CHRONIC KIDNEY DISEASE

This study will test whether the drug finerenone can protect the retina (the light-sensitive layer at the back of the eye) in people with chronic kidney disease. About 40 adults with stage 2 to 4 kidney disease will receive finerenone, and researchers will measure changes in reti…

This study tests a weekly injection called survodutide in 120 adults with chronic kidney disease and high protein in their urine. The goal is to see if the drug can lower protein levels and protect kidney function over 36 weeks. Participants must already be on standard kidney med…

This study tests whether a daily synbiotic supplement (probiotics plus prebiotics) can lower inflammation and improve digestive symptoms in adults with chronic kidney disease who are not yet on dialysis. One hundred participants will take either the supplement or a placebo for 16…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The program includes digital tools, personalized guidance, and ongoing support. Researchers will compare it…

This early study tests a device called NEFRONIX that uses ultrasound waves on the kidneys. Twenty adults with chronic kidney disease will receive treatment three times a week for four weeks. Researchers will measure changes in kidney function and look for safety issues. The goal …

This study tests whether taking probiotics alongside standard anemia medication (erythropoietin) can improve red blood cell levels in adults with chronic kidney disease on dialysis. Eighty participants will receive either erythropoietin alone or erythropoietin plus a daily probio…

This study tests a new medicine called ABP-671 in about 80 adults with chronic kidney disease and high uric acid levels. The goal is to see if the drug can reduce protein leakage in urine, a sign of kidney damage, over 40 weeks. Participants will be randomly assigned to receive e…

This study tests a smart program for people with both knee osteoarthritis and obesity. The program uses AI-guided community exercise and continuous glucose monitoring to help control blood sugar, reduce knee pain, and improve daily function. Researchers will track 312 adults over…

This study tests whether starting four approved kidney disease medicines within 8 weeks is safe and effective for people with type 2 diabetes and chronic kidney disease. About 64 adults will be randomly assigned to either the rapid-start approach or usual care. Researchers will t…

This study tests a new medicine called HS-10390 in 182 adults with chronic kidney disease. The goal is to see if it can lower protein levels in urine, a sign of kidney damage. Participants must already be on standard blood pressure medicines. The trial compares HS-10390 to an act…

This study tests a program called Moxie that sends weekly health tips by mail and offers a mobile app to help people manage chronic conditions like heart disease, diabetes, and kidney disease. The goal is to see if it reduces the number of times people are readmitted to the hospi…

This study tests a new feature on a home dialysis machine for people with kidney failure. The feature, called FlexPoint, allows flexible fluid volume and dwell time during treatment. Researchers will compare standard treatment to the new feature in 24 adults who have been on auto…

This study will develop and test a mobile app that helps adults with chronic kidney disease in Vietnam track and manage their symptoms remotely. Sixty participants will use the app for six weeks to see if it is easy to use and helpful. The goal is to improve quality of life and r…

This study tests whether two types of amino acid supplements can safely improve muscle mass and strength in people with advanced chronic kidney disease who also have muscle loss (sarcopenia). About 20 adults aged 45–75 will take the supplements for 6 weeks each. The goal is to fi…

This study tests whether a sodium bicarbonate enema can help relieve constipation and reduce harmful waste products (uremic toxins) in people with chronic kidney disease (CKD). The idea is to use the gut as an extra route to remove toxins that damaged kidneys can't clear. The stu…

This study tests whether laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic problems. 35 adults with at least two related conditions (like high blood pressure, diabetes, or chroni…

This pilot study will test if a program that provides education, motivation, and social support can help prevent kidney disease from worsening in 50 adults with diabetes and early-stage chronic kidney disease. Participants will meet virtually with a nurse and complete surveys ove…

This study looks at how a diet high in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar in people with type 2 diabetes and chronic kidney disease. Researchers will ask 80 participants to follow either a high- or low-acid diet for 8 weeks …

This study tests whether a 12-week nutrition and lifestyle program works well for adults with chronic kidney disease. About 45 participants will either join group education sessions with cooking classes or receive standard nutrition advice. The goal is to see if people are willin…

This observational study will enroll 100 adults with chronic kidney disease to see if a diet that causes inflammation is linked to worse gum disease. Researchers will measure participants' gum health and calculate a dietary inflammation score from food records. The goal is to und…

This study will test two new non-invasive devices that measure how well tiny blood vessels work. Researchers will compare 165 adults in five groups: healthy people, those with high blood pressure, those with type 2 diabetes, and those with moderate or severe chronic kidney diseas…

This early-stage study tests an experimental drug called CTX001 in 72 healthy adults to see if it is safe and how the body processes it. The drug is being developed for conditions like anemia and chronic kidney disease where iron levels are off. Participants will take the drug by…

This study looks for early signs of artery hardening in people with both type 2 diabetes and chronic kidney disease. Using a safe neck ultrasound, researchers will check how common these hidden changes are and how they relate to kidney function and blood sugar. The goal is to hel…

This study follows 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to multiple chronic conditions such as diabetes, heart disease, and metabolic syndrome. Participants will have regular health checks, blood and urine te…

This study compares three common treatments for coronary artery disease—surgery, stents, and medication—to see how each affects kidney function over the long term. Researchers will track 1,700 patients for at least five years, measuring changes in kidney health and rates of new o…

This study will follow 300 adults with chronic kidney disease to see how well a urine test can detect early signs of kidney damage and track disease progression. Researchers will also observe how common medications called SGLT2 inhibitors (like empagliflozin) affect kidney functi…

This study looks at a new way to give recommended vaccines to adults with chronic diseases or weakened immune systems. Doctors will offer vaccines during hospital visits, admissions, or at discharge. The goal is to see how many patients accept and complete their vaccines, and to …

This study looks at how potassium from fresh foods (like fruits and vegetables) versus processed foods (like packaged snacks) affects blood potassium levels in people with advanced chronic kidney disease. 48 participants will try four different 10-day diets, with all meals provid…

This study looks at whether a simple calculation called the triglyceride-glucose (TyG) index can help predict insulin resistance in people who have both pre-diabetes and chronic kidney disease. Researchers will compare the TyG index with standard tests in 60 adults. If successful…

This study looks at why fluid builds up around the lungs in people with advanced chronic kidney disease (stages 3 to 5). Researchers will collect a small sample of chest fluid and blood from 100 adults to compare different diagnostic methods. The goal is to find the most accurate…

This study looks at why some people with chronic kidney disease in Spain may not have the same chance to get a kidney transplant. Researchers will review past studies, survey 3,000 patients and doctors, and test a training program to find and fix these unfair differences. The goa…

This study tests whether a special presentation style called Pecha Kucha helps people on hemodialysis better follow their fluid and diet restrictions. About 70 adults who have been on dialysis for at least 6 months will take part. One group gets the new teaching method, the other…

This study tests whether community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. CHWs will work one-on-one with participants to create personalized health plans and teach …

This study will follow 500 adults in Spain with chronic kidney disease and type 2 diabetes who are taking finerenone. Researchers want to see if a tool called the Klinrisk score, which estimates kidney disease progression, improves after 2 years of treatment. The study will colle…

This study looks at how common and severe gum disease is in people with rare kidney disorders like Alport syndrome, Fabry disease, and tuberous sclerosis, as well as lupus. Researchers will compare them to people with chronic kidney disease and healthy volunteers. Participants ge…

This study looks at how to safely use a diabetes medication (SGLT2 inhibitor) in people with type 1 diabetes and mild-to-moderate chronic kidney disease. Researchers will track blood sugar and ketone levels using continuous monitors to identify risk factors for diabetic ketoacido…