NEOPLASMS

This study tests a new oral drug called pocenbrodib, alone or with another drug (darolutamide), in 120 men with metastatic castration-resistant prostate cancer (mCRPC). The goal is to find safe doses and see if the combination can slow cancer growth. It is an early-stage trial, s…

This early-phase trial tests a new drug called Aza-TdC in adults with advanced solid tumors that have worsened after standard treatment or have no effective therapy. The drug is taken by mouth in 21-day cycles and aims to reactivate genes that may slow tumor growth. The main goal…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a low dose of radiation to help th…

This study looks at freezing ovarian tissue from young female cancer patients before they start cancer treatment, then re-implanting it later to restore fertility. The goal is to help these patients have children after surviving cancer. The study will track surgical complications…

This early study tests whether using focused ultrasound (NaviFUS) to temporarily open the blood-brain barrier can help the drug Avastin work better against recurrent glioblastoma, an aggressive brain cancer. Ten adults whose cancer has returned after standard treatment will recei…

This early-stage trial tests a new drug called Ris-Rez (GSK5764227) in 845 adults with advanced solid tumors that have spread or come back. The study checks if the drug is safe when given alone or with other cancer medicines like chemotherapy or immunotherapy. Researchers will al…

This study tests a new drug called nenocorilant combined with the immunotherapy nivolumab in people with advanced solid tumors that have not responded to standard treatments. The goal is to find the safest dose and see if the combination can shrink tumors. About 50 participants w…

This early-stage study tests an experimental pill called ABSK021 in people with advanced solid tumors (including a rare joint tumor called TGCT) who have run out of standard options. The main goal is to check safety and find the best dose, while also seeing if the drug can shrink…

This study tests if using focused ultrasound (sound waves) can help the drug Avastin work better for people with recurrent glioblastoma, an aggressive brain cancer. About 32 adults will either get Avastin alone or Avastin plus the ultrasound treatment. The goal is to see if the c…

This early-stage study tests a new treatment called IL-5 CAR-T cell therapy for people with a rare and hard-to-treat blood cancer called eosinophilic leukemia. The therapy uses a patient's own immune cells, modified to target and attack cancer cells. The main goals are to check s…

This study tests a two-step treatment for people whose brain tumors (gliomas) have come back after standard therapy. First, a laser is used to heat and destroy the tumor, followed by a short course of targeted radiation. The goal is to control the tumor safely and delay further g…

This trial tests whether giving two immunotherapy drugs (nivolumab with or without relatlimab) before surgery can help people with stage II-IIIa bladder cancer avoid bladder removal. About 90 adults will be randomly assigned to one of the two drug combinations. The main goal is t…

This study tests a new medicine, GSK5764227, that delivers a toxin directly to cancer cells to destroy them while leaving healthy cells alone. It is given together with standard treatments to people with advanced solid tumors like colorectal or prostate cancer. The main goals are…

This study creates a common framework to test multiple new cancer drugs in children and young adults (ages up to 21) with different types of cancer. About 105 participants will join, and each will receive a drug tailored to their specific cancer. The goal is to run several smalle…

This study offers a way for young female cancer patients to preserve their fertility. Ovarian tissue is removed and frozen before cancer treatment, then reimplanted later if the patient wants to start a family. The goal is to see if this procedure is safe and can lead to pregnanc…

This early-phase study tests a new drug called GSK5533524, alone or with other cancer treatments, in adults with advanced solid tumors that have stopped responding to standard therapies. The main goals are to find a safe dose and see if the drug can shrink tumors or slow cancer g…

This study tests a combination of two drugs, nilotinib (a pill) and paclitaxel (given by IV), for people with rare advanced cancers that have not responded to standard treatments. The goal is to see if the drugs can shrink or stop tumor growth. About 82 adults with specific rare …

This early-phase study tests a new drug, RO7673396, in people with advanced solid tumors that have a RAS mutation. The goal is to find a safe dose and see if the drug can shrink tumors, either alone or with other cancer treatments. About 405 adults with incurable cancers will tak…

This early-stage study tests an experimental drug called GSK5733584 in adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety and find the best dose. Researchers will also see if the drug can shrink tumors. …

This early-stage study tests a new drug called AST-201 in about 70 adults with advanced solid tumors that have a protein called GPC3. The main goal is to check the drug's safety and find the right dose. Researchers will also measure how the drug moves through the body and look fo…

This early-phase study tests a new treatment called JV-394 for people with T/NK cell lymphoma that has come back or not responded to standard therapy. JV-394 uses the patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The main goa…

