CHRONIC KIDNEY DISEASE

This study tested whether pentoxifylline, an existing medication, could reduce inflammation and slow the progression of chronic kidney disease in patients without diabetes. It involved 42 adults with moderate to advanced kidney disease. Researchers measured levels of inflammatory…

This study tested a new automated insulin delivery system for people with type 1 or type 2 diabetes who also have advanced kidney disease or are on dialysis. The system uses a sensor and a pump to automatically adjust insulin doses. Researchers compared eight weeks using this sys…

This study tested whether a special education program could help kidney patients better manage their long-term immunosuppressive medications and adjust to living with a chronic disease. Researchers worked with 78 patients who were starting these medications for the first time. Th…

This study tested whether the drug dapagliflozin could help adults with chronic kidney disease who do not have diabetes. Researchers compared the drug to a placebo pill over 12 months to see if it could slow kidney decline, improve anemia, and support heart health. About 100 part…

This study tested whether the medication MCI-196 could help control high phosphate levels in people with kidney failure who are on dialysis. The trial involved 245 adult dialysis patients who first received the medication for 12 weeks, then were randomly assigned to continue it o…

This study tested whether a standard, high-dose vitamin D supplement effectively raises vitamin D levels in children and teens with chronic kidney disease, kidney transplants, or nephrotic syndrome. Researchers also checked if this supplement caused any harmful increase in calciu…

This early-stage study tested the safety of an experimental oral drug called AZD4144 in people with both heart and kidney disease. Twenty-nine participants took either the drug or a placebo pill daily for 28 days. The main goal was to see if the drug was safe and to measure its e…

This study tested whether a weekly injection of the diabetes medication exenatide could help protect the heart and kidneys in people with type 2 diabetes who were at risk for heart problems and had mildly reduced kidney function. For 38 weeks, some participants received the real …

This study tested whether two different oral medications could help people with chronic kidney disease. Researchers enrolled 181 adults who were already on standard blood pressure medications. They measured how well the drugs reduced protein in urine and protected kidney function…

This study aimed to understand how the diabetes medication semaglutide might help protect the kidneys in people who have both type 2 diabetes and chronic kidney disease. Over one year, 106 participants received either semaglutide or a placebo injection weekly. Researchers used de…

This study tested the long-term safety of MCI-196, a medication that helps control high phosphorus levels in people with advanced kidney disease who are on dialysis. The research followed 632 patients for up to one year to monitor how well they tolerated the medication and whethe…

This study tested whether continuing a potassium-lowering medication called SZC after hospital discharge helps people with chronic kidney disease better maintain safe potassium levels compared to standard care. It involved about 186 adults who were hospitalized for high potassium…

This large, completed Phase 3 trial tested whether the drug MCI-196 could help control two common problems in people with kidney failure on dialysis: high phosphorus and high 'bad' cholesterol. The study involved 642 stable dialysis patients who were randomly assigned to receive …

This large, completed Phase 3 trial tested whether adding a charcoal-based medication called AST-120 to standard care could slow the worsening of moderate to severe chronic kidney disease (CKD). The study involved over 1,000 adults and aimed to see if the treatment could delay th…

This study tested a medical device called the FLEX System that creates dialysis access without major surgery. The device makes a connection between an artery and vein through a small needle puncture instead of an open surgical cut. Researchers followed 80 kidney failure patients …

This study tested if common, inexpensive water pills (diuretics) could help people with early-stage chronic kidney disease. Researchers wanted to see if reducing extra body fluid with these pills could lower the risk of heart problems and improve symptoms like tiredness. They mea…

This small pilot study tested whether a special anti-inflammatory diet, customized to fit different cultural food traditions, is practical and acceptable for people living with chronic kidney disease. Researchers worked with 18 adult participants from the Bronx to see if they cou…

This study tested whether adding the medication finerenone to standard care could better protect kidney function in adults with both chronic kidney disease and type 1 diabetes. Researchers compared finerenone against a placebo (inactive pill) in 241 participants over 6 months of …

This large study tested whether adding AST-120 to standard care could slow the worsening of moderate to severe chronic kidney disease. Over 1,000 patients were randomly assigned to receive either AST-120 or a placebo pill, and researchers tracked whether they needed dialysis, a k…

This study tested whether having a clinical pharmacist on the hospital team helps prevent medication errors in patients with kidney problems. Researchers compared three groups: one with no pharmacist, one where doctors got extra training, and one where a pharmacist actively revie…

This study tested whether a new weekly injection called CagriSema could slow kidney damage in adults with type 2 diabetes, chronic kidney disease, and overweight or obesity. It compared CagriSema against its individual components (semaglutide and cagrilintide) and a placebo over …

This study tested whether the drug MCI-196 could safely control high phosphorus levels in people with kidney failure on dialysis. Researchers compared the drug against a placebo in 336 patients over 16 weeks. The goal was to see if the drug could effectively manage this common an…

