CERVICAL CANCER

This study tests whether adding a drug called telaglenastat (which blocks glutaminase) to standard chemoradiation can help people with advanced cervical cancer live longer without the disease getting worse. About 42 adults with stage III–IVA cervical cancer will receive the combi…

This study tests a new drug called JSKN033 combined with standard chemotherapy, with or without another drug (bevacizumab), in people with advanced cervical cancer that has come back or spread. The goal is to see if the combination is safe and shrinks tumors. About 78 adults with…

This study tests a combination of three drugs (sacituzumab tirumotecan, iparomlimab, and tuvonralimab) given before surgery to people with locally advanced cervical cancer. The goal is to see if this treatment can completely eliminate the cancer before the operation. About 25 par…

This study tests whether combining two drugs, camrelizumab and famitinib, can help prevent cervical cancer from coming back after surgery. About 30 women with specific cancer types and stages will receive this treatment for up to two years. The main goal is to see how many remain…

This study tests a new way to give radiation therapy for several pelvic cancers (prostate, endometrial, cervical, and rectal). The approach uses daily scans to adjust the radiation beam to the exact shape of the tumor, allowing for fewer but stronger treatments. The goal is to se…

This study tests whether a new combination of drugs (LB1410 plus lenvatinib, with or without LB4330) works better than standard chemotherapy for people with advanced cervical cancer that has come back or spread. About 120 participants will be randomly assigned to one of the treat…

This study tests a combination of two drugs, Utidelone and Toripalimab, in people with recurrent or metastatic cervical cancer whose cancer has worsened after standard chemotherapy. The goal is to see if this treatment can shrink tumors and control the disease. About 32 participa…

This study tests an experimental immunotherapy called PDS0101 in 27 adults aged 25-65 who have both HIV and HPV type 16. The goal is to see if the treatment is safe and can strengthen the immune system's fight against HPV, which can cause cancers of the cervix, anus, and other ar…

This phase 3 trial tests a new drug called SYS6002 against standard chemotherapy for people with advanced cervical cancer that has returned or spread after prior treatments. About 412 adults aged 18-75 will be randomly assigned to receive either SYS6002 or a chemotherapy chosen b…

This study will test if combining at-home self-sampling for HPV with digital colposcopy (a camera exam of the cervix) can help find cervical cancer and pre-cancer faster and more accurately. About 700 women aged 30-65 will take part, and researchers will compare the new approach …

This study tests a special microscope that takes detailed pictures of cervical tissue right where the patient is, without waiting for a lab. About 400 women in Mozambique and Brazil who need a cervical biopsy or LEEP procedure will join. The goal is to see if this new method can …

This study tests a program called MySHARE+ that uses text messages and at-home HPV test kits to help women living with HIV get screened for cervical cancer. About 130 women who haven't had a Pap smear in over a year will be enrolled. The goal is to see if this approach is easy to…

This study tests a program to help doctors and clinics improve cervical cancer screening and follow-up care. The program combines education and quality improvement methods, making it easier for clinicians to keep up with best practices while meeting their own certification requir…

This study compares two standard radiation methods for cervical and endometrial cancer: proton therapy and photon therapy. The goal is to see which causes fewer bowel side effects like diarrhea. About 116 newly diagnosed patients will be randomly assigned to one of the two treatm…

This study looks at whether a program focused on sexual health and lifestyle can help women who have finished cervical cancer treatment feel better about their sexual function and overall quality of life. About 120 women who have completed surgery, radiation, or other treatments …

This study looks at whether hand and foot exercises can reduce nerve damage (numbness, tingling) caused by chemotherapy in older adults with gynecological cancer. About 74 people aged 65 and older will take part. The goal is to see if these exercises improve quality of life and r…

This study will develop and test an AI system that helps doctors make treatment decisions for pregnant women with cervical cancer. The AI will be compared to a real team of doctors to see if it can provide accurate and fast recommendations. About 150 participants will be involved…

This study uses a special 3D ultrasound to look at blood flow inside cervical and ovarian tumors. Researchers want to see if blood flow patterns can help predict how the disease will progress. About 100 adult women with these cancers or precancerous changes will take part, along …

This study will enroll 600 people with endometrial or cervical cancer to see if a blood test can detect cancer recurrence earlier than standard methods. Participants give blood samples at diagnosis, after treatment, and during follow-up. The goal is to improve monitoring and guid…

This study looks at how to best screen for and manage HPV in women living with HIV, who are at higher risk for cervical cancer. Researchers will test a new method that identifies specific HPV types and measures viral load. The goal is to see if this approach is practical for a la…

This study looks at ways to make cervical cancer screening easier for women with HIV, who are at higher risk for this cancer. Researchers will talk to patients and doctors to find out what gets in the way of screening and follow-up care. They will also explore if allowing women t…

This study will test whether a short, face-to-face educational program can improve women's knowledge about cervical cancer and their attitudes toward the HPV vaccine. About 100 women aged 18-49 in Van, Turkey will take part. Half will receive the education, and the other half wil…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps patients manage follow-up care and feel more in control of their health. The goal is to see if the program is helpful and practical for use …

This study works with 80 women with HIV in South Africa who have had an abnormal Pap smear. Researchers will interview patients and providers to understand why some women miss follow-up appointments. Based on what they learn, they will create a support program and test if it help…