CHRONIC KIDNEY DISEASE

This study tests whether giving elderly patients with kidney disease a personalized amount of fluids, guided by a lung water monitor, can prevent acute kidney injury after a heart imaging procedure called coronary angiography. About 320 participants aged 60 and older with chronic…

This study tests whether a heart failure drug called eplerenone is safe and helpful for people who also have severe chronic kidney disease. Previous studies excluded these patients due to safety concerns, but newer treatments may lower the risks. The trial will enroll 40 particip…

This study tests a drug called etelcalcetide in children aged 28 days to under 18 years who have chronic kidney disease and are on dialysis. The goal is to see if the drug can safely lower high levels of parathyroid hormone, which can cause bone and heart problems. About 56 parti…

This study tests an injection called UBT251 in 180 adults who are overweight or obese and have chronic kidney disease. The goal is to see if it can reduce protein in the urine, a sign of kidney damage, over 24 weeks. Participants will receive either the drug or a placebo, and the…

This study tests a new treatment called AdiaVita, made from umbilical cord stem cells and glutathione, in 100 adults with chronic kidney disease (stages 2-4). Participants receive monthly IV infusions for 3 months and use a skin spray at home. The goal is to see if the treatment …

This study tests whether combining budesonide and ambrisentan can reduce protein in the urine and slow kidney function decline in people with IgA nephropathy, a chronic kidney disease. About 129 adults with mild to moderate kidney damage will receive both drugs for 36 weeks. The …

This study tests a new oral solution called ACE Reno in 300 adults with chronic kidney disease from various causes like diabetes or high blood pressure. The goal is to see if taking it four times daily for 12 weeks can reduce protein in the urine and help keep kidneys working lon…

This study looks at whether a program of aerobic and strength exercises can improve physical performance and quality of life in adults with chronic kidney disease, whether they are on dialysis or not. About 50 participants will be randomly assigned to either an exercise group or …

This study tests whether community pharmacists can safely prescribe medications that protect the kidneys in people with type 2 diabetes and early kidney disease. About 120 adults without a family doctor will be randomly assigned to either pharmacist-led care using a step-by-step …

This study tests roxadustat, a pill taken three times a week, to treat anemia in children and teenagers with chronic kidney disease. Anemia means low red blood cells, which can cause tiredness. Current treatment requires injections, but this pill might be easier. About 100 kids w…

This early-stage study tests whether IGT-303 is safe for people with chronic kidney disease. About 94 healthy volunteers and kidney disease patients will receive either the drug or a placebo. Researchers will monitor side effects and how the drug moves through the body.

This study tests whether a virtual weight management program, including a weight-loss drug, can help people with obesity and advanced kidney disease lose enough weight to become eligible for a kidney transplant. About 60 adults will either join the program or continue their usual…

This study tests whether a new drug called HRS-1780 can slow down kidney function loss in people with chronic kidney disease. About 1,978 adults with moderate to severe kidney damage will receive either the drug or a placebo, on top of their usual care. The main goal is to see if…

This study tests whether people with chronic kidney disease can safely eat fruits and vegetables with higher potassium instead of restricting them. Thirty adults with moderate-to-severe kidney disease will try both diets in random order, with home delivery of produce. Researchers…

This study tests whether empagliflozin, a medicine already used for diabetes, can help children aged 2 to 17 with chronic kidney disease (CKD). About 120 kids will be randomly assigned to take the drug or a placebo for 6 months, then all will receive the drug for another year. Re…

This study looks at whether empagliflozin, a drug used for diabetes and chronic kidney disease, is safe for people who have received a kidney transplant. About 264 veterans will take the drug to see if it causes side effects like infections or affects their transplant. The goal i…

This early-stage study tests a new drug called OJR520 in healthy people and those with chronic kidney disease. The main goal is to check if the drug is safe and how the body processes it. About 112 participants will receive either the drug or a placebo. This research is the first…

