Acute coronary syndrome

This completed Phase 2 trial tested whether a single daily polypill (containing a statin, aspirin, and a blood thinner) could improve medication adherence in 140 patients who had a heart attack and received a stent. The study compared the polypill to usual care with separate pill…

This trial investigates whether gentle electrical stimulation of the ear (specifically the vagus nerve area) during emergency heart attack treatment can reduce heart muscle damage and improve recovery. Researchers are enrolling 110 adults having their first major heart attack who…

This study looked at over 17,000 people who had a heart attack to compare two blood thinners: prasugrel and ticagrelor. Hospitals switched from ticagrelor to prasugrel in a stepwise way to see which drug better prevents death, another heart attack, or stroke. The goal is to find …

This large phase 3 study tested whether milvexian, an oral blood thinner, can reduce the risk of major cardiovascular events like heart attack, stroke, or death in people who recently had an acute coronary syndrome (heart attack or unstable angina). Over 14,000 participants took …

This study looked at whether follow-up visits by phone or video are as safe as in-person visits for people who had a heart attack and received a stent. 88 patients were split into two groups: one had telemedicine check-ups at 1, 3, and 6 months, and the other had standard office …

This study tested whether a drug-coated balloon can stabilize fatty plaques in heart arteries that are at risk of rupturing and causing a heart attack. Researchers treated 45 patients with a recent heart condition, using a special balloon to deliver medication directly to the pla…

This study tested whether giving a more powerful antiplatelet drug (prasugrel or ticagrelor) for one month after a heart attack, along with a standard blood thinner, could reduce heart attacks, strokes, and deaths in people with atrial fibrillation. The 602 participants were then…

This study tested a combination of two drugs, rivaroxaban and ticagrelor, in 40 patients with atrial fibrillation who had a stent placed. The goal was to see if this combo causes less bleeding and prevents heart attacks or strokes better than current treatments. Patients took the…

This study tested whether evolocumab (Repatha), a drug that lowers LDL cholesterol, can reduce inflammation and improve heart function in people who recently had a mild heart attack (NSTEMI). Sixty participants received either evolocumab or a placebo within 24 hours of admission.…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study looked at over 3,400 people with acute coronary syndrome (a heart attack or unstable angina) who received a stent to open blocked arteries. Researchers compared two types of stents (biostable vs. biodegradable polymer) and two doses of the blood thinner prasugrel (5 mg…

This study looked at whether doing cardiac rehab at home, or a mix of home and clinic sessions, works as well as going to the clinic for all sessions. 206 heart patients participated, using a mobile health platform and home exercise. The goal was to see if flexible options could …

This study tested a new, simpler method called JINS for placing drug-coated stents in heart arteries. Researchers wanted to see if it could help achieve better stent placement while reducing extra radiation and complications from balloon inflation. The study involved 161 people w…

This study tested whether the anti-inflammatory drug colchicine can reduce complications like irregular heartbeat, heart sac inflammation, and heart damage after coronary artery bypass surgery. 100 patients who had a recent heart attack and needed bypass surgery were randomly ass…

This study looked at 556 people with coronary artery disease to confirm that the Orsiro drug-eluting stent is safe and effective in everyday use. The stent releases sirolimus to prevent artery re-narrowing. Researchers tracked how many patients had heart-related death, heart atta…

This study looked at how well the Xience Sierra drug-coated stent works in a broad group of heart disease patients, including those with diabetes or prediabetes. Over 1,700 participants received the stent during a routine procedure to open blocked arteries. Researchers tracked he…

This trial tested a new type of stent (a small mesh tube) that slowly dissolves after being placed in a heart artery. The stent is coated with a drug to prevent the artery from narrowing again. Over 1600 patients with stable heart disease or a mild heart attack received either th…

This study tested whether monthly text messages with heart-health tips could help people who had a heart attack better control their risk factors and avoid future heart problems. 370 participants received either usual care or usual care plus text messages for one year. The goal w…

This completed study looked at whether moderate-dose statins work as well as high-dose statins in lowering 'bad' LDL cholesterol after a heart attack. 190 adults aged 25-85 took either a moderate or high dose of atorvastatin or rosuvastatin daily for 3 months. The goal was to see…

This study looked at whether the drug vericiguat can help people who have had a heart attack or unstable angina and also have a weak heart (ejection fraction below 45%). The main goal was to see if it lowers the chance of dying from heart problems or being hospitalized for heart …

