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Simple test could cut unnecessary hospital visits for chest pain

NCT ID NCT05827237

Diagnosis Sponsor: Leiden University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether a clinical decision rule, combining a 5-question heart score with a rapid blood test, could safely reduce unnecessary hospital referrals for chest pain. Nearly 950 adults with new chest pain were seen by their general practitioner. The goal was to see if the rule could accurately rule out a heart attack or major heart problems within 6 weeks to 6 months, while also being cost-effective.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Clinical decision rule (Marburg Heart Score and high-sensitive troponin I point of care test)
What this could lead to
If successful, this decision rule could help general practitioners safely identify low-risk chest pain patients, reducing unnecessary hospital referrals and healthcare costs.
What could go wrong
The rule may not be accurate enough in all populations, and false negatives could miss a heart attack. The study was completed but results are not yet widely implemented.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

946 people

The number who actually took part.

Started

Aug 2021

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥18 years of age * Acute chest pain * Seen by general practitioner Exclusion Criteria: * \<1 hour since onset of symptoms * Inability to speak or understand Dutch * Hemodynamic instability

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Conditions

The condition(s) this trial relates to.

acute coronary syndrome Chest Pain myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute coronary syndrome Chest pain Myocardial infarction

Contacts and locations

Locations

  • Leiden University Medical Center

    Leiden, South Holland, 2300 RC, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.