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Cancer drug combo trial for kids halted early

NCT ID NCT04544995

First seen Jan 21, 2026 · Last updated Jun 17, 2026 · Updated 22 times

Summary

This early-stage study tested a combination of two drugs, niraparib and dostarlimab, in children and teens (ages 6 months to 17 years) with solid tumors that had come back or were not responding to treatment. The goal was to find a safe dose and see if the drugs could shrink tumors. The study was terminated early, so results are limited.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • GSK Investigational Site

    Birmingham, B4 6NH, United Kingdom

  • GSK Investigational Site

    Sutton, SM2 5PT, United Kingdom

Conditions

The condition(s) this trial relates to.

adrenal cortex carcinoma Ewing sarcoma neoplasm neuroblastoma osteosarcoma rhabdomyosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.