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New master trial aims to speed up cancer treatments for kids

NCT ID NCT05999994

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This trial tests several cancer drugs in children and young adults with solid tumors. It uses a master protocol to test different drug combinations more efficiently. About 105 participants will receive one of eight drugs, including ramucirumab, cyclophosphamide, and others. The goal is to find which treatments work best for different cancers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ramucirumab, Cyclophosphamide, Vinorelbine, Gemcitabine, Docetaxel, Abemaciclib, Irinotecan, Temozolomide
What this could lead to
If successful, this could identify effective drug combinations for different childhood cancers, leading to better treatment options.
What could go wrong
This is an early-phase trial with only 105 participants, so results may not apply to all patients. The drugs may cause side effects or not work as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 105 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2020

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

1 year to 39 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Participants must meet all of the inclusion criteria below. Additional criteria are specified in the protocol amendment (individual addenda) to which the participant will enroll. * Have either measurable or evaluable disease using standard techniques by the Response Evaluation Criteria in Solid Tumors, Version 1.1 (RECIST 1.1). * The participant has a Lansky (\<16 years of age) or Karnofsky (≥16 years of age) performance score of at least 50. * Participants must have discontinued all previous treatments for cancer or investigational agents greater than or equal to (≥)7 days after the last dose and must have recovered from clinically significant side effects. * The participant has adequate hematologic and organ function. * Female participants of childbearing potential must have a negative urine or serum pregnancy test within 7 days prior to first dose. * Both female and male participants of childbearing potential must agree to use highly effective contraceptive precautions during the trial and for at least 3 months following the last dose of study drug. Participants will be ineligible if they meet any of the exclusion criteria below. Additional criteria are specified in the protocol amendment to which the participant will enroll. * Participants with severe and/or uncontrolled concurrent medical disease or psychiatric illness/social situation that, in the opinion of the investigator, could cause unacceptable safety risks or compromise compliance with the protocol. * Participants who have active infections requiring therapy. * Participants who have had allogeneic bone marrow or solid organ transplant. * Participants who have had, or are planning to have, certain invasive procedures. * Female participants who are pregnant or breastfeeding.

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Conditions

The condition(s) this trial relates to.

neoplasm primary interstitial lung disease specific to childhood

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adolescent Child Neoplasms

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    63 sites in 9 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ann & Robert H Lurie Children's Hospital of Chicago

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Azienda Ospedaliera Di Padova

    RECRUITING

    Padova, 35128, Italy

  • C.S. Mott Children's Hospital

    NOT_YET_RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • Centre Leon Berard

    NOT_YET_RECRUITING

    Lyon, 69008, France

  • Centre Leon Berard

    RECRUITING

    Lyon, 69008, France

  • Children's Healthcare of Atlanta, Inc. at Egleston

    NOT_YET_RECRUITING

    Atlanta, Georgia, 30322, United States

  • Children's Hospital of Colorado

    RECRUITING

    Denver, Colorado, 80218, United States

  • Children's Hospital of Orange County

    RECRUITING

    Orange, California, 92868, United States

  • Children's Hospital of Philadelphia

    COMPLETED

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Mercy Hospital

    RECRUITING

    Kansas City, Missouri, 64108, United States

  • Children's National Medical Center

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • Childrens Hospital of Alabama

