CHRONIC KIDNEY DISEASE

This study tested a drug called MCI-196 in 245 adults on dialysis with high phosphate levels. After a 12-week dose adjustment period, some patients switched to a placebo for 4 weeks to see if the drug truly kept phosphate levels down. The goal was to manage a common complication …

This early-stage study tested a new drug called AZD4144 in 29 adults who have both heart disease and chronic kidney disease. The main goal was to check if the drug is safe and to see how it affects inflammation markers in the blood. Participants took either the drug or a placebo …

This study tested a new drug called BAY 3283142 in over 1,200 adults with chronic kidney disease (CKD) who had high levels of a protein called albumin in their urine. The goal was to see if adding this drug to standard treatment could lower urine albumin better than a placebo. Pa…

This study tested whether AST-120, a charcoal-like pill taken by mouth, could delay the need for dialysis or kidney transplant in people with moderate to severe chronic kidney disease. Over 1,000 adults participated, and researchers tracked how long it took for kidney function to…

This study tested whether the drug finerenone can slow the worsening of chronic kidney disease in people with type 1 diabetes. About 241 adults took either finerenone or a placebo pill for 6 months, along with their usual treatments. Researchers measured changes in urine protein …

This study tested a drug called ziltivekimab in 36 adults with advanced chronic kidney disease to see if it could reduce inflammation, which is linked to heart problems. Participants received either a low dose, a high dose, or a placebo injection every 4 weeks for 3 doses. The ma…

This study looked at whether pentoxifylline, a drug used for blood flow issues, can lower inflammation and slow kidney disease in non-diabetic patients. 42 adults with moderate to severe chronic kidney disease took part. Researchers measured changes in inflammatory markers to see…

This study tested whether a once-weekly injection of exenatide (a diabetes drug) could improve heart and kidney health in 57 adults with type 2 diabetes, mild kidney disease, and early heart stiffness. Participants received either the drug or a placebo for 38 weeks. Researchers m…

This study tested two experimental drugs, HRS-1780 and henagliflozin, in 181 adults with chronic kidney disease. The goal was to see if these drugs could reduce protein in the urine, a sign of kidney damage, over 13 weeks. Participants were already on standard blood pressure medi…

This study tested an automated insulin delivery system (a smart pump) in 15 adults with type 1 or type 2 diabetes who also had advanced kidney disease or were on dialysis. Participants used the system for 8 weeks, then switched to their usual care for another 8 weeks. The goal wa…

This study looked at whether the usual vitamin D supplement (cholecalciferol) helps children with chronic kidney disease, kidney transplants, or nephrotic syndrome reach healthy vitamin D levels. 43 children took a single high-dose vitamin D vial, and researchers checked their vi…

This study tested the long-term safety of a drug called MCI-196 in 116 adults with advanced chronic kidney disease who are on dialysis and have high phosphorus levels. The goal was to see if the drug is safe and helps control phosphorus over a year. Participants took flexible dos…

This study looked at 186 adults with chronic kidney disease who had high potassium levels while in the hospital. Researchers compared continuing a drug called SZC after discharge versus standard care. The goal was to see if SZC helps maintain normal potassium levels and reduces h…

This study tested a new device called the FLEX System that creates a connection between an artery and a vein using a tube inserted through the skin, instead of surgery. The goal was to see if this method is safe and works well for people with chronic kidney disease who need dialy…

This study compared a once-daily pill called orforglipron to insulin glargine in about 2,700 adults with type 2 diabetes who were also overweight or obese and had increased heart or kidney risk. The main goal was to see if orforglipron could delay or prevent major heart problems …

This study tested the long-term safety of a drug called MCI-196 in 632 adults with advanced kidney disease on dialysis who have high phosphorus levels. Participants took the drug for up to 52 weeks to see how well it controls phosphorus and lowers LDL cholesterol. The goal is to …

This study tested a drug called MCI-196 in 642 adults on dialysis who had high phosphorus and cholesterol levels. Participants took either MCI-196 or a placebo for 12 weeks to see if the drug could safely lower both phosphorus and LDL cholesterol. The goal is to help manage heart…

This study tested a new drug called BAY3283142 in 75 people with mild to moderate high blood pressure. The drug helps relax blood vessels and is being developed for chronic kidney disease. Participants took different doses or a placebo for up to 10 weeks to check for side effects…

