Interstitial lung disease

This phase 2 trial tests an oral drug called PIPE-791 in 324 adults with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. Participants take either a low or high dose of PIPE-791 or a placebo daily for several months. The main goal is t…

This phase II trial tests whether a drug called BIO 300, made from a soy compound, can prevent severe lung inflammation (pneumonitis) in people with early-stage non-small cell lung cancer who also have interstitial lung disease. About 25 participants will receive BIO 300 along wi…

This study tests whether the drug nerandomilast can slow lung scarring in people with autoimmune diseases like rheumatoid arthritis or scleroderma. About 400 adults whose lung function hasn't improved with standard treatment will take either nerandomilast or a placebo twice daily…

This study tests a medicine called nerandomilast in children aged 2 to 17 with fibrosing interstitial lung disease, a condition where lung tissue becomes scarred and stiff. The goal is to see if the drug is safe and how the body processes it, and to get early signs of whether it …

Researchers are testing an inhaled drug called mosliciguat in people who have pulmonary hypertension caused by interstitial lung disease, a condition where lung scarring leads to high blood pressure in the lungs. The phase 3 trial enrolls about 376 participants who receive either…

This study looks at the long-term safety and effectiveness of belimumab in adults with lung scarring (interstitial lung disease) caused by systemic sclerosis or other connective tissue diseases. About 514 people who completed earlier trials will receive belimumab for up to severa…

This phase 2 trial tests an injected drug called TX000045 in 25 people who have high blood pressure in the lungs due to scarring lung disease. The main goal is to see if the drug lowers lung blood pressure and is safe over 16 weeks. Researchers will also check for side effects an…

This study tests whether belimumab (Benlysta), a drug already used for lupus, can improve lung function and skin thickening in adults with scleroderma-related interstitial lung disease. About 300 participants will receive either belimumab or a placebo added to their standard care…

This phase 3 trial tests whether belimumab (Benlysta) can stabilize or improve lung function in adults with interstitial lung disease caused by connective tissue diseases like rheumatoid arthritis or lupus. About 440 participants will receive either belimumab injections or a plac…

This Phase 2 trial tests an experimental inhaled medication called LTI-03 in about 120 people with idiopathic pulmonary fibrosis (IPF), a progressive lung disease that causes scarring and breathing difficulty. Participants will inhale LTI-03 or a placebo twice daily for 24 weeks.…

This study tests an inhaled medicine called L606 for people with high blood pressure in the lungs due to lung disease. About 344 adults will be randomly assigned to receive L606 or a placebo. The main goal is to see if L606 helps them walk farther in six minutes and delays worsen…

This study tests a new inhaled drug, mosliciguat, added to an existing treatment (treprostinil) for people with high blood pressure in the lungs caused by lung scarring. The goal is to see if the combination is safe and tolerable. About 20 adults with this condition will particip…

This small study will test a drug called emapalumab in 5 adults with a rare, rapidly worsening lung disease linked to dermatomyositis. The drug is already used for a similar immune overreaction condition. Researchers will check if it improves oxygen needs, lung function, and CT s…

This trial tests whether a combination of four immunosuppressant medications can improve survival in people with myositis who develop rapidly progressing interstitial lung disease (RP-ILD), a serious condition with a high early mortality rate. The study will enroll 80 adults with…

This study tests whether new investigational drugs can improve lung function in people with scleroderma-related lung scarring. About 400 adults with this condition will receive either the study drug or a placebo for 52 weeks. The main goal is to see if the drug helps preserve or …

This early-stage study tests a new treatment called CABA-201 for people with systemic sclerosis (scleroderma), a disease that causes hardening of the skin and can damage organs. The treatment uses a patient's own immune cells, modified to target and destroy faulty B cells that dr…

This study tests a stem cell transplant using the patient's own blood cells to treat severe scleroderma (systemic sclerosis) that hasn't improved with standard drugs. The goal is to see if this high-dose therapy is safe and can stop the disease from getting worse. The trial enrol…

