NEOPLASMS

This early-stage study tests a new drug, RO7673396, in people with advanced solid tumors that have a RAS mutation. The goal is to find a safe dose and see if the drug can shrink tumors when used alone or with other cancer treatments. About 405 participants will take part in two s…

This study is testing the drug vorolanib in people with advanced kidney cancer that cannot be removed by surgery or has spread. It is for those who need a second treatment after the first one stopped working. The goal is to see how long the drug controls the cancer and what side …

This early-stage study tests a device that uses sound waves to help a standard cancer drug reach the brain more effectively in people with recurrent glioblastoma, an aggressive brain tumor. Ten participants will receive the drug bevacizumab along with focused ultrasound to see if…

This early-phase study tests an experimental oral drug called ABSK021 in people with advanced solid tumors (including a rare joint tumor called TGCT) who have run out of standard options. The main goal is to check the drug's safety and find the right dose. Researchers will also w…

This early-phase trial tests a new oral drug, Aza-TdC, in adults with advanced solid tumors that have not responded to standard treatments. The drug aims to 'turn back on' genes that may slow tumor growth. The main goals are to check safety and find the best dose.

This early-stage study tests a new drug called GSK5533524, alone or with other cancer treatments, in about 97 adults with advanced solid tumors that have stopped responding to standard therapies. The main goals are to find a safe dose and see if the drug can shrink tumors or slow…

This early-stage study tests a new treatment called JNJ-87704916, a virus designed to infect and kill cancer cells. It is injected directly into tumors, either alone or with another drug (cetrelimab), for people with advanced solid tumors that have not responded to standard thera…

This study tests an experimental oral drug (GSK5460025) in adults with advanced solid tumors that have specific genetic features (dMMR or MSI-H), which often make them harder to treat. The trial has two parts: first, finding a safe dose and checking for side effects; second, seei…

This early-stage trial tests whether a specially engineered virus, G207, is safe for children with cerebellar brain tumors that have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a low dose of radiation is given to help the …

This early-stage study tests a new drug, JNJ-88549968, designed to help the immune system attack cancer cells in people with certain blood cancers (myelofibrosis or essential thrombocythemia) caused by a CALR gene mutation. The main goals are to check safety and find the best dos…

This study tests a way to preserve fertility in young women and girls (ages 0-35) with cancer or other illnesses that could damage their ovaries. Doctors will freeze a piece of ovarian tissue before cancer treatment starts, then later re-implant it to try to restore fertility. Th…

This study offers female cancer patients a way to preserve their fertility. Doctors freeze a piece of ovarian tissue before cancer treatment starts, then re-implant it after treatment ends. The goal is to help these patients have children in the future. Up to 100 women aged 0-35 …

This study tests a new drug called nenocorilant combined with an immunotherapy (nivolumab) in people with advanced solid tumors that have stopped responding to standard treatments. The goal is to find the safest dose and see if the combination can shrink tumors. About 50 adults w…

This early-phase study tests a new medicine, GSK5764227, that delivers a toxin directly to cancer cells to destroy them while leaving healthy cells alone. About 84 adults with advanced colorectal or prostate cancer will receive the drug alongside standard treatments. The main goa…

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors, including mesothelioma, that have not responded to standard therapy. The treatment involves collecting a patient's own immune cells, modifying them in a lab to recognize and att…

This study tests a two-step treatment for people whose brain tumors (gliomas) have returned after standard care. First, a laser is used to heat and destroy tumor tissue, followed by a short course of targeted radiation. The goal is to see if this approach is safe and can help con…

This study is testing whether a coordinated care program helps older adults complete their planned digestive cancer chemotherapy. It will enroll 144 participants aged 75 and older who are starting treatment. The goal is to see if early support from a team of specialists helps pat…

This study tests whether adding the experimental drug SLC-3010 to the standard drug axitinib works better than axitinib alone for people with advanced clear cell kidney cancer that has already been treated once. About 78 participants will be randomly assigned to one of the two tr…

This study aims to see if a new imaging agent called [18F]RCCB6 can improve the detection of kidney cancer, especially the most common type (clear cell renal cell carcinoma). Researchers will enroll 300 adults with confirmed or suspected kidney cancer to measure how well the trac…

This study is testing a special pad (PadKit™) that women wear for 4-6 hours to collect cells from the uterus. The goal is to see if the pad can gather enough cells to tell the difference between normal cells, pre-cancer, and cancer. Researchers will also ask participants about co…

This study tests a nurse-led program called OncoMoveNurse that helps cancer patients be more physically active while getting chemotherapy. The goal is to see if the program is practical and can improve patients' well-being and mood. About 50 adults with cancer will take part, and…

This study tracks children and adults who have already received gene-modified T cells in earlier trials. Researchers will watch for side effects, check how long the modified cells last, and monitor overall health for up to 15 years. The goal is to better understand the long-term …

This study looks at 500 adults having cancer surgery to see which risk score best predicts if they will need intensive care afterward. Researchers will compare several scoring systems to find the most accurate one. The goal is to help doctors plan better and use hospital resource…

This study follows up to 250 people who have already received ADP adoptive cell therapy for cancer. Researchers will track delayed side effects and serious health events for up to 15 years after the last treatment. The goal is to understand the long-term safety of this therapy, n…

This study collects blood, bone marrow, urine, and tissue samples from up to 6,000 people with cancer or blood disorders, as well as from healthy family members who are stem cell donors. The samples are used in lab research to understand diseases better, improve current treatment…

This study is testing a mobile health app designed to help cancer patients remember to take their oral anticancer pills and report any side effects. The app also helps patients communicate with their care team and find support for financial or social needs. Researchers will enrol…

This study collects tissue and fluid samples (like blood, urine, and tumor tissue) from up to 5,000 adult and pediatric cancer patients at the NIH Clinical Center. The samples are used for research to better understand cancer and develop new tests and treatments. Participants don…

This study enrolls people with cancer who are already participating in other studies at the National Cancer Institute. Researchers will collect and link medical records and research samples from all of a participant's past, current, and future studies. The goal is to better under…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy using a special machine called the MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to see if this technology improves survival, tumor control, and qualit…