Could a TB drug supercharge depression therapy?
NCT ID NCT05591677
First seen Jan 05, 2026 · Last updated May 23, 2026 · Updated 23 times
Summary
This study tests whether taking D-Cycloserine (DCS), a drug that affects brain receptors, before a non-invasive brain stimulation therapy called iTBS can better ease depression symptoms than the therapy alone. About 180 adults with treatment-resistant major depression will receive daily iTBS sessions for 4 weeks, plus either a placebo or one of two doses of DCS. Researchers will track mood changes and side effects to find the safest and most effective combination.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Monash Alfred Psychiatry Research Centre
Melbourne, Victoria, 3004, Australia
Conditions
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