This phase 3 trial tests an inhaled drug called treprostinil palmitil in 344 adults with pulmonary hypertension caused by interstitial lung disease. Participants take the drug or a placebo once daily for 24 weeks. The main goal is to see if the drug helps them walk farther in six…

This phase 3 study tests the long-term safety of an inhaled drug called treprostinil palmitil for people with pulmonary hypertension caused by interstitial lung disease. About 344 adults who completed an earlier trial will take the drug for up to 2 years. Researchers will track s…

This study tests an experimental oral drug called ROC-101 in 40 adults with pulmonary arterial hypertension (PAH) or pulmonary hypertension linked to interstitial lung disease (ILD-PH). Participants take the drug alongside their standard care for 24 weeks, with a long-term follow…

This Phase 2 trial tests an inhaled drug called LAM-001 (sirolimus) in 85 adults who have pulmonary hypertension (high blood pressure in the lungs) along with interstitial lung disease (lung scarring). The study compares the drug to a placebo to see if it improves blood flow in t…

This early study tests a new stem cell therapy called REGEND001 for people with interstitial lung disease (ILD), a group of conditions that scar the lungs and make breathing difficult. The treatment uses a patient's own regenerative cells, collected from the airways during a scop…

This study tests a drug called H01 (hymecromone) in adults with interstitial lung disease, a condition that causes lung scarring and makes breathing hard. The goal is to see if H01 can lower a marker of lung damage and improve lung function. Participants take the drug as a tablet…

This phase 2 trial tests whether abatacept (Orencia) can improve lung disease in people with common variable immunodeficiency (CVID). About 38 children and adults will receive either the drug or a placebo for 6 months. The main goal is to see if lung damage on CT scans shrinks by…

This early-stage trial tests a single dose of an inhaled drug called RJ026 in 42 healthy volunteers and 42 people with interstitial lung disease (ILD). The goal is to see how much drug reaches the lungs and blood, and whether it is safe. Researchers hope that inhaling the drug wi…

This phase 3 study tests whether an inhaled drug called treprostinil can slow the worsening of lung function in people with progressive pulmonary fibrosis, a condition where lung scarring gets worse over time. About 698 adults will receive either the drug or a placebo four times …

This study is testing the safety of an inhaled dry powder form of treprostinil (LIQ861) for people with pulmonary hypertension (high blood pressure in the lungs) due to lung disease. About 80 adults will take the drug using a special inhaler, and researchers will monitor for side…

This early-stage trial is testing a new drug called GSK4527363 in healthy volunteers and people with active lupus or lupus-related lung disease. The main goal is to check safety and how the body handles the drug. Around 142 participants will take part across four groups, includin…

This study offers continued access to the inhaled drug TPIP for people with pulmonary arterial hypertension (PAH) or pulmonary hypertension linked to interstitial lung disease (PH-ILD) who have already completed a related study. Participants must have successfully finished prior …

This study tests whether JAK inhibitors work better than calcineurin inhibitors as the first treatment for lung scarring in people with antisynthetase syndrome. About 80 adults with active lung disease will be followed for 12 months to see which drug improves breathing and surviv…

This study tests a stem cell treatment for people with autoimmune diseases (like lupus or scleroderma) that cause lung scarring and breathing problems. Sixteen adults will receive infusions of donor fat-derived stem cells to see if it is safe and can improve lung function. The go…

This study tests whether the drug senicapoc can prevent lung scarring from getting worse in people with progressive fibrotic interstitial lung disease (ILD) or idiopathic pulmonary fibrosis (IPF). About 140 adults will take either senicapoc or a placebo daily for 26 weeks, and do…

This study tests whether combining two drugs, nintedanib and tocilizumab, works better than standard treatments (like mycophenolate) for people with systemic sclerosis (scleroderma) who also have lung scarring. The trial will enroll 86 adults and follow them for 56 weeks, measuri…

This study tests a drug called nemolizumab in 162 adults with systemic sclerosis, a disease that causes skin thickening and can harm internal organs. Participants receive either nemolizumab or a placebo as a shot under the skin for 52 weeks. The main goal is to see if the drug re…

