MAJOR DEPRESSIVE DISORDER

This study tests whether a special type of acupuncture (intradermal acupuncture) can help adults with major depression safely lower or stop their SSRI antidepressant medication. About 114 participants who are already planning to reduce their SSRI dose will be randomly assigned to…

This study tests whether a single oral dose of CYB003, a drug similar to psilocybin (found in magic mushrooms), can help relieve symptoms of depression and anxiety. Forty adults with major depressive disorder and moderate-to-severe anxiety will receive either CYB003 or a placebo.…

This study tests whether the drug bupropion can safely reduce symptoms of major depression in children and adolescents aged 7 to 17. About 246 participants will receive either the drug or a placebo (a dummy pill) for several weeks. Researchers will measure changes in depression s…

This study is testing whether a combination of whole-body hyperthermia (a treatment that raises your body temperature) and cognitive behavioral therapy (a type of talk therapy) can help ease symptoms of major depression. The study will include 60 adults with depression who will r…

This early study tests a new, non-invasive brain stimulation device for people with depression that hasn't improved with standard treatments. About 20 adults will try the device to see if it's safe and can ease their symptoms. The goal is to find a new option for those who haven'…

This study tests whether breathing nitrous oxide (laughing gas) can reduce depression symptoms in people whose depression hasn't improved with at least two medications. 120 adults aged 18-65 with moderate to severe depression will be randomly assigned to receive either the gas or…

This study looks at whether a safe, mild brain stimulation technique called tDCS can help adults with moderate depression sleep better and feel better. Participants will use a home-based device and track their sleep and mood changes. The goal is to see if better sleep leads to fe…

This study tests whether low-dose laser acupuncture can improve sleep in people with major depression and insomnia. 120 adults will receive 30 laser sessions over six weeks, plus their usual depression medication. Researchers will measure sleep quality, depression levels, and saf…

This study tests whether daridorexant, a sleep medication, can improve both insomnia and depression symptoms in people with major depressive disorder. About 134 adults with stable depression and insomnia will receive either the drug or a placebo for three months. Researchers will…

This study tests whether using a gentle brain stimulation device (tDCS) at home, twice a day for three weeks, can help ease depression symptoms. It involves 30 adults with depression who are not taking any antidepressant medication. Participants are randomly assigned to receive r…

This study tests whether two anti-inflammatory drugs, celecoxib or minocycline, can reduce depression symptoms in people with major depressive disorder or bipolar depression. About 42 adults aged 18-65 with moderate to severe depression will take one of the drugs for 8 weeks. Res…

This early-phase study tests an experimental drug called PDC-1421 to see if it is safe and can help relieve depression in people with cancer. About 12 adults with stage I-III cancer and moderate to severe depression will take the drug for up to 5 weeks. Researchers will measure m…

This study looks at how S-ketamine, a fast-acting antidepressant, affects tiny energy-producing parts of cells called mitochondria in people with treatment-resistant depression. Researchers will take blood samples before, shortly after, and six weeks after treatment to see if cha…

This study tests whether a brain stimulation treatment called iTBS can be improved by customizing it for each person with treatment-resistant depression. Researchers will use brain wave measurements (EEG) to find the best stimulation settings for each participant. The goal is to …

This study explores whether artificial intelligence can support people already in therapy for anxiety or depression. Researchers will enroll 204 adults who are currently seeing a therapist. Participants will use an AI tool alongside their regular sessions to see if it improves sy…

This study tests a new way to monitor muscle activity during electroconvulsive therapy (ECT) for depression, bipolar disorder, or schizophrenia. It compares a standard arm tourniquet with a newer method using a vein tourniquet and low-dose medication. The goal is to see which met…

This study explores whether data from your smartphone (like activity or usage patterns) can predict when depression symptoms might return. Researchers will track 320 adults who have been treated for depression and are currently well. If successful, this could lead to an app that …

This study tests a group program designed to help veterans with serious mental illness feel more comfortable and confident working with their healthcare teams. The goal is to improve collaboration so that care better matches each veteran's personal goals. About 119 veterans from …

This study aims to find better ways to diagnose bipolar disorder and predict when mood episodes will happen. Researchers will track sleep, movement, and decision-making in 600 people using smartwatches and computer tasks. The goal is to tell bipolar disorder apart from depression…

This study looks at how different types of non-invasive brain stimulation change mood and brain activity in 200 adults with major depression. Participants will receive three types of stimulation and have MRI scans while taking antidepressants. The goal is to understand how brain …

This study looks at how the brain handles stopping and ignoring distractions in people with bipolar disorder or major depression. Researchers will use brain scans and thinking tasks with emotional faces to find differences between the two conditions. The goal is to improve diagno…

This study looks at how different types of brain stimulation affect brain activity in 250 military Veterans with major depression. Researchers will use transcranial magnetic stimulation (TMS) and EEG to measure brain changes. The goal is to develop more personalized brain stimula…

This study looks at whether simple eye tests (electroretinography) can predict how well antidepressants work in people with major depression. About 108 adults starting a common antidepressant will have eye tests and depression questionnaires before treatment and again at 6 and 12…