CERVICAL CANCER

This study tests whether the drug MGD019 can help control advanced cervical cancer that has spread or come back. About 47 people who have not yet received treatment will take part. The goal is to see if the drug improves survival.

This study tests a new antibody drug, acasunlimab, in people with advanced solid tumors that have not responded to standard treatments. The first part checks safety and finds the best dose, while the second part tests how well it works alone or with other cancer drugs. About 429 …

This phase 3 study tests whether adding the drug AK104 to standard chemotherapy (with or without bevacizumab) helps people with persistent, recurrent, or metastatic cervical cancer live longer without their disease worsening. About 445 women who have not had prior systemic therap…

This study tests whether adding targeted radiation (SBRT) to the immunotherapy drug atezolizumab can shrink tumors better than atezolizumab alone in people with cervical cancer that has come back or spread. About 21 adults with advanced cervical cancer will receive both treatment…

This early-phase study tests a new drug called AB598, alone or with other treatments, in about 40 people with advanced solid tumors like lung, bladder, or ovarian cancer. The main goal is to check if the drug is safe and tolerable. Participants must have measurable tumors and be …

This study is for people with advanced solid tumors (like lung, bladder, or skin cancer) that have stopped responding to standard immunotherapy drugs called PD-1/PD-L1 inhibitors. Researchers are testing a new combination of immune-boosting drugs to see if they can shrink tumors …

This early-phase study tests a new drug called AI-061, which combines two immunotherapy agents (anti-PD-1 and anti-CTLA-4) into one treatment. The goal is to find the safest dose and see if it can shrink tumors in people with advanced cancers like melanoma, lung, and ovarian canc…

This study tests whether a mix of three immunotherapy drugs can shrink tumors in people with advanced HPV-related cancers that have spread. About 51 adults with cancers like cervical, anal, or throat cancer will receive the drugs for up to a year. The goal is to control the disea…

This early-phase trial tests a new drug called IMGN151 in adults with certain gynaecological cancers that have come back. The study aims to find a safe dose and check for side effects. About 256 participants with recurrent endometrial, ovarian, fallopian tube, primary peritoneal,…

This study tests the drug pembrolizumab in about 1,600 people with advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can shrink tumors and to identify biomarkers that predict response. Participants receive pembrolizumab and are m…

This early-phase study tests a personalized cell therapy called T-Plex for people with advanced solid tumors that have not responded to standard treatments. The therapy uses a patient's own immune cells, engineered to recognize and attack cancer cells. The main goal is to check s…

This study tests a new drug called Q702 combined with pembrolizumab (an immunotherapy) in people with advanced esophageal, stomach, liver, or cervical cancer that has worsened after prior treatment. The goal is to see if the combination is safe and shrinks tumors. About 120 parti…

This study tests a new drug called RNDO-564, alone or with another drug (pembrolizumab), in people with advanced solid tumors (like lung, bladder, or breast cancer) that no longer respond to standard treatments. The main goals are to check safety, find the best dose, and see if t…

This study tests an experimental drug called HFB200301, given alone or with another drug (tislelizumab), in adults with advanced solid tumors like stomach, kidney, or lung cancer. The goal is to find a safe dose and see how well people tolerate it. About 72 participants will take…

This study tests whether a combination of two drugs (camrelizumab and famitinib) works better than standard chemotherapy for women with cervical cancer that has returned or spread. About 443 women aged 18-75 who have not had prior treatment for advanced disease will take part. Th…

This study tests an HPV vaccine (PRGN-2009) alone or with a drug called M7824 in adults with HPV-positive cancers like cervical, anal, and throat cancers. The goal is to find a safe dose and see if the combination boosts the immune system to fight the cancer better. Participants …

This study tests a new drug called SKB264 in people with advanced solid tumors (like lung, breast, or ovarian cancer) that have not improved with standard treatments. The goal is to find the best dose and see if it can shrink tumors. About 1,410 participants will receive the drug…

This early-phase study tests a new drug called LY4101174 in people with advanced or metastatic solid tumors that have come back or spread. The drug is designed to target and attack cancer cells while sparing healthy ones. The study will check if the drug is safe and what dose wor…

This study is testing an experimental drug called AZD5305, a PARP inhibitor, in people with advanced solid tumors like ovarian, breast, pancreatic, and prostate cancer. The goal is to see if the drug is safe and tolerable when given alone or with other cancer treatments. About 70…

This study tests a combination of three drugs (entinostat, PDS01ADC, and bintrafusp alfa) in adults with advanced cancers linked to HPV or certain colon cancers that haven't responded to standard treatments. The goal is to find a safe dose and see if the treatment can shrink tumo…

This study compares two ways to help 360 cervical cancer survivors quit smoking. One group gets phone counseling and personalized text messages, while the other gets standard quitline support. The goal is to see which approach helps more people stay smoke-free for two years.