This study tests whether hydroxychloroquine, a drug used for malaria and arthritis, can safely improve breathing in children with interstitial lung disease caused by genetic mutations. Researchers will enroll 60 children and randomly assign them to receive the drug or not, measur…

This study tests whether quercetin, a natural compound found in many fruits and vegetables, can slow lung scarring and improve breathing in people with pulmonary fibrosis. Half of the 100 participants will take quercetin pills daily for 24 weeks, while the other half receive stan…

This early-stage study tests whether inhaling a mist made from donated human amniotic fluid is safe for people with interstitial lung disease (ILD), a condition that scars the lungs and makes breathing hard. About 50 adults aged 40 to 90 with mild to moderate ILD will receive the…

This study compares telitacicept, a newer biologic drug, against the standard treatment cyclophosphamide for lupus patients who also have interstitial lung disease (ILD). About 100 adults with early lupus and ILD will receive either telitacicept or cyclophosphamide, plus usual ca…

This study tests whether tetrandrine tablets can improve lung function in people with interstitial lung disease caused by connective tissue disease (like lupus or scleroderma). One hundred adults will receive either tetrandrine or a placebo for 24 weeks, alongside their usual tre…

This study compares two ways of using a heart-lung support machine (ECMO) during lung transplants: using it routinely for all patients versus using it only when problems arise. About 218 adults with end-stage lung disease will take part. The goal is to see which approach leads to…

This study tests an experimental oral drug called INS018_055 in 40 adults with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. The main goal is to check the drug's safety over 12 weeks. Participants will be randomly assigned to r…

This trial tests whether a personalized 'treatable traits' care model—where patients see a lung specialist, physiotherapist, psychologist, and dietitian together—can improve quality of life and slow disease progression in people with interstitial lung disease. About 110 participa…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study tests whether an artificial intelligence (AI) tool that analyzes a simple ECG can help doctors find undiagnosed pulmonary hypertension (high blood pressure in the lungs) in people with interstitial lung disease. About 900 adults with severe lung scarring will be random…

This trial tests whether a newer type of CT scan, called photon-counting CT, can help doctors identify idiopathic pulmonary fibrosis (IPF) more accurately than the standard high-resolution CT scan. The study will enroll 156 adults with interstitial lung disease who need a multidi…

This study evaluates whether an AI software called AccuPulmo CT Portal can accurately detect pulmonary fibrosis, a type of lung scarring, on chest CT scans. Researchers will compare the AI's readings against assessments by three lung specialists using 900 past scans. The goal is …

This study will test a handheld ultrasonic spirometer against a conventional hospital spirometer in 100 adults with chronic respiratory diseases like COPD or asthma. Each participant will use both devices to see if the portable one gives accurate and reliable results. If successf…

This study aims to find better, non-invasive tests to diagnose and predict the course of interstitial lung disease (ILD). Researchers will test blood and breath samples from 750 people, including pigeon fanciers at high risk for ILD and patients already diagnosed. The goal is to …

This study is testing a device called Inflammacheck that measures chemicals in a person's breath to see if it can help tell the difference between lung cancer, other lung diseases, and healthy lungs. Researchers will collect breath samples from 140 adults and use AI to build a di…

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This early-phase study tests a radioactive tracer called Cu-DOTA-ECL1i that binds to certain inflammatory cells in the lungs. Researchers will use PET scans to see how the tracer spreads in people with fibrotic lung disease, comparing it to CT scans and clinical status. The goal …

This study tests whether a quick, non-invasive lung ultrasound can detect interstitial lung disease in people with rheumatoid arthritis. About 280 adults with RA and risk factors for lung disease will get an ultrasound, and results will be compared to standard chest CT scans. If …

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases, such as COPD, pneumonia, and pulmonary edema. Researchers will measure LSI in 700 adults with various lung conditions and healt…

