MAJOR DEPRESSIVE DISORDER

This study looks at the long-term safety and effectiveness of azetukalner in adults with major depressive disorder who have already completed a previous phase 3 trial. About 460 participants will take the drug as their only treatment and be monitored for side effects and changes …

This early-stage study tests a new drug called LY03021 in 98 healthy adults aged 18 to 45. The main goal is to check safety and how the body processes the drug. It is a first step toward possibly treating depression, but does not involve patients with depression yet.

This study looks at whether taking a fecal transplant (FMT) in a pill can improve symptoms of major depression and irritable bowel syndrome (IBS). About 133 adults with depression, with or without IBS, will either get FMT or continue their usual treatment. The goal is to see if c…

This study tests a personalized mobile health program (iTAB-CV + Self-Monitoring) to help people with bipolar disorder or major depression stick to their blood pressure medications. 176 participants will be randomly assigned to use the app plus self-monitoring, or self-monitoring…

This study looks at whether psilocybin, a hallucinogenic drug, can help people who have both major depression and alcohol use disorder. About 90 adults aged 21-65 will receive psilocybin in a controlled setting. Researchers will measure changes in depression symptoms and drinking…

This study tests a brain pacemaker (deep brain stimulation) for people with severe depression that hasn't improved with other treatments. About 16 adults aged 22-70 will have electrodes placed in a brain area linked to mood. The goal is to see if this reduces depression symptoms …

This study is testing a home-based program designed to help prevent long-term memory decline in older adults at risk for Alzheimer's disease. The program combines brain-training exercises with a gentle, non-invasive brain stimulation technique called tDCS, which is delivered by a…

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training. The goal is to improve attention and reduce depression symptoms. About 70 adults with m…

This study looks at the long-term safety and effectiveness of an experimental drug called CYB003 for people with major depressive disorder. It includes 468 adults who already completed earlier studies with CYB003. Participants may receive extra doses to see if the drug continues …

This study tests an experimental oral drug, NMRA-335140, against a placebo in 332 adults with major depressive disorder. The goal is to see if the drug reduces depression symptoms over 6 weeks. Participants who finish may join an open-label extension study.

This study tests whether a new drug called SP-624 can safely reduce depression symptoms in adults with major depressive disorder. About 456 people will receive either SP-624 or a placebo (a dummy pill) to compare results. The main goal is to see if the drug improves mood and dail…

This study tests a new treatment called low-intensity focused ultrasound (LIFUP) for people with depression that hasn't improved with standard treatments. The ultrasound targets a small area deep in the brain linked to mood. The goal is to see if it is safe and can reduce depress…

This study tests whether a personalized brain stimulation technique (pBFS-guided rTMS) can safely improve symptoms in 100 adults with moderate to severe depression that hasn't responded to other treatments. Participants receive different doses of the stimulation or a sham (fake) …

This study tests whether taking D-Cycloserine (DCS), a drug that affects brain receptors, before a non-invasive brain stimulation therapy called iTBS can better ease depression symptoms than the therapy alone. About 180 adults with treatment-resistant major depression will receiv…

This study tests a brain stimulation device called SAINT® for people with major depression who haven't gotten better with medication. About 1000 adults will receive 10 treatments each day for 5 days. The goal is to see if this approach can quickly improve depression symptoms.

This study looks at whether adding a low dose of Adderall XR (a stimulant) to repetitive transcranial magnetic stimulation (rTMS) can better ease depression symptoms. About 30 adults with hard-to-treat depression will be randomly assigned to receive either Adderall or a placebo p…

This study aimed to test if transcranial magnetic stimulation (TMS) combined with talk therapy could help teenagers aged 13 to 17 with major depression that didn't improve with standard treatments. Participants would have received daily TMS sessions for two weeks, along with week…

This study tests an experimental oral drug, NMRA-335140, against a placebo in 332 adults with major depressive disorder. Participants take the drug or placebo daily for 6 weeks to see if it reduces depression symptoms. The goal is to find a new treatment option for people with de…

This small pilot study tests whether Imagery Rescripting, a type of talk therapy that helps people change upsetting mental images, can reduce depression and negative beliefs. Ten adults with major depressive disorder will receive weekly sessions after a waiting period. Researcher…

This study tests a new treatment called TEST that uses a weaker electric current than standard electroconvulsive therapy (ECT) for people with depression that hasn't improved with other treatments. The goal is to see if TEST is safe, practical, and can help lift depression while …

This small study tests whether psilocybin, the active ingredient in magic mushrooms, can change how the brain adapts and grows (neuroplasticity) in people with major depression. 18 adults who haven't gotten better with standard antidepressants will receive psilocybin in a control…

This study tests a type of brain stimulation called intermittent theta burst stimulation (iTBS) for people with major depression. It involves 30 adults who are already on stable antidepressant medication but still have significant symptoms. The goal is to see if iTBS can further …

This pilot study explores whether using a personalized frequency for repetitive transcranial magnetic stimulation (TMS) can safely and effectively ease symptoms in adults with severe major depressive disorder who haven't improved with multiple medications or therapy. Ten particip…

This study was designed to see if online group therapy (CBT with mindfulness) works as well as in-person therapy for adults with major depression. It planned to include people with at least mild depression and compare changes in mood and anxiety. However, the study was withdrawn …