This early-phase study tests a virus (JNJ-87704916) that is injected directly into tumors to kill cancer cells. It is being tested alone and with another drug (cetrelimab) in people with advanced solid tumors who have run out of standard treatments. The main goals are to check sa…

This study looks at how well the drug vorolanib works for people with advanced kidney cancer that cannot be removed by surgery or has spread. It is for patients who need a second treatment after their first one stopped working. The study will track how long the cancer stays under…

This study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. The trial involves about …

This early-phase study is testing a new chemotherapy drug (JNJ-1761981) that is injected directly into tumors in people with advanced solid tumors that have not responded to standard treatments. The goal is to find a safe and effective dose, and to see if it can shrink the treate…

This study tests whether adding the experimental drug SLC-3010 to the standard drug axitinib works better than axitinib alone for people with advanced clear cell kidney cancer that has worsened after first treatment. About 78 adults will be randomly assigned to one of the two gro…

This early-stage study tests a new drug, JNJ-88549968, in about 220 adults with certain blood cancers (myelofibrosis or essential thrombocythemia) caused by a CALR gene mutation. The drug is designed to help the immune system attack cancer cells. The main goals are to check safet…

This early-phase study tests a new drug called JNJ-87890387 in people with advanced solid tumors that have spread or cannot be removed. The drug is designed to help the immune system attack cancer cells. The main goals are to find a safe dose and to check for side effects. About …

This study tests an experimental oral drug, GSK5460025, alone or with other cancer drugs, in adults whose solid tumors have specific genetic changes (dMMR or MSI-H) that make them harder to treat. The goal is to see if the drug can shrink tumors and to check its safety and how th…

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors that have high levels of a protein called mesothelin, including mesothelioma. Participants' own immune cells are collected, modified in a lab to better attack cancer, and then gi…

This study looks at whether adding a special dye-enhanced mammogram every two years to the standard yearly 3D mammogram can find breast cancer more effectively in women who have already had breast cancer. The goal is to catch new cancers early while keeping false alarms low. Abou…

This study tests a new radioactive imaging agent called [18F]RCCB6 for PET/CT scans to see if it can better detect kidney cancer, especially the most common type, clear cell renal cell carcinoma. Researchers will enroll 300 adults with confirmed or suspected kidney cancer. The go…

This early-stage study tests a new injection called [18F]LY4214835 to see if it is safe and how it spreads in the body. It includes healthy volunteers and people with cancer. The goal is to improve how doctors see tumors using imaging scans.

This study tests a program called ENABLE-SG, which provides phone-based coaching sessions to people recently diagnosed with advanced cancer and their caregivers. The goal is to help them manage stress, symptoms, and planning early on, rather than waiting for a crisis. Researchers…

This study tests whether a 12-week personalized exercise program, done at home with a trainer guiding via video, can improve quality of life and reduce common side effects like fatigue, anxiety, and nerve pain in cancer survivors. About 350 adults who finished cancer treatment wi…

This study tests whether a special massage called manual lymph drainage can help reduce swelling in the face and neck caused by radiation therapy for head and neck cancer. About 40 people who finished radiation within the past year will be enrolled. The main goal is to see if a l…

This study tests whether a specially designed video game can help people aged 60 and older manage nausea and vomiting caused by chemotherapy. About 610 participants will be randomly assigned to play the game or receive standard care. Researchers will track how severe their sympto…

This study tests whether a special team of doctors, nurses, and other experts can help people aged 75 and older with digestive cancer complete more of their planned chemotherapy or targeted therapy. About 144 participants will either receive this extra support or standard care. T…

This study tests whether eating all food within a 10-hour window each day can reduce severe, long-lasting fatigue in blood cancer survivors. About 96 adults who finished cancer treatment at least 2 months ago will either follow this time-restricted eating plan or receive standard…

This study tests a nurse-led program to help cancer patients be more physically active while receiving chemotherapy. About 50 adults with cancer will take part. The program includes activity plans, safety checks, and support tools. The goal is to see if this approach is practical…

This study tests an experimental drug called LY3537021 to see if it can better control nausea and vomiting caused by chemotherapy in adults with cancer. About 204 participants will receive either the drug or a placebo, and researchers will track who has no vomiting and does not n…

This study is creating a digital program to help East Asian immigrants with cancer build resilience and start conversations about advance care planning with their families. Researchers will interview religious leaders and test the tool with 84 patients to see if it is easy to use…

This study is not testing a new treatment. Instead, it will collect and analyze information from up to 40,000 cancer patients receiving different types of radiation therapy. The goal is to better understand outcomes and side effects, and to find ways to improve patient care.

