CHRONIC KIDNEY DISEASE

This study is testing whether a new drug called BAY 3283142, when added to standard kidney disease treatments, can reduce excess protein in urine (albuminuria) which indicates worsening kidney function. About 700 adults with chronic kidney disease will receive either the study dr…

This study aimed to test whether an experimental drug called volenrelaxin could help adults with chronic kidney disease by reducing protein in urine and protecting kidney function. The trial was designed to compare volenrelaxin against a placebo over 24 weeks in participants alre…

This study is testing whether a daily pill called finerenone can help slow the progression of chronic kidney disease in adults who are not taking a common class of kidney-protective drugs (RAS inhibitors). About 180 participants will be randomly assigned to take either finerenone…

This study is testing whether a single dose of the drug ravulizumab can protect the kidneys of people with chronic kidney disease who are having planned heart surgery. The goal is to prevent serious kidney injury and related complications that can occur after surgery. About 736 p…

This study tested if giving a drug for anemia (darbepoetin alfa) just once a month works as well as giving it every two weeks for people with advanced kidney disease who are not on dialysis. The goal was to see if the less frequent schedule could maintain healthy red blood cell l…

This study aims to understand how well the medication dapagliflozin works and how safe it is for Chinese adults with chronic kidney disease. It involves 731 participants who will take the drug to see if it can slow the worsening of their kidney function. The research focuses on m…

This large, late-stage study is testing whether a new monthly injection called ziltivekimab can reduce the risk of major heart problems like heart attacks and strokes. It involves about 6,200 people who already have heart disease, chronic kidney disease, and signs of body-wide in…

This study is looking at whether the amount of sugar in the urine can tell doctors if a common kidney disease drug (SGLT2 inhibitor) is effectively protecting the kidneys. Researchers will follow 300 adults with chronic kidney disease who are already taking the drug to see if uri…

This study is observing how a kidney-protecting drug called finerenone is used and how safe it is for patients with chronic kidney disease and type 2 diabetes in real-world Chinese hospitals. It will track 5,000 patients' health records to see how their kidney function and potass…

This study is testing whether keeping blood pressure very low (under 120) is better than the usual target (under 140) for patients with advanced kidney or thyroid cancer who are starting specific cancer drugs. The goal is to see if this intensive approach is doable, safe, and hel…

This study is investigating whether the medication tirzepatide, which is approved for weight loss and diabetes, can improve kidney health in people who are overweight or obese and have chronic kidney disease. Researchers will use special MRI scans to see if the drug increases oxy…

This large study in Japan is investigating whether SGLT2 inhibitor drugs, often used for diabetes, can help delay or reduce anemia in people with chronic kidney disease (CKD). Researchers will compare 15,000 patients who take these drugs with those who do not, tracking when anemi…

This large, late-stage study is testing whether a new once-daily pill called orforglipron is as safe and effective as standard insulin injections for adults with type 2 diabetes who also have obesity or are overweight and are at higher risk for heart problems. It will involve abo…

This study is comparing two ways of doing peritoneal dialysis to see which one is better at protecting a patient's remaining natural kidney function and reducing harmful stress on the body. It involves 100 new dialysis patients in Mexico who will be randomly assigned to receive e…

This study is testing a 16-week diet coaching and cooking class program designed to help Black adults at risk for kidney disease eat healthier. The goal is to see if this community-based approach is practical and acceptable to participants. Researchers will measure if the program…

This study aims to find a better way to treat sudden gout attacks in people with advanced kidney disease or kidney transplants. It compares two medications—anakinra and prednisone—to see which one reduces pain faster and with fewer side effects. The trial involves about 200 hospi…

This study is testing if an online exercise program supervised by physical therapists can help people with chronic kidney disease. It will also check how reliable certain tools are for measuring muscle strength and activity. The goal is to see if remote exercise is a safe and pra…

This study is testing whether a 6-month exercise program during dialysis sessions can help kidney patients. Forty participants will either do combined aerobic and strength exercises three times a week during treatment or receive their usual care. Researchers will measure changes …

This study tests whether providing comprehensive education about kidney disease and treatment options helps veterans make more informed choices about dialysis. It compares veterans who receive this special education to those who get standard care, looking at whether more choose a…

This study is collecting health records from 150,000 people in the US who have chronic kidney disease and type 2 diabetes. Researchers are comparing the health of people who take the approved drug finerenone with those who don't, to see if it helps prevent heart attacks and heart…

This study aims to see if a simple blood test result, called the neutrophil-to-lymphocyte ratio (NLR), can predict which kidney dialysis patients have or are at risk for peripheral artery disease (PAD). Researchers will study 120 adult patients on regular dialysis to check for th…

This study is observing 4,500 adults with chronic kidney disease and type 2 diabetes who are starting the medication finerenone as part of their regular doctor's care. Researchers will collect information for one year to learn how the drug is used in real-world settings, includin…

This study aims to learn more about how the drug finerenone works for people in India who have chronic kidney disease and type 2 diabetes. Researchers will look back at the medical records of about 1,200 patients who were already prescribed this approved medication. The goal is t…

This study aims to understand why some people with type 2 diabetes have a harder time controlling their blood sugar and develop kidney problems. Researchers will collect health information, lifestyle details, and blood samples from 1000 adults with diabetes in Mexico. By analyzin…

This study aims to understand why kidney disease is common and dangerous in people with pulmonary hypertension (a serious heart-lung condition). Researchers will check blood and urine samples from 350 hospitalized patients to look for substances that might signal early kidney dam…