AGE-RELATED MACULAR DEGENERATION

This early-phase study tests a new medicine called RO7669330, given as an eye injection, for people with geographic atrophy (a form of advanced age-related macular degeneration that causes vision loss). The main goal is to check safety and tolerability in about 132 participants. …

This study tests the safety of a monthly eye injection called ASP3021 in 20 Japanese adults aged 40+ with geographic atrophy, a form of advanced age-related macular degeneration that causes gradual vision loss. Participants receive 12 monthly injections into the affected eye and …

This study tests a small telescope implant (SING IMT) placed inside the eye to improve central vision in people with end-stage age-related macular degeneration (AMD). About 76 participants aged 55 and older will receive the implant and be followed for 12 months with eye exams and…

This early-stage study tests a stem cell therapy called ASP7317 for people with geographic atrophy, the advanced form of dry age-related macular degeneration that causes central vision loss. The treatment involves injecting special cells under the retina to replace damaged ones. …

This study looks at how well a biosimilar drug called MY-1701P (similar to Eylea) works for people with wet age-related macular degeneration, a condition that causes vision loss. About 54 patients will receive the drug and have their vision and eye health checked regularly. The g…

This study tests a new drug called VOY-101 in 60 people aged 60 and older with advanced dry age-related macular degeneration (AMD), a condition that causes vision loss. The goal is to see if the drug can slow the growth of damaged areas in the retina and preserve vision. Particip…

This study tests a new medicine called ABBV-6628 for people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes vision loss. About 66 adults aged 50 and older will receive injections into the eye to see if the drug is safe and how it work…

This study explores a new way to detect age-related macular degeneration (AMD) using special patterns of light based on quantum science. The goal is to spot the disease before it damages central vision, when treatment can still prevent blindness. About 50 participants with and wi…

This study tests whether teaching people with age-related macular degeneration, diabetic retinopathy, or glaucoma simple strategies—like using brighter lights, larger print, and smartphone apps—can help them manage their medications more safely and independently. About 50 partici…

This early-phase study tests whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration (including retinitis pigmentosa, Stargardt disease, and dry age-related macular degeneration). Researchers believe the drug may…

This study looks at whether taking a daily mix of lutein, zeaxanthin, and fish oil for six months can improve thinking skills, eye health, and bone density in healthy adults. About 80 participants will take either the supplement or a placebo. The goal is to see if these nutrients…

This study will collect eye images from 1,000 adults aged 50 and older, both healthy and with age-related macular degeneration (AMD), from up to 25 countries. The goal is to create a high-quality dataset that researchers can use to develop artificial intelligence (AI) tools for s…

This study looks at fluid from inside the eyes of people with wet age-related macular degeneration (AMD) to understand why 20-40% do not respond well to standard anti-VEGF injections. Researchers will compare samples from good and poor responders to find other molecules driving t…

This study looks at what 'visual frailty' means for people aged 60 and older who have age-related macular degeneration (AMD). Researchers will measure vision, reading ability, daily function, mental health, and other health conditions to create a new assessment tool. The goal is …

This study collects blood, tissue, and health information from people with and without retinal diseases like age-related macular degeneration and diabetic retinopathy. Researchers will store these samples and data in a biorepository to help future studies understand why some peop…