PREECLAMPSIA

The ROOT study is testing whether personalized nutrition and lifestyle plans, based on a woman's genes and nutrient levels, can reduce the risk of pregnancy complications like preterm birth, preeclampsia, and gestational diabetes. Researchers will enroll 500 pregnant women and co…

This study tests two progestin-only birth control pills—drospirenone and norethindrone—to see which one helps control high blood pressure after a pregnancy complicated by preeclampsia. Fifty women will take one of the pills daily for six weeks after leaving the hospital. The goal…

This study tests whether a mobile health program—combining home blood pressure monitoring with virtual coaching—can help midlife women control high blood pressure after having had a hypertensive disorder of pregnancy (like preeclampsia). About 50 women who had such a pregnancy 10…

This study looks at whether giving blood pressure medicine (enalapril) to women after they have had preeclampsia can help protect their hearts. Researchers will enroll 60 new mothers to see if they are willing to take part and how their blood pressure responds. The goal is to fin…

This study tests whether a quick bedside ultrasound can help doctors decide if new mothers with preeclampsia need a diuretic (water pill) to lower their blood pressure. About 96 postpartum patients will be enrolled. The goal is to see if this approach speeds up blood pressure rec…

This study tests a personalized support program called PTBCARE+ for pregnant individuals at high risk of delivering early. The program includes a stress reduction toolkit, a website/app, care coordination, and optional massage. Researchers will compare stress levels and birth out…

This study tests whether taking progesterone early in pregnancy can prevent preeclampsia, a condition that causes high blood pressure and organ damage. Over 600 low-risk pregnant women will either receive nightly vaginal progesterone or standard care. Researchers will track who d…

This study will test whether mindfulness training, combined with a wearable biosensor that tracks stress, can help prevent preeclampsia in pregnant women at risk. 90 women will be split into three groups: mindfulness plus the wearable, mindfulness alone, or standard prenatal care…

This study tests an injection called topefilgrastim in 100 pregnant women at high risk for preeclampsia, a serious condition that can harm both mother and baby. Participants are split into two dose groups or a control group to see if the drug can lower the chance of developing pr…

This study tests whether telling doctors when a pregnant person is at high risk for preeclampsia helps more patients get low-dose aspirin to prevent it. About 1,000 pregnant women at risk will take part. Doctors in some clinics will receive alerts; others will not, and researcher…

This study tests whether taking 2,000 IU of vitamin D daily during pregnancy can prevent preeclampsia, eclampsia, and HELLP syndrome in about 2,000 pregnant women in Uganda. Half the women will receive vitamin D and half a placebo, and researchers will track outcomes up to six we…

This study looks at whether stretching or aerobic exercises can help women with mild preeclampsia. Sixty first-time pregnant women, ages 20-30, will do one type of exercise for six weeks. Researchers will measure blood pressure and urine protein levels to see which exercise works…

This study looks at whether measuring the collapsibility of the internal jugular vein in the neck using ultrasound can predict a dangerous drop in blood pressure after spinal anesthesia in women with preeclampsia having a C-section. Researchers will measure the vein before anesth…

This study looks at whether hand-stimulating the breast to express milk from week 28 of pregnancy is safe for women at high risk of preterm birth. Researchers will compare how long pregnancy lasts, how much milk is available at birth, and the milk's nutritional content. The goal …

This study will check if a formula called fullPIERS can accurately predict serious complications in 50 pregnant women with preeclampsia. Researchers will use information like blood pressure, kidney function, and symptoms to calculate risk. If the model works, it could help doctor…

This study aims to understand what causes preeclampsia, a serious pregnancy condition. Researchers will measure a protein called sFlt1 in the blood of 500 women, including those with and without the condition. The goal is to find better ways to diagnose and treat this disease in …

This study looks at whether allied-health professionals (like pharmacists or nurses) can help recruit and follow women who had preeclampsia during pregnancy. Participants will check their blood pressure at home and work with a research pharmacist for 12 months. The goal is to see…

This study will measure a substance called kynurenine in the blood of 204 pregnant women, some with chronic kidney disease and some without. The goal is to see if kynurenine levels are linked to preeclampsia, a serious condition that can harm both mother and baby. Researchers hop…

This study looks at 1300 women with type 1 diabetes to see if a high risk for preeclampsia early in pregnancy is linked to heart disease years later. Researchers will check for plaque in neck arteries and other heart risk factors at least 3 years after the last pregnancy. The goa…

This study will observe 120 pregnant women with high blood pressure or preeclampsia to see if certain ultrasound scans and blood tests can predict which cases will become severe. The goal is to find better ways to identify women at risk for serious complications for both mother a…