This pilot study tested a combined transplant from a partially matched family donor. It aimed to treat patients who had both a serious blood disorder (like leukemia) and advanced kidney disease at the same time. The goal was to cure the blood disorder and restore kidney function …

This study looked at whether changing when patients eat during their kidney dialysis treatment could help keep their blood pressure stable and make the dialysis work better. Researchers tested different meal times on 40 adults with kidney failure who regularly receive dialysis. T…

This early-stage study tested the safety of a new oral drug, BAY3283142, in people with high blood pressure and chronic kidney disease. The drug is designed to relax blood vessels. For 10 weeks, 75 participants took either the drug or a placebo pill, and researchers monitored the…

This study tested if a new drug called MCI-196 could lower bad cholesterol (LDL) in people with severe kidney disease who are on dialysis. It compared MCI-196 to a common cholesterol drug (simvastatin) and to a placebo (a dummy pill). The goal was to see if the new drug worked as…

This study aimed to see if a type of diabetes medication (SGLT2 inhibitors) could help protect kidney function in people with chronic kidney disease, whether they had diabetes or not. Researchers compared changes in a key measure of kidney health (eGFR) in 60 adult participants w…

This study tested the long-term safety and effectiveness of a drug called MCI-196 for people on dialysis who have high phosphate levels in their blood. It involved 116 adult patients on stable dialysis treatment. The main goal was to see how safe the drug was over a year, while a…

This study tested whether a diabetes drug called dapagliflozin could improve heart health in people with kidney failure who need regular dialysis. Researchers gave 220 patients either the drug or a placebo pill daily for six months to see if it reduced heart muscle thickening, a …

This study tested if a small, wearable heart monitor could detect dangerous spikes in potassium levels in people on dialysis. Thirty-two patients wore a chest sensor during their dialysis sessions while their blood potassium was checked. Researchers compared the heart signal patt…

This study tested whether a simple, guided meditation practice could help people on long-term dialysis feel less anxious and more spiritually at peace. 58 adult patients were randomly assigned to either practice a 15-minute guided meditation or just rest quietly during their dial…

This study tested two simple, drug-free methods to reduce the pain of needle insertion for patients on dialysis. 75 patients were randomly assigned to either listen to calming music, look at a mirror showing their healthy arm, or receive standard care during the procedure. Resear…

This study tested whether weekly mindfulness sessions led by nurses could help people on long-term dialysis feel better mentally and stick to their complex treatment plans. Eighty patients were split into two groups: one received six weekly mindfulness sessions, while the other r…

This study aimed to understand if a drug used to control phosphate in kidney disease patients (colestilan) changes how the body processes a common blood pressure medication (candesartan). It involved 18 healthy male volunteers who took both drugs at different times. Researchers m…

This study tested whether sharing the results of a specific genetic test with patients and their doctors leads to better health outcomes. It focused on people of African ancestry with high blood pressure who have a gene variant (APOL1) that increases their risk for kidney disease…

This study aimed to monitor the safety of the drug Forxiga (dapagliflozin) when used by over 1,000 patients with chronic kidney disease in real-world medical settings. It specifically looked to identify any unexpected side effects and understand what factors might influence safet…

This study aimed to understand the link between chronic kidney disease and heart disease risk in older adults. Researchers measured blood vessel health in 101 participants aged 65+ with kidney disease using ultrasound, blood tests, and other non-invasive checks. The goal was to i…

This study looked at whether certain molecules in the blood could help doctors detect chronic kidney disease earlier and predict which patients might not respond well to common anemia treatments. Researchers compared 180 people—60 healthy individuals, 60 with moderate kidney dise…

This small pilot study tested whether treating constipation in people with chronic kidney disease might improve their kidney health. Researchers gave 14 patients with both conditions a constipation treatment and checked if it was practical to deliver. They measured changes in kid…

This study was a survey of 608 heart and kidney specialists. Its purpose was to understand how these doctors think about and use a specific blood test (hsCRP) to detect hidden inflammation in patients with combined heart and kidney diseases. The goal was to gather real-world info…

This study aimed to understand how a specific protein made by the kidneys, called uromodulin, influences the relationship between salt in the diet and blood pressure in people with chronic kidney disease. Researchers enrolled 130 adult patients to measure their salt intake, blood…

This early-stage study aimed to check the safety and how the body processes a new oral drug called KBP-5074 in people with severe chronic kidney disease. It involved 11 patients, some on dialysis and some not, to see how they tolerated single doses. The main goal was to gather in…

This was the first study in humans to test the safety of a new oral medicine called NNC0705-0001. The medicine is being developed to treat chronic inflammation, which increases the risk of heart and kidney disease. The study involved 116 healthy adults to see how safe the drug is…