University Of Maryland, Baltimore

This early-stage study tested the safety and immune response of a new oral vaccine designed to prevent two common bacterial causes of severe diarrhea: Shigella and a type of E. coli (ETEC). Healthy adult volunteers received either the vaccine or a placebo in a single dose, and re…

This study tested whether a chewing gum containing dietary nitrate (a compound found in vegetables like beets) could improve gum health and heart health. For three weeks, adults with mild to moderate gum irritation chewed either the special gum or a placebo gum. Researchers measu…

This early-stage study tested the safety and best dose of a two-drug combination (venetoclax pills plus pegcrisantaspase infusions) for adults with acute myeloid leukemia (AML) that has returned or didn't respond to previous treatments. The goal was to see if this new combination…

This small pilot study tested a counseling program adapted for young adults experiencing their first episode of psychosis who also use cannabis. The program aimed to educate participants about lower-risk cannabis use, help them stay engaged in their mental health care, and take t…

This small, completed pilot study tested if using newer technology could help people with type 2 diabetes manage their condition better from home. Researchers gave 30 participants smart insulin pens and continuous glucose monitors (CGMs) and used telemedicine for check-ins, compa…

This study tested whether changing how lab results are reported to doctors could reduce unnecessary antibiotic prescriptions for patients on ventilators in the ICU. It involved 161 adult patients across 6 intensive care units. Researchers compared periods where labs used a modifi…

This study tested whether a special type of fast hip muscle training is better than regular strength training for preventing falls in older adults. Researchers worked with 97 generally healthy, independent adults aged 65 and older. They compared the two training methods over 12 w…

This study tested a 12-month workplace wellness program designed to reduce stress and improve heart health for staff in long-term care facilities. It involved 159 staff and residents across six sites to see if the program was practical and showed early signs of working. Researche…

This small pilot study tested whether combining a supervised aerobic exercise program with the antidepressant medication duloxetine could help older adults who have both painful knee osteoarthritis and depression. The goal was to see if this combined approach was practical to del…

This study tested whether gentle touch and massage therapy could help very premature babies in the hospital. Researchers compared 32 infants who received the therapy to those who got standard care. They wanted to see if the therapy helped babies gain weight faster, feel less pain…

This study tested a new rehabilitation program to improve arm and hand function in people living with long-term effects of a stroke. Researchers compared a combined therapy using a robot and gentle electrical muscle stimulation against therapy using just the robot. The goal was t…

This small study explored whether a 6-week home training program for breathing muscles could help childhood cancer survivors. Seven participants performed breathing exercises at home and were monitored weekly. The goal was to see if this training could improve how their bodies co…

This study tested whether using a virtual reality (VR) app at home could help improve memory, attention, and thinking skills in adults 65 and older who had a mild traumatic brain injury (like a concussion). Researchers compared a group doing VR cognitive exercises to a control gr…

This study tested a smartphone app designed to help people who recently finished cancer treatment. The app digitized their follow-up care plan, letting them track symptoms, diet, or exercise. Researchers compared the app to the usual paper-based care plan to see if it helped redu…

This study tested whether suvorexant, an FDA-approved sleep medication, improves daytime symptoms like fatigue, mood, and thinking in older adults with chronic insomnia. Forty participants were randomly assigned to receive either the medication or a placebo pill for about two wee…

This study tested whether luteolin, a natural compound found in foods like celery and chamomile tea, could help improve symptoms and thinking problems in people with schizophrenia. For 12 weeks, 85 participants with schizophrenia or schizoaffective disorder took either luteolin c…

This small study aimed to understand how a non-invasive brain stimulation technique (TMS) affects brain activity in people with schizophrenia. Ten participants received both real and fake (sham) TMS sessions while researchers measured their brain signals. The goal was to gather i…

This study aimed to understand how aging and body fat influence inflammation in the body. Researchers enrolled 100 veterans to see if a program combining moderate weight loss and aerobic exercise could reduce inflammation. The goal was to gather knowledge, not to provide a direct…

This small, early study aimed to see if two different compounded estrogen creams deliver a similar amount of hormone into the body. It involved 8 healthy postmenopausal women who applied the creams to their thighs. The main goal was to measure and compare hormone levels in the bl…

This study aimed to understand how a brain chemical called KYNA affects thinking and memory in people with schizophrenia. Researchers gave 88 participants a dietary supplement (tryptophan) to increase KYNA, and then tested if another supplement (NAC) could block its effects. They…

This early research study explored whether the antidepressant fluoxetine (Prozac) could improve the body's automatic nervous system responses during exercise in people with Type 1 diabetes. The goal was to see if the medication could help prevent dangerous drops in blood sugar (h…

This study aimed to understand how the hormone epinephrine, which the body releases during low blood sugar, affects blood vessel health and clotting factors. Researchers gave carefully controlled doses of epinephrine to 32 healthy volunteers and measured changes in blood vessel f…