This study tests a special PET scan that uses a radioactive tracer to find collagen buildup in the lungs, a sign of early scarring. Researchers will scan 30 people, including relatives of patients with pulmonary fibrosis and those with early lung abnormalities. The goal is to see…

This study tests whether using a robotic arm during a lung biopsy helps doctors get better tissue samples to diagnose interstitial lung disease. About 30 adults with unclear CT scans will be randomly assigned to either standard or robotic-assisted bronchoscopy. The goal is to see…

This study tests whether a simple, non-invasive nail microscope exam (capillaroscopy) can help doctors find connective tissue disease faster in people newly diagnosed with interstitial lung disease. 48 adults will get the exam alongside standard care. The goal is to see if this e…

This early-phase study is testing a new imaging agent called [68Ga]CBP8 to see if it can safely and accurately detect collagen buildup (scarring) in the lungs. Researchers will compare scans from healthy volunteers, lung cancer patients, and people with pulmonary fibrosis. The go…

This study looks at whether automated software can consistently measure the amount of lung scarring (interstitial lung disease) on chest CT scans. Researchers will scan 150 adults with known lung scarring twice in a row to see if the measurements match. The goal is to improve the…

This study tests whether a generative AI tool can help doctors diagnose complications and co-existing diseases in people with rheumatoid arthritis. The AI reviews patient records and suggests possible issues like lung or heart problems. Doctors then decide if the AI's suggestions…

This study is testing a new type of PET scan tracer (68Ga-FAPI) to see if it can better detect lung and kidney problems in people with ANCA-associated vasculitis, a rare autoimmune disease. The tracer targets specific cells linked to tissue scarring. Researchers will enroll 30 ad…

This study tests a drug called nerandomilast in 80 people aged 40+ who have early lung changes and a family history of pulmonary fibrosis. Participants take either the drug or a placebo twice daily for up to 3 years. Doctors monitor lung function and scans to see if the drug slow…

Researchers are testing whether a six-week home-based pulmonary rehabilitation program can improve quality of life and exercise capacity in adults with interstitial lung disease. Participants are randomly assigned to either the home exercise program with weekly phone check-ins or…

This study tests a mobile app called SUPPORT-T that helps patients with progressive pulmonary fibrosis and their caregivers access palliative care from home. The app includes nurse-guided telehealth visits and virtual support groups over one year. Researchers want to see if the a…

This study tests whether N-acetyl cysteine (NAC) and a short course of steroids can reduce severe shortness of breath after lung radiation in people with both lung cancer and interstitial lung disease. About 98 participants will receive either NAC or placebo, plus either steroids…

This study tests whether a 16-week home exercise program can improve daily function in 30 adults with pulmonary hypertension linked to interstitial lung disease. Participants will receive daily texts or emails with aerobic and strength exercises. Researchers will measure changes …

This study tests a lightweight, battery-powered device called MoblO2 that automatically adjusts oxygen flow to keep blood oxygen levels steady during activity. It is designed for people with COPD or interstitial lung disease who need supplemental oxygen when exerting themselves. …

This study looks at whether using portable oxygen during physical activity can improve quality of life, exercise ability, and shortness of breath in people with mild-to-moderate interstitial lung disease. Participants will receive oxygen for 8 weeks, and some will also get extra …

This study investigates whether drinking nitrate-rich beetroot juice twice a day for three days can improve exercise capacity in people with idiopathic pulmonary fibrosis (IPF), a lung scarring disease that limits activity. Researchers will compare the juice to a placebo in a sma…

This study tests whether three 15-minute hypnosis sessions can help people with persistent breathlessness from cancer, COPD, interstitial lung disease, or chronic heart failure feel more in control of their breathing. Researchers will measure changes using a standard questionnair…

This study looks at whether drinking beetroot juice, which is high in nitrate, can help people with fibrotic interstitial lung disease exercise longer. Participants will drink either nitrate-rich or nitrate-free beetroot juice and then do a cycling test. The goal is to see if the…

This study tests whether L-menthol, a minty compound, can reduce breathlessness and help people with interstitial lung disease (ILD) exercise longer. About 20 adults with ILD will try L-menthol and a placebo in random order, comparing their breathing and exercise ability. The goa…