This study tests whether a smartphone app can help doctors and young adults with chronic kidney disease (CKD) follow the latest treatment guidelines. The app provides reminders, education, and care recommendations to delay kidney disease progression. About 80 participants aged 16…

This study tests whether letting patients with chronic kidney disease manage their own blood pressure medications, with guidance from a pharmacist, works better than standard care. About 160 veterans with kidney disease and high blood pressure will take part. The goal is to see i…

This study tests whether red propolis, a natural bee product, can lower inflammation and oxidative stress in people with chronic kidney disease. Researchers will measure changes in inflammatory markers in 40 patients who are not yet on dialysis. The goal is to see if this supplem…

This study tests whether a 6-week aerobic exercise program can reduce cardiovascular risk in 90 adults with chronic kidney disease or rheumatoid arthritis. Participants will do three 45-minute exercise sessions per week. Researchers will measure artery stiffness, blood vessel fun…

This study tests a new once-weekly injection called NNC0519-0130 in 465 adults with chronic kidney disease, with or without type 2 diabetes, who are also overweight or obese. The goal is to see if the drug can improve kidney function and is safe compared to an existing medicine (…

This study tests a new device that creates dialysis access through a small skin puncture instead of open surgery. It is for adults with kidney failure who need dialysis. The goal is to see if the procedure is safe and works well, with follow-up for up to five years.

This study tests whether adding finerenone to standard blood pressure medicines can reduce protein in the urine of children aged 6 months to 18 years with chronic kidney disease. About 219 participants will receive either finerenone or a placebo for 6 months. The goal is to see i…

This study looks at the long-term safety of adding finerenone to standard blood pressure medicines for children aged 1 to 18 with chronic kidney disease and proteinuria (protein in urine). About 100 kids who were in an earlier study will take finerenone for up to 18 months. Resea…

This early-phase study tests whether a new drug called tegoprubart, along with other medications, can safely help islet cell transplants work better in people with type 1 diabetes and chronic kidney disease. About 10 adults will receive the transplant and take immunosuppressants …

This study tests whether orforglipron, a daily pill, can reduce major heart problems (like heart attacks and strokes) and slow kidney disease in people who already have heart or kidney issues. About 7,140 participants will receive either orforglipron or a placebo for up to 5 year…

This study looks at whether taking the blood pressure medication ramipril once or twice a day is better for kidney function in people who have both chronic kidney disease and heart failure. Researchers will measure changes in kidney health and inflammation markers after 30 days. …

This study is testing an artificial intelligence (AI) system that reads kidney biopsy images to help diagnose chronic kidney disease. Researchers will compare the AI's results to the standard diagnosis made by pathologists. The goal is to see how accurate the AI is at identifying…

This study looks at whether combining exercise with blood flow restriction training can improve exercise ability and tolerance in people with chronic kidney disease. Researchers will measure breathing muscle function and heart health in 120 participants. The goal is to find a saf…

This study looks at whether exercising during dialysis or right before it works better for people with kidney failure. About 72 adults on dialysis will be split into two groups and do supervised exercises twice a week for 12 weeks. The goal is to see which timing improves walking…

This study is creating a large database of 8,000 adults with heart, kidney, or metabolic diseases (like diabetes). Researchers will collect medical records, imaging, and lab results, then follow participants for up to 5 years. The goal is to better understand these conditions and…

This study looks at whether people with inflammatory bowel disease (Crohn's or ulcerative colitis) have more kidney problems than the general population. Researchers will compare 3,000 IBD patients with 3,000 healthy volunteers using blood tests, urine tests, and kidney imaging. …

This study is observing 500 adults in South Korea with chronic kidney disease and type 2 diabetes who are taking the medication finerenone as part of their regular care. Researchers want to learn why doctors prescribe it, how long patients stay on it, and what side effects occur.…

This study is a registry that will follow 3,000 Chinese adults with chronic kidney disease (CKD) to see how they are treated in real life and what happens to their health over time. It does not test a new drug or treatment, but simply collects information to better understand the…

