CHRONIC KIDNEY DISEASE

This 5-year study is testing whether the medication orforglipron can reduce serious heart and kidney problems in people who already have heart disease or chronic kidney disease. Researchers will compare orforglipron against a placebo in about 7,140 participants to see which group…

This study tests a new weekly injection called NNC0519-0130 for people with chronic kidney disease who also have overweight or obesity, with or without type 2 diabetes. Researchers want to see if it's safe, how the body processes it, and if it can improve kidney function and help…

This study is testing whether a combination of two existing drugs—budesonide and ambrisentan—can help people with IgA nephropathy, a type of kidney disease. Researchers want to see if this treatment can reduce protein in the urine and slow the decline of kidney function over 36 w…

This small pilot study is testing whether a device that gently stimulates a nerve through the ear is safe and tolerable for people with chronic kidney disease. Researchers want to see if this stimulation affects heart rate variability and blood pressure, which are linked to heart…

This study is testing whether a medication called empagliflozin can help slow the progression of chronic kidney disease in children and adolescents aged 2 to 17. For the first six months, participants are randomly assigned to receive either the real drug or a placebo pill, follow…

This study aims to find the best daily schedule for taking the medication ramipril to help protect kidney function in people who have both chronic kidney disease and a type of heart failure. Researchers will compare taking one larger dose per day versus two smaller doses over 30 …

This study is testing if a virtual weight management program can help people with severe obesity and advanced kidney disease lose enough weight to qualify for a lifesaving kidney transplant. Participants will either join the program, which includes coaching and a weight-loss medi…

This study is testing if a new care model helps veterans with chronic kidney disease better control their high blood pressure. It compares patients who manage their own blood pressure medications with a pharmacist's guidance against those who just monitor at home and receive stan…

This study is testing an oral pill called roxadustat as a potential new treatment for anemia (low red blood cells) in children and teenagers with chronic kidney disease. The goal is to see if this pill, taken three times a week for up to a year, is a safe and effective alternativ…

This study is testing a drug called etelcalcetide in children and infants with advanced kidney disease who are on dialysis. The drug aims to control a common and serious hormone problem that causes bone disease and growth problems. Researchers want to see if it is safe and effect…

This large Phase 3 study is testing whether an investigational drug called HRS-1780 can slow the decline of kidney function in adults with chronic kidney disease. Nearly 2,000 participants will receive either HRS-1780 tablets or a placebo in addition to their standard care. The m…

This study is testing if a heart failure drug called eplerenone is safe and might help people who have both weak hearts and severe kidney disease. Doctors are enrolling 40 patients who have been excluded from past trials due to safety concerns about their kidneys. The main goal i…

This study is testing whether a new oral solution called ACE Reno can help protect kidney function in people with various types of kidney disease. About 300 adults with kidney problems from diabetes, high blood pressure, autoimmune conditions, or other causes will take the soluti…

This study is testing whether adding a new oral medicine called finerenone to standard kidney care helps children with chronic kidney disease. Researchers want to see if the combination reduces protein leaking into urine better than standard care alone. About 219 children, aged 6…

This study aims to learn about the long-term safety of a medication called finerenone when given to children and young adults (ages 1-18) who have chronic kidney disease and proteinuria. Participants will take finerenone along with their standard kidney medication for up to 18 mo…

This study is testing if a personalized aerobic exercise program can help lower the risk of heart disease in people with chronic kidney disease or rheumatoid arthritis. Researchers will compare three groups: one doing supervised exercise, one receiving educational phone calls, an…

This is the first study in people to test the safety of an experimental drug called AZD4248. Researchers will give single and multiple doses to healthy volunteers and people with diabetic kidney disease to see how the body handles it and check for side effects. A separate part of…

This study is testing a new device called the Velocity System that creates a dialysis access point using a small skin puncture and a catheter, avoiding traditional open surgery. It will enroll 126 adults with kidney failure who need dialysis access to see if this less invasive me…

This study is testing whether people with chronic kidney disease can safely eat more potassium-rich fruits and vegetables. Researchers will provide 30 participants with home-delivered produce that is either high or low in potassium for six weeks each, then switch. The goal is to …

This early-stage study aims to find out if a new drug called IGT-303 is safe for people. It will test single and multiple doses given as shots under the skin or into a vein. Researchers will compare the drug to a placebo in about 94 healthy volunteers and people with chronic kidn…

This study aims to find out if starting two kidney medications, vicadrostat and empagliflozin, at the same time works better for controlling kidney disease than starting them one after the other. It will involve about 416 adults whose chronic kidney disease is at risk of getting …