This study looked at whether a herbal capsule called Xuesaitong (made from Panax notoginseng) can help patients who recently had a heart attack and a stent placed. Sixty adults took the capsule for 4 weeks. Researchers measured changes in platelet genes, proteins, and metabolites…

This completed trial tested whether taking two blood thinners (clopidogrel and aspirin) for 12 months after a heart stent procedure is better than aspirin alone for people with multiple blocked coronary arteries. Over 8,000 patients were enrolled across 100 centers. The main goal…

This study tested whether taking aspirin twice a day (200 mg total) works better than the standard once-daily dose (100 mg) to prevent another heart attack, stroke, or urgent heart procedure in diabetic patients who recently had a heart attack. About 2,500 participants were follo…

This pilot study tested whether a hybrid cardiac rehabilitation program, combining a few clinic visits with mostly home-based telehealth sessions, is feasible for heart attack survivors. Ten participants were enrolled to see if they would join and stick with the program. The stud…

This study tested whether adding evolocumab, a drug that lowers bad cholesterol, to standard care helps people who recently had a heart attack. The goal was to see if it reduces cholesterol and inflammation in the heart and blood vessels. 100 adults aged 25 to 90 who had a specif…

This study tested whether adding a drug called inclisiran to standard care helps lower 'bad' LDL cholesterol more effectively in people who recently had a heart attack. About 400 participants received either the new care pathway including inclisiran or usual care alone. The goal …

This study tested whether adding a special pressure wire measurement (FFR) to standard angiography helps doctors decide the best treatment for people with multiple blocked heart arteries. Over 900 patients were randomly assigned to get either angiography alone or angiography plus…

This completed study tested whether SGLT2 inhibitors (dapagliflozin or empagliflozin), taken daily, can reduce heart failure hospitalizations, repeat heart attacks, and death in 450 non-diabetic patients who had a heart attack treated with stenting. Participants received the drug…

This study looked at whether using different blood test cutoffs for men and women can better diagnose heart attacks. Current tests use the same cutoff for both sexes, which may miss heart attacks in women and over-diagnose them in men. Researchers tested new sex-specific cutoffs …

This study is testing whether measuring a protein called copeptin in the blood, alongside the standard troponin test, can help doctors quickly rule out a heart attack in people arriving at the emergency room with chest pain. Participants with chest pain that started within the la…

This trial evaluates a new high-sensitivity blood test (Mindray hs-cTnI) for diagnosing heart attacks in people arriving at the emergency room with symptoms like chest pain. Researchers will compare the test's accuracy against an existing approved test, using blood samples taken …

This study tested whether offering genetic screening to younger heart attack patients (under 60) can uncover hidden cases of Familial Hypercholesterolemia (FH), an inherited condition causing very high cholesterol. Researchers recruited 140 patients admitted with a heart attack a…

This study tested whether a simple bedside heart ultrasound measurement, called the S' wave, can help emergency doctors quickly identify acute coronary syndrome (heart attack or unstable angina) in patients with chest pain. Researchers enrolled 66 adults who came to the ER with c…

This study tested a new software program that analyzes heart angiogram images to measure blood flow blockages without needing to insert a pressure wire into the artery. Researchers reviewed the records of 100 patients who had both an angiogram and an invasive pressure measurement…

This study tested a portable, unshielded magnetocardiography (MCG) device in the emergency department to see if it could reliably detect heart attacks. 124 patients with symptoms of acute coronary syndrome participated. The main goal was to see if the device could collect usable …

This study tested whether a clinical decision rule, combining a 5-question heart score with a rapid blood test, could safely reduce unnecessary hospital referrals for chest pain. Nearly 950 adults with new chest pain were seen by their general practitioner. The goal was to see if…

This study tested whether a non-invasive procedure called remote ischemic preconditioning (RIPC) can prevent kidney damage caused by contrast dye in diabetic patients undergoing coronary angiography. The procedure involves using a blood pressure cuff to briefly restrict blood flo…

Researchers test whether adjusting cardiac rehabilitation to each person's muscle power profile and heart rate variability helps heart attack survivors recover better. Adults who had acute coronary syndrome in the past six months and received a stent or bypass surgery join the st…

This study looks at whether tai chi exercises and wearable fitness trackers can help people who have survived a heart attack (acute coronary syndrome) become more physically active. About 70 adults who are currently inactive will take part. The goal is to see if this approach is …

This study tested whether acupressure, a technique that applies pressure to specific points on the body, can reduce anxiety and improve vital signs like blood pressure and heart rate in people hospitalized with acute coronary syndrome (ACS). Sixty-eight adults with a first-time A…