This pilot study tests whether semaglutide (Ozempic), a drug used for diabetes and obesity, is safe and tolerable for weight loss in people with advanced lung disease. Eight participants with conditions like COPD or pulmonary fibrosis will take weekly injections for 12 weeks. Res…

This study aims to see if bundling all routine tests and doctor visits into one coordinated hospital trip can save time for people with interstitial lung disease. About 152 adults with the condition will either receive standard care or the new streamlined approach. The goal is to…

This study tests whether doing special breathing exercises (inspiratory muscle training) before a lung transplant can help people recover more quickly after surgery. Researchers will enroll 90 adults with lung disease who are waiting for a transplant. The goal is to see if these …

This study tests whether a 12-week home-based pulmonary rehabilitation program, combined with health coaching, can improve quality of life and physical activity in people with fibrotic interstitial lung disease. Participants will do daily breathing exercises, balance walks, and m…

This study tests whether two drugs, duloxetine and amitriptyline, can reduce chronic coughing in people with interstitial lung disease (ILD). 25 participants will receive either a low or high dose of one drug or a placebo for 4 weeks. The main goal is to see if cough frequency de…

This study tests whether analyzing a patient's phlegm can help doctors choose better treatments for chronic cough in interstitial lung disease (ILD). About 120 adults with ILD and daily cough for at least 8 weeks will be randomly assigned to either phlegm-guided treatment or stan…

The Pulmonary Fibrosis Foundation runs an online registry where people with pulmonary fibrosis or interstitial lung disease, their caregivers, and their family members can share information about their health and experiences. Participants enroll themselves and answer questions ov…

This study explores whether a technique called LIBS, which maps chemical elements in lung tissue, can help doctors identify possible environmental or workplace causes of chronic lung diseases. Researchers will analyze stored biopsy samples from 70 adult patients using LIBS and an…

This observational study follows patients with fibrotic interstitial lung disease (ILD) to see how their self-efficacy and quality of life change over time. Participants either undergo inpatient pulmonary rehabilitation or receive regular outpatient care. Researchers use question…

This study is creating a registry of medical information from people with interstitial lung disease (ILD). Researchers will collect past, current, and future health records from up to 5,000 adults treated at the UPMC Simmons Center. The goal is to build a database that can be use…

This study is a registry that will follow about 900 adults with both interstitial lung disease and pulmonary hypertension. Researchers will collect information on patients' medical history and track changes in their condition over time. The goal is to better understand these dise…

This research project is looking at people with interstitial lung diseases (which affect the tissue around the air sacs) and airway diseases (like COPD). The goal is to better understand how these conditions often occur together and with other health problems. By studying a large…

This study follows 500 adults with progressive pulmonary fibrosis (a type of lung scarring) for 24 months. Researchers will collect medical images, lung function tests, and blood samples to better classify the disease and predict its course. The goal is to improve how doctors ide…

This registry is following 3,000 adults with idiopathic pulmonary fibrosis (IPF) or other chronic fibrosing interstitial lung diseases (ILDs) to understand how these conditions progress over time. Researchers collect information on symptoms, treatments, quality of life, and store…

This study compares oxygen readings taken from the finger and the earlobe during a six-minute walk test in people with interstitial lung disease. The goal is to see if one location gives more accurate measurements of oxygen levels during exercise. The results could help doctors d…

This study looks at how immunosuppression treatment changes lung scarring in people with certain types of interstitial lung disease (not IPF). Using advanced PET and MRI scans, researchers will measure collagen buildup and tissue damage. The goal is to better understand the effec…

This study is creating a registry and biobank for people with interstitial lung diseases (ILD), including sarcoidosis, idiopathic pulmonary fibrosis, and hypersensitivity pneumonitis. Researchers will collect medical data and biological samples from up to 1,000 participants to su…

This study tests whether bundling key tests like scans and lung function tests into a single, fast-tracked appointment can help people with suspected interstitial lung disease get a diagnosis sooner. About 92 adults will be randomly assigned to either the usual step-by-step testi…