This study tests whether combining two drugs, dostarlimab and cobolimab, can shrink tumors or slow the disease in people with advanced or recurrent cervical cancer. About 66 participants with measurable tumors will receive the combination. The main goal is to see how many patient…

This study tests a drug called AK104 (cadonilimab) in 18 adults with a rare and fast-growing type of cervical cancer that has come back or spread. The goal is to see if the drug can stop the cancer from growing for at least 6 months. Participants must have already tried standard …

This study tests a combination of two drugs (zimberelimab and lenvatinib) in 30 people with advanced cervical cancer that got worse after prior immunotherapy. The goal is to see if this combo can shrink tumors or slow the disease. Participants must have tried platinum-based chemo…

This study explores whether a non-invasive electroacupuncture technique can detect persistent viruses, like HPV and SARS-CoV-2, in 30 women with advanced cervical cancer. Researchers will measure electrical signals at specific body points to see if they match viral presence. The …

This early-phase study tests whether injecting a radioactive sugar (18F-FDG) into the cervix before a PET/CT scan can more clearly show which pelvic lymph nodes contain cancer in women with stage IB1 cervical cancer or high-grade endometrial cancer. About 42 women scheduled for s…

This study looks at how well different two-step cervical cancer screening methods work in Botswana, using an HPV test first. About 3,000 women aged 25 and older will take part, including those living with HIV. The goal is to find the most accurate and affordable way to catch earl…

This study looks at whether mailing self-sampling HPV test kits to Asian and Asian American women who are behind on screening can help them get tested for cervical cancer. About 111 women in Houston, Texas, who haven't had a Pap test in years will receive a kit to collect their o…

This study looks at whether giving women a free self-sampling device (SSD) through their general practitioner can increase cervical cancer screening rates among those who haven't had a Pap smear in 6 years. About 3,375 women aged 31-64 in Flanders will be randomly assigned to rec…

This study tests a program called Game Changers for Cervical Cancer Prevention in Uganda. It involves 1,400 women who have already been screened for cervical cancer. These women are trained to encourage their female friends and family members who have never been screened to get t…

This large Phase 3 trial is testing a new 9-valent HPV vaccine designed to protect against nine types of human papillomavirus. It aims to prevent cervical cancer, precancerous lesions, and genital warts in healthy women aged 18 to 45. The study compares the new vaccine's effectiv…

This study tests whether adding a special yoga and physiotherapy program to standard care can lower stress in women undergoing brachytherapy for cervical cancer. About 98 women will take part, with half receiving the program and half getting usual care. The goal is to see if this…

This study tests a program called Journey Ahead that helps women with gynecologic cancers (like ovarian, endometrial, or cervical cancer) improve their coping and communication skills. About 30 women who have been diagnosed or had a recurrence in the past 5 years will take part. …

This study looks at whether teaching women with cervical cancer about healthy habits can improve their quality of life, physical activity, self-esteem, and mood. About 28 women will be split into two groups: one gets health education through meetings and social media for 12 weeks…

This study looks at whether offering HPV testing and immediate treatment for early cervical changes is practical and acceptable in Burkina Faso, Côte d'Ivoire, Guatemala, and the Philippines. Over 17,600 women will be screened, and researchers will measure how many complete treat…

This study is testing whether advanced PET and MRI scans can better measure oxygen levels, blood flow, and metabolism in high-grade brain tumors and cervical cancers. About 20 adults with newly diagnosed or recurrent tumors will receive two types of scans. No treatment is given; …

This study tests a program called Potlako+ that combines community education, help for healthcare workers, and patient guides to speed up cancer detection and treatment. About 874 adults in Botswana with possible cancer symptoms will take part. Half of the communities get the pro…

This study aims to improve health literacy among women who are about to leave jail. About 279 participants will receive education on cervical and breast cancer, contraception, and sexually transmitted diseases. The goal is to empower them with knowledge to make healthier choices …

This study aims to improve cervical cancer prevention in Kenya by screening adult women for high-risk HPV and vaccinating girls. Researchers will enroll 300 more women and girls to learn what helps or hinders participation. The goal is to make screening and vaccination easier and…

This study measures oxygen levels inside cervical cancer tumors during a type of radiation treatment called brachytherapy. Ten adults with cervical cancer will have tiny oxygen sensors placed in their tumors during the procedure. The goal is to learn how oxygen levels relate to t…

This study tests better ways to help women in Kenya get screened for breast and cervical cancer and complete needed follow-up care. About 5,400 women aged 30-55 will take part. The goal is to find which strategies work best to catch cancer early and save lives.

This study screens up to 1,150 adults with advanced solid tumors (like head and neck, cervical, or lung cancer) to check their genetic markers. Researchers look for specific HLA types and tumor antigens to see if patients might qualify for future cell therapy trials. No treatment…

This study looks at how low oxygen levels and high fluid pressure inside cervical cancer tumors affect how well radiation therapy works. Researchers will measure these factors in 500 patients before and during treatment. The goal is to find the best way to identify tumors that ma…

This study aims to find better ways to measure oxygen levels in cervical cancer tumors. Low oxygen (hypoxia) makes tumors harder to treat with radiation. Researchers will use MRI scans and genetic tests on 30 patients to see which markers best identify hypoxic tumors. The goal is…

This study looks at how well women with cervical cancer finish their treatment and how many side effects they have, comparing those who also have HIV to those who do not. About 180 women in India with advanced cervical cancer will be followed during their standard treatment. The …

This study was designed to compare the standard Pap smear with a new blood test that looks for three proteins to detect abnormal cervical cells. It planned to include adults aged 18-85 in good general health. However, the study was withdrawn before enrolling any participants, so …

This study surveys 300 transgender men in France aged 25-65 who still have a cervix. It aims to understand why many skip cervical cancer screening and what helps or hinders their access. The goal is to identify obstacles and solutions to make screening more inclusive.

This study tests a web-based system called CATSystem that helps doctors follow guidelines for cervical cancer screening and treatment. About 6,600 women at 10 Kenyan hospitals will take part. The goal is to see if the tool increases the number of women who get proper screening an…

This study was designed to test a mobile health app that helps patients with recurrent head and neck or gynecologic cancers track their symptoms, treatment side effects, and quality of life. The goal was to see if patients find the app easy to use and helpful. However, the study …