AGE-RELATED MACULAR DEGENERATION

This early-stage trial is testing a new drug called VOY-101 in 60 people with advanced dry age-related macular degeneration (AMD), a leading cause of vision loss. The drug is injected into the eye and aims to slow the growth of damaged areas (geographic atrophy) and preserve reti…

This study tests a device that delivers tiny electrical pulses to the eye area in people with intermediate to advanced dry age-related macular degeneration (AMD). The goal is to see if it can safely slow vision loss or improve eyesight. One hundred participants will receive eithe…

This study tests a new medicine called ABBV-6628 for people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes vision loss. About 66 adults aged 50 and older will receive eye injections of the study drug or an approved treatment (SYFOVRE…

This Phase 3 trial is testing faricimab (Vabysmo) in 50 people with a specific form of wet age-related macular degeneration called polypoidal choroidal vasculopathy (PCV). The goal is to see if a personalized treat-and-extend schedule can maintain vision while allowing longer gap…

This study tests whether taking a daily supplement of lutein, zeaxanthin, and fish oil for six months can improve thinking skills, eye health, and bone density in healthy adults. Researchers will enroll 80 people with low levels of a key eye pigment. Participants will take either…

This early-stage study tests the safety of a new drug called BBC1501, given as an injection into the eye, for people with wet age-related macular degeneration (nAMD). The trial involves 18 adults aged 50 and older who have already received standard treatment. The main goal is to …

This study tests the safety of a monthly eye injection called ASP3021 in 20 Japanese adults aged 40 and older who have geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. Participants will receive 12 monthly injections into the affecte…

This study tests whether high-dose atorvastatin (a statin drug) can improve vision in people with intermediate age-related macular degeneration (AMD). Researchers will measure how quickly participants' eyes adjust to darkness and track changes in fatty deposits (drusen) in the re…

This study tests whether taking krill oil capsules daily for 3 months can reduce drusen (fatty deposits) in the eyes of people with early or intermediate dry age-related macular degeneration (AMD). 24 adults will receive either krill oil or a placebo. The main goal is to see if t…

This study tests a new medicine called tiespectus (EYE201) for wet age-related macular degeneration, a leading cause of vision loss. About 960 people will receive either tiespectus or the standard treatment aflibercept via eye injections. The goal is to see if tiespectus can impr…

This study looks at how well a biosimilar drug called Yesafili works for people with wet age-related macular degeneration (AMD). About 54 participants will switch from the standard drug Eylea to Yesafili. Doctors will check vision and eye health to see if the biosimilar is a safe…

This early-stage study tests a stem cell therapy called ASP7317 for people with geographic atrophy, the advanced form of dry age-related macular degeneration that causes central vision loss. The treatment involves injecting special cells under the retina to replace damaged ones. …

This early-stage study tests a new treatment called C.001 for people with retinal diseases that cause vision loss, such as geographic atrophy and Stargardt disease. The treatment is given as a single injection into the eye. The main goal is to check if it is safe, and researchers…

This study tests a new medicine called tiespectus (EYE201) for wet age-related macular degeneration, a leading cause of vision loss. About 960 people will receive either tiespectus or the standard treatment aflibercept via eye injections. The goal is to see if tiespectus works as…

This study tests a special camera that takes detailed images of the retina using many wavelengths of light. Researchers hope it can find early signs of eye diseases like age-related macular degeneration, diabetic retinopathy, and glaucoma. About 1,000 adults in Melbourne, Austral…

This study tests a new way to detect age-related macular degeneration (AMD) earlier than current methods. Researchers will use special laser light patterns to see if people with early AMD perceive them differently than those with healthy vision. The goal is to catch the disease b…

This study looks at whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may calm overactive cells in the retina. The study involves …

This study tests whether shifting text to healthier parts of the visual field can help people with age-related macular degeneration read faster and make fewer mistakes. About 108 participants with central vision loss will try two different text-remapping methods. The goal is to f…

This study tests whether a gentle electrical brain stimulation, called a-tDCS, can make reading training more effective for people with age-related or juvenile macular degeneration. About 30 participants will do six reading training sessions while receiving either real or fake st…

This study tests a small telescope implant for people with end-stage age-related macular degeneration (AMD) who have lost central vision. About 76 adults aged 55 and older will receive the implant and be followed for 12 months. The goal is to see if the device safely improves vis…

This study tests whether teaching people with age-related macular degeneration, diabetic retinopathy, or glaucoma simple strategies—like using extra lighting, large-print labels, and smartphone apps—can help them manage their medications with fewer errors. About 50 participants w…

This study collects blood, tissue, and health information from 650 people with and without retinal diseases like age-related macular degeneration and diabetic retinopathy. The goal is to build a database for future research, not to test any treatment. Participants will have eye e…

This study aims to find out why 20-40% of people with wet age-related macular degeneration (AMD) don't respond well to standard anti-VEGF injections. Researchers will collect fluid from inside the eye of 117 patients and compare those who respond well to treatment with those who …

This study uses special cameras to take ultra-detailed pictures of the back of the eye in people with retinal diseases like macular degeneration and retinitis pigmentosa. Researchers aim to develop new ways to diagnose and track these conditions by measuring cell density and func…

This study is collecting eye images from 1,000 adults aged 50 and older, with or without age-related macular degeneration (AMD), from up to 25 countries. The goal is to create a high-quality, diverse dataset that researchers can use to train artificial intelligence (AI) to screen…

This study is creating a large database of eye measurements from 3,000 people with inflammatory eye diseases like diabetic retinopathy and age-related macular degeneration. Researchers will use advanced imaging to collect detailed information from both the front and back of the e…

This study will test a vision screening program for adults over 70 with chronic conditions in Danish general practices. Researchers want to see if it's feasible and acceptable to screen for vision problems like glaucoma, cataracts, and macular degeneration. Participants will have…

This study tests two simple ways to help people attend eye hospital appointments after being screened for age-related macular degeneration, diabetic retinopathy, or glaucoma. About 3,000 participants who need a follow-up visit will get either a text reminder, a home visit from a …

This study uses a special camera to take ultra-detailed pictures of the retina, the light-sensitive layer at the back of the eye. Researchers want to see individual cells in both healthy eyes and eyes with diseases like Stargardt disease, retinitis pigmentosa, and age-related mac…

This study tests two advanced eye imaging techniques—central microperimetry and radial OCT—to see if they can more accurately measure the progression of geographic atrophy, a severe form of age-related macular degeneration that can lead to blindness. Researchers will follow 80 ad…

This study looks at what 'visual frailty' means in older adults (60+) who have age-related macular degeneration. Researchers will measure vision, reading ability, mental health, and daily function to create a new assessment tool. The goal is to better understand and monitor visio…

This study uses a special camera called the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO) to take very detailed pictures of the retina in people with inherited retinal degenerations like retinitis pigmentosa. Researchers want to see how the structure and function of the r…

This study watches how early damage in age-related macular degeneration (AMD) grows over time. Researchers will use special eye scans to measure changes in the retina and see how they affect vision and daily life. The goal is to find better ways to detect and track the disease ea…