CERVICAL CANCER

This study looked at how well the HPV vaccine protects against HPV infections that can cause cancer in Rwandan women aged 18-28, both with and without HIV. Researchers measured infections and antibody levels years after vaccination, and also tested a simple, low-cost way to confi…

This study tested whether adding the targeted drug cetuximab to standard radiation and chemotherapy (cisplatin) helps control cervical cancer better than radiation and cisplatin alone. It included 76 patients with stage IB2 to IIIB cervical cancer that could not be surgically rem…

This early-phase study tested whether adding the immunotherapy drug nivolumab to standard chemoradiation is safe for people with locally advanced cervical cancer. Twenty-one adults took part, receiving nivolumab alongside radiation and cisplatin, followed by up to six months of n…

This study tested whether using MRI scans to guide brachytherapy (a type of internal radiation) works better than the standard X-ray method for women with locally advanced cervical cancer. Over 1,000 participants received either MRI-guided or X-ray-guided treatment. The goal was …

This study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy helps women with advanced cervical cancer live longer. Over 600 women with persistent, recurrent, or metastatic cervical cancer took part. The results showed that the combination improv…

This study tested a type of internal radiation called high-dose brachytherapy in 43 people with cervical, endometrial, esophageal, prostate, or biliary cancer. The goal was to see if the radiation implants could be placed accurately to deliver a high dose directly to the tumor. P…

This study tested a new drug called tisotumab vedotin against standard chemotherapy in 502 people with cervical cancer that had spread or returned. Participants were randomly assigned to receive either the new drug or one of five chemotherapy options. The main goal was to see if …

This study looked at 236 women with high-risk early-stage cervical cancer who had already had surgery. They all received chemotherapy and radiation, and half also got extra chemo afterward. The goal was to see if the extra chemo helped keep the cancer from coming back. The result…

This study tested a combination of three drugs (afuresertib, sintilimab, and chemotherapy) in 22 adults with solid tumors like lung, cervical, or stomach cancer that had stopped responding to prior immunotherapy. The goal was to find the safest dose and see if the combo could shr…

This study looked at whether using an anti-cancer cream (5-fluorouracil) in the vagina after surgery is acceptable and helpful for treating cervical precancer in 180 South African women living with HIV. The goal was to see if women would stick with the treatment and find it accep…

This early-stage trial tested a new treatment for people with HPV-positive head and neck or cervical cancer that has spread or come back. The therapy uses a patient's own immune cells, engineered to recognize and attack HPV-infected cancer cells. Some cells were also modified to …

This study tested a combination of an immunotherapy drug (cemiplimab) and a vaccine (ISA101b) in 113 adults with advanced HPV16-positive cervical cancer that had worsened after standard chemotherapy. The goal was to see if the combination could shrink tumors and improve survival.…

This study tested two immunotherapy drugs, tiragolumab and atezolizumab, alone or together, in 172 people with advanced cervical cancer that had spread or returned after chemotherapy. The goal was to see if the combination could shrink tumors better than one drug alone. Participa…

This early-stage study tested a new drug called RP903 in 69 people with advanced solid tumors (like ovarian, breast, or cervical cancer) who had no other treatment options. The main goal was to check the drug's safety and find the right dose, not to cure the cancer. While some pa…

This study tested a new device called the Femscope Calm Collect Device for collecting cervical cells for cancer screening. Researchers wanted to see if it works as well as the traditional brush method but causes less pain and discomfort. 13 healthy women aged 21-45 took part, eac…

This study looked at whether a self-collected sample (like a swab you do at home) can be used to screen for cervical cancer as accurately as a sample collected by a doctor. Researchers tested new DNA markers that measure changes in HPV and human genes to better identify women at …

This study looked at whether mailing self-test kits for HPV (the virus that can cause cervical cancer) could help more women get screened. It involved nearly 2,500 minority and underserved women who were overdue for screening. The goal was to see if a simple at-home test could ma…

This study tested a simple idea: give women who haven't had a cervical cancer screening in over three years a self-sampling kit to use at home. Researchers recruited 656 women aged 50 to 65 in two French departments with low screening rates. The goal was to see if offering the ki…

This study tested whether using a vaginal dilator after brachytherapy for cervical cancer improves sexual function, self-compassion, and quality of life. Eighty women completed surveys at 1, 4, and 12 weeks. The goal was to see if this simple tool can ease treatment side effects.