This study looks at whether giving extra oxygen during a 6-minute walk test helps people with chronic lung disease walk farther and feel better. About 114 adults with conditions like COPD or interstitial lung disease will do two walking tests—one with their usual oxygen and one w…

This study follows 2,000 children who receive stem cell transplants to better understand and detect lung injuries that can occur after the procedure. Researchers will track participants for two years, collecting samples and health data to find ways to diagnose problems earlier. T…

This study looks at whether an artificial intelligence (AI) tool can predict if lung scarring (pulmonary fibrosis) will get worse over time. Researchers will analyze CT scans from 200 people with either idiopathic pulmonary fibrosis (IPF) or other types of interstitial lung disea…

This study aims to understand why breathlessness varies among people with different lung diseases like COPD, asthma, and ILD. Researchers will measure lung function, exercise ability, and breathing patterns in 75 participants (50 with lung disease and 25 healthy controls). The go…

This study follows 4,000 people with interstitial lung disease (including conditions like pulmonary fibrosis and sarcoidosis) to understand how the disease naturally changes over time. Researchers will collect medical data and blood samples, and compare them to a healthy control …

This study is testing whether people with pulmonary fibrosis can safely replace half of their regular clinic visits with home monitoring. Participants will use a home spirometer, pulse oximeter, and a smartphone app to track their health and communicate with their care team. The …

This study will enroll 25 adults with interstitial lung disease or COPD to investigate the physical origins of ultrasound artifacts seen in lung scans. Researchers will compare ultrasound findings with CT scans and wearable sensor data to understand what these artifacts really me…

This study looks at why people with interstitial lung disease (ILD) often feel breathless and have trouble exercising. Researchers think leg muscle problems might be a cause. They will measure leg muscle strength and structure in 40 ILD patients and test how extra oxygen affects …

This observational study aims to find early biomarkers that can predict if a person's lung scarring (pulmonary fibrosis) will get worse quickly. Researchers will follow 450 adults with various types of interstitial lung disease, including IPF and other fibrotic conditions. Partic…

This study looks at how interstitial lung disease (ILD) affects people with rheumatic diseases like rheumatoid arthritis and lupus in Mexico. Researchers will track 312 patients over time to see how the lung disease progresses and what factors might make it worse. The goal is to …

This study looks at 750 people with rheumatoid arthritis (RA) who are 45 or older to find early signs of interstitial lung disease (ILD), a serious lung complication. Researchers will use CT scans and track changes over 3-5 years to identify risk factors. The goal is to better un…

This study is creating a repository of blood samples from 635 people with interstitial lung diseases (ILD), pneumonia, and healthy volunteers. Researchers hope these samples will help identify biomarkers to improve diagnosis and treatment. No experimental treatments are given; pa…

This study aims to find better ways to detect lung scarring (interstitial lung disease) early in people with connective tissue diseases like scleroderma or rheumatoid arthritis. Researchers will analyze tiny particles in the blood called extracellular vesicles and use AI to exami…

This study tests whether special PET and MRI scans can predict how fast lung scarring (pulmonary fibrosis) will get worse in 60 adults aged 18-80 with certain types of this disease. Participants will have scans and breathing tests over 2 years. The goal is to see if these imaging…

This study will use advanced MRI techniques to measure oxygen levels in the lungs of 50 people with early-stage idiopathic pulmonary fibrosis (IPF). The goal is to see if MRI can identify areas of low oxygen, which may be linked to disease progression. This is an observational st…

This study looks at whether a new digital education and self-management program is practical and helpful for people with fibrotic interstitial lung disease. About 80 participants will use the program on their phone or computer during rehab or clinic visits. Researchers will measu…

This study looks at 100 adults with fibrosing interstitial lung diseases (a type of lung scarring) to see if things like mold, dust, air pollution, and other home factors make the disease progress faster. Researchers will compare patients whose disease is getting worse to those w…

