MAJOR DEPRESSIVE DISORDER
Clinical trials for MAJOR DEPRESSIVE DISORDER explained in plain language.
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Depression drug study halted early: what happened?
Disease control TerminatedThis study looked at the long-term safety and effectiveness of an experimental drug called AXS-05 for people with treatment-resistant depression (depression that hasn't improved with other treatments). The study enrolled 181 adults who either completed a prior AXS-05 study or cur…
Matched conditions: MAJOR DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: Axsome Therapeutics, Inc. • Aim: Disease control
Last updated May 26, 2026 05:01 UTC
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New depression pill shows promise in Late-Stage trial
Symptom relief TerminatedThis study tested whether adding REL-1017 to standard antidepressant therapy could better reduce depression symptoms in adults with major depressive disorder. About 236 participants took either REL-1017 or a placebo pill daily, along with their usual medication. The trial was sto…
Matched conditions: MAJOR DEPRESSIVE DISORDER
Phase: PHASE3 • Sponsor: Levomecor Inc. • Aim: Symptom relief
Last updated May 26, 2026 05:10 UTC
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New depression pill shows promise in early trial
Symptom relief TerminatedThis study tested a new drug called REL-1017 as an extra treatment for people with major depression who didn't get enough help from standard antidepressants. The trial was stopped early after enrolling 27 adults. Researchers measured changes in depression symptoms using a standar…
Matched conditions: MAJOR DEPRESSIVE DISORDER
Phase: PHASE3 • Sponsor: Levomecor Inc. • Aim: Symptom relief
Last updated May 18, 2026 12:01 UTC
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Can a phone app help veterans with mental illness recognize emotions and prevent suicide?
Knowledge-focused TerminatedThis study tested a smartphone-based program to help veterans with serious mental illness (like PTSD, bipolar disorder, or schizophrenia) who struggle to recognize their own emotions—a condition called alexithymia. The goal was to see if improving emotion awareness could reduce s…
Matched conditions: MAJOR DEPRESSIVE DISORDER
Phase: PHASE1 • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated May 26, 2026 05:02 UTC
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Psilocybin depression study Follow-Up cut short
Knowledge-focused TerminatedThis study was designed to observe 26 people with major depressive disorder for one year after they received a single dose of psilocybin or niacin in a previous trial. Researchers planned to track depression symptoms through surveys and phone interviews at 3, 6, 10, and 12 months…
Matched conditions: MAJOR DEPRESSIVE DISORDER
Sponsor: Usona Institute • Aim: Knowledge-focused
Last updated May 18, 2026 12:12 UTC
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Brain test to predict PTSD drug success falls short
Knowledge-focused TerminatedThis study aimed to see if a simple brain-wave test could predict which veterans with PTSD or depression would get the most relief from common antidepressants called SSRIs. Researchers planned to enroll 94 participants over 5 years, but the study was stopped early after only 26 p…
Matched conditions: MAJOR DEPRESSIVE DISORDER
Phase: PHASE4 • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated May 11, 2026 20:47 UTC