University Of Maryland, Baltimore

This study tested how well the drug primaquine prevents the return of P. vivax malaria in 160 adults. Participants had uncomplicated malaria and normal G6PD levels. The goal was to see if a short treatment could stop relapses, aiming for a complete cure.

This early-stage study tested a new oral vaccine designed to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Fifty-three healthy adults received the vaccine to check for side effects and to see if it triggers an immune response. The goal is to develop …

This study tests a physical therapy program designed to help older patients who rely on a ventilator to breathe. The program includes exercises to improve strength, endurance, balance, and lung function. Researchers want to see if this approach can help patients regain mobility a…

This study tests a digital smoking cessation program called BecomeAnEx, adapted for people with serious mental illness who want to quit or reduce smoking. Participants use a website, text messaging, and real-time coaching from a remote quit-smoking expert, plus an online communit…

This pilot study looked at whether giving e-cigarettes to adults aged 50 and older who are in treatment for opioid use disorder could help them cut down on smoking. The 36 participants were not trying to quit smoking at the start. Researchers measured how many people switched to …

This study tested a new way to care for people who inject drugs and have hepatitis C. Along with standard hepatitis C treatment, participants were offered HIV prevention medication and buprenorphine for opioid use disorder. The goal was to see if this combined approach could cure…

This study tested whether H.P. Acthar Gel can improve symptoms and quality of life in people with CNS sarcoidosis, a rare condition where inflammation affects the brain and spinal cord. Four adults with the disease received the gel to see if it could control disease activity and …

This pilot study tested whether using smart insulin pens together with continuous glucose monitors (CGMs) can improve blood sugar control in adults with type 2 diabetes. Thirty participants used these devices to track their glucose levels and insulin doses. The goal was to see if…

This study tested a simple change in how lab results for respiratory cultures are reported to doctors. For patients on ventilators who did not meet clinical criteria for pneumonia, the lab report noted that the bacteria found might just be harmless colonization. The goal was to s…

This early-stage trial tested a combination of two drugs, pegcrisantaspase and venetoclax, in 27 adults whose acute myeloid leukemia had come back or not responded to standard treatments. The main goal was to find safe doses and check for side effects. Researchers also looked at …

This study tested whether a chewing gum containing dietary nitrate (a natural compound found in leafy greens and beets) could improve gum health and heart health in adults with mild gum disease. Thirty participants were randomly assigned to use either the nitrate gum or a placebo…

This pilot study tested a counseling program called the Teen Marijuana Check Up, adapted for young adults (ages 13–35) who have early psychosis and use cannabis. The program uses motivational interviewing and personalized feedback over two sessions to help participants reduce or …

This study looked at whether fast, powerful hip exercises can improve balance and reduce falls in older adults. Researchers compared high-speed hip resistance training to slower strength training in 97 healthy adults aged 65 and older. The goal was to see if faster exercises help…

This study tests whether limiting food intake to a 10-hour window each day for 12 weeks can reduce persistent fatigue in cancer survivors who completed treatment 2 months to 2 years ago. Half the participants follow the eating schedule; the other half receive general healthy life…

This trial investigates whether acupuncture can reduce pain and improve function in people with spinal cord injury. Participants receive either acupuncture with electrical stimulation plus ear acupuncture, or standard care alone, for eight weeks. The study measures pain levels, q…

This study looked at whether brief Christian prayer, given in person or virtually, can lower pain and anxiety in adults visiting a family medicine clinic. 180 participants with moderate or higher pain or anxiety were randomly assigned to receive prayer or listen to 5 minutes of r…

This study tested a home-based telerehabilitation system for veterans with multiple sclerosis. The system provided exercise instructions and tracked daily logs to help improve balance and mobility. Fifty-one participants used the system to see if it was feasible and acceptable, w…

This study tested whether luteolin, a natural supplement found in celery and chamomile tea, can improve symptoms of schizophrenia. 85 adults with schizophrenia or schizoaffective disorder took either luteolin or a placebo for 12 weeks. Researchers measured changes in overall symp…

This study looked at whether gentle touch and massage therapy can help very premature babies in the NICU. 32 babies were split into two groups: one received massage therapy plus standard care, the other received standard care alone. Researchers tracked how long each baby stayed i…