This study tested a new drug called MCI-196 to see if it lowers 'bad' cholesterol better than a placebo and as well as the standard drug simvastatin in people with advanced chronic kidney disease who are on dialysis. About 260 adults on stable dialysis took part. The goal is to m…

This study tested a pill called AST-120 (a type of charcoal that absorbs toxins in the gut) in over 1,000 adults with moderate to severe chronic kidney disease. The goal was to see if adding it to standard care could delay the need for dialysis, a kidney transplant, or a doubling…

This study tested whether dapagliflozin, a drug used for diabetes, can improve heart structure and be safe in people with kidney failure who are on dialysis. 220 adults on maintenance dialysis (with or without diabetes) received either the drug or a placebo. The goal was to see i…

This study tested a drug called MCI-196 to see if it can lower high phosphorus levels in people with advanced kidney disease who are on dialysis. High phosphorus can cause serious health problems. The trial involved 336 adults and compared MCI-196 to a placebo over several weeks.…

This study tested whether an education program based on Roy's Adaptation Model helps kidney patients on immunosuppressive therapy improve their self-efficacy, medication adherence, and overall adaptation to chronic disease. Researchers enrolled 78 adults receiving immunosuppressi…

This study tested a combined bone marrow and kidney transplant from a partially matched family donor for 10 people with both a serious blood disorder and chronic kidney disease. The goal was to treat both conditions with one donor, potentially reducing the need for lifelong anti-…

This study tested whether a new investigational medicine called CagriSema (a combination of two drugs) can reduce kidney damage in people with chronic kidney disease, type 2 diabetes, and overweight or obesity. About 626 participants received either CagriSema, one of its componen…

This study tested the drug dapagliflozin in 100 adults with chronic kidney disease (but not diabetes) to see if it could slow kidney decline, improve anemia, and protect the heart. Participants took either dapagliflozin or a placebo daily for 12 months alongside their usual care.…

This study tested a short questionnaire called SCORED to see if it can accurately identify adults in Asia who are at risk for chronic kidney disease (CKD). Over 1,400 people took part. The goal was to see how well the questionnaire works as a simple, non-invasive screening tool t…

This study looked at whether pentoxifylline, a drug that improves blood flow, could prevent kidney injury caused by contrast dye used in medical imaging. Researchers studied 70 adults with chronic kidney disease in the intensive care unit who needed dye for procedures like heart …

This study tested two drug-free methods to help people on dialysis sleep better and feel more comfortable. Sixty patients in Cyprus received either reflexology (a special foot massage) or sleep hygiene education. Both approaches improved sleep and comfort, but reflexology worked …

This study tested whether a simple bedtime mindfulness meditation could help people on hemodialysis feel less anxious and more spiritually well. 58 adults on long-term dialysis were split into two groups: one practiced guided meditation during their sessions for four weeks, while…

This study tested two simple, drug-free ways to reduce pain when inserting needles for dialysis. 75 adults were split into three groups: one listened to calming music, one looked at their healthy arm in a mirror, and one received usual care. Pain levels were measured right after …

This study looked at whether nurse-led mindfulness sessions could help people on hemodialysis feel better emotionally and follow their treatment more closely. Eighty adults on dialysis were split into two groups: one received six weekly mindfulness sessions, and the other got sta…

This study looked at whether a 10-minute vibration massage or a 10-minute static stretching exercise could reduce muscle cramps and stress in people undergoing hemodialysis. Thirty adults with chronic kidney disease who experienced leg cramps during dialysis were randomly assigne…

This study looked at whether eating at different times during hemodialysis affects blood pressure stability and how well the treatment removes toxins. Researchers divided 40 kidney disease patients into groups that ate at set times or followed their usual habits. The goal is to f…

This study looked at whether treating constipation in people with chronic kidney disease (CKD) is practical and might improve health. Fourteen adults with both CKD and constipation received treatment. The main goal was to see if patients would follow the treatment and provide sam…

This early-stage study tested a single dose of the experimental drug KBP-5074 in 11 people with severe chronic kidney disease, including some on dialysis. The main goal was to check safety and how the drug moves through the body. No treatment benefits were measured; the study was…

This study examined whether starting a higher dose of two common antidepressants (venlafaxine or duloxetine) increases the risk of serious events like emergency visits, hospital stays, or death within 30 days in older adults (66+) with chronic kidney disease. Researchers analyzed…