    NOT_YET_RECRUITING

    Birmingham, Alabama, 35233, United States

  • Childrens Hospital of Los Angeles

    COMPLETED

    Los Angeles, California, 90027, United States

  • Chris O'Brien Lifehouse

    COMPLETED

    Camperdown, 2050, Australia

  • Cook Children's Hospital

    ACTIVE_NOT_RECRUITING

    Fort Worth, Texas, 76104-2724, United States

  • Dana-Farber Cancer Institute

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02215, United States

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore

    RECRUITING

    Roma, 00168, Italy

  • Golisano Children's Hospital of Southwest Florida

    RECRUITING

    Fort Myers, Florida, 33908, United States

  • Hospital General Universitario Gregorio Marañon

    RECRUITING

    Madrid, 28007, Spain

  • Hospital General Universitario Gregorio Marañon

    RECRUITING

    Madrid, 28007, Spain

  • Hospital Infantil Universitario Niño Jesús

    RECRUITING

    Madrid, 28009, Spain

  • Hospital Sant Joan de Déu

    RECRUITING

    Esplugues de Llobregat, 8950, Spain

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, 8035, Spain

  • Hospital Universitari i Politecnic La Fe

    RECRUITING

    Valencia, 46026, Spain

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, 28046, Spain

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, 28046, Spain

  • Hospital Universitario Virgen Del Rocio

    RECRUITING

    Seville, 41013, Spain

  • Hospital Universitario Virgen Del Rocio

    RECRUITING

    Seville, 41013, Spain

  • Hospital Universitario de Canarias

    RECRUITING

    San Cristóbal de La Laguna, 38320, Spain

  • Hospital de la Santa Creu i Sant Pau

    RECRUITING

    Barcelona, 08025, Spain

  • Hyogo Prefectural Kobe Children's Hospital

    RECRUITING

    Kobe, 650-0047, Japan

  • IRCCS Istituto Ortopedico Rizzoli

    RECRUITING

    Bologna, 40136, Italy

  • Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest

    RECRUITING

    Bordeaux, 33076, France

  • Institut Curie

    NOT_YET_RECRUITING

    Paris, 75248, France

  • Istituto Clinico Humanitas

    RECRUITING

    Rozzano, 20089, Italy

  • Istituto Nazionale dei Tumori

    RECRUITING

    Milan, 20133, Italy

  • Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia

    RECRUITING

    Candiolo, 10060, Italy

  • Kyushu University Hospital

    RECRUITING

    Fukuoka, 812-8582, Japan

  • Leids Universitair Medisch Centrum

    RECRUITING

    Leiden, 2333 ZA, Netherlands

  • Lifespan Cancer Institute

    RECRUITING

    Providence, Rhode Island, 02906, United States

  • Mayo Clinic in Florida

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • Medical College of Wisconsin

    NOT_YET_RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

  • National Cancer Center Hospital

    RECRUITING

    Chūōku, 104-0045, Japan

  • Nationwide Children's Hosp

    RECRUITING

    Columbus, Ohio, 43205-2664, United States

  • Oregon Health and Science University

    NOT_YET_RECRUITING

    Portland, Oregon, 97201, United States

  • Ospedale Bambino Gesu

    RECRUITING

    Roma, 00165, Italy

  • Peter MacCallum Cancer Centre

    COMPLETED

    Melbourne, 3000, Australia

  • Phoenix Children's Hospital

    RECRUITING

    Phoenix, Arizona, 85016, United States

  • Phoenix Children's Hospital

    RECRUITING

    Phoenix, Arizona, 85016, United States

  • Prinses Maxima Centrum

    RECRUITING

    Utrecht, 3584 CS, Netherlands

  • Riley Hospital for Children

    ACTIVE_NOT_RECRUITING

    Indianapolis, Indiana, 46202-5225, United States

  • Royal Children's Hospital

    COMPLETED

    Melbourne, 3052, Australia

  • Royal Manchester Children's Hospital

    RECRUITING

    Manchester, M13 9WL, United Kingdom

  • Royal Marsden Hospital

    RECRUITING

    London, SW3 6JJ, United Kingdom

  • Royal Marsden Hospital

    RECRUITING

    London, SW3 6JJ, United Kingdom

  • Seattle Children's Hospital Research Foundation

    RECRUITING

    Seattle, Washington, 98105, United States

  • Texas Childrens Hospital

    NOT_YET_RECRUITING

    Houston, Texas, 77025, United States

  • The Christie NHS Foundation Trust

    RECRUITING

    Manchester, M20 4BX, United Kingdom

  • UCL- Saint Luc

    RECRUITING

    Brussels, 1200, Belgium

  • UCLA Medical Center

    NOT_YET_RECRUITING

    Los Angeles, California, 90095, United States

  • UPMC Children's Hospital of Pittsburgh

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

  • Universitaetsklinikum Essen

    RECRUITING

    Essen, 45147, Germany

  • Universitaetsklinikum Freiburg

    RECRUITING

    Freiburg im Breisgau, 79106, Germany

  • Universitaetsklinikum Hamburg-Eppendorf

    RECRUITING

    Hamburg, 20251, Germany

  • Universitair Ziekenhuis Gent

    COMPLETED

    Ghent, 9000, Belgium

  • University College Hospital - London

    RECRUITING

    London, NW1 2PG, United Kingdom

  • University of Minnesota Hospital

    NOT_YET_RECRUITING

    Minneapolis, Minnesota, 55455, United States

  • University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • University of Texas Southwestern Medical Center at Dallas

    RECRUITING

    Dallas, Texas, 75390-9063, United States

  • Washington University Medical School

    COMPLETED

    St Louis, Missouri, 63110, United States

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