whether a mobile phone app can help pregnant women at high risk for preeclampsia in Karachi, Pakistan, monitor their blood pressure and symptoms at home. Fifty women will use the app to send daily readings to their healthcare team, who can then respond if ne…

This study looks at why pregnant women living at high altitudes have higher rates of preeclampsia and poor fetal growth. Researchers will collect tissue samples from women having scheduled C-sections in Denver (low altitude) and Summit County (high altitude) to compare how their …

This study looks at 500 women who had preeclampsia during pregnancy to see if exercise stress tests can find early signs of heart failure with preserved ejection fraction (HFpEF). Researchers will compare heart function in these women to those without preeclampsia. The goal is to…

This study looks at whether a blood gas measurement called base excess differs between pregnant women with severe preeclampsia and those with normal blood pressure. Researchers will test 100 women before delivery to see if abnormal base excess levels are linked to more severe dis…

This study follows 100 women who had preeclampsia, HELLP syndrome, or kidney problems during pregnancy. Researchers will measure blood vessel stiffness and collect health data over time. The goal is to better understand long-term heart and kidney risks and improve future care.

This study looks at why low-dose aspirin doesn't always prevent preeclampsia, a serious pregnancy complication. Researchers will study genetic and lab factors in 130 women who had preeclampsia before and took aspirin in a later pregnancy. The goal is to understand why aspirin wor…

This study aims to understand how tiny particles called exosomes, released from the placenta, may cause preeclampsia—a serious pregnancy condition involving high blood pressure. Researchers will collect blood and placenta samples from 64 women with preeclampsia and study these pa…

This study looks at how a pregnant person's metabolism—specifically insulin resistance and fat burning—may be linked to placenta health and pregnancy complications like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high or moderate risk for p…

This study is for pregnant people at risk for preeclampsia who are taking aspirin as part of their care. Researchers want to see how aspirin changes tiny particles from the placenta in the blood. They hope to create a blood test that can better monitor placental health and predic…

This study aims to find early molecular signs of preeclampsia, a serious pregnancy condition, by examining tissue from the womb (maternal-fetal interface) collected between weeks 9 and 15 of pregnancy. Researchers will compare samples from women who later develop preeclampsia wit…

This study looks at how pregnant women at risk for preeclampsia process aspirin and how that relates to signs of metabolic problems. Researchers will measure aspirin breakdown products and other health markers in blood and urine. The goal is to better understand why some women st…