This study tested whether wearing an eye-ear sleep band, which blocks light and noise, could improve sleep quality in 100 adults admitted to a coronary care unit with acute coronary syndrome. Each patient spent one night with the band and one night with standard care, in random o…

This study followed over 1,000 people who had a heart attack and were given a quick-acting intravenous blood thinner called cangrelor during a procedure to open blocked arteries. Researchers wanted to see how often bleeding occurred when patients then switched to a different oral…

This study checked how well 109 heart attack survivors in Nepal took their prescribed medicines and what made it hard for them. Researchers used a simple questionnaire to find out. The goal is to help doctors and patients improve medicine-taking habits and prevent future heart pr…

This study looks at how a heart-lung bypass machine called VA-ECMO affects the heart's own pumping ability in people with cardiogenic shock caused by a heart attack. Researchers will measure pressure and volume inside the heart at different levels of machine support. The goal is …

This study investigates whether fibromuscular dysplasia (FMD), a condition that causes abnormal growth in artery walls, is more common in people who have had a spontaneous coronary artery dissection (SCAD) — a tear in a heart artery that can cause a heart attack, often in young w…

This study investigates whether a blood test measuring how platelets clump under high shear forces can distinguish a first acute coronary syndrome from a recurrent one. Researchers will enroll 97 adults with unstable angina or early heart attack. The goal is to see if this test o…

This study looks at whether a coaching program called BA-HD is practical and well-liked by adults who had a heart attack in the last 2 to 12 months and feel depressed. Sixty participants from three states will either get the coaching or usual care. The goal is to prepare for a la…

This study tests whether a tool called the HEART score can accurately predict the risk of serious heart problems in people who come to the emergency room with chest pain. The HEART score uses medical history, EKG results, age, risk factors, and a blood test to classify patients a…

This study looks at whether the neck-to-waist ratio can help identify patients with high blood pressure and a specific type of heart attack. Researchers measured body shapes of 238 adults arriving at the emergency room with chest pain. The goal is to see if simple body measuremen…

This study looked at 49 adults aged 30-65 who had a first heart attack about 4 months earlier. Researchers used brain scans to see if changes in the brain's blood vessels or structure are linked to memory or thinking problems. The goal is to better understand these issues and hel…

This study looked at how well two types of stents (small mesh tubes) placed in heart arteries after a heart attack become covered by the body's own cells. 22 people who had a heart attack were randomly assigned to get either a SYNERGY stent or a bioresorbable scaffold. Doctors us…

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This study tracked 555 adults hospitalized with acute coronary syndrome (a serious heart condition) to see how quickly they called for help and what factors influenced their recovery. Researchers focused on delays in calling an ambulance and how those delays affected short- and l…

This study looked at whether certain cells and substances in the blood can help predict if a person who has had a heart attack or unstable angina will have another heart problem within a year. Researchers took blood samples from 180 patients and tracked their health for one year.…

This study looked at how well hospitals follow the standard protocol for giving heparin, a blood thinner, to patients with blood clots or heart issues. Researchers checked 100 patients to see if their heparin doses were adjusted correctly based on blood test results. The goal was…

This study combined data from over 5,000 people to see if a simple blood test (troponin) and risk scores used by paramedics can accurately identify those having a heart attack before they reach the hospital. The goal is to improve how patients are triaged and treated early. No ne…

This study tested whether giving heart attack patients remote monitoring devices to use at home could reduce the need for hospital readmissions. 337 participants with high cardiovascular risk took part. The goal was to see if telemedicine could safely provide necessary diagnostic…

This study reviewed medical records of 139 people with advanced chronic kidney disease who had a heart attack. Researchers wanted to see if getting a coronary angiogram (a special X-ray of the heart arteries) soon after the heart attack was linked to living longer and needing dia…

This study looked at 552 people hospitalized with acute coronary syndrome, a serious heart condition. Researchers calculated a value called the leukoglycemic index (LGI) from routine blood tests and compared it to the SYNTAX score, which measures how complex the coronary artery d…

This study tested a new combination of very low-dose aspirin (20 mg twice daily) plus a blood thinner called rivaroxaban (2.5 mg twice daily) in 48 adults with chronic coronary syndromes. Researchers compared this new regimen to standard aspirin alone (75 mg once daily) and stand…

This study tested whether a computer-based decision support system (DSS) helps doctors start or intensify cholesterol-lowering treatments earlier in patients who have had a heart attack. Over 1,100 patients from multiple hospitals took part. The DSS provided risk estimates but di…

