CHRONIC KIDNEY DISEASE

This study tests if the drug finerenone can reduce protein leakage in urine (a sign of kidney damage) better than a placebo. It involves 180 adults with chronic kidney disease who are not taking certain common blood pressure medicines. The goal is to see if finerenone can help co…

This study tests a monthly injection called ziltivekimab to see if it can lower the chance of heart attacks and strokes in people who already have heart disease, chronic kidney disease, and signs of inflammation. About 6,200 participants will receive either the active drug or a p…

This study tests whether a 16-week diet coaching program, including cooking classes, can help Black Americans at risk for chronic kidney disease stick to the DASH diet. About 48 adults with early kidney disease or risk factors like diabetes or high blood pressure will take part. …

This study aimed to test a drug called volenrelaxin in adults with chronic kidney disease to see if it could improve kidney function and reduce protein in the urine. The trial was planned to last about 24 weeks and required participants to already be on standard blood pressure me…

This study tests a single dose of the drug ravulizumab to see if it can prevent serious kidney problems after heart surgery in people with chronic kidney disease (CKD). About 736 adults with moderate to severe CKD will receive either the drug or a placebo before their planned hea…

This study tests whether drinking nitrate-rich beetroot juice every day for three months can improve blood vessel health, movement, and thinking in people with chronic kidney disease (CKD). About 92 adults with moderate CKD will take part. The goal is to see if this simple supple…

This study looks at whether keeping blood pressure very low (below 120 mmHg) is better than the usual target (below 140 mmHg) for people with advanced kidney or thyroid cancer who are starting certain targeted cancer drugs. The goal is to reduce the risk of heart and kidney probl…

This study tested whether a once-monthly injection of darbepoetin alfa can keep hemoglobin levels stable in people with advanced chronic kidney disease who are not on dialysis. 40 Korean adults completed the 12-week evaluation, and the monthly dosing was found to be as effective …

This study looks at two ways of doing peritoneal dialysis (a treatment for kidney failure) in 100 new patients. One method uses a standard full dose, while the other uses a smaller, tailored dose based on how much kidney function remains. The goal is to see which approach better …

This study tests whether tirzepatide, a medication for weight and diabetes management, can improve kidney health in 140 adults with overweight or obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat …

This study tests the drug dapagliflozin in 731 Chinese adults with chronic kidney disease to see if it can slow kidney function decline and reduce complications. Participants take the drug alongside their current treatments. The goal is to gather safety and effectiveness data for…

This study tests whether starting two kidney medications (vicadrostat and empagliflozin) at the same time is better than starting them one after the other in adults with chronic kidney disease at risk of worsening. About 416 participants will take the drugs daily for 3 months, wi…

This study looks at whether a 6-month program of combined aerobic and resistance exercise, done during dialysis sessions, can improve muscle strength, body composition, and daily function in people with chronic kidney disease. Forty patients will be split into an exercise group a…

This study looks at whether online exercise programs supervised by physical therapists can help people with chronic kidney disease improve muscle strength and function. Researchers will also check if the tools used to measure strength are reliable. About 50 adults with CKD (on di…

This study tests whether anakinra works better than prednisone for treating gout flares in people with advanced chronic kidney disease or who have had a kidney transplant. Gout causes sudden, painful joint inflammation, and standard treatments like colchicine and NSAIDs are not s…

This study tests a digital mindfulness app called Calm Health in 26 adults with chronic kidney disease. Participants use the app for 6 weeks while wearing a wrist sensor to track sleep, activity, and heart rate. The goal is to see if the app is easy to use and if it helps reduce …

This study aims to understand why some people with diabetes develop kidney disease, especially in Ecuador. Researchers will look at social, environmental, and biological factors in over 10,000 adults, including those with and without diabetes or kidney problems. The goal is to fi…

This study reviews medical records of 1200 Indian adults with chronic kidney disease and type 2 diabetes who started finerenone between 2022 and 2024. Researchers will describe how doctors prescribed the drug, dose changes, and effects on kidney function and potassium levels. The…

This study looks at health records from 150,000 people with chronic kidney disease and type 2 diabetes to see how safe and effective the drug finerenone is in everyday medical care. Researchers will compare those who take finerenone with those who do not, focusing on heart attack…

This study looks at 120 adults on regular dialysis to see if a simple blood test called the neutrophil-to-lymphocyte ratio (NLR) can help detect peripheral artery disease (PAD), a condition where arteries in the legs narrow. The goal is to find a cheap, easy way to identify patie…

This study is observing 350 adults with pulmonary hypertension to see if certain markers in urine and blood are linked to worsening kidney function. Researchers will track kidney decline, need for dialysis, and death. The goal is to better understand the connection between these …

This study observes over 4,600 adults with chronic kidney disease and type 2 diabetes who are already taking finerenone as part of their routine care. Researchers will collect data from medical records and doctor visits for 12 months to see how the drug is used, why it might be s…

This study uses health records from 15,000 people with chronic kidney disease in Japan to see if SGLT2 inhibitors (a type of diabetes medicine) are linked to a lower risk of developing anemia. Researchers will also track changes in anemia treatments and costs over time. The goal …

This study tests whether removing aged, worn-out cells can improve physical frailty and stem cell health in 30 adults aged 40-80 with moderate-to-severe chronic kidney disease and diabetes. Participants receive a senolytic drug combination, and researchers measure changes in cell…

This study will enroll 1,000 adults with type 2 diabetes in Mexico to find out which clinical, lifestyle, and genetic factors are linked to poor blood sugar control and kidney damage. Participants will provide medical history, undergo physical tests, answer questionnaires, and gi…

This study looks at 300 adults with chronic kidney disease who are already taking a standard SGLT2 inhibitor. Researchers want to see if the amount of sugar in their urine is linked to changes in protein levels in their urine, which is a key marker of kidney health. The goal is t…

This study looks at whether a special education program helps veterans with advanced chronic kidney disease learn more about their condition and make informed choices about dialysis. About 656 veterans will take part, with some receiving the program and others getting standard ca…

This study was designed to see how a new experimental drug for chronic kidney disease, called nurandociguat, affects the way the body processes two common medicines (rosuvastatin and dabigatran) in healthy adults. The goal was to gather safety and drug-interaction information for…