This study is testing whether an experimental injection called UBT251 can help protect kidney function and reduce body weight in adults who are overweight or obese and have chronic kidney disease. About 180 participants will receive either the UBT251 injection or a placebo (dummy…

This study is testing a new artificial intelligence (AI) system designed to help doctors diagnose chronic kidney disease from biopsy images. Researchers will collect kidney biopsy images from about 2,900 patients. They will compare the AI system's diagnosis to the expert diagnosi…

This study tests whether personalized fluid therapy guided by lung water monitoring can prevent kidney damage in elderly patients with existing kidney problems who undergo coronary angiography. Researchers will compare two groups: one receiving standard care and one receiving flu…

This study is testing whether a special type of exercise training can help people with chronic kidney disease feel better and become more active. Researchers want to see if combining regular exercise with blood flow restriction (using bands to gently limit blood flow during worko…

This study aims to find the best time for physical therapy for people receiving dialysis treatment. Researchers will compare exercising during dialysis sessions versus exercising before dialysis starts. The goal is to see which timing leads to better improvements in walking abili…

This study is testing a training program designed to help patients with advanced chronic kidney disease and their caregivers make health decisions together more effectively. The program, delivered remotely by a coach, teaches communication and support skills. Researchers are comp…

This study is testing whether a structured exercise program can help people with chronic kidney disease feel better and function better in daily life. It will enroll 50 adults with kidney disease, including some on dialysis. Participants will be randomly assigned to either follow…

This is the first study in humans testing a new drug called OJR520. Researchers want to understand how safe it is and how the body processes it in both healthy volunteers and people with chronic kidney disease. The study will test different doses to find what's tolerable before m…

This study is collecting information about how a recently approved kidney medication called finerenone is actually used by patients in everyday medical care. Researchers will analyze existing health records from 50,000 people in the US and Asia who have both chronic kidney diseas…

This study is testing whether a 12-week education and support program helps hospitalized African American adults with advanced chronic kidney disease. Participants receive education sessions, phone calls, and text messages about managing their condition and planning for future tr…

This study looks back at existing medical records to understand how dapagliflozin, a medication already approved for chronic kidney disease, is used and how well it works in routine Spanish healthcare. Researchers will analyze data from over 14,000 patients to see how the drug af…

This large observational study aims to collect real-world information on how patients with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease are currently managed. It will enroll 35,000 adults from many countries to track their treatments, doctor …

This is a large observational study that will follow 90,000 people in China, including those with and without kidney disease, to better understand how chronic kidney disease starts and gets worse over time. Researchers will collect real-world health data to identify risk factors …

This study aims to collect real-world information on how chronic kidney disease (CKD) is managed in China and what happens to patients over time. It will follow 3,000 adults with CKD for nearly two years, observing their treatments and health outcomes. The goal is to better under…

This large research study aims to understand why some people develop serious health problems related to metabolic syndrome, like heart disease and fatty liver. Researchers will collect blood, urine, and stool samples from over 6,000 participants, both with and without metabolic s…

This study aims to create better formulas for measuring how the human body uses energy (metabolism). Researchers will compare 2000 healthy volunteers and people with conditions like diabetes or cancer. They will use detailed scans and breath tests during short hospital stays to u…

This study aims to understand why people with chronic kidney disease (CKD) often experience a sharp rise in blood pressure during exercise, which can limit their ability to be active. Researchers will measure nerve and blood vessel responses in 156 participants, some with CKD and…

This study aims to understand how taking many different medications affects the health of older adults living with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will follow 2,000 participants aged 65 and older for two years, asking them to co…

This study aims to understand how the kidney-protecting drug finerenone is actually used by doctors and patients in South Korea. Researchers will observe and collect information from about 500 adults with chronic kidney disease and type 2 diabetes who are starting this already-ap…

This study aims to better understand Gastric Antral Vascular Ectasia (GAVE), a condition where blood vessels in the stomach enlarge and can cause pain, nausea, and bleeding. Researchers will measure how often these symptoms occur and how they relate to how well the stomach emptie…

This study aims to find out if using common pain relievers called NSAIDs for a short time after surgery is safe for children who already have mild-to-moderate kidney disease. Researchers will follow 80 children after urology surgery to see if these medications increase their risk…

This study aims to understand how kidney transplant affects heart health in people with advanced kidney disease. Researchers will measure heart blood flow and function in 80 patients before and after transplant to see if improved kidney function reduces inflammation and helps the…

This study is testing three different educational approaches to help people with advanced kidney disease prepare for the surgery needed to create vascular access for hemodialysis. Researchers will compare standard education, a video and brochure package, and that same package plu…