This study looked at how long people who had a heart attack should take two blood-thinning medicines (aspirin plus a second drug). About 5,000 patients were randomly assigned to shorter or longer treatment. The goal was to find the best balance between preventing another heart at…

This study looked at blood clots from 380 people who had a heart attack or sudden cardiac death. Researchers wanted to see if the age and makeup of the clot could explain why some people die suddenly while others survive. They compared clots from sudden death victims, heart attac…

This study tested whether an augmented reality (AR) tool, accessed via a QR code on a smartphone, could help heart patients better understand their discharge instructions. 303 adults hospitalized for heart attack, heart failure, atrial fibrillation, or pacemaker implantation took…

This study looked at how different blood-thinning drugs are used in Italian hospitals for patients having a heart attack. Researchers collected information from over 2,800 patients to see which drug combinations and timing doctors actually use. The goal was to describe current pr…

This study combined data from over 1,700 patients who had a heart attack or unstable angina and underwent a special imaging test (OCT) of their heart arteries. Researchers aimed to find factors that predict plaque erosion, a common cause of heart attacks. The goal is to better un…

This study looked at 1,655 people who had a heart attack or unstable angina (acute coronary syndrome) to create a personalized risk model. Researchers used medical tests, genetic information, and other health data to predict who might have worse outcomes or complications from tre…

This completed study of 88 heart attack patients looked at why some develop kidney injury after receiving contrast dye during a procedure to open blocked arteries. Researchers analyzed medical records to find which factors—like age, lab results, or procedure details—were linked t…

This completed study looked at whether patients hospitalized for a heart attack, stroke, or other cardiovascular event received the right medications to prevent future problems. Researchers reviewed records of 129 patients to see if doctors prescribed cholesterol-lowering drugs a…

This study looked at 10,000 people who came to the emergency room with chest pain. Researchers tested new blood markers to see if they could diagnose heart attacks faster than current methods. The goal is to help doctors quickly rule out or confirm a heart attack, especially in t…

This study looked at 2000 adults with early heart disease to understand how inherited high cholesterol (familial dyslipidemia) contributes to heart attacks. Researchers reviewed medical records to find patterns in cholesterol levels. The goal was to highlight the need for better …

This study looked at 207 older adults (65+) who came to the emergency room with a heart condition called acute coronary syndrome. Researchers measured their usual physical activity levels using a questionnaire and tracked their heart health over time. They found that people who w…

This study looked at 407 people with a type of heart attack called NSTEMI to see if getting a heart procedure (coronary angiography) within 24 hours leads to better outcomes. Researchers checked how well following this timing guideline predicted death, another heart attack, strok…

This completed study looked at how levels of C-reactive protein (CRP), a marker of inflammation, change in 35 patients having emergency angioplasty for a heart attack. Researchers took blood samples before the procedure and at several time points up to 30 days after. The goal was…

This completed study looked at 1,000 heart attack patients to understand why some have no standard risk factors like smoking, high blood pressure, or diabetes. Researchers compared these 'SMuRF-less' patients to those with risk factors, examining their medical history, lab tests,…

This completed study looked at 1029 patients who had a heart attack or unstable angina and quit smoking. Researchers checked for certain gene mutations (called CHIP) in their blood. They wanted to see if these mutations are linked to a higher chance of future heart problems, like…

This study looked at 116 people who had a cardiac arrest outside the hospital and were treated with a machine called ECMO (which pumps and oxygenates blood). Researchers measured how well the heart was pumping at 28 days and 90 days after the arrest. The goal was to understand if…

This completed study looked at how different doses of aspirin, given with or without another drug called ticagrelor, affect the body's immune response. Healthy volunteers took the medications for 10-14 days, then received an injection that causes temporary flu-like symptoms to te…

This study monitored brain oxygen levels and electrical activity in 15 children aged 6 to 36 months during open heart surgery. Sensors placed on the forehead measured oxygen and brain waves every 5 minutes. The goal was to understand how these measurements relate to each other, w…

This early-stage study tested two blood-thinning drugs, vicagrel and clopidogrel, in 18 healthy adults with a specific gene type (CYP2C19 normal metabolizers). The goal was to compare how the body absorbs and processes each drug. Researchers measured drug levels in the blood and …

This study looked at 362 adults who had a heart attack to understand why they waited before going to the hospital. Researchers collected information on symptoms, travel time, and other barriers. The goal is to find patterns that can help doctors and communities reduce delays and …