AGE-RELATED MACULAR DEGENERATION

This study compared two different dosing schedules of brolucizumab (Beovu) in 52 people with wet age-related macular degeneration (AMD) who had not responded well to previous treatment. Participants received the drug as an eye injection either on a fixed schedule or with adjustme…

This study tested a robotic arm that holds a tiny needle steady during eye surgery for people with bleeding under the retina caused by age-related macular degeneration. The robot helped surgeons inject a clot-busting medicine (tPA) precisely under the retina. The main goals were …

This study tested a drug normally used for Parkinson's disease (carbidopa-levodopa) in 35 people with wet age-related macular degeneration (AMD). The goal was to see if it could improve vision and reduce the need for standard eye injections. Participants took the oral drug alongs…

This study tested whether a pre-filled syringe of the medicine SB11 (a biosimilar to ranibizumab) is easy for eye doctors to use. Thirty adults with wet age-related macular degeneration, macular edema from retinal vein occlusion, or myopic choroidal neovascularization received on…

This study tested an experimental drug called ALK-001 in people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes blind spots. About 200 participants received the drug and 100 received a placebo. The goal was to see if ALK-001 could slo…

This study tested whether the antibiotic minocycline, taken as a pill twice daily for at least 3 years, could safely slow the growth of geographic atrophy—an advanced form of age-related macular degeneration that causes blind spots. Thirty-seven adults aged 55 and older with geog…

This study checks the long-term safety of an eye injection called avacincaptad pegol for people with geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 278 adults who finished a previous study of this drug will receive the injec…

This study tested whether a drug used for Parkinson's disease (carbidopa-levodopa) could help people with wet age-related macular degeneration (AMD), a leading cause of vision loss. Twenty participants who had not yet received standard treatment took the drug for a short time. Re…

This study tested whether an AI tool can help eye doctors diagnose four common retinal diseases (diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, and glaucoma) more accurately and quickly. Ten doctors from five hospitals read fundus images both with…

This study tested whether injections of aflibercept (Eylea) into the eye could prevent the development of wet age-related macular degeneration (AMD) in people at high risk. 128 participants with early signs of AMD in one eye and wet AMD in the other eye received either Eylea or a…

This study tested whether a steroid eye drop called loteprednol can reduce pain after routine eye injections for age-related macular degeneration. 64 patients received either loteprednol or artificial tears after their injection and rated their pain over one week. The goal is to …

This completed study looked at 556 people to understand how night vision problems are connected to early age-related macular degeneration (AMD). Participants took vision tests and had detailed eye imaging. The goal was to find reliable markers that could help design future treatm…

This completed study looked at two different imaging methods—standard OCT B-scans and newer OCT angiography—to monitor wet age-related macular degeneration (AMD) in 68 patients. The goal was to see if using OCT angiography changed how often patients received anti-VEGF injections …

This study followed 20 adults aged 55 and older with geographic atrophy, an advanced form of age-related macular degeneration that causes central vision loss. Researchers measured changes in the damaged area of the retina every few months for nearly 4 years. The goal was to under…

This study tested four different approaches to find and treat eye diseases like cataracts, glaucoma, and diabetic retinopathy in communities in Nepal. Over 87,000 people aged 50 and older took part. The goal was to see which method—comprehensive screening, cataract camps, communi…

This study looked at whether special eye scans (SDOCT) can predict vision loss and worsening of age-related macular degeneration (AMD) in people at moderate to high risk. Researchers followed 470 participants from the AREDS2 trial, taking detailed images of the back of the eye to…

This completed study from Erasmus Medical Center tested whether personalized risk profiling (including genetic testing) and coaching motivate people with age-related macular degeneration (AMD) to change their lifestyle. 150 participants received standard lifestyle advice plus die…

This completed study followed 26 people aged 55 and older with early age-related macular degeneration (AMD) or healthy eyes for up to 5 years. Researchers used eye exams, imaging, and vision tests to track changes in the retina and visual function. The goal was to better understa…

This study looked at proteins in the eye fluid of 100 people with wet age-related macular degeneration (AMD). The goal was to measure certain growth factors that might explain why about 37% of patients do not respond well to standard anti-VEGF injections. Researchers collected a …

This study examined how COVID-19 lockdowns changed health behaviors and medication use in over 1,300 people with chronic conditions like heart disease, multiple sclerosis, and macular degeneration. Researchers looked at whether patients stopped or changed their medications, faced…

This study looked at 360,000 French patients who received eye injections for conditions like age-related macular degeneration. The goal was to find out how often a serious eye infection called endophthalmitis happens within 28 days after the injection. Researchers analyzed data f…

This study looked at how vision changes over time in 60 people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes permanent vision loss. Researchers used past medical records and eye scans to see which features of the retina are linked t…

This study followed 57 people with age-related macular degeneration (AMD) for up to 5 years to see how their eyes adjust to darkness. Participants had yearly eye exams and dark adaptation tests, where they sat in a dark room and pressed a button when they saw a light. The goal wa…

This study looked at whether telling healthy adults their genetic risk for age-related macular degeneration (AMD) encourages them to eat more carotenoid-rich foods, which are good for eye health. Eighty Caucasian participants aged 18 to 64 without AMD were given genetic risk info…

This study gathered eye scans from 1,000 people with intermediate age-related macular degeneration (AMD) to find patterns that predict if the disease will get worse. Researchers analyzed images taken over two years to see which eyes developed new or larger areas of damage. The go…

This study looked at whether a simple test measuring how fast eyes recover in the dark can help track early to middle dry age-related macular degeneration (AMD). Researchers followed 217 adults aged 50 and older, with or without AMD, for up to 5 years. The goal was to see if chan…

This study followed 516 elderly French people for up to 8 years to see how many develop age-related macular degeneration (AMD), a leading cause of blindness. Researchers looked at genetic, clinical, and lifestyle factors that might increase risk. The goal is to better understand …