This study aimed to see if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce suicidal thoughts and depression in adults visiting the emergency department. Participants would have had major depressive disorder and be at immediate risk. The trial …

This study tests an oral medication called MM120 for adults with major depressive disorder. About 149 participants will receive either MM120 or a placebo for 12 weeks, followed by a 40-week period where everyone can get the active drug. The main goal is to see if MM120 reduces de…

This study compares two types of brain stimulation—Magnetic Seizure Therapy (MST) and Electroconvulsive Therapy (ECT)—in 100 adults with severe depression that hasn't improved with standard treatments. The goal is to see which therapy works better for lifting mood and which cause…

This study tests whether up to two doses of psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults who have both cancer and major depressive disorder. About 56 participants will receive either psilocybin or a placebo in a group setting with t…

This study aimed to see if breathing nitrous oxide (laughing gas) could help people with major depression, especially those who hadn't improved with other treatments. It planned to compare four weekly sessions of nitrous oxide to a placebo. However, the study was withdrawn before…

This study tests whether inhaling nitrous oxide (laughing gas) can quickly reduce suicidal thoughts in adults hospitalized for depression. About 50 participants will receive either nitrous oxide or a placebo gas, plus their usual treatment. The goal is to see if this approach is …

This study tests whether adding mindfulness-based therapy to usual care helps people with serious mental illness (like schizophrenia, bipolar disorder, or major depression) feel better and improve their quality of life. Researchers will enroll 160 adults from a community mental h…

This study tests whether giving three TMS sessions in a single day is safe and effective for adults with major depressive disorder. TMS uses magnetic pulses to stimulate the brain without surgery. The trial involves 37 participants aged 22-85 and compares the accelerated approach…

This study tests a way to make transcranial magnetic stimulation (TMS) work better for older adults with depression. Researchers use brain scans to personalize the treatment for each person. The goal is to improve mood and brain function in people aged 60 to 79.

This study checks if a Samsung smartwatch can tell when someone has major depression. About 220 adults (135 with depression and 85 healthy) wear the watch for 3 months. The watch tracks heart rate, sleep, and steps, and participants answer daily surveys about their mood. The goal…

This study looks at how stress impacts long-term mood and thinking skills in older adults with depression. Researchers will use brain scans to understand these changes. The goal is to find ways to prevent future problems with mood and memory.

This study looks at how a fast type of brain stimulation called iTBS affects the brains of 22 adults with major depression. Participants will have brain scans before and after a single session, then undergo 6 weeks of daily treatment. The goal is to understand how iTBS changes br…

This study looks at whether certain brain wave patterns (called gamma oscillations) can predict how well ketamine therapy works for people with treatment-resistant depression. Researchers will measure brain activity before and during ketamine treatment in 100 adults. The goal is …

This study aims to find clues that show which patients with treatment-resistant depression will respond best to a single dose of IV ketamine. Researchers will study 40 adults with depression or bipolar disorder who haven't improved with other treatments. Participants will receive…

This study was designed to understand why electroconvulsive therapy (ECT) for severe depression can cause temporary memory and thinking problems. Researchers planned to use EEG brain wave tests to track changes in brain activity during ECT. The study was withdrawn before enrollin…

This study tests whether choosing depression treatments based on a person's specific symptoms (like loss of pleasure or anxiety) works better than usual care. Researchers will enroll 150 adults with major depressive disorder. The goal is to see if this personalized approach leads…

This study is collecting data from 350 people with major depression to build an AI tool that helps doctors choose the best antidepressant. Researchers are analyzing genetics, gut bacteria, immune markers, and brain activity. The goal is to create a personalized treatment guide, b…

This study uses MRI scans to track brain changes in 40 adults with major depressive disorder who are receiving transcranial magnetic stimulation (TMS) therapy. Participants will have three MRI scans over six weeks to monitor how the brain responds to treatment. The goal is to bet…

This study looks at how transcranial magnetic stimulation (TMS) affects the brains of people with depression. Researchers use MRI scans to see changes in brain connections. About 54 adults who are already getting TMS as part of their care will take part. The goal is to understand…

This study aims to find ways to predict which depression treatment will work best for each person. Researchers will use a special brain imaging technique called TD-fNIRS to measure brain activity in 540 adults with major depressive disorder before they start different treatments …

This study looks at how a single dose of the antidepressant citalopram, given through an IV, affects brain activity when combined with a type of brain stimulation called theta burst stimulation (TBS). Thirty adults with major depression who haven't gotten better with other treatm…

This study looks at 10 people with severe depression that hasn't improved with other treatments. They will get a special brain implant that can both stimulate a key area and record electrical signals. The goal is to find patterns in these signals that show when the treatment is w…

This study looks at how the brain processes pain in people with depression who may be at risk for suicide. Researchers will use brain scans (fMRI) while participants experience mild pressure pain. The goal is to find brain patterns linked to suicide capability, which could help i…

This study looks at how a brain area called the subgenual cingulate responds to transcranial magnetic stimulation (TMS) in people with depression. Researchers will use MRI scans to see if TMS activates this region and how it changes over a 6-week treatment course. 50 adults with …

This study tests whether mild whole body hyperthermia (gentle heating) can reduce depression symptoms, and whether a drug that blocks an immune protein called IL-6 changes that effect. About 35 adults with major depression will receive either the drug or a placebo before the heat…