This study tested whether adding the drug aprepitant to standard anti-nausea medicines could better prevent nausea and vomiting caused by chemotherapy in 143 women with gynecologic cancers like ovarian or cervical cancer. Participants received either the three-drug combo or a pla…

This study tested whether a 4-week exercise program before surgery could help women with cervical cancer recover faster. 34 women scheduled for a hysterectomy were split into two groups: one did special pelvic floor and strength exercises, the other did general exercises. After s…

This study tested whether a simple walking program, using fitness trackers, helps cancer patients tolerate their daily chemotherapy and radiation treatments without missing doses. 166 adults with various cancers (brain, head/neck, lung, GI, or cervical) who were scheduled for cur…

This study looked at ways to improve the diagnosis of cervical precancer in women who had abnormal screening results. Researchers tested a scoring system during colposcopy to see if it could accurately identify precancer and help decide when biopsies are not needed. The goal is t…

This study involved 40 adults with advanced cervical cancer who had completed curative treatment. Researchers wanted to see if adding a PET/CT scan within two months after therapy would change the doctor's next steps compared to using MRI alone. The goal was to understand how oft…

This study looked at whether showing patients with cervical or uterine cancer a detailed video about brachytherapy (a type of internal radiation) improves their understanding and satisfaction. About 80 women took part, and researchers compared those who saw the video plus standar…

This study looks at how well the drug T-DXd works compared to usual treatments for people with advanced HER2-positive solid tumors (like lung, colon, and ovarian cancers). Researchers will use data from past clinical trials and real-world patient records to compare survival rates…

This study tested a new way to help women living with HIV get screened for HPV, a virus that can cause cervical cancer. The program used simple scripts and videos to address fears and stigma. Researchers measured how many women got screened and followed up after a positive result…

This study looked at whether using a PET-scan on the first day of brachytherapy (a type of internal radiation) is possible for people with advanced cervical cancer. Fourteen patients who had already received chemoradiation took part. The main goal was to see if the PET-scan could…

This study looked at 386 women with cervical, uterine, or ovarian cancer to compare complication rates between standard laparoscopic surgery and robot-assisted laparoscopic surgery. The goal was to see which approach leads to fewer problems within the first six months after the o…

This study tested whether a special clinic for women who finished treatment for early-stage breast or gynecologic cancer is practical. About 200 women used an app to report their symptoms, which triggered check-ins from nurses or dietitians when needed. The goal was to see if thi…

This study looked at 22 women with cervical cancer to see if having an empty bladder (using a catheter) or a full bladder (filled with 120cc of fluid) is better during a type of radiation called brachytherapy. The goal was to measure how much radiation reaches nearby organs like …

This study looked at people with advanced solid tumors (like lung, bladder, or skin cancer) who had been on immunotherapy (PD-1/PD-L1 inhibitors) for one year and whose disease was stable. It randomly assigned them to either stop treatment or continue until their cancer got worse…

This study tested a new follow-up approach for people treated for gynecologic cancers like ovarian, endometrial, cervical, or vulvar cancer. Instead of seeing a doctor every time, patients met with a nurse at every other visit and used a smartphone app to learn self-management sk…

This study looked at 111 people who had surgery for early-stage cervical or vulvar cancer to find out how many develop lower leg swelling (lymphedema) after lymph node removal. Participants filled out a questionnaire about their symptoms. No new treatments or tests were given—the…

This study tested a program designed to reduce the stigma around cervical cancer and encourage more women to get screened. Researchers worked with 310 married women aged 30-60 in Nepal, comparing those who received the stigma-reduction program to those who did not. The goal was t…

This study follows up with 1,710 women from an earlier study to see how well HPV testing alone works for cervical cancer screening over 10 years. Participants provide a cervical sample for both HPV and cell testing. The goal is to compare the long-term safety and effectiveness of…