This study explores whether machine learning can analyze breathing test results to predict chronic respiratory diseases like asthma and COPD. Researchers will compare a newer technique called oscillometry with standard spirometry in 50 adults. The goal is to see if this approach …

This study aims to develop a noninvasive way to detect blood vessel changes in the lungs of people with Group 3 pulmonary hypertension (PH) using a special MRI technique. Researchers will compare MRI results with lung tissue from 30 patients awaiting lung transplant. The goal is …

This study is gathering detailed information from 470 adults with chronic inflammatory lung diseases like asthma, COPD, and cystic fibrosis, as well as healthy volunteers. Researchers will analyze clinical, biological, and lifestyle factors to identify distinct disease subtypes. …

This study looks at small molecules (metabolites) in the blood and urine of people with pulmonary hypertension caused by lung fibrosis. Researchers want to see how these metabolites change with treatment and whether they can tell who will respond well. The goal is to better under…

This study is for children and adults with interstitial lung disease, a group of conditions that scar the lungs and make breathing hard. Researchers will follow 3000 patients and their relatives for up to 10 years, collecting medical data and genetic information. The goal is to l…

This study looks at people with interstitial lung disease (ILD) and obstructive sleep apnea (OSA) to learn more about these conditions. Researchers will collect medical data, lung samples, and sleep test results from 70 participants. The goal is to find better ways to diagnose an…

This study uses a special type of MRI (called 129Xe gas exchange MRI) to take detailed pictures of how the lungs and heart work together. Researchers want to understand how these images change after treatments like blood transfusions or oxygen therapy. The study involves 125 adul…

This study is testing a newer technique called cryobiopsy, which uses a freezing probe to take tissue samples from the lungs. The goal is to see how safe and accurate it is for diagnosing conditions like lung disease, tumors, or infections. Researchers at a French hospital will s…

This study is building a large collection of blood, tissue, and fluid samples from 7,000 people with lung cancer, other chest diseases, or lung transplants. The goal is to help researchers learn more about what causes these diseases, how to find them early, and how to treat them …

This study will use advanced CT scans to look at both the lungs and heart in people with interstitial lung disease (ILD). The goal is to find early signs of heart problems, which are common but often missed until serious. Researchers hope to create better ways to predict and mana…

This study is testing a special MRI technique that uses a harmless xenon gas to create detailed images of lung function. Researchers will compare healthy volunteers and people with interstitial lung disease to see if the method can detect problems with air flow, lung structure, a…

This study is creating a database to help doctors find early signs of interstitial lung disease (ILD) in people who have other health conditions that put them at risk. About 412 adults with such conditions will be screened and followed over time. The goal is to improve early dete…

This study aims to develop a simple, non-invasive way to detect lung diseases like cancer, asthma, and COPD by analyzing DNA and proteins from cough samples. Researchers will collect cough specimens from 2000 adults, including smokers and non-smokers, and compare them to samples …

This study looks at whether standard breathing exercises and extra muscle-strengthening breathing training can affect a specific gene (HOTAIR) in people with rheumatoid arthritis who also have lung disease. Researchers will compare two groups: one doing standard rehab and one add…

This study explores whether functional MRI can help doctors tell different types of interstitial lung disease apart and track how they change over time. About 200 adults with certain lung conditions will get MRI scans alongside standard CT scans. The goal is to see if MRI can pro…

This study will observe 800 adults with rheumatoid arthritis in Austria to create a standard screening method for lung complications. Researchers will use CT scans, lung function tests, and AI analysis to identify those at high risk. The goal is to detect lung problems earlier an…

This study will examine chest CT scans from 500 adults with rheumatoid arthritis, connective tissue diseases, or idiopathic pulmonary fibrosis to better understand lung disease patterns. Researchers want to see which scan features are most common in rheumatoid arthritis-related i…

This study surveys 384 adults in Türkiye who have completed a pulmonary rehabilitation program for lung conditions like COPD or asthma. Researchers want to learn how satisfied patients are and how the rehab team's structure affects their experience. No new treatment is being test…