New model aims to predict heart attack outcomes
NCT ID NCT04068909
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 1,655 people who had a heart attack or unstable angina (acute coronary syndrome) to create a personalized risk model. Researchers used medical tests, genetic information, and other health data to predict who might have worse outcomes or complications from treatment. The goal was to help doctors make better treatment decisions, but the study did not test any new drug or procedure.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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1,655 people
The number who actually took part.
- Started
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Nov 2014
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Study population consists of consistently hospitalized patients with ACS from 4 vascular centers of Moscow, Kazan, Astrakhan and Krasnodar
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients with acute coronary syndrome without ST-segment elevation meeting the criteria of a very high, high or intermediate risk, and patients from the low-risk group, if they have episodes of myocardial ischemia in any way Very high risk (1 criterion is sufficient) * Pulmonary edema, most probably due to ischemia. * The newly appears or increased noise of mitral regurgitation. * Rhythm of the gallop, newly developed or intensified wheezing in the lungs. * Hypotension against ischemia * Ischemia refractory to treatment * Persistent ventricular tachycardia or the occurrence of ventricular rhythm disturbances during an attack of ischemia High risk (1 criterion is sufficient) * An anginal attack more than 20 minutes within the next 48 hours before admission * Transitional elevations ST (duration less than 20 min) * GRACE score \> 140 points * Increased cardiospecific markers of necrosis. (you must have at least 2 criteria) * Age\> 75 years. * Angina pectoris with transient changes ST\> 0.05 mV. Intermediate risk (1 criterion is sufficient) * Age\> 75 years. * Angina pectoris with transient changes ST\> 0.05 mV. * Inversion of the T wave on ECG (≥ 0.2 mV). * GRACE score 104-139 points (it is necessary to have at least 2 criteria) * Angina of rest (\<20 min), stopped spontaneously or with the help of nitroglycerin (NG). * Anamnesis of pathology of peripheral or cerebral arteries, * Postponed myocardial infarction, including painless, history of revascularization (PCI or CABG) * Diabetes. * Chronic renal failure (GFR \<50 mL / min) Low risk All other patients with suspicion of ACS require a survey to identify episodes of ischemia 2. Patients with acute coronary syndrome with ST-segment elevation Patients who were hospitalized with symptoms due to acute myocardial infarction (the duration of infarction is no more than 10 days, by the time of hospitalization) and at least one of the following additional criteria identified upon admission to hospital: * ST elevation: a persistent ST increase of 1 mm in two adjacent leads from the limbs, or an ST increase of 2 mm in two adjacent thoracic leads * the appearance of a new left bundle branch block * dynamics of acute myocardial infarction 3. Signed informed consent to participate in the study Exclusion Criteria: * Lack of patient consent to participate in the study * Impossibility of contact with the patient after discharge after index event
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Other studies related to the condition(s) this trial covers.
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