This small study is testing a device that gently stimulates a nerve in the ear to see if it is safe and tolerable for people with chronic kidney disease (CKD). The goal is to gather early data on how the device affects heart rate and blood pressure, which may help design future s…

This early-stage study tests a new drug called AZD4248 in healthy volunteers and people with chronic kidney disease and type 2 diabetes. The main goal is to check if the drug is safe and how the body processes it. The study also looks at whether people can reliably measure their …

This study aims to improve how we measure metabolism—the rate your body burns calories—by looking at body shape and composition. Researchers will compare healthy volunteers and people with conditions like diabetes, obesity, or cancer. Participants spend two days in the hospital f…

This study watches 80 people with advanced kidney disease who are waiting for a kidney transplant. Researchers will measure heart blood flow and function before and after the transplant to see if the new kidney helps the heart. The goal is to understand how kidney disease and inf…

This study looks at whether giving non-steroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, to children with mild-to-moderate chronic kidney disease after surgery increases their risk of acute kidney injury. About 80 children aged 18 months and older will be monitored. The…

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 people with and without metabolic syndrome. The goal is to identify biological markers that predict disease progression and help create personalized prevention and treatment plans. Part…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and why their blood pressure rises during activity. Researchers will measure muscle oxygen and pH levels in 110 veterans with and without CKD. The goal is to understand the body's response, n…

This study looks at health records from over 14,000 people with chronic kidney disease in Spain to see how the drug dapagliflozin is used and how well it works in real life. Researchers will track changes in kidney function, hospital visits, and costs over about three years. No n…

This study tests an online decision aid called "My Heart Care and CKD" for people with both chronic kidney disease and heart disease. The tool helps patients and doctors understand the risks and benefits of heart procedures like angiograms or surgery, which can be riskier for kid…

This study is following 90,000 people in China, including those with and without chronic kidney disease (CKD), to see how the disease develops and gets worse over time. Researchers will track changes in kidney function and other health markers. The goal is to learn more about CKD…

This study looks at whether a 12-week education and support program can help African American patients with advanced chronic kidney disease learn more about their condition and how to manage it. About 180 hospitalized adults will either receive the program or standard care. The g…

This study tests different ways to help people with advanced chronic kidney disease and their caregivers work together when making health decisions. About 128 patient-caregiver pairs will receive coaching sessions to improve communication and support skills. The goal is to find t…

This study is building a special collection of blood and urine samples from 800 adults with sickle cell disease or sickle cell trait. Researchers will use these samples, along with medical records, to learn how kidney disease starts and gets worse in people with the sickle cell g…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and tests ways to improve their fitness. Researchers will measure changes in exercise capacity and blood pressure in 156 participants, including CKD patients, kidney transplant recipients, an…

This study looks at three different ways to teach people with advanced kidney disease about getting a special blood vessel (called vascular access) for dialysis. About 360 adults will be placed into one of three groups: one gets a video and brochure, another gets the video plus e…

This study is a large registry that collects information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers will observe how these conditions are managed in everyday medical practice, including treatments, hospi…

This study looks at real-world data from 50,000 people in Asia and the US who have both chronic kidney disease and type 2 diabetes and are taking the drug finerenone as part of their regular care. Researchers will collect information on patients' age, other health conditions, and…

This study follows 1,300 children with chronic kidney disease (CKD) over many years to learn how their kidney function declines and what factors affect their health. Participants are aged 6 months to 22 years and have mild to moderate kidney damage. The goal is to better understa…

This study aims to learn more about Gastric Antral Vascular Ectasia (GAVE), a condition where stomach blood vessels enlarge and may bleed, causing pain and nausea. Researchers will use questionnaires and a breath test to measure symptoms and stomach function in 30 adults with GAV…

This study looks at how taking multiple medications affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older in Shaanxi Province, China, over two years. The goal is to…