This study looked at 130 adults with chronic kidney disease to see if a kidney protein called uromodulin affects how salt intake influences blood pressure. Researchers measured salt intake through urine tests and tracked blood pressure over 24 hours. The goal was to understand wh…

This study looked at how a class of diabetes drugs called SGLT2 inhibitors affect kidney function in people with chronic kidney disease (CKD). Researchers compared 60 patients with and without diabetes to see if the drugs changed their estimated glomerular filtration rate (eGFR),…

This study looked at how colestilan, a drug that lowers phosphate levels, changes the way the body absorbs candesartan, a blood pressure medicine. 18 healthy men took candesartan at different times around their colestilan dose. The goal was to see if timing matters, so doctors ca…

This study looked at 388 people with end-stage kidney disease to see if starting dialysis at the right time, based on a new mathematical formula, could lower death rates and improve quality of life. Participants were split into groups that started dialysis earlier or later accord…

This study looked at whether giving African American adults with high blood pressure early access to genetic testing for APOL1 gene variants (which increase kidney disease risk) helps improve blood pressure control and kidney care. About 6,800 participants were randomly assigned …

This study tested whether a small, wearable ECG device can detect high potassium levels (hyperkalemia) in people on dialysis. Thirty-two adults with chronic kidney disease wore the sensor during dialysis sessions over six weeks. Researchers compared ECG readings with blood test r…

This completed study surveyed 608 heart and kidney doctors to understand their awareness and use of a blood test called hsCRP, which measures inflammation. The goal was to learn what doctors think about using this test to identify inflammation in patients with heart disease, kidn…

This study looked at 5,000 older adults (66+) with low kidney function who started taking nortriptyline, a common antidepressant. Researchers compared those on higher doses (over 10 mg/day) to those on a low dose (10 mg/day) to see if they had more emergency visits, hospital stay…

This study looked at 49 veterans with early chronic kidney disease (CKD) and high blood pressure. Researchers wanted to see if common water pills (diuretics) could reduce extra fluid in the body and improve heart health and symptoms like fatigue. They measured fluid levels and he…

This study looked at how semaglutide, a diabetes medicine, affects the kidneys in people with type 2 diabetes and chronic kidney disease. About 106 participants received either semaglutide or a placebo injection once a week for a year. Researchers used MRI scans, blood and urine …

This early-stage study tested a new oral medicine, NNC0705-0001, in 116 healthy adults to see if it is safe and how the body handles it. The medicine is being developed to treat chronic inflammation, which can lead to heart and metabolic diseases. Participants received either the…

This study looked at whether a culturally-tailored anti-inflammatory diet is practical and well-liked by racial/ethnic minorities with chronic kidney disease. 18 adults from the Bronx took part. Researchers measured diet changes and asked participants if they liked the diet. The …

This study looked at 88 adults with chronic kidney disease (stages 2 to 5) to understand how oral health problems like tooth decay and gum disease relate to kidney function. Researchers measured dental health, nutrition, and inflammation over 12 months. The goal was to see if den…

This study looked at blood vessel health in 101 elderly patients (65+) with chronic kidney disease who were not on dialysis. Researchers used ultrasound and blood tests to measure signs of vessel damage that could raise heart risk. The goal was to better understand how kidney dis…

This study looked at whether having a clinical pharmacist work directly with doctors on hospital rounds can reduce medication problems in patients with kidney impairment. Researchers studied 160 adults with reduced kidney function who were taking drugs that need dose adjustments.…

This study looked at data from 348 people with type 2 diabetes in Germany who use the myTherapy app. The goal was to see how many have elevated levels of albumin in their urine, which is an early sign of kidney disease. Researchers tracked these levels over about a year to unders…

This study monitored over 1,000 people with chronic kidney disease (but not on dialysis) who were taking the drug Forxiga. Researchers tracked side effects and factors that might affect safety. The goal was to gather real-world safety information, not to test if the drug works.

This study measured four specific molecules in the blood of 180 people, including healthy volunteers and kidney disease patients at different stages. The goal was to see if these molecules could help diagnose chronic kidney disease early or predict resistance to anemia treatment …

This study observed over 6,500 Chinese adults with chronic kidney disease and type 2 diabetes who started taking the drug finerenone. Researchers looked at patient health records to understand how the drug is used in real life, including its effects on kidney function and potassi…