PREECLAMPSIA

This study tests whether a one-time IV treatment of stem cell exosomes can repair blood vessel damage in 80 women who recently had preeclampsia. Half receive the treatment, half a placebo, with follow-up at one week. The goal is to reduce their higher risk of future heart disease…

This study tests whether taking low-dose aspirin after a pregnancy complicated by preeclampsia can repair blood vessel damage and reduce the higher risk of heart disease these women face. Researchers will measure blood vessel function in 40 women who had preeclampsia in the past …

This study tests whether adding a specially trained doula to standard care helps new moms with pregnancy-related high blood pressure get healthier after birth. About 454 women will either get usual blood pressure monitoring or extra support including a doula, weight checks, and b…

This study tests a medication called ravulizumab in pregnant people with severe preeclampsia or HELLP syndrome, serious conditions that can harm both mother and baby. The goal is to see if the drug can improve health markers and extend pregnancy length. About 14 participants will…

This study tests whether keeping blood pressure below 140/90 mmHg in pregnant women with preeclampsia or high blood pressure can safely extend the pregnancy. About 132 women between 23 and 35 weeks pregnant will be randomly assigned to either tight blood pressure control or stand…

This study tests whether taking spironolactone for three months after giving birth can help lower blood pressure and improve heart health in women who had preeclampsia or high blood pressure during pregnancy. The trial includes 204 women who were overweight before pregnancy and n…

This study tests whether using a CPAP machine during pregnancy can reduce the risk of high blood pressure disorders, such as preeclampsia, in women with mild to moderate sleep apnea. About 1,500 pregnant women will be randomly assigned to receive CPAP or usual care. The goal is t…

This study tests whether metformin, a drug used for diabetes, can safely prolong pregnancy in women diagnosed with preterm preeclampsia. Currently, the only way to stop the condition is to deliver the baby early, which can cause health problems for the newborn. The trial will enr…

This large study tests whether taking 162 mg of aspirin daily is better than the standard 81 mg dose for preventing high blood pressure disorders (like preeclampsia) during pregnancy. About 10,700 pregnant individuals at increased risk will be followed to see which dose works bes…

This study aims to find early molecular clues in pregnancy tissue that could predict preeclampsia, a serious condition affecting mothers and babies. Researchers will collect small tissue samples from over 2,000 women between weeks 9 and 15 of pregnancy. By comparing samples from …

This study is observing 1,000 pregnant people at risk for preeclampsia who are taking aspirin as part of their care. Researchers will collect blood samples up to four times during pregnancy to analyze tiny particles called extracellular vesicles. The goal is to find protein patte…

This study is testing two new ultrasound methods to see if they can tell the difference between healthy pregnancies and those affected by fetal growth restriction (FGR), where the baby is smaller than expected. Researchers will compare these new scans in 60 pregnant women, some w…

This study looks at 500 women who had preeclampsia to see if exercise stress testing can detect early signs of heart failure with preserved ejection fraction (HFpEF). Researchers will compare heart function and blood markers between these women and those with normal pregnancies. …