This study tracks the long-term safety of people who have already received a type of cell therapy called ADP adoptive cell therapy. Researchers will monitor up to 250 participants for up to 15 years after their last treatment to see if any delayed side effects occur. The goal is …

This study looks at whether online health education workshops are practical for teenagers and young adults (ages 15-25) with cancer in France. About 48 participants will take part in three digital sessions designed to help them manage their illness and treatment. The goal is to s…

This study is creating a large database of 2000 people whose cancer has spread to the liver. Researchers will collect information on patients' health, treatments, and outcomes to learn more about the disease and improve future care. No new treatments are being tested; the goal is…

This study aims to develop a machine learning tool to predict heart damage in 600 cancer patients receiving certain chemotherapy drugs (anthracyclines or HER2-targeted therapies). Researchers will collect data over one year to see who develops heart problems. The goal is to creat…

This observational study will enroll up to one million adults to understand how health, environment, and lifestyle affect aging and disease. Researchers will link participants' clinical data with information from public records, such as pollution and social factors, to create a d…

This study collects tumor tissue and medical information from 1,500 people with pancreatic cancer. The goal is to build a large biobank that scientists can use to better understand the disease and develop new treatments. Participants undergo standard diagnostic procedures, and no…

This study looks at new ways to screen for anal precancer (aHSIL) in people at high risk, such as those with weakened immune systems. Researchers will test different screening methods, alone or combined, to see which works best. They will also study DNA and immune factors linked …

This study will follow 1,000,000 adults aged 18 and older for the rest of their lives. Researchers will collect health measurements and track who develops diseases, becomes frail, or dies. The goal is to find which tests best predict how well people age, so doctors can one day of…

This study collects blood, bone marrow, urine, and tissue samples from up to 6,000 people with cancer or blood disorders, as well as from healthy family members who are stem cell donors. The samples are used for research to better understand diseases, improve treatments, and find…

This study looks for proteins and other markers in the blood of 2000 adults with or suspected of having cancer. The goal is to find markers that may help doctors confirm a cancer diagnosis, choose the right treatment, and predict how well a patient will respond or if the cancer w…

This study tests whether allowing patients to move freely after a PET scan injection affects the quality of the images. 284 adults will be randomly assigned to either rest or move around. The goal is to see if free movement leads to the same clear images as staying still, which c…

This study enrolls people with cancer who are already participating in other studies at the National Cancer Institute. Researchers will collect and link medical records and research samples from all of a person's past, current, and future studies. The goal is to better understand…

This study aims to find immune system markers that can predict how well a cancer patient responds to radiotherapy. Researchers will analyze blood samples from 40 adults who have already completed radiotherapy without major side effects. The goal is to personalize future cancer tr…

This study is testing a new smartphone app designed to help cancer patients remember to take their oral anticancer medications and report any side effects. The app also helps patients communicate with their care team and find support for financial or social needs. Researchers wil…

This study collects tissue and fluid samples from up to 5,000 cancer patients to help researchers learn more about cancer and develop new tests and treatments. Samples are taken from routine procedures or from extra biopsies done just for research. The goal is to build a resource…

This study aims to learn more about Li-Fraumeni syndrome (LFS), a genetic condition that raises the risk of several cancers. Researchers will study up to 5,000 people with LFS or related cancer histories to find new genes, understand how the TP53 gene works, and identify factors …

This study looks at different scoring systems to see which best predicts whether a person will need intensive care after cancer surgery. Researchers will follow 500 adults having cancer surgery and compare the accuracy of these tools. The goal is to help doctors plan better and u…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study watches how immunotherapy affects physical fitness and daily life in 67 adults with advanced solid cancers. Participants do fitness tests and fill out questionnaires before starting treatment and again 12 weeks later. Researchers also take blood samples and follow heal…

This study follows children and adults who have already received gene-modified T cells in a previous trial. Researchers will watch for long-term side effects, check if the modified cells persist, and monitor overall health. No new treatment is given—the goal is to understand the …

This study is testing a new online learning tool designed to help people with cancer improve their ability to find and understand health information on the internet. About 660 cancer patients will take part, and they will be randomly assigned to use the online tool, read a PDF wi…

This study uses online surveys to learn about the real-life experiences of people diagnosed with cancer and their caregivers. Researchers want to understand the emotional, physical, social, and financial challenges they face. The goal is to use this information to improve support…