University Of Maryland, Baltimore

This trial tests whether a weekly IV antibiotic called oritavancin, given alongside medication for opioid use disorder, can help people finish treatment for serious infections like bloodstream or bone infections without needing to stay in a nursing facility. The study enrolls adu…

This phase 2 trial tests a new approach called UPPROACH for people with loco-regionally advanced endometrial cancer who have had surgery. The treatment combines intensity-modulated proton beam therapy (IMPT) with standard chemotherapy (carboplatin and paclitaxel) given at the sam…

This study tested a dramatic approach: rapidly cooling trauma patients whose hearts had stopped from severe bleeding. Doctors flushed ice-cold saline into the aorta to induce deep hypothermia, then performed emergency surgery to stop the bleeding before slowly rewarming the patie…

This study looked at whether adding the drug pioglitazone to a keyhole brain surgery (MIPS) could help people recover from a severe bleeding stroke. Only one person took part before the study was stopped early. The goal was to see if the combination was safe and helped clear the …

This study tested whether imatinib, a drug used for certain cancers, could help hospitalized adults with COVID-19. Participants received either imatinib or a placebo alongside standard care. The trial was stopped early and only included 21 people, so no firm conclusions can be dr…

This early-phase trial tested whether nicotinamide riboside (a form of vitamin B3 sold as Niagen) could help repair nerve damage in people with type 2 diabetes or prediabetes. Only 10 participants were enrolled before the study was terminated. The main goal was to measure changes…

This study tests a new type of MRI scan that uses a special contrast agent called hyperpolarized pyruvate to see how prostate cells use energy. The goal is to safely distinguish cancerous from normal tissue in men with suspected or known prostate cancer. Participants receive the …

This study looked at whether intensive treatment for gum disease (periodontitis) could prevent dementia in older adults who already have mild cognitive impairment and narrowed neck arteries. Participants received either standard dental care or deep cleaning and root planing. The …

This study tested whether a 12-week program of walking and resistance exercises or nutrition education could reduce nerve pain caused by platinum chemotherapy. The trial enrolled 36 adults with cancer who were receiving oxaliplatin or cisplatin. The study was terminated early, so…

This study looked at whether body weight affects how breast cancer responds to aromatase inhibitors (AIs) like Anastrozole and Letrozole. Researchers gave standard doses of these drugs to 42 postmenopausal women with hormone-sensitive breast cancer before surgery. The goal was to…