This study tested a smartphone app called POSTHOC that helps cancer survivors manage symptoms and track healthy behaviors after finishing treatment. Fifty-one adults who recently completed cancer therapy used the app or received standard care for 12 weeks. The goal was to see if …

This study tested whether combining robotic arm training with functional electrical stimulation (FES) helps people with chronic stroke improve arm movement more than robotic training alone. 24 adults who had a stroke at least 6 months earlier participated. The goal was to see if …

This study tested whether virtual reality (VR) exercises can improve memory and thinking in adults aged 65 and older who had a mild traumatic brain injury. Thirty participants used VR at home for six weeks. The goal was to see if VR could help with attention, memory, and visual s…

This study tested suvorexant (Belsomra), an FDA-approved sleep medication, in 40 older adults with insomnia. Participants took the drug or a placebo for two weeks while wearing a motion tracker and completing smartphone surveys about their sleep, mood, and thinking. The goal was …

This study looked at whether adding the antidepressant duloxetine to a walking program helps older adults with both knee osteoarthritis and depression. All 43 participants received the same combination treatment. The goal was to see if the approach is feasible and if it reduces p…

This trial investigates whether genetic variations in the CES1 gene influence how the body responds to the blood thinners clopidogrel and aspirin. Healthy Amish adults will take clopidogrel for a week, then a single dose of aspirin, with blood tests measuring platelet function be…

This study looks at whether older adults (55+) in methadone treatment for opioid use disorder can use smartphone-based cognitive games to track and possibly improve their thinking skills. Thirty participants will play short brain-training tasks twice a day for 15 days. The main g…

This study aims to create a better tool for measuring opioid cravings in people being treated for opioid use disorder. Researchers will show participants opioid-related images and objects, then interview them about their feelings and thoughts. The goal is to improve how cravings …

This trial investigates how a single oral dose of cannabigerol (CBG), a natural compound from the cannabis plant, affects healthy adults. Over five sessions, participants receive either a placebo or one of four doses of CBG, then undergo eight hours of monitoring including blood …

This trial investigates whether a common genetic variation in the CES1 gene affects how the body processes two antiplatelet drugs, clopidogrel and ticagrelor. Healthy volunteers of Amish descent will take each drug for eight days in a crossover design, and researchers will measur…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study looked at how watching someone else experience pain relief can actually reduce your own pain. Researchers used brain scans to see which parts of the brain are involved in this effect. 211 healthy adults took part, and the goal was to understand the brain mechanisms beh…

This study looked at whether a 6-week breathing muscle training program is possible for childhood cancer survivors and how it affects their breathing during exercise. Seven survivors who finished cancer treatment at least a year ago took part. The goal was to see if they could st…

This study tested whether a 6-week breathing muscle training program is feasible for typically developing children aged 6-12. Researchers measured how well children completed the training and how it affected their breathing during exercise. The goal was to understand the diaphrag…

This study looked at 100 overweight veterans to see if losing weight and doing aerobic exercise could lower inflammation linked to aging. Researchers measured inflammatory chemicals from fat tissue and checked fitness, body composition, and blood sugar. The goal was to understand…

This study looked at how a supplement called N-acetylcysteine (NAC) affects brain chemicals and thinking in 88 adults with schizophrenia or related disorders. Participants took tryptophan to raise a brain chemical called kynurenic acid, then had cognitive tests and brain scans. T…

This study looked at how a non-invasive brain stimulation technique called TMS affects brain activity in people with schizophrenia. Ten participants received both real and fake TMS in separate sessions. Researchers measured brain connections and electrical signals before and afte…

This study tested a worksite wellness program designed to reduce stress and improve cardiovascular health among long-term care workers. 159 staff and residents participated. The program included health promotion and safety education, and researchers also looked at whether healthi…

This study looked at whether two specially made estrogen creams deliver similar amounts of the hormone into the blood. Eight postmenopausal women aged 45 to 65 used both creams, and researchers measured hormone levels after single and repeated use. The goal was to check quality, …

This completed early-phase study looked at how epinephrine (adrenaline) affects blood vessel function and clotting in 32 healthy adults. Researchers gave participants epinephrine or a placebo and measured changes in artery dilation. The goal was to better understand why people wi…

This early study tests whether the antidepressant fluoxetine (Prozac) can improve the body's nervous system response during exercise in people with type 1 diabetes. Many with diabetes avoid exercise due to fear of low blood sugar. The study includes 64 adults—half with type 1 dia…