University Of Maryland, Baltimore

This study aims to see if modern, intensive medication therapy alone can keep the one-year stroke risk below 5% for people who have had a minor stroke or warning sign and a narrowed neck artery. It will observe 114 participants who are considered lower risk, tracking their health…

This is a first-in-human safety study testing a new, experimental CAR-T cell therapy called CAR19.20.22 in adults with B-cell lymphomas that have returned or not responded to at least two prior treatments. The therapy uses the patient's own immune cells, engineered to attack canc…

This small pilot study is testing whether providing e-cigarettes is a practical way to help adults aged 50 and older, who are in treatment for opioid addiction and currently smoke, switch from regular cigarettes. Participants are not trying to quit smoking. The study compares giv…

This study compares three different dental procedures for treating deep cavities in children's baby molars. The goal is to see which method works best to save the tooth, prevent pain, and avoid extraction. The procedures involve either removing part of the tooth's inner pulp or s…

This is an early safety study testing a new drug called CRD3874-SI in adults with acute myeloid leukemia that has returned or not responded to other treatments. The drug is designed to activate a protein in the body called STING, which may help the immune system find and kill can…

This early-stage study is testing whether suvorexant, a medication approved for insomnia, might help people with opioid addiction by reducing their desire to use drugs. About 75 participants with opioid use disorder will stay in a hospital for about two weeks. They will receive e…

This study is testing a home-based telehealth program designed to help coordinate medical and mental health care for people with serious mental illnesses like schizophrenia or bipolar disorder. It will enroll 300 adults who receive services from community mental health agencies t…

This study is testing if adding an experimental drug called bavituximab to an approved immunotherapy (pembrolizumab) can help control advanced head and neck cancer that has started growing again after prior immunotherapy. It is for adults whose cancer has spread or returned and w…

This study is testing if adding a short, precise course of radiation (SBRT) to standard immunotherapy and chemotherapy is safe for people with extensive-stage small cell lung cancer. It focuses on patients whose cancer does not shrink enough after the first two cycles of standard…

This early, withdrawn study aimed to see if a natural hormone called GLP-1 could protect the blood vessels of people with type 1 diabetes from damage caused by repeated episodes of low blood sugar (hypoglycemia). The researchers wanted to test if giving GLP-1 during these episode…

This study is testing whether a special diet can help control symptoms of schizophrenia. Fifty adults with schizophrenia or schizoaffective disorder will follow either a ketogenic diet (very low in carbs, high in fat) or a standard diet for comparison. Researchers will measure ch…

This study is testing whether a smartphone app and special 'smart' labels can help people with Crohn's disease or ulcerative colitis remember to take their medication. About 123 adults starting a new pill or injection treatment will use the app for a year. The goal is to see if t…

This study is testing a program to help people living with HIV in Botswana quit smoking. It combines counseling support with a quit-smoking medication called varenicline. The goal is to reduce the serious health risks smoking adds to HIV and see if this approach can work well in …

This pilot study is testing whether a full hip replacement (arthroplasty) leads to better recovery than the standard metal screws (internal fixation) for older adults with a specific type of hip fracture. It involves 40 participants aged 60+ and will follow them for one year to g…

This study aimed to find the best length of time for patients to take antibiotics after surgery to clean an infected knee or hip replacement. It planned to compare different treatment durations to see which one best prevents the infection from coming back while minimizing side ef…

This study aims to find out how common undiagnosed atrial fibrillation (an irregular heartbeat) is in women over 70, a group at high risk for stroke. Researchers are enrolling 120 women with no prior diagnosis to wear a heart monitor for two weeks. The goal is to detect this cond…

This study aimed to see if an ultrasound machine or a special near-infrared light device (called a VeinViewer) works better to find veins in adults who are hard to stick for an IV in the emergency room. The goal was to reduce wait times and improve the first-attempt success rate …

This large study in Mali is testing whether giving a single dose of the antibiotic azithromycin to pregnant women during prenatal care and to infants during vaccination visits can prevent stillbirths and reduce deaths in babies up to one year old. Nearly 100,000 participants will…

This study is testing if a specific eating pattern can help prevent frailty in older men undergoing hormone therapy for prostate cancer. Researchers will compare a 12-week program of time-restricted eating (eating all meals within a set daily window) to a regular diet. The goal i…

This study aimed to see if a new way to measure and fit the part of a breast pump that goes on the breast (called a flange) helps parents of babies in the NICU. Parents would have been randomly assigned to try the new fitting method or the standard one. The main goal was to see i…

This study is testing whether using immersive virtual reality (VR) can help reduce chronic jaw pain. Researchers are comparing real VR to a fake VR placebo to see how each affects the brain's natural pain control systems. They are working with about 260 adults who have had jaw pa…

This early-stage study is testing a new, non-surgical procedure for people with severe, medication-resistant facial pain called trigeminal neuralgia. Doctors use an MRI machine to guide focused ultrasound waves through the skull to target a tiny area deep in the brain. The goal i…

This study aims to understand how low blood sugar affects blood vessel function and increases the risk of heart problems. Researchers are testing whether a natural gut hormone called GLP-1 can change these harmful effects. The study involves 28 adults, half with type 2 diabetes a…

This study aims to teach clinicians and researchers how to guide others in using a medical ketogenic diet, which is a very low-carb, high-fat eating plan. The 40 participants will first take a class and then have the option to try the diet themselves for four weeks in a group set…

This study is a first step to see if a larger trial is possible. It aims to find out if researchers can successfully recruit patients and collect good data to compare two recovery approaches after leg or hip fracture surgery: walking immediately versus waiting 6-12 weeks. The goa…

This study aims to learn how the oral typhoid vaccine affects the normal bacteria and immune system in the intestines. Researchers are enrolling adults already scheduled for a routine colonoscopy and dividing them into groups that either receive the vaccine before or after the pr…

This study is testing whether older adults (age 55+) receiving methadone treatment for opioid addiction can use brief, game-like smartphone tasks to measure their memory and focus. Over 15 days, 30 participants will complete short daily brain games to see if this remote approach …

This study aims to understand how regular physical activity during pregnancy affects the placenta's health and function. Researchers will follow 40 pregnant women, collecting health information and biological samples to see if active lifestyles improve how the placenta supports t…

This small lab study is checking if a single dose of the pain reliever diclofenac changes a specific brain chemical in people with alcohol use disorder. Twelve participants will take either the drug or a placebo pill once, and researchers will measure their blood. The goal is to …

This study aims to understand if a person's genes can predict how they will respond to a common diabetes drug called canagliflozin. Researchers are giving the drug to 700 healthy Amish volunteers and measuring its effects on the body. They will then look for genetic patterns link…

This study is testing whether existing, approved drugs can help red blood cells work better under extreme stress from cold temperatures and low oxygen, like those found at high altitudes. Researchers will take blood samples from 50 healthy adults to see how the drugs affect the c…

This study aims to find out which of two common Invisalign attachment designs works better. Researchers will compare 'optimized' and 'conventional' attachments to see which one bonds to teeth more precisely and keeps its shape longer during treatment. The goal is to help make Inv…