University Of Maryland, Baltimore

This study is testing whether doctors can safely lower radiation doses for people with HPV-positive throat cancer to reduce side effects while still keeping the cancer under control. It will enroll 132 adults who are having either surgery followed by radiation or radiation as the…

This study is testing whether a 12-week exercise program can safely help people with recently healed diabetic foot ulcers become more mobile. Researchers want to see if increasing activity through a mix of in-person and home exercises improves walking ability and overall function…

This study aims to improve the precision of radiation therapy for lung cancer by better tracking how tumors move when patients breathe. Researchers will combine a special MRI scan taken before treatment with X-ray images taken during treatment to create a more accurate motion mod…

This study compares two standard radiation treatments for cervical and endometrial cancer patients. Researchers want to see which causes fewer digestive side effects like diarrhea. The study will enroll 116 patients who will receive either proton or photon radiation therapy.

This study is testing if sending people with diabetes home from the hospital with a continuous glucose monitor (CGM) helps them manage their blood sugar better than the traditional finger-stick method. The goal is to see if better daily glucose control leads to fewer trips back t…

This study is creating and testing a new support service designed to help young people (ages 13-35) with early psychosis stay connected to their specialized treatment programs. The service uses trained 'navigators' to provide extra support to patients and families who are at risk…

This small pilot study aims to see if it's practical to run a larger trial testing a pain-blocking injection before surgery. The injection, called a nerve block, is given to older adults with broken legs to numb the area. Researchers want to know if this common pain control metho…

This study is testing a new type of membrane made from human placental tissue to see if it helps preserve jawbone better than a standard collagen membrane after a tooth is pulled. The goal is to keep the jaw from shrinking, which makes placing a dental implant later much simpler.…

This study is testing two new computer-generated risk scores designed to give doctors an early warning. One score predicts a patient's risk of developing sepsis in the next four hours, and the other predicts their risk of serious deterioration. The goal is to see if providing the…

This study aims to develop and validate a new blood test that looks for DNA changes to diagnose breast cancer. It will enroll 450 participants, including people with breast cancer, those at high risk, and healthy volunteers, over about 5 years. The goal is to create a less invasi…

This study is testing whether a specially designed mobile phone app can help young men who have sex with men better manage their HIV risk and care. It will compare two groups: one that gets immediate access to the app for 12 months, and another that gets delayed access. The main …

This study aims to see if giving the antibiotic vancomycin by mouth can prevent a serious gut infection called C. diff in older patients who are already taking other antibiotics. About 200 participants will be randomly assigned to either receive the vancomycin pill along with the…

This study is testing a wearable robot designed to help people who have recently had a stroke or traumatic brain injury (TBI) regain movement in their legs. The robot guides patients through stretching, sensory stimulation, and movement games, even if they are currently paralyzed…

This study tests whether using virtual reality (VR) for exercise can help older adults stay active during hospital stays. Researchers want to see if VR exercise is practical and helps patients maintain their physical strength and mental well-being while hospitalized. The study wi…

This study is testing whether a personalized exercise app called Gingko Active helps improve strength, balance, and endurance better than following exercises from a standard paper booklet. Researchers will enroll 60 adults aged 45 and older, including those with well-managed high…

This is a small, early-stage study to check if a common diabetes pill (glibenclamide) is safe and might help reduce nerve pain in people with multiple sclerosis (MS). Ten participants will first take the drug for a few days to ensure it's safe, then continue for three months to s…

This study is testing whether a portable electrical stimulation device can be used safely and effectively at home by people with frozen shoulder. Ten participants will use the device daily for four weeks alongside their usual clinic therapy. Researchers want to see if this home t…

This study is testing if chewing sugar-free gum can make the bowel preparation for a colonoscopy easier to tolerate. Researchers will randomly assign 160 participants to either chew gum or not during their prep to see if it reduces nausea and discomfort. The goal is to find a sim…

This study is testing whether a ketone supplement drink can help reduce cravings and ease withdrawal symptoms for people with opioid use disorder. Fifty adults starting inpatient withdrawal treatment will take either the ketone drink or a placebo three times a day for a week. Res…

This study is testing a special robotic elliptical machine to see if it can help people with knee osteoarthritis. The machine is designed to train the muscles that control side-to-side and twisting knee motions, which are important for joint stability. Researchers want to see if …

This study aims to see if structured activities can help reduce apathy—a lack of motivation or interest—in older adults with memory problems living in assisted living. Researchers will compare two activities: a personalized volunteering opportunity within the community and a guid…

This study is testing a new 6-month training program for assisted living staff to improve their daily care interactions with residents who have Alzheimer's or related dementias. It will involve 100 residents across four communities. The goal is to see if better interactions can r…

This study aims to find new signs in eye scans that show how the multiple sclerosis (MS) drug ublituximab is working inside the body. Researchers will enroll 30 people with relapsing MS—half starting the drug and half on other stable treatments—and perform special eye scans over …

This study aims to understand why some people's windpipes narrow (tracheal stenosis) and how the tissue heals after standard procedures to open it. Researchers will compare two common surgical techniques in 40 patients and analyze tiny tissue samples to see how genes change durin…

This study aims to see if a specific, guided method for giving fluids during heart surgery helps protect the kidneys from injury. It will compare this guided method to standard care in 100 adults having common heart operations. Researchers will measure special markers in the bloo…

This study aims to understand how different people respond to the diabetes medication sitagliptin. Researchers are recruiting 400 healthy, non-diabetic volunteers from the Old Order Amish community in Pennsylvania. Participants will take part in two clinic visits over 7 weeks whe…

This study aims to understand how the nasal spray flu vaccine affects the immune system in the nose and throat. Researchers will give the FDA-approved nasal vaccine to 25 people scheduled for tonsil or adenoid removal surgery for sleep apnea. They will then study the removed tiss…

This study aims to see if a future, larger trial comparing surgery to non-surgical care for pelvic fractures in older adults is possible. It will follow 120 patients to check if patients and surgeons are willing to participate in such a trial and if patient data can be collected …