NEOPLASMS

This early-stage trial tested a new drug called PF-07820435, alone or with another drug (sasanlimab), in 9 people with advanced solid tumors like lung or skin cancer. The goal was to check safety and see if the drug shrinks tumors. However, the study was terminated, so results ar…

This early-phase trial tested an experimental drug called OC-001, given alone or with the immunotherapy avelumab, in 73 people with various advanced or metastatic cancers (like lung, breast, and bladder cancer). The main goals were to check safety and how the drug moves through t…

This phase 3 study tested a new drug called pralsetinib against standard chemotherapy for people with a specific type of advanced lung cancer that has a RET gene fusion. The goal was to see if pralsetinib could better delay cancer growth. The trial was terminated early, so full r…

This early-phase study tested a new drug (PF-07826390) alone or with another drug (sasanlimab) in people with advanced solid tumors like lung, colon, kidney, and ovarian cancers. The goal was to check safety, find the right dose, and see if the drug shrinks tumors. Only 10 people…

This early-stage study tested a combination of two drugs, niraparib and dostarlimab, in children and teens (ages 6 months to 17 years) with solid tumors that had come back or were not responding to treatment. The goal was to find a safe dose and see if the drugs could shrink tumo…

This study tested a new drug (NKT2152) combined with two other medicines (palbociclib and sasanlimab) in people with advanced clear cell kidney cancer that had worsened after prior treatments. The goal was to see if the combination was safe and could shrink tumors. The trial was …

This early-phase study tested a drug called EO-3021 in 88 adults with advanced stomach or other solid tumors that have a specific marker (CLDN18.2). The goal was to check safety and see if tumors shrink. The study was stopped early, but the results help researchers understand how…

This study tested a new drug called modakafusp alfa, alone or with pembrolizumab, in 45 adults with advanced solid tumors or melanoma that couldn't be removed by surgery. The main goals were to check safety and find the best dose. The study was terminated early, so results are li…

This study compared two ways of giving palliative radiotherapy to people with cancer that has spread to the bones. The goal was to see which method better controls nausea and vomiting caused by radiation, while also managing pain. About 160 adults with bone metastases took part, …

This study looked at how moderate or severe liver problems change the amount of the cancer drug oral azacitidine in the blood. It was designed for adults with certain blood cancers. The study was stopped early after only 2 people enrolled, so the results are very limited.