University Of Maryland, Baltimore

This phase 2 trial tests whether the immunotherapy drug cemiplimab can be used alone before surgery for certain patients with early-stage non-small cell lung cancer (NSCLC) that can be removed. The goal is to see if some patients can safely skip chemotherapy and its harsh side ef…

This study tests whether a surgical guide with an internal irrigation channel can reduce heat generated during dental implant surgery. Heat from drilling can damage bone and affect implant healing. The trial compares this new guide to the standard external irrigation method in 40…

This study tests whether a membrane made from donated placental tissue can better preserve the jawbone after a tooth is pulled, compared to a standard collagen membrane. Twelve adults needing a single back tooth extracted and later replaced with a dental implant will take part. T…

This study tests a drug called mirikizumab, which is already approved for other conditions, in people with schizophrenia who have a specific immune marker (AGA IgG antibodies). The goal is to see if it can improve negative symptoms like lack of motivation and pleasure, as well as…

This study tests a combination of high-protein supplements, mobility-based physical therapy, and neuromuscular electric stimulation in older adults (60+) who have been in the ICU for at least two weeks and now have muscle weakness. The goal is to see if this approach can improve …

This study tests whether giving people with diabetes a continuous glucose monitor (CGM) when they leave the hospital helps them control their blood sugar better than traditional finger-stick testing. 120 participants will be randomly assigned to use either a CGM or finger sticks …

This study is testing a new blood test that looks for changes in DNA to help diagnose pancreatic cancer. Researchers will collect blood samples and medical records from 450 people with or at high risk for pancreatic cancer. The goal is to see if this test can find cancer earlier …

This early-stage study tests whether wearable biosensors (like a wristband or earphones) can detect malaria infection before symptoms appear. 32 healthy adults will be exposed to the malaria parasite or a placebo in a controlled setting. Researchers will compare biosensor reading…

This study is testing a new blood test that looks for specific DNA changes (called epigenetic changes) to help diagnose breast cancer. Researchers will collect blood samples from 450 people, including those with breast cancer, healthy volunteers, and others, and follow them for a…

This study is for people with HPV-related oropharyngeal (throat) cancer, which often responds well to treatment. The goal is to see if lowering the radiation dose to certain areas can reduce side effects like dry mouth without hurting the chance of curing the cancer. About 132 pa…

This study tests two simple activities—volunteering inside the assisted living community or joining a current events discussion group—to see if they can reduce apathy in residents with mild to moderate memory problems. About 200 people aged 55 and older will take part for 6 month…

This trial tests whether taking a placebo pill that patients know is inactive — called an open-label placebo — can help reduce chronic pain from temporomandibular disorders (TMD). Some participants also receive a brief behavioral session to boost their expectations. The study foc…

This study tests a robot-aided elliptical trainer designed to improve knee control in directions other than just bending and straightening. The goal is to reduce knee pain and improve function in 36 adults aged 45-85 with knee osteoarthritis. Participants will use the device to r…

This study tests a mobile app called DockTales, designed for adults with chronic pain. The app lets users track pain and sleep through short diaries, body maps, and journaling, with an optional AI feature for reflection. Researchers want to see if the app is easy to use and engag…

This study tests whether a ketone supplement drink can reduce cravings and withdrawal symptoms in adults with opioid use disorder who are undergoing detox in a treatment center. Fifty participants will receive either the ketone drink or a placebo three times daily for seven days.…

This trial compares standard radiation therapy with a new method that specifically avoids damaging small airways in the lungs. The goal is to see if this airway-sparing approach helps patients with stage III non-small cell lung cancer retain better breathing function after treatm…

This study explores whether using a virtual reality headset can help reduce pain for adults with sickle cell disease during a painful crisis. Participants will try different types of headset experiences—like watching a 2D video or exploring a 3D world—during their infusion center…

This Phase 2 study tests lebrikizumab (Ebglyss) in 15 adults with moderate-to-severe prurigo nodularis, a skin condition causing intense itching and hard bumps. Participants receive injections every two weeks for 24 weeks. The main goals are to measure how much itching decreases …

This study looks at whether using a home-based electrical stimulation device, along with standard physical therapy, can help reduce pain and improve shoulder function in people with frozen shoulder. Ten adults diagnosed with the condition will use the device at home while continu…

This study compares two doses of the antibiotic ceftriaxone for adults hospitalized with pneumonia (but not in the ICU). The goal is to see if a 1-gram daily dose works just as well as a 2-gram daily dose while causing fewer side effects. About 430 participants will be followed t…

Low-risk thyroid cancer grows very slowly and has a 99% survival rate, but choosing among three treatment options can be stressful. This study gives patients a decision aid pamphlet right after diagnosis, before they see a surgeon. The pamphlet explains the options and lists ques…

This early study tests whether an extended-release form of glibenclamide (glyburide), a diabetes drug, can safely reduce nerve pain in people with multiple sclerosis. Ten adults with MS and moderate-to-severe nerve pain will receive either the drug or a placebo. The main goal is …

This study tests whether a 12-week exercise program can safely improve mobility in people aged 50 and older who have recently healed from a diabetic foot ulcer. Participants will either do seated cycling and strength exercises or follow standard care guidance. The goal is to see …

This study aims to develop and validate a new questionnaire to measure opioid withdrawal symptoms. Researchers will work with people who have experienced opioid withdrawal to identify all possible symptoms and refine the tool through interviews and testing. The goal is to create …

This study looks at how 'leaky' the gut is and what bacteria live in the intestines of 150 very low birth weight preterm babies. Researchers want to understand why some babies develop a life-threatening gut emergency called NEC. They will measure gut permeability using harmless s…

This study looks at whether using a special fluid management system (ACUMEN) during heart surgery can help prevent kidney damage. About 100 adults having bypass or valve surgery will be enrolled. Researchers will measure kidney injury markers and track how much fluid is given, ai…

This study aims to understand why some people develop a narrowing of the windpipe (tracheal stenosis) and how the tissue heals after standard laser treatments. Researchers will analyze small tissue samples taken during two common procedures—wedge resection and radial incision—in …

This study looks at how healthy people without diabetes respond to sitagliptin, an FDA-approved diabetes medication. Researchers want to understand why some people's bodies process sugar differently after taking the drug. About 400 healthy Amish adults will take part in two clini…

This study will give the nasal flu vaccine to 25 people who are already scheduled to have their tonsils or adenoids removed for sleep apnea. Researchers will then study the removed tissue to see how the vaccine affects immune cells near the nose. The goal is to better understand …