New antibody combo shows promise in Hard-to-Treat cancers
NCT ID NCT03917381
First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 30 times
Summary
This study tests a new antibody drug, acasunlimab, in people with advanced solid tumors that have not responded to standard treatments. The first part checks safety and finds the best dose, while the second part tests how well it works alone or with other cancer drugs. About 429 participants will receive active treatment, and the study lasts about 74 weeks per person.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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ARENSIA Exploratory Medicine LLC
Kyiv, Ukraine
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ASST Sette Laghi "Ospedale di Circolo e Fondazione Macchi "
Varese, Italy
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AUSL Romagno-Ravenna
Ravenna, Italy
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Azienda Ospedaliero Universitaria di Parma
Parma, Italy
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BKMK Hospital
Kecskemét, Hungary
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Clinica Universidad de Navarra
Pamplona, 31008, Spain
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Dom Lekarski SA
Szczecin, Poland
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Emory University
Atlanta, Georgia, 30322, United States
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Fakultni nemocnice Brno
Brno, Czechia
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Fakultni nemocnice Olomouc
Olomouc, Czechia
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Gulhane Training and Research Hospital
Ankara, Turkey (Türkiye)
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Hadassah Medical Organization HMO - Sharett Institute of Oncology
Jerusalem, 12000, Israel
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High Technology Hospital Medcenter
Batumi, Georgia
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Hospital Clinico De Valencia
Valencia, 46010, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario La Princesa
Madrid, Spain
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Hospital Universitario Vall dHebron
Barcelona, 08035, Spain
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Hospital Universitario Virgen de la Victoria
Málaga, Spain
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IOB-Hospital Quironsalud Barcelona
Barcelona, 8023, Spain
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IRCCS - Istituto Europeo di Oncologia IEO
Milan, Italy
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Istituto Nazionale Tumori - Fondazione Pascale Italy
Naples, Italy
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LLC "TIM - Tbilisi Institute of Medicine"
Tbilisi, Georgia
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LTD Consilium Medulla
Tbilisi, Georgia
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Levine Cancer Institute, Atrium Health
Charlotte, North Carolina, 28204, United States
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MD Anderson Cancer Center Madrid
Madrid, Spain
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Maria Sklodowska Curie National Research Instutute of Oncology
Warsaw, Poland
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Mayo Clinic
Phoenix, Arizona, 85054, United States
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Mayo Clinic
Jacksonville, Florida, 32224, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Medical Point Izmir Hospital
Cordaleo, Turkey (Türkiye)
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Medpolonia Sp. z o.o.
Poznan, Poland
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NEXT Oncology Madrid
Madrid, 28223, Spain
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NYU Langone
New York, New York, 10016, United States
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Nemocnice AGEL Ostrava-Vítkovice a.s.
Nový Jičín, Czechia
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Norton Healthcare Inc
Louisville, Kentucky, 40202, United States
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Onkologiai Klinika
Debrecen, Hungary
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Policlinico San'Orsola
Bologna, Italy
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Policlinico Uni. Campus Bio-Medico
Roma, Italy
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Pulmonology Hospital Törökbálinti
Törökbálint, Hungary
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Rambam Health Care Campus RHCC - Rambam Medical Center
Haifa, Israel
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Regina Elena National Cancer Institute
Rome, Italy
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START Madrid-CIOCC
Madrid, 28050, Spain
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START Madrid-FJD, Hospital Fundación Jiménez Díaz
Madrid, 28040, Spain
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START Midwest
Grand Rapids, Michigan, 49546, United States
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Sheba Medical Center, Ramat Gan
Tel Litwinsky, 52621, Israel
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Specialist Hospital in Prabuty
Prabuty, Poland
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Tbilisi State Medical University and Ingorovka High Medical Technology University Clinic Ltd
Tbilisi, Georgia
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Tel Aviv Sourasky Medical Center
Tel Aviv, 64239, Israel
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Trakya University Hospital
Edirne, Turkey (Türkiye)
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UNC Chapel Hill
Chapel Hill, North Carolina, 27514, United States
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University Hospital Brno
Brno, Czechia
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University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
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University of Iowa Hospitals
Iowa City, Iowa, 52242, United States
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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Uniwersyteckie Centrum Kliniczne
Gdansk, Poland
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Yale University Cancer Center
New Haven, Connecticut, 06520-8028, United States
Conditions
Explore the condition pages connected to this study.