PREECLAMPSIA

This study tests whether a one-time IV treatment of stem cell exosomes can repair blood vessel damage in 80 women who recently had preeclampsia. Preeclampsia raises the risk of heart disease later in life, and current treatments don't fully heal the blood vessels. Half the partic…

This study tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and health education. Researchers want to see if it lowers blood pressure and helps…

This study tests whether taking spironolactone for three months after delivery can lower blood pressure and improve heart health in women who had preeclampsia or gestational hypertension. About 204 women with overweight or obesity before pregnancy will be randomly assigned to rec…

This study tests whether taking atorvastatin for 3 months after pregnancy can reduce the long-term risk of heart disease in women who had high blood pressure disorders like preeclampsia. 76 postpartum women will receive either atorvastatin or a placebo, starting after they stop b…

This study tests whether taking low-dose aspirin after pregnancy can repair blood vessel damage in women who had preeclampsia. Preeclampsia increases the risk of heart disease later in life, even in otherwise healthy women. Researchers will measure blood vessel function in 40 wom…

This study tests whether MitoQ, a mitochondrial antioxidant, can improve blood vessel function and placental health in pregnant people with severe preeclampsia. Researchers will measure blood flow in the arm, skin, and placenta to see if MitoQ helps restore normal function and pr…

This study tests a medication called ravulizumab in pregnant women with severe preeclampsia or HELLP syndrome. The goal is to see if the drug can help control the disease by targeting the immune system. About 14 participants will be enrolled, and researchers will measure blood ma…

This study tests a blood-filtering device (apheresis) to remove a harmful protein called sFlt-1 and restore a healthy balance in pregnant women with preeclampsia. The goal is to safely prolong pregnancy and reduce the risks of very early delivery. About 100 women with preeclampsi…

This study looks at whether using a CPAP machine during pregnancy can help prevent high blood pressure disorders like preeclampsia. About 1,500 pregnant women with mild to moderate sleep apnea will use CPAP or standard care. The goal is to see if treating sleep apnea leads to hea…

This study tests whether carefully lowering blood pressure in pregnant women with preeclampsia or gestational hypertension can help them stay pregnant longer, reducing risks for both mother and baby. About 132 women between 23 and 35 weeks pregnant will be randomly assigned to ei…

This study tests whether adding a specially trained doula to usual home blood pressure monitoring helps women with pregnancy-related high blood pressure achieve better blood pressure control one year after giving birth. About 454 women who had preeclampsia, eclampsia, or gestatio…

This study tests whether metformin, a drug used for diabetes, can safely prolong pregnancy in women diagnosed with preterm preeclampsia. Currently, the only way to stop the condition from worsening is to deliver the baby early, which can cause health problems for the newborn. The…

This early-stage study tests a single injection of CBP-4888 in 60 hospitalized pregnant women with preterm preeclampsia (a serious blood pressure disorder). The goal is to find a safe dose and see how the drug affects the body. Participants receive standard care plus one shot, an…

This study looks at whether a lung ultrasound can spot fluid overload early in women with severe preeclampsia. About 202 pregnant women will get ultrasounds at three key times: when admitted, right after giving birth, and 7-10 days later. The goal is to prevent a serious breathin…

This study is testing whether a quick, non-invasive test of blood vessel function can help predict and diagnose preeclampsia and other high blood pressure disorders in pregnancy. Researchers will follow 400 first-time pregnant women, measuring vessel health early in pregnancy and…

This study looks at three substances in the blood (sFlt-1/PlGF ratio, osteoprotegerin, and soluble endoglin) to see if they can help doctors diagnose and monitor preeclampsia, a serious pregnancy condition involving high blood pressure. Researchers will measure these markers in 1…

This study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can prevent preeclampsia in pregnant women at high risk. Preeclampsia is a serious condition causing high blood pressure and organ damage. The trial will enroll 100 women earl…

This study looks at whether natural salicylates (compounds similar to aspirin) found in foods can help prevent preeclampsia, a serious pregnancy condition. Researchers will track the diets of 500 pregnant women and measure salicylate levels in their blood and urine. The goal is t…

This study tests whether taking 162 mg of aspirin daily is better than the standard 81 mg dose for preventing dangerous high blood pressure disorders during pregnancy. Over 10,000 pregnant individuals at increased risk will be enrolled. The goal is to find the most effective dose…

This study tests whether a non-invasive physiotherapy technique that stimulates the vagus nerve can help lower blood pressure in pregnant women with preeclampsia. About 210 women will receive either standard blood pressure medication alone or medication plus this gentle therapy. …

This study looks at how living at high altitude changes blood flow in the womb during pregnancy. Researchers will collect tissue samples from women having scheduled C-sections in Denver (low altitude) and Summit County (high altitude) to compare artery function. The goal is to un…

This study is for pregnant people at risk for preeclampsia who are taking aspirin as part of their care. Researchers want to see how aspirin changes tiny particles from the placenta in the blood. They hope to create a blood test that can better monitor placental health and predic…

This study tests two new ultrasound techniques to see if they can better detect placental problems in pregnancies with fetal growth restriction (FGR), where the baby is smaller than expected. Researchers will compare these scans in 60 pregnant women—some with healthy pregnancies …

This study follows 100 women who had preeclampsia, HELLP syndrome, or kidney disease during pregnancy to monitor their heart and kidney health over time. Researchers will measure blood vessel stiffness and collect blood samples for a biobank. The goal is to better understand long…

This study aims to find early molecular signs of preeclampsia, a serious pregnancy condition, by examining tissue from the womb (maternal-fetal interface) collected between weeks 9 and 15 of pregnancy. Researchers will compare samples from women who later develop preeclampsia wit…

This study explores whether a mobile phone-based program can help monitor pregnant women at high risk for preeclampsia in Karachi, Pakistan. Researchers will enroll 50 women to track their blood pressure and symptoms at home, aiming to see if this approach is practical and accept…

This study aims to understand why low-dose aspirin does not always prevent preeclampsia, a serious pregnancy complication. Researchers will look at genetic and lab factors in 130 women who had preeclampsia before and took aspirin in a later pregnancy. The goal is to find clues th…

This study looks at how pregnant women at risk for preeclampsia process aspirin and how that relates to signs of metabolic problems. Researchers will measure aspirin breakdown products and other health markers in blood and urine. The goal is to better understand why some women st…

This study looks at how the body burns fat and uses insulin during pregnancy, and how that might affect the placenta. Researchers will follow 50 pregnant women at risk for preeclampsia or gestational diabetes. The goal is to better understand these conditions, not to test a new t…

This study looks at why women who had preeclampsia during pregnancy are more likely to develop heart disease later in life. Researchers will test how a specific receptor in blood vessels affects function after a high-salt diet. Forty women (some with past preeclampsia, some witho…

This study looks at whether using a blood test (sFlt-1/PlGF) to decide when to deliver can lower the number of labor inductions in pregnant women with mild preeclampsia at term. About 750 women will be randomly assigned to either standard care or marker-guided care. The goal is t…

This study looks at 500 women who had preeclampsia during pregnancy to see if exercise stress tests can find early signs of heart failure with preserved ejection fraction (HFpEF). Researchers will compare these women to those with normal pregnancies. The goal is to better identif…

This study looks at tiny particles called exosomes released from the placenta that might cause preeclampsia, a serious pregnancy condition involving high blood pressure. Researchers will collect blood and placenta samples from 64 women with preeclampsia to study these particles i…

This study looks at whether a blood gas test can help tell how severe preeclampsia is in pregnant women. Researchers will compare results from 100 women with severe preeclampsia and 100 healthy pregnant women. The goal is to see if abnormal base excess levels are linked to worse …